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Gabriel, une église médiévale d’Éthiopie

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ISBN: 9782701803241 9782821882614 Year: Language: French
Publisher: Centre français des études éthiopiennes
Added to DOAB on : 2017-06-15 11:03:13
License: OpenEdition licence for Books

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Une question est à l'origine de cet ouvrage : comment le camp royal éthiopien s'organisait-il à la période médiévale ? Pour tenter d'y répondre, un site fut choisi, Meshala Maryam dans le Manz (Sawa), où une église royale avait été fondée par un souverain éthiopien dans la seconde moitié du XVe siècle. De nombreuses traces au sol aux alentours de l'enceinte de l'église laissaient penser que se trouvaient-là les vestiges du camp royal. Plusieurs campagnes de fouilles ont eu lieu à Meshala Mary...

Les narrateurs d’Auschwitz

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ISBN: 9782760626638 9782821897687 Year: Language: French
Publisher: Presses de l’Université de Montréal
Added to DOAB on : 2018-01-26 15:12:21
License: OpenEdition licence for Books

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Prendre l'Histoire à rebrousse-poil pour faire entendre les voix de ses victimes ; exposer la barbarie que cachent la culture et le progrès technique ; montrer que la mémoire n'est pas l'affaire du passé, mais du présent et que l'écriture peut et doit faire justice. Telle est l'entreprise d'Esther Cohen, qui s'inscrit entre autres dans le sillage de Walter Benjamin et Jacques Derrida. Son livre se veut, comme les œuvres qui le nourrissent, un acte de résistance contre le silence et l'indiffér...

Lande

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ISBN: 9781529206197 9781529207873 9781529206180 9781529206210 9781529206227 Year: Pages: 154 Language: English
Publisher: Policy Press
Subject: Sociology
Added to DOAB on : 2019-04-24 11:21:03
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Available Open Access under CC-BY-NC licence. How can Archaeology help us understand our contemporary world? This ground-breaking book reflects on material, visual and digital culture from the Calais “Jungle” – the informal camp where, before its destruction in October 2016, more than 10,000 displaced people lived. LANDE: The Calais 'Jungle' and Beyond reassesses how we understand ‘crisis’, activism, and the infrastructure of national borders in Refugee and Forced Migration Studies, foregrounding the politics of environments, time, and the ongoing legacies of empire. Introducing a major collaborative exhibit at Oxford’s Pitt Rivers Museum, the book argues that an anthropological focus on duration, impermanence and traces of the most recent past can recentre the ongoing human experiences of displacement in Europe today.

Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198153 Year: Pages: 191 DOI: 10.3389/978-2-88919-815-3 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.

Aux origines de Lyon

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ISBN: 9782906190061 9782916125213 Year: Language: French
Publisher: Alpara
Added to DOAB on : 2017-06-12 09:40:29
License: OpenEdition licence for Books

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Depuis quelques années, Lyon a connu un nombre impressionnant de chantiers de sauvetage - qui ont plus d’une fois défrayé la chronique ! La rue des Farges, le Verbe-Incarné, les fouilles liées au métro, d’autres encore. Ces chantiers ont livré des masses considérables d’informations et de matériel, qui renouvellent en grande partie nos connaissances. Ce livre, qui est né d’une rencontre scientifique, se propose de faire le point sur les origines de Lyon. En premier lieu, sont présentés les p...

