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Extractable and Non-Extractable Antioxidants

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ISBN: 9783039214372 / 9783039214389 Year: Pages: 234 DOI: 10.3390/books978-3-03921-438-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-12-09 11:49:15
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The Special Issue “Extractable and Non-Extractable Antioxidants” gives an updated view on antioxidants—both in their extractable and non-extractable form—in the different food groups, their products thereof, and food preparations as well as byproducts and biomass waste. The potential beneficial properties of these compounds and nutraceutical formulations are described in the various studies covered in this Special Issue.

Keywords

anthocyanins --- polyphenolic compounds --- classic extraction --- ultrasound assisted extraction --- antioxidant capacity --- daidzein --- cyclodextrin --- inclusion complex --- antioxidant activity --- trans-cinnamaldehyde --- ?-cyclodextrin --- self-inclusion --- anti-inflammation --- antioxidant --- Pleurotus ostreatus --- antioxidant activity --- polyphenols --- digestibility --- fermentation --- cereals --- legumes --- Chinese mistletoes --- phenolics --- phenolic contents --- antioxidant activity --- forest residues --- phenolic compounds --- natural antioxidants --- quercitrin --- value-added by-products --- Camellia sinensis --- black teas --- catechins --- antioxidant activity --- LC-ESI-Q-TOF-MS --- principal component analysis --- extractable --- non-extractable --- antioxidant activity --- agglomerative hierarchical clustering --- principal component analysis --- multivariate analysis --- nuclear magnetic spectroscopy --- nitric oxide scavengers --- pre-column HPLC method --- Aloysia triphylla --- phenolics --- antioxidants --- dietary supplements --- botanicals --- bioactive compounds --- antioxidants --- study approach --- integrated food research --- dedicated databases --- dietary assessment. --- biorefinery --- circular economy --- grape seed --- bio-based --- chemometrics --- Cagnulari marc --- Naviglio Extractor® --- green extraction --- endothelial cell --- oxidative stress --- polyphenols --- berries jam --- phenolic acids --- flavonols glycosides --- degradation --- HPLC-ESI/MS --- antioxidant properties --- digestive enzyme --- nutrient --- polymerization --- proanthocyanidins --- eggplant --- flour --- phenolics --- antioxidant activity --- functional ingredient --- sour cherry --- anthocyanins --- extractable polyphenols --- non-extractable polyphenols --- Italian popular recipes --- food composition database --- antioxidant properties --- extractable compounds --- non-extractable compounds --- ferric reducing antioxidant power (FRAP) --- total polyphenol content (TPC) --- n/a

Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family

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ISBN: 9783038979340 / 9783038979357 Year: Pages: 152 DOI: 10.3390/books978-3-03897-935-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
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The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities. These include the ability to reduce phospholipid hydroperoxides, phospholipase A2 activity, and an acyl transferase activity that is important in phospholipid remodeling. This book describes the available models for investigating the unique functions of PRDX6 and its role in normal physiological function, as well its roles in the pathophysiology of diseases including cancer, diseases of the eye, and male fertility.

Biocatalysis and Pharmaceuticals: A Smart Tool for Sustainable Development

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ISBN: 9783039217083 / 9783039217090 Year: Pages: 176 DOI: 10.3390/books978-3-03921-709-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
Added to DOAB on : 2019-12-09 11:49:16
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Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area. By reading the excellent contributions gathered in this book, it is possible to have an updated idea about new advances and possibilities for a new exciting future.

Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis

Authors: --- ---
ISBN: 9783039210848 / 9783039210855 Year: Pages: 308 DOI: 10.3390/books978-3-03921-085-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-06-26 08:44:06
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The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility

