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Cancer Nanotheranostics: What Have We Learned So Far?

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197767 Year: Pages: 128 DOI: 10.3389/978-2-88919-776-7 Language: English
Publisher: Frontiers Media SA
Subject: Chemistry (General) --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Abstract

After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.

MEMS Technology for Biomedical Imaging Applications

Authors: ---
ISBN: 9783039216048 9783039216055 Year: Pages: 218 DOI: 10.3390/books978-3-03921-605-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:16
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Biomedical imaging is the key technique and process to create informative images of the human body or other organic structures for clinical purposes or medical science. Micro-electro-mechanical systems (MEMS) technology has demonstrated enormous potential in biomedical imaging applications due to its outstanding advantages of, for instance, miniaturization, high speed, higher resolution, and convenience of batch fabrication. There are many advancements and breakthroughs developing in the academic community, and there are a few challenges raised accordingly upon the designs, structures, fabrication, integration, and applications of MEMS for all kinds of biomedical imaging. This Special Issue aims to collate and showcase research papers, short commutations, perspectives, and insightful review articles from esteemed colleagues that demonstrate: (1) original works on the topic of MEMS components or devices based on various kinds of mechanisms for biomedical imaging; and (2) new developments and potentials of applying MEMS technology of any kind in biomedical imaging. The objective of this special session is to provide insightful information regarding the technological advancements for the researchers in the community.

Keywords

tilted microcoil --- electromagnetically-driven --- surface micromachining --- polyimide capillary --- MEMS --- ego-motion estimation --- indoor navigation --- monocular camera --- scale ambiguity --- wearable sensors --- photoacoustic --- microelectromechanical systems (MEMS) --- miniaturized microscope --- lead-free piezoelectric materials --- high frequency ultrasonic transducer --- needle-type --- high spatial resolution --- ultrahigh frequency ultrasonic transducer --- Si lens --- tight focus --- finite element simulation --- low noise amplifier (LNA) --- noise figure --- smart hydrogels --- bio-sensors --- chemo-sensor --- electrochemical sensors --- transduction techniques --- near-field microwave --- microwave resonator --- microwave remote sensing --- potentiometric sensor --- gold nanoparticles --- metal oxide field-effect transistor --- chemo-FET --- bio-FET --- photoacoustic imaging --- microelectromechanical systems (MEMS) --- MEMS scanning mirror --- micromachined US transducer --- microring resonator --- acoustic delay line --- MEMS mirror --- Lissajous scanning --- pseudo-resonant --- sensing --- imaging --- display --- MEMS actuators --- microendoscopy --- confocal --- two-photon --- wide-filed imaging --- photoacoustic --- fluorescence --- scanner --- capacitive micromachined ultrasonic transducer (CMUT) --- acoustics --- micromachining --- capacitive --- transducer --- modelling --- fabrication --- 3D Printing --- piezoelectric array --- ultrasonic transducer --- ultrasonic imaging --- micro-optics --- bioimaging --- microtechnology --- microelectromechanical systems (MEMS) --- in vitro --- in vivo --- cantilever waveguide --- electrostatic actuator --- non-resonating scanner --- optical scanner --- push-pull actuator --- rib waveguide --- n/a

Magnetic Nanoparticles

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ISBN: 9783039282685 9783039282692 Year: Pages: 406 DOI: 10.3390/books978-3-03928-269-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2020-04-07 23:07:08
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The present book covers all research areas related to magnetic nanoparticles, magnetic nanorods, and other magnetic nanospecies, their preparation, characterization, and various applications, specifically emphasizing biomedical applications. The chapters written by the leading experts cover different subareas of the science and technology related to various magnetic nanospecies—providing broad coverage of this multifaceted area and its applications. The different topics addressed in this book will be of great interest to the interdisciplinary community active in the area of nanoscience and nanotechnology. It is hoped that this collection and its various chapters will be important and beneficial for researchers and students working in various areas related to bionanotechnology, materials science, biosensor applications, medicine, and many others. Furthermore, this book is aimed at attracting young scientists and introducing them to this field, in addition to providing newcomers with an enormous collection of literature references.

Keywords

cellulase immobilization --- magnetic nanoparticles --- stability --- functionalized nanoparticles --- green chemistry --- magnetic nanoparticles --- enzyme immobilization --- controlled drug delivery --- supporting materials --- iron oxide nanoclusters --- superparticles --- magnetically responsive photonic crystals --- collective behaviors --- magnetic separation --- bioimaging --- magnetic Janus particles --- (bio)sensing --- static --- self-propelled --- magnetic nanoparticles --- iron oxide --- pharmaceutics --- magnetism --- therapy --- development --- nanotechnology --- magnetic nanoparticles (MNPs) --- cancer biomarkers --- MNPs synthesis --- MNPs functionalization --- sensors --- cancer detection --- cancer treatment --- cancer screening --- magnetic/targeted drug delivery --- optical sensor --- magnetic nanoparticle --- imaging --- surface plasmon resonance --- surface-enhanced Raman spectroscopy --- fluorescence spectroscopy --- near infrared spectroscopy --- extracellular vesicles --- superparamagnetic iron oxide nanoparticles --- magnetic resonance imaging (MRI) --- magnetic nanoparticles --- magnetic nanowires --- magnetic nanotubes --- core-shell composition --- biosensors --- Magnetic bead --- marine toxin --- toxin capture --- toxin detection --- antibody --- aptamer --- immunoassay --- immunosensor --- electrochemical biosensor --- magnetic nanoparticles --- surface functionalization --- immobilization support --- separation probe --- analytical platform --- food safety --- magnetic particles --- sensor --- biomarkers --- cells/cancer cells --- food analytes --- pathogens --- pharmaceuticals --- real sample matrices --- optical --- electrochemical --- surface sensitive methods --- NiCu magnetic nanoparticles --- physical and chemical methods --- surface modification --- biomedicine --- magnetic hyperthermia --- curie temperature --- magnetic hyperthermia --- cancer --- nanoparticles --- magnetic relaxation --- magnetic anisotropy --- heat generation --- multifunctional nanoparticles --- graphene oxide --- photothermal therapy --- magnetic nanoparticle systems --- bio-ferrofluids --- nanomedicine --- single core --- multi-core --- synthesis --- functional coating --- physical-chemical properties --- structural characterization --- magnetorheology --- magnetic nanoparticles --- nanocarriers --- controlled drug delivery --- high-resolution medical imaging --- cancer biomarkers --- circulating cancer cells --- fluorescent probes --- magnetite --- superparamagnetism --- biodetection --- magnetofection --- imaging --- therapy --- tissue engineering --- n/a

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