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Toxins in Drug Discovery and Pharmacology

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ISBN: 9783038428619 9783038428626 Year: Pages: XII, 304 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Public Health
Added to DOAB on : 2018-05-04 11:37:49
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Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as untapped cocktails of biologically active compounds that are being increasingly recognized as a new emerging source of peptide-based therapeutics. Venomous animals are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharmacology for their own biological purposes by producing venoms that contain a structural and functional diversity of neurotoxins. These neurotoxins appear to be highly selective ligands for a wide range of ion channels and receptors. Therefore, they represent interesting lead compounds for the development of analgesics, anti-cancer drugs, drugs for neurological disorders such as multiple sclerosis, Parkinson' s disease, Alzheimer' s disease, and other therapeutics.This Special Issue of Toxins aims to provide a comprehensive look at toxins and toxin-inspired leads and will focus on the mechanisms of action, structure–function relationships, and evolution of pharmacologically interesting venom components, including the most recent developments related to the emergence of venoms as an underutilized source of highly evolved bioactive peptides with clinical potential.

Recent Advances in Hydro- and Biohydrometallurgy

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ISBN: 9783039212996 / 9783039213009 Year: Pages: 212 DOI: 10.3390/books978-3-03921-300-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This Special Issue of Minerals presents recent, select studies that highlight advances in the fields of hydro- and biohydrometallurgy. It aims to attract the interest of readers and especially of young scientists and students in this fascinating scientific discipline.

Berry Crop Production and Protection

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ISBN: 9783039210947 / 9783039210954 Year: Pages: 158 DOI: 10.3390/books978-3-03921-095-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General)
Added to DOAB on : 2019-08-28 11:21:27
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Berry crops include, but are not limited to, the genera: Fragaria (strawberry, Rosaceae), Ribes (currant and gooseberry, Grossulariaceae), Rubus (brambles: raspberry and blackberry; Rosaceae), Vaccinium (blueberry, cranberry and lingonberry; Ericaceae) and Vitis (grapes, Vitaceae). The significant role of these fruits in maintaining human health has increased their popularity and production, dramatically, across the world. This Special Issue of Agronomy covers berry crops in the areas of breeding, genetics, germplasm, production systems, propagation, plant and soil nutrition, pest and disease management, postharvest, health benefits, marketing and economics and other related areas. The aim will be to bring together a collection of valuable articles that will serve as a foundation of innovative ideas for production and protection of health-promoting berry crops in changed environment.

Multi-Walled Carbon Nanotubes

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ISBN: 9783039212293 / 9783039212309 Year: Pages: 184 DOI: 10.3390/books978-3-03921-230-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-08-28 11:21:27
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Since their discovery, multi-walled carbon nanotubes (MWCNTs) have received tremendous attention due to their unique electrical, optical, physical, chemical, and mechanical properties. Remarkable advances have been made in the synthesis, purification, structural characterization, functionalization, and application of MWCNTs. Their particular characteristics make them well suited for a plethora of applications in a number of fields, namely nanoelectronics, nanofluids, energy management, (electro)catalysis, materials science, construction of (bio)sensors based on different detection schemes, multifunctional nanoprobes for biomedical imaging, and sorbents for sample preparation or removal of contaminants from wastewater. They are also useful as anti-bacterial agents, drug delivery nanocarriers, etc. The current relevant application areas are countless. This Special Issue presents original research and review articles that address advances, trends, challenges, and future perspectives regarding synthetic routes, structural features, properties, behaviors, and industrial or scientific applications of MWCNTs in established and emerging areas.