Keywords

branched-chain keto acids --- serum --- muscle --- HPLC-Q-TOF/MS --- wood --- odor --- volatile organic compounds --- gas chromatography-olfactometry --- Wuyi Rock tea --- quality --- UPLC-QTOF MS --- UPLC-QqQ MS --- metabolite profiling --- metabolomics --- cluster analysis --- cultivars --- Lycium ruthenicun --- flavonoid --- ruthenicunoid A --- SIRT1 --- Asphodeline lutea --- HPLC-PDA --- heavy metals --- tyrosinase --- diabetes --- neurodegenerative disease --- color analysis --- pigments --- MAE --- HPLC-PDA --- SFE --- Thymus algeriensis --- rare earth elements --- flow injection --- inductively coupled plasma-mass spectrometry --- seawater --- Hericium erinaceuns mycelium --- high-speed counter-current chromatography (HSCCC) --- genistein --- daidzein --- Fe3O4 --- modification --- alginate --- alkaloid --- ultrasound assisted extraction --- gelatin --- actinidin --- bovine hide --- physicochemical properties --- gel strength --- Semen Cuscutae --- ultra-high-performance liquid chromatography coupled to electrospray ionization mass spectrometry --- chlorogenic acids --- flavonoids --- steamed Panax notoginseng --- saponins --- extraction --- optimization --- antioxidant activity --- response surface methodology --- hematopoiesis --- microwave processing --- response surface methodology --- minor ginsenosides --- blood-enriching activity --- hemostatic activity --- ionic liquids --- sample preparation --- microextraction --- solid-phase microextraction --- dispersive liquid-liquid microextraction --- single-drop microextraction --- stir bar sorptive extraction --- stir cake sorptive extraction --- rosuvastatin --- metformin --- HILIC --- LC-MS --- therapeutic drug monitoring --- oolong tea --- Tieguanyin tea cultivar --- metabolite profiling --- UPLC-QTOF MS --- metabolomics --- Ajuga genevensis --- near-infrared spectroscopy --- dry extract --- fluid bed process --- microNIR --- in-line monitoring --- total polyphenolic content --- antioxidant --- flavonoids --- mouse melanoma B16 cells --- Panax notoginseng --- surfactant --- n/a --- ultra-high-performance liquid chromatography tandem mass spectrometry --- GHB --- GHB glucuronide --- nails --- endogenous values --- walnut septum --- polyphenols --- phytosterols --- HPLC-MS/MS --- Ultra-Turrax extraction --- biological activity --- antioxidant activity --- experimental design --- optimization --- phytochemicals

Synthesis and Applications of Biopolymer Composites

Authors: ---
ISBN: 9783039211326 / 9783039211333 Year: Pages: 312 DOI: 10.3390/books978-3-03921-133-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This book, as a collection of 17 research articles, provides a selection of the most recent advances in the synthesis, characterization, and applications of environmentally friendly and biodegradable biopolymer composites and nanocomposites. Recently, the demand has been growing for a clean and pollution-free environment and an evident target regarding the minimization of fossil fuel usage. Therefore, much attention has been focused on research to replace petroleum-based commodity plastics by biodegradable materials arising from biological and renewable resources. Biopolymers—polymers produced from natural sources either chemically from a biological material or biosynthesized by living organisms—are suitable alternatives for addressing these issues due to their outstanding properties, including good barrier performance, biodegradation ability, and low weight. However, they generally possess poor mechanical properties, a short fatigue life, low chemical resistance, poor long-term durability, and limited processing capability. In order to overcome these deficiencies, biopolymers can be reinforced with fillers or nanofillers (with at least one of their dimensions in the nanometer range). Bionanocomposites are advantageous for a wide range of applications, such as in medicine, pharmaceutics, cosmetics, food packaging, agriculture, forestry, electronics, transport, construction, and many more.

Keywords

nanocellulose --- protease sensor --- human neutrophil elastase --- peptide-cellulose conformation --- aerogel --- glycol chitosan --- ?-tocopherol succinate --- amphiphilic polymer --- micelles --- paclitaxel --- chitosan --- PVA --- nanofibers --- electrospinning --- nanocellulose --- carbon nanotubes --- nanocomposite --- conductivity --- surfactant --- Poly(propylene carbonate) --- thermoplastic polyurethane --- compatibility --- toughness --- biopolyester --- compatibilizer --- cellulose --- elastomer --- toughening --- biodisintegration --- heat deflection temperature --- biopolymers composites --- MgO whiskers --- PLLA --- in vitro degradation --- natural rubber --- plasticized starch --- polyfunctional monomers --- physical and mechanical properties --- cross-link density --- water uptake --- chitosan --- deoxycholic acid --- folic acid --- amphiphilic polymer --- micelles --- paclitaxel --- silk fibroin --- glass transition --- DMA --- FTIR --- stress-strain --- active packaging materials --- alginate films --- antimicrobial agents --- antioxidant activity --- biodegradable films --- essential oils --- polycarbonate --- thermal decomposition kinetics --- TG/FTIR --- Py-GC/MS --- wheat gluten --- potato protein --- chemical pre-treatment --- structural profile --- tensile properties --- biocomposites --- natural fibers --- poly(3-hydroxybutyrate-3-hydroxyvalerate) --- biodegradation --- impact properties --- chitin nanofibrils --- poly(lactic acid) --- nanocomposites --- bio-based polymers --- natural fibers --- biomass --- biocomposites --- fiber/matrix adhesion --- bio-composites --- mechanical properties --- poly(lactic acid) --- cellulose fibers --- n/a

Biological Potential and Medical Use of Secondary Metabolites

Authors: ---
ISBN: 9783039211876 / 9783039211883 Year: Pages: 284 DOI: 10.3390/books978-3-03921-188-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.

