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Current Aspects of Radiopharmaceutical Chemistry

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ISBN: 9783038971627 9783038971634 Year: Pages: 216 DOI: 10.3390/books978-3-03897-163-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine --- Chemistry (General)
Added to DOAB on : 2018-09-19 11:46:43
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Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging techniques which are widely used in nuclear medicine for the diagnosis and treatment follow-up of many major diseases. They use biomolecules as probes, which are labeled with radionuclides of short half-lives, synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. Their design and development require a rather interdisciplinary process involving many different disciplines of natural and health sciences. In addition to their diagnostic and therapeutic purposes in the field of nuclear medicine, radiopharmaceuticals provide powerful tools for in vivo pharmacology during the process of pre-clinical drug development to identify new drug targets, investigate the pathophysiology of diseases, discover potential drug candidates, and evaluate the pharmacokinetics and pharmacodynamics of drugs in vivo. Furthermore, they allow molecular imaging studies in various small-animal models of disease, including genetically engineered animals. The current collection of articles provides unique examples covering all major aspects in the field.

Targets, Tracers and Translation – Novel Radiopharmaceuticals Boost Nuclear Medicine

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ISBN: 9783039213139 / 9783039213146 Year: Pages: 214 DOI: 10.3390/books978-3-03921-314-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-12-09 11:49:15
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This is the fourth Special Issue in Pharmaceuticals within the last six years dealing with aspects of radiopharmaceutical sciences. It demonstrates the significant interest and increasing relevance to ameliorate nuclear medicine imaging with PET or SPECT, and also radiotherapeutical procedures.Numerous targets and mechanisms have been identified and have been under investigation over the previous years, covering many fields of medical and clinical research. This development is well illustrated by the articles in the present issue, including 13 original research papers and one review, covering a broad range of actual research topics in the field of radiopharmaceutical sciences.

Keywords

breast cancer --- 68Ga --- GRPR --- NPY(Y1)R --- peptide heterodimers --- PET/CT imaging --- sentinel lymph node --- dextran --- mannose --- 99mTc-radiopharmaceuticals --- glutamate --- metabotropic glutamate receptor subtype 5 --- [18F]PSS232 --- ketamine --- ceftriaxone --- positron emission tomography --- allosteric modulator --- MMPEP --- ABP688 --- pretargeting --- Fusarinine C --- rituximab --- click chemistry --- multimerization --- PET --- gallium-68 --- carbonic anhydrase IX --- girentuximab --- renal cell carcinomas --- 177Lu-radiopharmaceuticals --- radioimmunotherapy --- neuroinflammation --- microglia --- carbon-11 --- radiochemistry --- positron emission tomography --- hypoxia --- radiosensitizer --- benzotriazine-1,4-dioxide (BTDO), benzotriazine-1-monoxide (BTMO), tirapazamine (TPZ), SR 4317 --- radioiodination --- tropomyosin receptor kinase --- positron emission tomography --- neurodegeneration --- oncogenic fusions --- [11C]meta-hydroxyephedrine --- radiosynthesis --- separation --- apparent molar activity --- cholecystokinin-2 receptor --- minigastrin --- molecular imaging --- radiometals --- technetium-99m --- hydrazinonicotinic acid (HYNIC) --- PSMA-617 --- salivary gland uptake --- prostate cancer --- endoradiotherapy --- Chloramine T --- electrophilic radioiodination --- iodine-131 --- Iodo-Gen® --- oxidizing agent --- ?-CIT. --- tumor hypoxia --- PET --- small animal imaging --- azomycin nucleosides --- [18F]FMISO --- bombesin --- gastrin-releasing peptide --- gastrin-releasing peptide receptor --- tumor targeting --- 99mTc-radioligand --- metabolic stability --- neprilysin-inhibition --- phosphoramidon --- n/a --- n/a

Instruments and Methods for Cyclotron Produced Radioisotopes

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ISBN: 9783039282029 / 9783039282036 Year: Pages: 230 DOI: 10.3390/books978-3-03928-203-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Technology (General)
Added to DOAB on : 2020-01-30 16:39:46
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The focus of this Special Issue is aimed at enhancing the discussion of Engineering Education, particularly related to technological and professional learning. In the 21st century, students face a challenging demand: they are expected to have the best scientific expertise, but also highly developed social skills and qualities like teamwork, creativity, communication, or leadership. Even though students and teachers are becoming more aware of this necessity, there is still a gap between academic life and the professional world. In this Special Edition Book, the reader can find works tackling interesting topics such as educational resources addressing students’ development of competencies, the importance of final year projects linked to professional environments, and multicultural or interdisciplinary challenges.

Keywords

cyclotron --- PET --- titanium-45 --- unconventional radionuclides --- cyclotron --- targetry --- thermal study --- recycling of [18O]-water --- enrichment grade --- fractional distillation --- azeotropic mixtures --- molecular sieve desiccant --- 165Er --- 52Mn --- irradiation --- separation --- resin --- radiometals --- heavy Rare Earth Elements (hREE) --- liquid targets --- medical cyclotron --- radiometals --- gallium-68 --- copper-64 --- copper-61 --- purification --- disposable kit --- radiopharmaceuticals --- radionuclide production --- target stations --- targetry --- 70 MeV cyclotron --- beam energy --- ion accelerator --- medical cyclotron --- ion source --- filament --- cyclotron --- medical isotopes --- SPECT --- cyclotron --- medical radioisotope production --- radioactive impurities --- cross-section --- stacked-foils --- gamma spectroscopy --- thick target yield --- Radionuclide Yield Calculator --- cyclotron target --- carbon-11 --- recoil escape --- boron nitride nanotubes --- BNNTs --- cyclotrons --- radionuclide production --- solid, liquid and gas targets --- PET --- medical isotopes --- Ga-68 --- solid target --- radioisotopes --- medical radioisotopes --- radioisotope targetry --- solid radioisotope targets --- radioisotope target processing --- medical cyclotrons --- cyclotron --- targetry --- solid target --- metal 3D-printing --- target temperature --- radiometals --- radionuclides --- radioisotopes --- medical radioisotopes --- radioisotope targetry --- solid radioisotope targets --- radioisotope target processing --- medical cyclotrons --- PET --- medical isotopes --- solid target system --- radioisotope production --- Molybdenum-100 --- cyclotron --- molybdenum material recovery --- actinium-225 --- thorium --- spallation --- proton target --- ANSYS --- targeted alpha therapy --- cyclotron --- stack-foil --- monitor reaction --- cyclotron solid target --- radioisotope production --- magnetron sputtering --- thick film deposition --- cyclotron --- powder target --- thermal study --- vortex target --- Gallium-68 --- Technetium-99m --- medical Sc radioisotopes --- radioisotope production --- thick target yield measurements --- cross-section reconstruction --- numerical analysis --- cyclotrons --- targets --- target chemistry --- radioisotopes --- theranostics

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