Keywords

water based nanofluid --- carbon-nanotubes --- boundary layer --- heat generation --- thermal radiation --- curved stretching sheet --- numerical solution --- Single-Walled Carbon Nanotube (SWCNT) --- Multi-Walled Carbon Nanotube (MWCNT) --- MHD --- Casson model --- stretching sheet --- non-linear thermal radiation --- HAM --- zeolitic imidazolate framework --- multi-walled carbon nanotubes --- magnetic solid phase extraction --- organochlorine pesticides --- agricultural irrigation water --- Pd-CNT nanohybrids --- functionalized CNTs --- polarity --- semi-homogeneous catalysis --- heck reaction --- nanomaterials --- multi-walled carbon nanotubes --- synthesis methods --- electrochemical properties --- electrochemical sensors --- electroanalysis --- sensing applications --- multiwalled carbon nanotubes --- gold(I) --- gold(III) --- adsorption --- elution --- gold nanoparticles --- adsorption --- multi-walled carbon nanotubes --- nonylphenol --- kinetics --- multi-walled carbon nanotubes --- graphene oxide --- cerium oxide --- lubricating oil additives --- multi-wall carbon nanotube (MWCNT) --- azide-alkyne click chemistry --- RAFT polymerization --- PMMA --- carbon nanotubes --- composites --- radar absorbing materials --- complex permittivity --- chloride diffusion --- cement mortars --- carbon nanotubes --- mechanical properties --- electrical properties --- hydrophobic drugs --- drug delivery --- functionalized carbon nanotubes --- dissolution rate --- nanomedicine --- polymeric composites --- silicone rubber --- Ionic liquid --- carbon materials --- structural --- EMI shielding --- n/a

Coordination Chemistry of Silicon

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ISBN: 9783038976387 Year: Pages: 225 DOI: 10.3390/books978-3-03897-639-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Inorganic Chemistry
Added to DOAB on : 2019-03-08 11:42:05
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The chemistry of silicon has always been a field of major concern due to its proximity to carbon on the periodic table. From the molecular chemist's viewpoint, one of the most interesting differences between carbon and silicon is their divergent coordination behavior. In fact, silicon is prone to form hyper-coordinate organosilicon complexes, and, as conveyed by reports in the literature, highly sophisticated ligand systems are required to furnish low-coordinate organosilicon complexes. Tremendous progress in experimental, as well as computational, techniques has granted synthetic access to a broad range of coordination numbers for silicon, and the scientific endeavor, which was ongoing for decades, was rewarded with landmark discoveries in the field of organosilicon chemistry. Molecular congeners of silicon(0), as well as silicon oxides, were unveiled, and the prominent group 14 metalloid proved its applicability in homogenous catalysis as a supportive ligand or even as a center of catalytic activity. This book focuses on the most recent advances in the coordination chemistry of silicon with transition metals as well as main group elements, including the stabilization of low-valent silicon species through the coordination of electron donor ligands. Therefore, this book is associated with the development of novel synthetic methodologies, structural elucidations, bonding analysis, and also possible applications in catalysis or chemical transformations using related organosilicon compounds.

Keywords

silanetriols --- disiloxane tetrols --- silsesquioxanes --- condensation --- molecular cage --- platinum --- primary silane --- hydrido complex --- oxidative addition --- ligand-exchange reaction --- X-ray crystallography --- Si–Cl activation --- germylene --- digermene --- digermacyclobutadiene --- palladium --- cluster --- cyclic organopolysilane --- template --- bridging silylene ligand --- isocyanide --- hydrogen bonds --- silicon --- 2-silylpyrrolidines --- stereochemistry --- X-ray crystallography --- Baird’s rule --- computational chemistry --- excited state aromaticity --- Photostability --- dye-sensitized solar cell --- disilanylene polymer --- photoreaction --- surface modification --- TiO2 --- silylene --- germylene --- N-heterocyclic carbene --- oxidative addition --- siloxanes --- host-guest chemistry --- supramolecular chemistry --- main group coordination chemistry --- hydrogen bonding --- adsorption --- bond activation --- bonding analysis --- density functional theory --- distorted coordination --- molecular orbital analysis --- silicon surfaces --- disilene --- functionalization --- ?-electron systems --- silicon --- N-heterocyclic carbenes --- bromosilylenes --- silyliumylidenes --- dehydrobromination --- silicon cluster --- siliconoid --- nanoparticle --- computation --- silicon --- N-heterocyclic carbenes --- silyliumylidenes --- small molecule activation --- mechanistic insights --- organosilicon --- reductant --- N-Heterocyclic tetrylene --- salt-free --- germanium --- germanethione --- germathioacid chloride --- N-heterocyclic carbines --- ?-chloro-?-hydrooligosilane --- titanium --- ruthenium --- dehydrogenative alkoxylation --- cluster --- isomerization --- silicon --- siliconoid --- subvalent compounds --- AIM --- DFT --- intermetallic bond --- 29Si NMR spectroscopy --- X-ray diffraction

