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Analysis of Peptides and Proteins by Electrophoretic Techniques

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ISBN: 9783039212279 9783039212286 Year: Pages: 110 DOI: 10.3390/books978-3-03921-228-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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Abstract

The characterization of peptides and proteins is central to understanding their function and expression in biological matrices. Moreover, these macromolecules are important biomarkers of many human diseases. In recent years, the performance of separation techniques based on electromigration have significantly increased. The development of microdevices has reduced sample consumption and waste production while high-sensitivity detectors, such as mass spectrometry (MS) or laser-induced fluorescence (LIF), have significantly improved with regards to separation efficiency and detection limits. All of these advancements have led to appreciably enlarged fields of application. Nowadays, a multitude of studies using separation techniques based on electromigration to study proteins and peptides from numerous real matrices are available in the literature. This Special Issue covers the most recent knowledge and advances in the study of peptides and proteins using several electrophoresis techniques, as well as the characterization of relevant proteins and peptides in application areas such as clinical studies, functional foods, and toxicology.

Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies

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ISBN: 9783039216147 9783039216154 Year: Pages: 162 DOI: 10.3390/books978-3-03921-615-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:15
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Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.

Keywords

newborn screening --- sickle cell disease --- India --- tribal --- non-tribal --- Guthrie spots --- cord blood --- automated HPLC --- (recommended) screening panel --- policy making --- harmonisation --- patient advocacy --- Sickle Cell Disease --- ‘Getting to Outcomes’ --- newborn screening) --- sub-Saharan Africa --- Nigeria --- Kaduna State --- implementation science --- public health engagement --- glucose-6-phosphate dehydrogenase --- G6PD deficiency --- point-of-care --- diagnostics --- malaria --- Plasmodium vivax --- screening --- sickle cell disease --- newborn --- mass spectrometry --- hemoglobinopathies --- newborn screening --- methods --- review --- sickle cell disease --- neonatal screening program --- registry --- birth prevalence --- newborn screening --- sickle cell disease --- hemoglobinopathy --- laboratory methods --- neonatal screening --- hemoglobin pattern --- HPLC --- IEF --- capillary electrophoresis --- sickle cell disease --- high performance liquid chromatography (HPLC) --- ?-globin gene --- sickle cell disease --- newborn screening --- Caribbean --- newborn screening --- sickle cell disease --- MALDI-TOF --- mass spectrometry --- thalassemia --- prevention --- neonatal screening --- sickle cell disease --- hemoglobinopathies --- sickle cell disorder --- patient organisations --- patient representatives --- service users --- sickle cell and thalassaemia screening programme --- health policy --- screening --- sickle cell disease --- newborn --- thalassemia --- burden of disease --- newborn screening --- hemoglobinopathies --- sickle cell disease (SCD) --- pathophysiology --- hydroxyurea/hydroxycarbamide --- haemolysis --- vaso-occlusive crisis --- acute chest syndrome --- end-organ damage --- bone marrow transplant --- anaemia --- foetal haemoglobin --- gene therapy for haemoglobinopathies --- n/a

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