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Towards Elimination of Dog Mediated Human Rabies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452996 Year: Pages: 148 DOI: 10.3389/978-2-88945-299-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health --- Animal Sciences
Added to DOAB on : 2018-02-27 16:16:44
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Abstract

Rabies is an ancient zoonotic viral disease that still exerts a high impact on human and animal health. The disease is almost 100% fatal after clinical signs appear, and it kills tens of thousands of people per year worldwide, particularly in Africa and many parts of Asia. Although the disease in humans can be prevented by timely post-exposure prophylaxis, its access and affordability is limited in rabies endemic countries. With 99% of infections in humans caused by rabid domestic dog bites, controlling the infection in this reservoir population has been proven to be most effective to reduce and eliminate human rabies cases. In this context, this Research Topic invited contributions on the control and elimination of dog mediated human rabies. Publications on epidemiological, educational, policy-related and economic aspects of dog and human rabies surveillance, implementation of control in dogs and humans and scientific documentation of success stories were consolidated. We hope that these articles contribute to reaching the ambitious goal, set by key players in global health, of the elimination of dog mediated human rabies by 2030.

New Insights into Parvovirus Research

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ISBN: 9783039283101 / 9783039283118 Year: Pages: 342 DOI: 10.3390/books978-3-03928-311-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2020-06-09 16:38:57
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Viruses in the Parvoviridae family constitute one of the most diverse and intriguing fields of research. While they all share an ssDNA genome and a small capsid, they can differ widely in structure, genome organization and expression, virus–cell interaction, and impact on the host. Exploring such diversity and unraveling the inherent complexity in these apparently simple viruses is an ongoing endeavor and commitment for the scientific community. The translational implications of research on parvoviruses are relevant. Within the family, some viruses are important human and veterinary pathogens, in need of diagnostic methods and antiviral strategies; other viruses have long been studied and engineered as tools for oncolytic therapy, or as sophisticated gene delivery vectors, and can now display their wide and expanding applicative potential. This Special Issue of Viruses collects recent contributions in the field of parvovirus research, with a focus on new insights and research on unresolved issues, as well as new approaches exploiting systemic methodologies. Evolution, structural biology, viral replication, virus–host interaction, pathogenesis and immunity, and viral oncotherapy are a selection of the topics addressed in the issue that can be of relevance to the community involved in parvovirus research and of interest to a wider audience.

Keywords

human bocavirus --- children --- acute gastroenteritis --- parvovirus --- human bocavirus 1 --- RNA-seq --- transcription profile --- human airway epithelia --- AAV2 --- adeno-associated virus --- bisulfite PCR --- CpG methylation --- DNA virus --- Parvoviridae --- telbivudine --- B19V --- circulating angiogenic cells --- apoptosis --- caspase-3 --- BIRC3 (cIAP-2) --- parvovirus --- viral metagenomics --- virus diversity --- virus phylogeny --- agricultural pests --- arthropod --- mite --- viral communities --- viral ecology --- Carnivore protoparvovirus 1 --- canine parvovirus --- feline panleukopenia virus --- NS1 --- NS2 --- sequence analysis --- evolution --- Bombyx mori bidensovirus --- RACE --- RT-qPCR --- transcription mapping --- overlapping promoters --- parvovirus --- densovirus --- single stranded DNA virus --- X-ray crystallography --- Cryo-EM --- antibody interactions --- receptor interactions --- parvovirus --- viral metagenomics --- canine chapparvovirus --- Adeno-associated virus --- AAV --- protease --- phospholipase-A2 --- PLA2 --- rodent protoparvoviruses --- oncolytic activity --- tumor microenvironment --- immunomodulation --- preclinical --- clinical trials --- B19V --- parvovirus --- uncoating --- divalent cations --- capsid stability --- genome externalization --- trafficking --- nuclear targeting --- equine parvovirus-hepatitis --- horses --- commercial horse serum --- phylogeny --- chapparvovirus --- parvovirus evolution --- endogenous viral elements --- Parvoviridae --- densovirus --- homology modeling --- new viruses --- oncolytic virus immune therapy --- rodent protoparvoviruses --- H-1PV --- combination therapies --- second generation parvovirus treatments --- parvovirus B19 --- B19V --- erythrovirus --- diagnosis --- dilated cardiomyopathy --- inflammatory cardiomyopathy --- myocarditis --- prognosis --- parvovirus B19 --- erythroid progenitor cells --- antiviral compounds --- intravenous immunoglobulin (IVIG) --- hydroxyurea --- cidofovir --- brincidofovir --- coumarin derivatives --- flavonoids --- alpaca --- virus --- Bocaparvovirus --- genome --- next-generation sequencing --- metagenomics --- parvovirus B19 --- adenoviral vector --- cell cycle arrest --- apoptosis --- anti-cancer --- insect --- Lepidoptera --- insect parvovirus --- chitin --- peritrophins --- glycans --- biocontrol --- parvovirus --- structural biology --- genetics --- oncolytic viruses --- antivirals

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