Polymeric Materials: Surfaces, Interfaces and Bioapplications

Authors: --- --- --- --- et al.
ISBN: 9783038979623 / 9783038979630 Year: Pages: 342 DOI: 10.3390/books978-3-03897-963-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General)
Added to DOAB on : 2019-06-26 08:44:06
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This book collects the articles published in the Special Issue “Polymeric Materials: Surfaces, Interfaces and Bioapplications”. It shows the advances in polymeric materials, which have tremendous applications in agricultural films, food packaging, dental restoration, antimicrobial systems, and tissue engineering. These polymeric materials are presented as films, coatings, particles, fibers, hydrogels, or networks. The potential to modify and modulate their surfaces or their content by different techniques, such as click chemistry, ozonation, breath figures, wrinkle formation, or electrospray, are also explained, taking into account the relationship between the structure and properties in the final application. Moreover, new trends in the development of such materials are presented, using more environmental friendly and safe methods, which, at the same time, have a high impact on our society.

Keywords

corn stalk fiber --- friction composite --- friction and wear --- worn surface morphology --- antifouling coatings --- biofouling --- natural biofilms --- single-stranded conformation polymorphism --- polydimethylsiloxane --- multidimensional scale analysis --- antimicrobial coatings --- porous surfaces --- breath figures --- antimicrobial polymer --- coatings --- hydrogel --- protein-repellent polymer --- surface-attached polymer network --- polymer cross-linking --- alginate modification --- calcium chloride --- microparticles --- spray drying --- prolonged drug release --- gradient wrinkles --- UV/ozone --- irradiance --- polymeric composites --- bonding agents --- antibacterial --- oral biofilms --- periodontal pathogens --- caries inhibition --- recycling --- polypropylene --- biodegradable polymers --- degradation --- inmiscibility --- hemicelluloses --- chitosan --- composite films --- oxygen barrier property --- food packaging --- nanosecond laser surface modification --- ABS (Acrylonitrile-Butadiene-Styrene) --- surface wettability --- superhydrophobic --- superhydrophilic --- poly(x-chlorostyrene) --- honeycomb --- breath figures --- conformational entropy --- spinal anatomy --- intervertebral disc --- degenerative disc disease --- herniated disc --- spinal fusion --- total disc replacement --- tissue engineering --- Electrically conductive polymers --- Electroactive biomaterials --- Electrical stimulation --- Smart composites --- Bioelectric effect --- Drug delivery --- Artificial muscle --- bio-based --- fossil --- hybrids --- blends --- packaging --- bio-based polymers --- antimicrobial --- biodegradable --- sustainable --- eco-friendly --- graphene oxide --- chitosan --- composites --- scaffolds --- tissue engineering --- surface modification/functionalization --- surface segregation --- micro- and nanopatterned films --- blends and (nano)composites --- coatings --- surface wettability --- stimuli-responsive materials/smart surfaces --- bioapplications