Keywords

Juniperus --- secondary metabolites --- diterpenes --- flavonoids --- lignans --- cytotoxic --- antitumor --- antibacterial --- amentoflavone --- deoxypodophyllotoxin --- frankincense --- Boswellia --- cembranoids --- cneorubenoids --- boswellic acids --- molecular docking --- Scabiosa --- flavonoids --- iridoids --- pentacyclic triterpenoids --- antioxidant --- anti-inflammatory --- antibacterial --- anticancer --- Cordyceps militaris --- xanthine oxidase --- antioxidant --- antibacterial --- cordycepin --- GC-MS --- Artemisia species --- Artemisia vachanica --- artemisinin --- HPLC-PAD --- Tajikistan --- Malus x domestica --- Tuscany --- ancient varieties --- nutraceutics --- antioxidants --- polyphenols --- sugars --- pectin --- defensins --- secondary metabolites --- plant defense --- antimicrobial and anticancer activity --- medicine --- innate immunity --- cannabis --- cannabinoids --- therapeutics --- toxicology --- analytical determination --- legalization --- natural products --- biosynthetic gene clusters --- secondary metabolites --- antiSMASH --- Mitragyna speciosa --- kratom --- secondary metabolites --- therapeutic uses --- toxicology --- analysis --- Maytenus chiapensis --- Celastraceae --- quinonemethide triterpenoids --- pristimerin --- tingenone --- HPLC-PDA --- Ocimum sanctum --- Lamiaceae --- (-)-rabdosiin --- cytotoxic activity --- triterpenoids --- phenolic derivatives --- nanoemulsion --- essential oils --- vector control --- infectious diseases --- TCM --- phytochemistry --- LC-MS/MS --- antioxidant activity --- ABTS --- DPPH --- FRAP --- ascorbic acid --- EGCG --- total phenolics --- antimicrobial activity --- sargaquinoic acid --- sarganaphthoquinoic acid --- antiplasmodial --- malaria --- PPAR-? --- sargahydroquinoic acid --- sarganaphthoquinoic acid --- sargachromenoic acid --- inflammation --- bowel diseases --- secondary metabolites --- biological activities --- medicinal applications --- plants --- seaweeds

Curcumin in Health and Disease

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ISBN: 9783039214495 / 9783039214501 Year: Pages: 274 DOI: 10.3390/books978-3-03921-450-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:15
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The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.

Keywords

brain ischemia --- curcumin --- Alzheimer’s disease --- neurodegeneration --- amyloid --- tau protein --- autophagy --- mitophagy --- apoptosis --- genes --- glioblastoma multiforme --- autophagy --- mitophagy --- curcumin --- chaperone-mediated autophagy --- Akt/mTOR signaling --- transmission electron microscopy --- Curcuma longa --- turmeric tuber --- Zingiberaceae --- TLC bioautography --- antimicrobial agents --- ImageJ --- TLC-MS --- hydrostatic counter-current chromatography --- centrifugal partition chromatography --- curcumin --- death receptor --- apoptosis --- curcumin --- anticancer --- structure activity relationship --- cellular pathway --- mechanism of action --- delivery system --- wound --- wound healing --- diet --- nutrition --- micronutrients --- macronutrients --- curcumin --- amino-acids --- vitamins --- minerals --- curcumin --- oxidative metabolites --- inflamm-aging --- cancer --- metabolic reprogramming --- direct protein binding --- IL-17 --- STAT3 --- SHMT2 --- ageing --- anti-cancer --- autophagy --- microbiota --- senescence --- senolytics --- curcumin --- transthyretin --- amyloidosis --- protein aggregation --- protein misfolding --- drug discovery --- curcumin --- renal cell cancer --- tumor growth --- tumor proliferation --- cell cycling --- curcumin --- reflux esophagitis --- gastroprotection --- gastric ulcer --- Helicobacter pylori --- gastric cancer --- curcumin --- complementary medicine --- cancer treatment --- supportive care --- antioxidants --- anti-inflamation --- ulcerative colitis --- Crohn’s disease --- necrotizing enterocolitis --- curcumin --- inflammatory bowel disease --- curcumin --- silica --- chitosan --- nanoparticles --- anti-tumor --- antioxidant activity --- n/a

