Search results: Found 9

Listing 1 - 9 of 9
Sort by
Personalizing Simulations of the Human Atria : Intracardiac Measurements, Tissue Conductivities, and Cellular Electrophysiology

Author:
Book Series: Karlsruhe transactions on biomedical engineering / Ed.: Karlsruhe Institute of Technology / Institute of Biomedical Engineering ISSN: 18645933 ISBN: 9783866446465 Year: Volume: 12 Pages: VI, 152 p. DOI: 10.5445/KSP/1000022290 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:59
License:

Loading...
Export citation

Choose an application

Abstract

This work addresses major challenges of heart model personalization. Analysis techniques for clinical intracardiac electrograms determine wave direction and conduction velocity from single beats. Electrophysiological measurements are simulated to validate the models. Uncertainties in tissue conductivities impact on simulated ECGs. A minimal model of cardiac myocytes is adapted to the atria. This makes personalized cardiac models a promising technique to improve treatment of atrial arrhythmias.

Analysis of Atrial Electrograms

Author:
Book Series: Karlsruhe transactions on biomedical engineering / Ed.: Karlsruhe Institute of Technology / Institute of Biomedical Engineering ISSN: 18645933 ISBN: 9783866448940 Year: Volume: 17 Pages: VI, 214 p. DOI: 10.5445/KSP/1000029058 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
License:

Loading...
Export citation

Choose an application

Abstract

This work provides methods to measure and analyze features of atrial electrograms - especially complex fractionated atrial electrograms (CFAEs) - mathematically. Automated classification of CFAEs into clinical meaningful classes is applied and the newly gained electrogram information is visualized on patient specific 3D models of the atria. Clinical applications of the presented methods showed that quantitative measures of CFAEs reveal beneficial information about the underlying arrhythmia.

Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment

Author:
Book Series: Karlsruhe transactions on biomedical engineering / Ed.: Karlsruhe Institute of Technology / Institute of Biomedical Engineering ISSN: 18645933 ISBN: 9783731500452 Year: Volume: 20 Pages: IX, 181 p. DOI: 10.5445/KSP/1000035360 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:01
License:

Loading...
Export citation

Choose an application

Abstract

Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.

Personalized Multi-Scale Modeling of the Atria: Heterogeneities, Fiber Architecture, Hemodialysis and Ablation Therapy

Author:
Book Series: Karlsruhe transactions on biomedical engineering / Ed.: Karlsruhe Institute of Technology / Institute of Biomedical Engineering ISSN: 18645933 ISBN: 9783866449480 Year: Volume: 19 Pages: XVI, 297 p. DOI: 10.5445/KSP/1000031226 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:02
License:

Loading...
Export citation

Choose an application

Abstract

This book targets three fields of computational multi-scale cardiac modeling. First, advanced models of the cellular atrial electrophysiology and fiber orientation are introduced. Second, novel methods to create patient-specific models of the atria are described. Third, applications of personalized models in basic research and clinical practice are presented. The results mark an important step towards the patient-specific model-based atrial fibrillation diagnosis, understanding and treatment.

Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves

Author:
Book Series: Karlsruhe transactions on biomedical engineering / Ed.: Karlsruhe Institute of Technology / Institute of Biomedical Engineering ISSN: 18645933 ISBN: 9783731505280 Year: Volume: 23 Pages: IX, 318 p. DOI: 10.5445/KSP/1000054615 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:02
License:

Loading...
Export citation

Choose an application

Abstract

Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF.

Sudden arrhythmic death: From basic science to clinical practice

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192694 Year: Pages: 136 DOI: 10.3389/978-2-88919-269-4 Language: English
Publisher: Frontiers Media SA
Subject: Physiology --- Science (General)
Added to DOAB on : 2015-12-03 13:02:24
License:

Loading...
Export citation

Choose an application

Abstract

With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future.

Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias

Author:
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196470 Year: Pages: 141 DOI: 10.3389/978-2-88919-647-0 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2016-08-16 10:34:25
License:

Loading...
Export citation

Choose an application

Abstract

The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that’s prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. The question then is what went wrong, why have these interventions proven to be so ineffective? An obvious answer is the drugs were designed to attack the wrong therapeutic target. Clearly, targeting single ion channels (using either isolated ion channels or single myocytes preparations) has proven to be less than effective. What then is the appropriate target? It is well established that cardiac electrical properties can vary substantially between single cells and intact preparations. One obvious example is the observation that action potential duration is much longer in isolated cells as compared to multi-cellular preparations or intact hearts. Due to the low electrical resistance between adjacent myocytes, the cells act in coordinated fashion producing “electrotonic interdependence” between neighboring cells. Myocardial infarction and/or acute ischemia provoke profound changes in the passive electrical properties of cardiac muscle. In particular, electrotonic uncoupling of the myocytes disrupts the coordinated activation and repolarization of cardiac tissue. The resulting compensatory changes in ionic currents decrease cardiac electrical stability increasing the risk for life-threatening changes in the cardiac rhythm. Thus, the electrical properties of myocardial cells must be considered as a unit rather than in isolation. It is the purpose of this Research Topic to evaluate the largely neglected relationship between changes in passive electrical properties of cardiac muscle and arrhythmia formation.

Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides

Authors: ---
ISBN: 9783039215829 9783039215836 Year: Pages: 212 DOI: 10.3390/books978-3-03921-583-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Cardiovascular
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.

Keywords

PCSK9 --- natriuretic peptides --- adipose tissue --- lipid metabolism --- LDL receptor --- insulin --- natriuretic peptides --- hypertension --- stroke --- cardiac hypertrophy --- linkage analysis --- genetic variants --- animal models --- BNP --- NT-proBNP --- heart failure --- cardiac dysfunction --- forensic medicine --- postmortem biochemistry --- angiotensin receptor–neprilysin inhibitor --- natriuretic peptides --- renin–angiotensin system --- heart failure --- arterial hypertension --- natriuretic peptide --- vascular --- endothelial cell --- cardiomyocyte --- fibroblast --- inflammation --- heart failure --- hypertension --- angiogenesis --- heart failure --- natriuretic peptides --- preserved ejection fraction --- natriuretic peptides --- heart failure --- atrial fibrillation --- remodeling --- Idiopathic Pulmonary Arterial Hypertension (IPAH) --- Natriuretic Peptide Clearance Receptor (NPR-C) signaling --- atrial natriuretic peptide --- hypertension --- heart failure --- cardiometabolic disease --- obesity --- metabolic syndrome --- cGMP --- guanylyl cyclase receptor A --- natriuretic peptides --- natriuretic peptide --- cardiorenal syndrome --- vasopressor --- vasodilator --- kidney --- medulla --- renin-angiotensin-aldosterone system --- Atrial Natriuretic peptide --- natriuretic peptides --- cardiac remodelling --- cardiac hypertrophy --- vascular homeostasis --- atrial natriuretic peptide --- guanylyl cyclase/natriuretic peptide receptor-A --- gene-knockout --- gene-duplication --- hypertension --- congestive heart failure --- natriuretic peptides --- arterial hypertension --- pulmonary arterial hypertension --- heart failure --- stroke --- atrial fibrillation --- ARNi --- MANP

New Lipid Lowering Therapies for Cardiovascular and Metabolic Diseases: Lessons from the Past and Future Challenges

Author:
ISBN: 9783039216765 9783039216772 Year: Pages: 116 DOI: 10.3390/books978-3-03921-677-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

This book illustrates some of the most recent research efforts that have been made in lowering plasma cholesterol levels in patients with CVD. Selected articles aimed to illuminate advances and urgent challenges in the management of CVD, including disease management using statin-combined therapeutic strategies.

Listing 1 - 9 of 9
Sort by
Narrow your search