Polymer Clay Nano-composites

Author:
ISBN: 9783039216529 / 9783039216536 Year: Pages: 246 DOI: 10.3390/books978-3-03921-653-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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This Special Issue focuses on the current state-of-the-art of “Polymer Clay Nano-Composites” for biomedical, anticorrosion, antibacterial, and other applications. Clay–polymer composite nanomaterials represent an emerging area of research. Loading polymers with clay particles essentially enhances the composite strength features. Of particular interest are different nano-assembly methods, such as silane mono and multilayers, polyelectrolyte layer-by-layer assembly, and others. An important development was reached for tubular and fibrous clay nanoparticles, such as halloysite, sepiolite, and imogolite. Polymer clay nanoparticles can be prepared as sheets with 1-nm thickness and width of a few hundred nm (e.g., kaolin and montmorillonite). Fibrous clays significantly reinforce the nano-composites in the assembly with biopolymers and other green polymers, leading to functional hybrid bio nano-composites. The scope of this Special Issue comprehensively includes the synthesis and characterization of polymer clay nano-composites used for several applications, including nano-clay polymer composites and hybrid nano-assemblies.

Keywords

polyimide --- graphene oxide --- composite --- mechanical properties --- indentation recovery --- AFM --- carbon fibers --- surface grafting --- halloysite nanotubes --- polymer composites --- interface --- fish gelatin --- halloysite nanotubes --- glycerol --- mechanical properties --- water resistance --- LAP --- hyaluronic acid --- doxorubicin --- CD44 receptor targeted --- sacrificial bond --- ionic network --- organic montmorillonite --- 1,2-polybutadiene --- in-situ intercalation --- clay–polymer nanocomposites --- atrazine --- radical polymerization --- hexadecyltrimethylammonium bromide --- phenyltrimethylammonium chloride --- FTIR --- TGA --- adsorption --- dental resins --- nanocomposite materials --- organically modified clays --- montmorillonite --- intercalation --- nanotechnology --- ammonium persulfate --- fuzzy optimization --- N,N?-methylenebisacrylamide --- Pareto set --- polyacrylic acid --- swelling capacity --- variable cost --- polyethylene oxide --- montmorillonite clays --- Pd catalysis --- catalytic composite --- positron annihilation --- doubly functionalized montmorillonite --- polystyrene --- soap-free emulsion polymerization --- thermal stability --- tribological property --- organo-clays --- polyamines --- clay-amine interaction mechanisms --- structure effects --- la uptake and release --- layered silicate --- sericite --- CTAB --- intercalation stability --- nanocomposites --- gelation kinetics --- sol–gel transition --- water shutoff --- silica sol --- cellulose nanofibrils --- halloysite nanotubes --- supercritical CO2 --- polystyrene foam --- blowing agent --- in situ polymerization --- attapulgite/polypyrrole nanocomposite --- halloysite nanotubes --- polysaccharide --- interfacial interactions --- reinforcing --- adsorption --- dispersion --- coatings --- whey protein isolate --- nanocomposites --- nanoclay, barrier --- morphology --- n/a

Resilience and Sustainability of Civil Infrastructures under Extreme Loads

Authors: --- --- ---
ISBN: 9783039214013 / 9783039214020 Year: Pages: 408 DOI: 10.3390/books978-3-03921-402-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 16:10:12
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There are many regions worldwide which are susceptible to extreme loads such as earthquakes. These can cause loss of life and adverse impacts on civil infrastructures, the environment, and communities. A series of methods and measures have been used to mitigate the effects of these extreme loads. The adopted approaches and methods must enable civil structures to be resilient and sustainable. Therefore, to reduce damage and downtime in addition to protecting life and promoting safety, new resilient structure technologies must be proposed and developed. This special issue book focuses on methods of enhancing the sustainability and resilience of civil infrastructures in the event of extreme loads (e.g., earthquakes). This book contributes proposals of and theoretical, numerical, and experimental research on new and resilient civil structures and their structural performance under extreme loading events. These works will certainly play a significant role in promoting the application of new recoverable structures. Moreover, this book also introduces some case studies discussing the implementation of low-damage structural systems in buildings as well as articles on the development of design philosophies and performance criteria for resilient buildings and new sustainable communities.

