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Frontiers in Toxicity and Functionalization of Nanomaterials

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ISBN: 9783038427360 9783038427353 Year: Pages: 182 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-03-16 13:37:44
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Over the last decade, various nanomaterials (NMs) have attracted tremendous attention with the incredible development in nanoscience and nanotechnology. Some NMs are explored increasingly for biomedical applications, including drug delivery carriers, imaging probes, antimicrobial agents, biosensors, and tissue engineering scaffolds. However, the in vitro and in vivo toxicities of NMs related to oxidative stress are the main obstacles to use them in biomedical fields. One of the most promising strategies to address these obstacles is functionalizing NMs with biocompatible molecules or materials. In this Special Issue, we are especially interested in manuscripts that advance the understanding of the interaction of NMs with cells, such as cellular responses to NMs, intracellular behaviors of NMs, therapeutic and imaging potentials of NMs, as well as the functionalization of NMs through coating, patterning and hybridization with other biomolecules for multifaceted biomedical applications.

Biodegradable Metals

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ISBN: 9783038973867 9783038973874 Year: Pages: 200 DOI: 10.3390/books978-3-03897-387-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General) --- Chemical Engineering
Added to DOAB on : 2018-12-06 10:15:09
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The interest in biocompatible and biodegradable metals, such as magnesium, is mainly related to their potential use as structural material for orthopedic and cardiovascular applications where a temporary medical device is required. However, in the case of magnesium, in vivo experiments have clearly shown that the corrosion degradation rate of magnesium and its alloys is too high and, hence, results in producing gas cavities that can promote the danger of gas embolism, tissue separation, and premature loss of mechanical integrity. The aim of this Special Issue on Biodegradable Metals is to explore and introduce innovative strategies to overcome the current limitations of magnesium.

Novel Biocomposite Engineering and Bio-Applications

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ISBN: 9783038973829 9783038973836 Year: Pages: 215 DOI: 10.3390/books978-3-03897-383-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Biotechnology
Added to DOAB on : 2019-01-17 12:18:18
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The engineering and utilization of biocomposites is a research field of major scientific and industrial interest worldwide. The biocomposite area is extensive and spans from structured and solid biocomposites (e.g., reinforced bioabsorbable polymers), films (e.g., antimicrobial barriers), to soft biocomposites (e.g., use of alginates, collagen and nanocellulose as components in bioinks for 3D bioprinting). Key aspects in this respect are the appropriate engineering and production of biomaterials, nanofibres, bioplastics, their functionalization enabling intelligent and active materials, processes for effective manufacturing of biocomposites and the corresponding characterization for understanding their properties.The current Special Issue emphasizes the bio-technological engineering of novel biomaterials and biocomposites, considering also important safety aspects in the production and use of bio- and nanomaterials.

Electrospun Nanofibers for Biomedical Applications

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ISBN: 9783039287741 / 9783039287758 Year: Pages: 308 DOI: 10.3390/books978-3-03928-775-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2020-06-09 16:38:57
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Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes’ composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds’ structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.

Keywords

sol-gel --- electrospinning --- hydroxyapatite --- nanofiber --- antibacterial --- titanium --- antibacterial coatings --- electrospinning --- nanocomposite coatings --- TiO2 photocatalytic --- orthopedic infections --- electrospinning --- 3D printing --- nanofibers --- encapsulation --- protein diffusion --- in vivo tissue engineering --- immuno-isolation --- transplantation --- electrospinning --- sputtering --- drug delivery --- wound dressing --- biocompatibility --- tissue engineering --- biomimetic scaffolds --- gelatin --- electrospinning --- micromolding --- biomaterials --- poly(lactic acid) (PLLA) --- bioactive glass --- scaffolds --- electrospinning --- composite fibres --- bone regeneration --- poly(vinylidene fluoride) --- composite nanofiber --- piezoelectricity --- antioxidant activity --- well-aligned nanofibers --- P(VDF-TrFE) --- piezoelectric nanogenerator --- preosteoblasts electrospinning --- silicone modified polyurethane nanofibers --- physical properties --- cell attachment --- cell proliferation --- cytotoxicity --- biopolymers --- packaging --- pharmaceutical --- biomedical --- electrospinning --- alginate --- gelatin fibers --- ZnO particles --- antibacterial activity --- electrospinning --- nanofibers --- fabrication --- therapeutics --- biomedical applications --- antibody immobilization --- electrospun nanofibers --- TNF-? capture --- human articular chondrocytes --- rheumatoid arthritis --- nanofibers --- microfluidic chip --- electrospinning --- live assay --- hepatocellular carcinoma cells --- PLA95 --- biocompatibility --- guided tissue regeneration (GTR) --- electrospinning --- electrospun fiber mats --- mechanobiology --- glioblastoma --- biomaterials --- finite element modeling --- electrospun nanofibers --- cancer treatment --- drug release --- nanomedicine --- biocompatible polymers --- hyperthermia