Myelin-Mediated Inhibition of Axonal Regeneration: Past, Present, and Future

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452064 Year: Pages: 116 DOI: 10.3389/978-2-88945-206-4 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-10-13 14:57:01
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Pioneering studies conducted in the 1980’s laid the foundation for the hypothesis that axonal regeneration is limited by CNS myelin, and the identification of myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein (OMgp) as inhibitors of neurite outgrowth firmly established myelin as a key factor in regenerative failure. Mechanistically, it has been shown that MAG, Nogo, and OMgp mediate inhibition by binding to either Nogo receptor (NgR) or paired immunoglobulin receptor B (PirB), and initiating a signaling cascade that culminates in the activation of RhoA.Since the discovery of these proteins, there has been tremendous interest in identifying compounds and molecular mechanisms that are capable of overcoming myelin-mediated inhibition. Many studies have focused on pharmacological antagonism of receptors and signaling intermediates, while others have sought to identify and enhance endogenous pro-regenerative pathways. The most notable example of the latter is the conditioning lesion effect, which led to the discovery of cyclic AMP’s ability to overcome inhibition by MAG and myelin. Many of the agents tested in these studies have been shown to promote axonal regeneration in vivo, and this research topic allows researchers to share information about new treatments that have been developed in both academia and industry. As we look toward the future, it is becoming increasingly clear that reversal of myelin-mediated inhibition alone will not be sufficient to produce functional recovery from spinal cord injury, and that other factors, such as astroglial scarring, the expression of chondroitin sulfate proteoglycans, neuronal cell death, and lack of neurotrophic support, must also be taken into consideration. Combinatorial approaches therefore hold a great deal of promise, and we hope to initiate a dialogue on how stem cell transplantation, chondroitinase ABC, gene therapy, growth-promoting agents, and other methods can be combined to optimize functional recovery. We introduce this topic in honor of the life and work of Dr. Marie T. Filbin (1955-2014). Through these articles, we highlight past achievements in the field, novel findings, unanswered questions and innovative ideas that we hope will lead to new advances in axonal regeneration.

Provence-Auschwitz

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ISBN: 9782853996938 9782821885578 Year: Language: French
Publisher: Presses universitaires de Provence
Added to DOAB on : 2017-11-21 16:19:30
License: OpenEdition licence for Books

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De 1939 à 1944, de nombreux camps d'internement existèrent dans l'actuelle région Provence-Alpes-Côte d'Azur. Le camp des Milles, près d'Aix-en-Provence, occupa, avec ses « annexes », plusieurs fonctions : camp d'internement pour ressortissants du Reich en 1939-1940, centre de transit pour étrangers désireux de quitter la France, lieu de regroupement des juifs étrangers raflés de l'été à l'automne 1942. À partir de sources peu explorées, cet ouvrage fait le point sur cette galaxie de l'inter...

Un dépôt d'objets gaulois à Larina

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ISBN: 9782906190085 9782916125237 Year: Language: French
Publisher: Alpara
Added to DOAB on : 2017-06-12 09:40:29
License: OpenEdition licence for Books

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La simple mention du nom des Allobroges suffit à évoquer le puissant peuple gaulois qui occupait l’actuel Dauphiné et avait pour capitale Vienne en Isère. Mais s’ils entrent très tôt dans l’Histoire grâce aux auteurs grecs et latins, leur culture matérielle et leur mode de vie nous restent très mal connus. Le présent ouvrage prend donc un relief tout particulier puisqu’il constitue l’une des rares publications récentes consacrées à un site gaulois dans cette région. Le camp de Larina est sur...

The Multi-Dimensional Contributions of Prefrontal Circuits to Emotion Regulation during Adulthood and Critical Stages of Development

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ISBN: 9783039217021 / 9783039217038 Year: Pages: 188 DOI: 10.3390/books978-3-03921-703-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-12-09 11:49:16
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The prefrontal cortex (PFC) plays a pivotal role in regulating our emotions. The importance of ventromedial regions in emotion regulation, including the ventral sector of the medial PFC, the medial sector of the orbital cortex and subgenual cingulate cortex, have been recognized for a long time. However, it is increasingly apparent that lateral and dorsal regions of the PFC, as well as neighbouring dorsal anterior cingulate cortex, also play a role. Defining the underlying psychological mechanisms by which these functionally distinct regions modulate emotions and the nature and extent of their interactions is a critical step towards better stratification of the symptoms of mood and anxiety disorders. It is also important to extend our understanding of these prefrontal circuits in development. Specifically, it is important to determine whether they exhibit differential sensitivity to perturbations by known risk factors such as stress and inflammation at distinct developmental epochs. This Special Issue brings together the most recent research in humans and other animals that addresses these important issues, and in doing so, highlights the value of the translational approach.

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