Keywords

corporation --- resilience --- disaster --- recovery --- Great East Japan Earthquake --- viscous damper --- hybrid damper --- seismic performance --- cyclic loading test --- silt --- subway induced vibration --- numerical simulations --- finite element --- infinite element boundary --- measurement --- substructure --- boundary technique --- inflection point --- hybrid simulation --- force-displacement control --- integration algorithm --- pseudodynamic test, earthquake --- nonlinearity --- model-based --- Brazier effect --- angle section --- Brazier flattening --- variational method --- numerical simulation --- beam --- reinforced concrete --- corrosion --- chloride ingress --- carbonation --- probabilistic --- sustainability prediction --- cold-formed steel structure --- cold-formed steel composite shear wall building --- mid-rise --- simplified modeling method --- seismic analysis --- shaking table test --- seismic damage --- simulation model --- system restoration --- water supply networks --- progressive collapse --- abnormal loads --- sudden column removal --- seismic connection detail --- energy-based approximate analysis --- structural robustness --- structural sensitivity --- mitigation --- shaking table test --- liquefaction --- settlement --- ground improvement --- resilience-based design --- dynamic structural analysis --- GM selection --- displacement response spectrum --- structural response estimates --- spectrum variance --- probabilistic framework --- reinforced concrete frames --- liquefaction --- response surface method --- artificial neural network --- Monte Carlo simulation --- optimized section --- precast slab --- concrete --- tapered cross section --- shear performance --- ground motion --- matching pursuit decomposition --- time-frequency energy distribution --- ratcheting effect --- nonlinear response --- flow --- analysis --- concrete --- girder --- damage --- NDE --- replaceable coupling beam --- beam --- shear wall --- cyclic reversal test --- seismic behavior --- settlement --- mined-out region --- railway construction --- dynamic model --- column-top isolation --- single-layer reticulated dome --- nonlinear time-history analysis --- damping effect --- hybrid simulation --- intermediate column --- subway station --- OpenFresco --- OpenSees --- resilience --- sustainability --- civil infrastructures --- extreme loads --- natural hazards --- earthquakes --- seismic performance --- energy dissipative devices

The Impact of Caffeine and Coffee on Human Health

Authors: ---
ISBN: 9783039218349 / 9783039218356 Year: Pages: 322 DOI: 10.3390/books978-3-03921-835-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-01-07 09:21:22
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The purpose of this Special Issue is to provide a thorough and up-to-date presentation of research investigating the impact of coffee and/or caffeine intake on various health outcomes. Areas of interest include, but are not limited to, the following topics: Human clinical trials of coffee or caffeine use in relation to disease or intermediate phenotypes. Epidemiological studies of habitual coffee or caffeine intake in relation to human health, among the general public, as well as, among special populations (i.e., children, pregnant women, diabetics, cancer patients, hypertensives, etc.). Mechanisms of action of nutrients and other bioactive components of coffee/caffeine. Studies integrating genetic or physiological markers of coffee/caffeine intake to investigations of coffee and health.

Keywords

accidental death --- caffeine --- caffeine intoxication --- intoxication --- Suicide --- HIV-HCV co-infection --- liver fibrosis --- coffee --- alcohol consumption --- coffee --- tea --- European Prospective Investigation into Cancer and Nutrition --- 24-h dietary recall --- whole-blood --- mRNA --- transcriptomics --- gene expression --- coffee --- the Norwegian Women and Cancer Cohort (NOWAC) --- caffeine --- myocardial perfusion --- coronary artery disease --- adenosine --- regadenoson --- dipyridamole --- caffeine intake --- assisted reproduction techniques --- risk factors --- implantation --- clinical pregnancy --- live birth --- epidemiology --- bias --- causation --- coffee --- pregnancy --- coffee --- depression --- cohort study --- Mendelian Randomization --- coffee --- caffeine --- behavior --- causality --- genetic epidemiology --- epidemiological methods --- cardiovascular disease --- coffee consumption --- gene-diet interaction --- longevity --- NADH dehydrogenase --- polymorphism --- serum chloride levels --- CYP1A2 --- ADORA2A --- time trial performance --- caffeine metabolism --- pharmacological ergogenic aid --- polymorphism --- anxiety --- ergogenic --- adenosine receptor --- cytochrome P450 --- caffeine --- pharmacogenomics --- coffee --- caffeine --- chlorogenic acids --- phenolic --- cognition --- cognitive --- mood --- age --- sex --- caffeine --- wine --- chocolate --- aging --- cognition --- adult --- coffee --- hearing --- protection --- tinnitus --- Caffeine --- placebo --- sport --- exercise --- health --- expectancy --- cognitions --- caffeine --- coffee --- systematic review --- pregnancy --- safety --- individual responses --- ergogenic aid --- supplement --- did not respond --- responders --- n/a --- caffeine --- coffee --- tea --- soda --- energy drinks --- mate --- guidelines --- country --- consumption --- population --- public policy --- coffee --- caffeine --- lipids --- biomarkers --- trial --- lysophosphatidylcholine --- lipidomics --- n/a