Self-Assembled Bio-Nanomaterials: Synthesis, Characterization, and Applications

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ISBN: 9783039285365 9783039285372 Year: Pages: 134 DOI: 10.3390/books978-3-03928-537-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Materials
Added to DOAB on : 2020-04-07 23:07:09
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Biomolecular self-assembly provides a green, facile, and highly effective method to synthesize various functional nanomaterials that have exhibited considerable potential in the fields of nanotechnology, materials science, biomedicine, tissue engineering, food science, energy storage, and environmental science. In this collection of articles, we presented recent advance in the synthesis, characterization, and applications of self-assembled bio-nanomaterials. In a comprehensive review article, the controlled self-assembly of biomolecules including DNA, protein, peptide, enzymes, virus, and biopolymers via internal interactions and external simulations is introduced and discussed in detail. In other research articles, the self-assembly of DNA, protein, peptide, bio-drugs, liquid crystal polycarbonates, and diblock copolymers to various biomimetic/bioinspired nanomaterials and their potential applications in nanopatterning, sensors/biosensors, drug delivery, anti-parasite, and water purification are demonstrated.

Biomaterials and Implant Biocompatibility

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ISBN: 9783039282166 9783039282173 Year: Pages: 420 DOI: 10.3390/books978-3-03928-217-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Physics (General) --- Science (General)
Added to DOAB on : 2020-04-07 23:07:09
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The scientific advances in life sciences and engineering are constantly challenging, expanding, and redefining concepts related to the biocompatibility and safety of medical devices. New biomaterials, new products, and new testing regimes are being introduced to

Keywords

carbonate apatite --- hydroxyapatite --- ?-tricalcium phosphate --- artificial bone substitute --- crystallite size --- dissolution rate --- hybrid dog --- bone levels --- dental implants --- neck design --- soft tissue dimensions --- peri-implantitis --- biofilm --- dental implants --- in vitro model --- MSN --- biopolymer --- drug delivery system --- in vitro kinetic studies --- articular cartilage defect --- bioplolymers --- C-reactive protein --- haptoglobin --- in vivo testing --- serum amyloid A --- serum protein fractions --- sheep --- contact lens --- materials --- biomedical implant --- smart dentin grinder --- autogenous particulate dentin graft --- tooth graft --- ground teeth --- human teeth --- bone grafts --- autologous graft --- dolomitic marble --- seashell --- CaCO3 derived-calcium phosphates --- modulated synthesis set-up --- SEM --- image analysis --- pre-osteoblasts --- titanium implants --- dental implants --- antibacterial coating --- gentamicin --- silver --- zinc --- cytotoxicity --- MC3T3-E1 --- Staphylococcus aureus --- plasma chemical oxidation --- bone infection --- local drug delivery --- bone graft --- demineralized bone matrix --- gentamicin --- regeneration --- colon cancer cells --- copper ions --- hydrogel sphere --- sodium alginate --- polyethyleneimine --- surface modification --- biocompatible metals --- coating techniques --- hydroxyapatite --- real-time live-cell imaging technology --- in vitro study --- biocompatibility --- 3D printing --- flow cytometry --- adipogenic mesenchymal stem cells --- porous SHS TiNi --- biocompatibility --- rheological similarity --- corrosion resistance --- bone substitution --- superparamagnetic scaffold --- composite --- laser direct writing --- static magnetic field --- extracellular matrix mineralization --- bone tissue engineering --- three-dimensional co-culture --- osteoblast --- endothelial cell --- microfiber scaffold --- osteogenesis --- angiogenesis --- tissue engineering --- diamond nanoparticles --- fish gelatin --- adipose-derived stem cells --- biocompatibility --- spaced TiO2 nanotubes --- osteoblast --- cell adhesion and morphology --- cell proliferation --- osteogenic differentiation --- protein–polymer matrices --- nanowelding --- single-walled carbon nanotubes --- point defects --- absorption --- laser radiation --- cell membrane --- mesenchymal stem cells --- osteogenic differentiation --- lactoferrin --- polymer composite --- bioceramics --- in vitro testing --- hydroxyapatite --- angiogenesis --- osteogenesis --- signaling pathways --- microRNA --- bioceramics --- bioactive glass --- hydroxyapatite --- root canal sealer --- bioactive glass --- mechanism --- caries --- review

