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Hybrid Modelling and Multi- Parametric Control of Bioprocesses

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ISBN: 9783038427452 9783038427469 Year: Pages: 148 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-02-16 08:40:41
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The goal of bioprocessing is to optimize process variables, such as product quantity and quality, in a reproducible, scalable, and transferable manner. However, bioprocesses are highly complex. A large number of process parameters and raw material attributes exist, which are highly interactive, and may vary from batch to batch. Those interactions need to be understood, and the source of variance must be identified and controlled.While purely data-driven correlations, such as chemometric models of spectroscopic data, may be employed for the understanding how process parameters are related to process variables, they can hardly be deployed outside of the calibration space. Currently, mechanistic models, models based on mechanistic links and first principles, are in the focus of development. They are perceived to allow transferability and scalability, because mechanistics can be extrapolated. Moreover, the models deliver a large range of hardly-measureable states and physiological parameters.The current Special Issue wants to display current solutions and case studies of development and deployment of hybrid models and multi-parametric control of bioprocesses. It includes: •Models for Bioprocess Monitoring•Model for Bioreactor Design and Scale Up•Hybrid model solutions, combinations of data driven and mechanistic models.•Model to unravel mechanistic physiological regulations•Implementation of hybrid models in the real-time context•Data science driven model for process validation and product life cycle management

Marine Biomolecules

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196616 Year: Pages: 97 DOI: 10.3389/978-2-88919-661-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Chemistry (General) --- General and Civil Engineering --- Biotechnology
Added to DOAB on : 2016-08-16 10:34:25
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Oceans include the greatest extremes of pressure, temperature and light, and habitats can range from tropical waters to ocean trenches, several kilometers below sea level at high pressure. With its 70% of the surface of our planet marine ecosystem still remains largely unexplored, understudied and underexploited in comparison with terrestrial ecosystems, organisms and bioprocesses. The biological adaptation of marine organisms to a wide range of environmental conditions in the specific environment (temperature, salinity, tides, pressure, radiation, light, etc.) has made them an enormous reservoir of interesting biological material for both basic research and biotechnological improvements. As a consequence marine ecosystem is valued as a source of enzymes and other biomolecules exhibiting new functions and activities to fulfill human needs. Indeed, in recent years it has been recognised as an untapped source of novel enzymes and metabolites even though, with regard to the assignment of precise biological functions to genes, proteins and enzymes, it is still considered as the least developed. Using metagenomics to recover genetic material directly from environmental samples, this biogenetic diversification can be accessed but despite the contributions from metagenomic technologies the new field requires major improvements. A few words on the complexity of marine environments should be added here. This complexity ranges from symbiotic relationships to biology and chemistry of defence mechanisms and from chemoecology of marine invasions up to the strategies found in prokaryotes to adapt to extreme environments. The interdisciplinary study of this complexity will enable researchers to find an arsenal of enzymes and pathways greatly demanded in biotechnological applications. As far as marine enzymes are concerned they may carry novel chemical and stereochemical properties, thus biocatalytically oriented studies (testing of suitable substrates, appropriate checking of reaction conditions, study of stereochemical asset of catalysis) should be performed to appropriately reveal this “chemical biodiversity” which increases interest for these enzymes. Among other biomolecules, polysaccharides are the most abundant renewable biomaterial found on land and in oceans. Their molecular diversity is very interesting; except polysaccharides used traditionally in food and non-food industries, the structure and the functionality of most of them are unknown and unexplored. Brown seaweeds synthesize unique bioactive polysaccharides: laminarans, alginic acids and fucoidans. A wide range of biological activities (anticoagulant, antitumor, antiviral, anti-inflammation, etc.) have been attributed to fucoidans and their role with respect to structure-activity relationship is still under debate. In this Research Topic, we wish to centralize and review contributions, idea and comments related to the issues above. In particular results of enzymatic bioprospecting in gross marine environment will be acknowledged along with research for structural characterization and biological function of biomolecules such as marine polysaccharides and all kind of research related to the complexity of bioprocesses in marine environments. Inter- and multi-disciplinary approach to this field is favoured in this Research Topic and could greatly be facilitated by the web and open access nature as well.

Advances in Food and By-Products Processing Towards a Sustainable Bioeconomy

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ISBN: 9783039217526 9783039217533 Year: Pages: 146 DOI: 10.3390/books978-3-03921-753-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
Added to DOAB on : 2020-01-07 09:08:26
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The bioeconomy initially focused on resource substitution, including the production of biomass from various resources; its conversion, fractionation, and processing by means of biotechnology; and chemistry and process engineering towards the production and marketing of food, feed, fuel, and fibre. Nevertheless, although resource substitution is still considered important, the emphasis has been recently shifted to the biotechnological innovation perspective of the bioeconomy, in terms that ensure environmental sustainability. It is estimated that around one-third of the food produced for human consumption is wasted throughout the world, posing not only a sustainability problem related to food security but also a significant environmental problem. Food waste streams, mainly derived from fruits and vegetables, cereals, oilseeds, meat, dairy, and fish processing, have unavoidably attracted the interest of the scientific community as an abundant reservoir of complex carbohydrates, proteins, lipids, and functional compounds, which can be utilized as raw materials for added-value product formulations. This Special Issue focuses on innovative and emerging food and by-products processing methods for the sustainable transition to a bioeconomy era.

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