Fluid Flow in Fractured Porous Media

Authors: ---
ISBN: 9783039214235 / 9783039214242 Year: Volume: 1 Pages: 578 DOI: 10.3390/books978-3-03921-424-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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The fluid flow in fracture porous media plays a significant role in the assessment of deep underground reservoirs, such as through CO2 sequestration, enhanced oil recovery, and geothermal energy development. Many methods have been employed—from laboratory experimentation to theoretical analysis and numerical simulations—and allowed for many useful conclusions. This Special Issue aims to report on the current advances related to this topic. This collection of 58 papers represents a wide variety of topics, including on granite permeability investigation, grouting, coal mining, roadway, and concrete, to name but a few. We sincerely hope that the papers published in this Special Issue will be an invaluable resource for our readers.

Keywords

scanning electron microscope (SEM) images --- permeability --- high temperature --- Darcy’s law --- confining pressures --- chemical grouts --- grain size of sand --- initial water contained in sand --- grouted sand --- macroscopic mechanical behaviors --- microstructure characteristics --- ductile failure --- gas concentration --- gob-side entry retaining (GER) --- limestone roof --- roof-cutting resistance --- roadside backfill body (RBB) --- solid backfill coal mining --- goaf --- water soaked height --- loose gangue backfill material --- deformation --- crushing ratio --- fracture grouting --- cement–silicate grout --- geophysical prospecting --- seepage --- Yellow River Embankment --- contiguous seams --- water-dripping roadway --- roadway deformation --- bolt support --- pervious concrete --- permeability coefficient --- porosity --- pore distribution characteristics --- strength --- soil–structure interface --- internal erosion --- critical hydraulic gradient --- orthogonal tests --- Pseudo Steady-State (PPS) constant --- finite-conductivity fracture --- conductivity-influence function --- normalized conductivity-influence function --- circular closed reservoir --- glutenite --- gravel --- hydraulic fracture --- numerical simulation --- propagation --- glauberite cavern for storing oil &amp --- gas --- thermal-hydrological-chemical interactions --- temperature --- brine concentration --- microstructure --- micro-CT --- damage --- cyclic heating and cooling --- physical and mechanical parameters --- failure mode --- acoustic emission --- anisotropy --- bedding plane orientation --- coal --- gas --- adsorption–desorption --- laboratory experiment --- pore pressure --- hydro-mechanical coupling --- fracture closure --- constitutive model --- effective stress --- debris flow --- dynamic characteristics --- numerical analysis --- debris-resisting barriers --- coal measures sandstone --- creep characteristics --- seepage pressure --- seepage-creep --- microscopic morphology --- Darcy flow --- heterogeneity --- numerical manifold method --- high-order --- refraction law --- hydraulic fracture network --- cohesive element method --- coal seams --- fracture propagation --- discontinuous natural fracture --- secondary fracture --- fault water inrush --- coupled THM model --- nonlinear flow in fractured porous media --- numerical model --- warning levels of fault water inrush --- bentonite-sand mixtures --- differential settlement --- deformation --- hydraulic conductivity --- crack --- geogrid --- enhanced permeability --- deviatoric stress --- mechanical behavior transition --- CH4 seepage --- volumetric strain --- strain-based percolation model --- rock-soil mechanics --- soft filling medium --- segmented grouting --- split grouting --- model experiment --- reinforcement mechanism --- longwall mining --- gob behaviors --- stress relief --- permeability --- gas drainage --- hard and thick magmatic rocks --- orthogonal ratio test --- similar simulation --- fracture --- bed separation --- disaster-causing mechanism --- artificial joint rock --- shear-flow coupled test --- hydraulic aperture --- roughness --- seepage pressure --- mixing --- conservative solute --- fractal --- roughness --- fracture --- transversely isotropic rocks --- failure mechanism --- particle flow modeling --- interface --- n/a --- fractured porous rock mass --- grouting experiment --- visualization system --- flow law --- layered progressive grouting --- sandstone and mudstone particles --- rheological deformation --- segmented rheological model --- rheological limit strain --- rheological test --- water-rock interaction --- dry-wet cycles --- slope stability --- laboratory experiment --- mechanical properties --- Xinjiang --- land reclamation --- management period --- soil particle size --- fluid flow in reclaimed soil --- effluents --- soil properties --- cohesive soils --- contamination --- time variation --- stabilization --- mixer --- viscoelastic fluid --- pore structure --- orthogonal test --- fluid–solid coupling theory --- similar-material --- regression equation --- optimum proportioning --- hydraulic fracturing --- gas fracturing --- oriented perforation --- fracture propagation --- damage mechanics --- fluid viscosity --- CO2 flooding --- supercritical CO2 --- CO2 geological storage --- tight sandstone gas reservoirs --- enhanced gas recovery --- flotation --- coal particle --- collision angle --- initial settlement position --- particle velocity --- adhesion efficiency --- green mining --- paste-like slurry --- XRD --- intelligent torque rheometer --- on-site monitoring --- cyclic wetting-drying --- deterioration --- sandstone --- mudstone --- elastic modulus --- uniaxial compressive strength --- permeability characteristics --- grading broken gangue --- compressive stress --- compression deformation --- mine shaft --- alternate strata --- surrounding rock --- shaft lining --- relief excavation --- consolidation process --- unsaturated soil --- semi-analytical solution --- impeded drainage boundary --- excess pore-pressures --- coalbed methane (CBM) --- soft coal masses --- pore structure --- fractal pore characteristics --- hydraulic fractures --- PPCZ --- multitude parameters --- propagation pattern --- stress interference --- naturally fracture --- filtration effects --- grout penetration --- unified pipe-network method --- two-phase flow --- fractured porous medium --- new cementitious material --- cement-based paste discharge --- XRD --- TG/DTG --- SEM --- MIP --- mechanical behaviors --- rock fracture --- shear-flow coupled test --- constant normal stiffness conditions --- transmissivity --- hydraulic aperture --- water inrush prevention --- backfill mining --- strata movement --- ground pressure --- floor failure depth --- water–rock interaction --- degradation mechanism --- mixed mode fracture resistance --- fracture criteria --- T-stress --- hydro-power --- high-steep slope --- fractured rock --- permeability --- seepage control --- gas-bearing coal --- electrical potential --- charge separation --- gas adsorption --- damage evolution --- Unsaturation --- chloride --- concrete --- coupling model --- numerical calculation --- debris flow --- forecasting --- rainfall-unstable soil coupling mechanism(R-USCM) --- scoops3D --- Jiaohe --- non-aqueous phase liquid --- finite element method --- two-phase flow --- mixed-form formulation --- FLAC --- pore structure --- movable fluid --- tight sandstones --- Ordos Basin --- tectonically deformed coal --- coal and gas outburst --- coal-like material --- mechanical properties --- deformation feature --- adsorption/desorption properties --- minerals --- mechanical properties --- uniaxial compressive strength --- crack distribution characteristics --- discrete element method --- lignite --- nitric acid modification --- pore structure --- surface characteristics --- adsorption performance --- n/a

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