Sol-Gel Chemistry Applied to Materials Science

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ISBN: 9783039213535 9783039213542 Year: Pages: 216 DOI: 10.3390/books978-3-03921-354-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:15
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Sol–gel technology is a contemporary advancement in science that requires taking a multidisciplinary approach with regard to its various applications. This book highlights some applications of the sol–gel technology, including protective coatings, catalysts, piezoelectric devices, wave guides, lenses, high-strength ceramics, superconductors, synthesis of nanoparticles, and insulating materials. In particular, for biotechnological applications, biomolecules or the incorporation of bioactive substances into the sol–gel matrix has been extensively studied and has been a challenge for many researchers. Some sol–gel materials are widely applied in light-emitting diodes, solar cells, sensing, catalysis, integration in photovoltaic devices, and more recently in biosensing, bioimaging, or medical diagnosis; others can be considered excellent drug delivery systems. The goal of an ideal drug delivery system is the prompt delivery of a therapeutic amount of the drug to the proper site in the body, where the desired drug concentration can be maintained. The interactions between drugs and the sol–gel system can affect the release rate. In conclusion, the sol–gel synthesis method offers mixing at the molecular level and is able to improve the chemical homogeneity of the resulting composite. This opens new doors not only regarding

Keywords

sol-gel method --- Fourier transform infrared spectroscopy (FTIR) analysis --- bioactivity --- biocompatibility --- sol–gel method --- organic-inorganic hybrids --- chlorogenic acid --- cytotoxicity --- biocompatibility --- silsesquioxanes --- thiol-ene click reaction --- in situ water production --- hydrophobic coatings --- cotton fabric --- paper --- NMR --- wettability --- sol-gel --- hollow sphere --- 1D structure --- sol-gel --- thin-disk laser --- Yb-doped glasses --- aluminosilicate glasses --- photoluminescence --- ultrasonic spray deposition --- tungsten oxide --- lithium lanthanum titanium oxide --- conformal coating --- Li-ion batteries --- sol-gel technique --- biomaterials --- cell proliferation --- cell cycle --- one transistor and one resistor (1T1R) --- organic thin-film transistor (OTFT) --- resistive random access memory (RRAM) --- sol-gel --- lithium-ion battery --- LiMnxFe(1?x)PO4 --- carbon coating --- pseudo-diffusion coefficient --- potential step voltammetry --- electrochemical impedance spectroscopy --- sol-gel --- oxyfluoride glass-ceramics --- nanocrystal --- optical properties --- sol-gel method --- SiO2–based hybrids --- poly(?-caprolactone) --- TG-DSC --- TG-FTIR --- X-ray diffraction analysis --- computer-aided design (CAD) --- mechanical analysis --- finite element analysis (FEA) --- composites --- organic–inorganic hybrid materials --- biomedical applications --- metal oxides --- multi-layer --- surface plasmon resonance --- optical sensors --- computer-aided design (CAD) --- mechanical analysis --- finite element analysis (FEA) --- composites --- hybrid materials --- biomedical applications

Biomedical Applications of Nanoparticles

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ISBN: 9783039285426 / 9783039285433 Year: Pages: 366 DOI: 10.3390/books978-3-03928-543-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-06-09 16:38:57
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This book provides an overview of the design and physico-chemical properties of nanoparticles developed for biomedical applications such as targeting and detection of pathologies, nanovectorization of drugs, radiosensitization, metal detection, and nanocomposite implants. The considerations necessary when developing a new nanomedicine are also developed, including toxicological investigation, biodistribution, and efficacy. This book provides an accurate and current representation of the field by addressing the promises and hurdles of nanomedicine via 20 different pertinent studies. Covering a wide range of areas, this book is an excellent partner for physico-chemists, doctors, pharmacologists, and biochemists working on nanosciences dedicated to medicine, both in industry and in academia.

Keywords

curcumin --- mitoxantrone --- synergism --- PEG --- chitosan nanoparticles --- hybrid Fe-Si nanoparticles --- laser pyrolysis --- Caco2 cells --- cytotoxicity --- oxidative stress --- upconversion nanoparticles --- nanocarriers --- drug delivery --- gene delivery --- photolysis --- cancer imaging --- cytoreduction surgery --- fluorescent nanoparticle --- near-infrared --- short-wave infrared --- Candida glabrata --- extracellular --- mycosynthesis --- MIC --- MBC --- MFC --- membrane integrity --- TEM --- FTIR --- surface-enhanced Raman spectroscopy (SERS) --- Ag-film --- Hg2+ ions detection --- SERS sensor --- nanocomposites --- medical devices --- middle ear prosthesis --- silver nanoparticles --- biocompatibility --- thermoplastic polymer --- dihydroartemisinin --- liposomes --- autophagy --- apoptosis --- breast cancer --- surface-enhanced Raman scattering (SERS) --- metal-enhanced fluorescence (MEF) --- dual functional imaging nanoprobe --- UiO-66 --- nanoparticles --- glioblastoma --- biocompatibility --- drug delivery --- alginate --- chitosan --- layer-by-layer --- magnetic nanoparticles --- drug delivery --- cancer --- curcumin --- lignin --- nanoparticle --- protein --- nanocellulose --- fibril --- enzyme --- heat --- self-assembly --- cross-link --- antibiotics --- nanoparticles --- biogenic nanoparticles --- antimicrobial --- antibiotic resistance --- multidrug resistant (MDR) microorganisms --- plasma --- nanomaterials --- nanomaterial synthesis --- plasma liquid Interactions --- non-thermal plasma --- biomedical applications --- core-shell nanoparticles --- biocompatible --- drug delivery --- anticancer --- SERS --- histamine --- nanostars --- nanophotonics --- computational electromagnetism --- surface enhanced Raman scattering --- SERS --- finite element method --- density functional theory calculations --- cell labeling --- cancer --- iron oxide superparamagnetic nanoparticles --- trans-resveratrol derivative --- drug delivery --- glioma --- gold nanoparticles --- radiosensitization --- thioredoxin reductase --- radiation --- prognosis --- biochemical mechanism --- nanodiamond --- targeted nanoparticles --- in vivo application --- cancer cell targeting --- antimiR --- nano-bio interaction

Advanced Glasses, Composites and Ceramics for High Growth Industries

Authors: --- ---
ISBN: 9783038979609 9783038979616 Year: Pages: 186 DOI: 10.3390/books978-3-03897-961-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Materials
Added to DOAB on : 2019-06-26 08:44:06
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Advanced Glasses, Composites and Ceramics for High-Growth Industries (CoACH) was a European Training Network (ETN) project (http://www.coach-etn.eu/) funded by the Horizon 2020 program. CoACH involved multiple actors in the innovation ecosystem for advanced materials, composed of five universities and ten enterprises in seven different European countries. The project studied the next generation of materials that could bring innovation in the healthcare, construction, and energy sectors, among others, from new bioactive glasses for bone implants to eco-friendly cements and new environmentally friendly thermoelectrics for energy conversion. The novel materials developed in the CoACH project pave the way for innovative products, improved cost competitiveness, and positive environmental impact. The present Special Issue contains 14 papers resulting from the CoACH project, showcasing the breadth of materials and processes developed during the project.

Recent Development of Electrospinning for Drug Delivery

Authors: --- ---
ISBN: 9783039281404 9783039281411 Year: Pages: 206 DOI: 10.3390/books978-3-03928-141-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-04-07 23:07:09
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Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.

Keywords

electrospinning --- gentamicin sulfate --- polylactide-co-polycaprolactone --- drug release kinetics --- tissue engineering --- growth factor --- diabetic --- wound healing --- nanocomposite --- electrospinning --- coaxial spinning --- core-sheath nanofibers --- biomedical --- drug delivery --- electrospinning --- scale-up --- processability --- biopharmaceuticals --- oral dosage form --- grinding --- aceclofenac --- nanofiber --- electrospinning --- scanning electron microscopy --- fourier transform infrared spectroscopy --- differential scanning calorimetry --- nanotechnology --- biotechnology --- probiotics --- Lactobacillus --- Lactococcus --- electrospinning --- nanofibers --- drying --- local delivery --- viability --- antibacterial activity --- bacterial bioreporters --- drug release --- electrospinning --- microfibers --- nanofibers --- UV imaging --- wetting --- in situ drug release --- nanofibers --- electrospinning --- poorly water-soluble drug --- piroxicam --- hydroxypropyl methyl cellulose --- polydextrose --- scanning white light interferometry --- nanotechnology --- nanofibers --- traditional electrospinning --- ultrasound-enhanced electrospinning --- drug delivery system --- haemanthamine --- plant-origin alkaloid --- electrospinning --- amphiphilic nanofibers --- self-assembled liposomes --- physical solid-state properties --- drug release --- electrospinning --- PCL --- gelatin --- clove essential oil --- antibacterial --- biocompatibility --- artificial red blood cells --- electrospinning and electrospray --- pectin --- oligochitosan --- hydrogel --- microcapsules --- electrospinning --- wound dressings --- solvent casting --- 3D printing --- polymeric carrier --- n/a

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