Synthesis, Study and Utilization of Natural Products

Authors: ---
ISBN: 9783039281527 / 9783039281534 Year: Pages: 234 DOI: 10.3390/books978-3-03928-153-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemical Engineering --- Technology (General)
Added to DOAB on : 2020-01-30 16:39:46
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Natural products and the preparations based on them play a stable and ever-increasing role in human and veterinary medicine, agriculture, in food and the cosmetic industry, and in an increasing number of other fields. Their importance is based on the fact that they are mostly bound to renewable sources, which in fact makes them valuable within a circular economy, inter alia. At the same time, natural products provide the origin of stereochemistry, optical activity, regioselectivity, chirality, and many other concepts and directions within science, development, and industry in a scope, which is indispensable. They serve as a constant powerful stimulus and model that inspires researchers to create new effective tools, similar to natural ones, for controlling bioregulation mechanisms and solving practical problems. This was the reason for organizing this Special Issue aimed at underlining the current developments in all the fields connected to natural products.

Keywords

insect sex pheromone --- tea tussock moth --- total synthesis --- resource chemistry --- phycocyanin --- biosynthesis --- antioxidant --- Spirulina --- gene expression --- apo-CpcB --- Plantago depressa --- octadecanoid --- fatty acid --- natural enantiomer --- anti-inflammation --- soy protein isolate --- bromelain --- triglycidylamine --- viscosity --- water resistance --- adhesive --- Ramulus mori --- polysaccharides --- bioactivity --- synthesis of natural products --- varioxiranol A --- 4-epi-varioxiranol A --- absolute structure --- Emericella variecolor --- caffeoylquinic acids --- chlorogenic acid --- derivatives --- lipid-lowering effects --- oleic acid-elicited --- HepG2 cells --- isosorbide --- reversible urethane linkages --- cell opening --- antioxidant activity --- radical scavenger --- flexible polyurethane foam --- tomato --- SlCOMT1 --- melatonin --- genetical transformation --- salt stress --- natural product --- RiPP --- ribosomally synthesized --- post-translationally modified peptides --- rheumatoid arthritis --- natural products --- polyphenol --- flavonoids --- phenolic acid --- stilbene --- ginkgolide --- platelet-activating factor receptor --- inhibitor --- pinocembrin --- microbial biosynthesis --- pharmacological activities --- pharmacokinetic features --- research progress --- triterpenoids --- bardoxolone methyl --- anticancer drug --- mitochondria --- apoptosis --- cancer cells --- cytotoxicity --- flow cytometry --- live-cell fluorescence microscopy --- PEGylated purpurin 18 --- photodynamic therapy --- photosensitizer --- phototoxicity --- singlet oxygen --- n/a

Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential

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ISBN: 9783039215324 / 9783039215331 Year: Pages: 442 DOI: 10.3390/books978-3-03921-533-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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This Special Issue Book, “Marine Bioactive Peptides: Structure, Function, andTherapeutic Potential"" includes up-to-date information regarding bioactivepeptides isolated from marine organisms. Marine peptides have been found invarious phyla, and their numbers have grown in recent years. These peptidesare diverse in structure and possess broad-spectrum activities that have greatpotential for medical applications. Various marine peptides are evolutionaryancient molecular factors of innate immunity that play a key role in host defense.A plethora of biological activities, including antibacterial, antifungal, antiviral,anticancer, anticoagulant, endotoxin-binding, immune-modulating, etc., makemarine peptides an attractive molecular basis for drug design. This Special IssueBook presents new results in the isolation, structural elucidation, functionalcharacterization, and therapeutic potential evaluation of peptides found inmarine organisms. Chemical synthesis and biotechnological production of marinepeptides and their mimetics is also a focus of this Special Issue Book.

Keywords

sea cucumber --- ACE-inhibitory peptide --- molecular docking --- structure-activity relationship --- plastein reaction --- Gracilariopsis lemaneiformis --- ACE-inhibitory activity --- peptide --- molecular docking --- SHRs --- prostate cancer --- Anthopleura anjunae oligopeptide --- DU-145 cells --- PI3K/AKT/mTOR signaling pathway --- cod skin --- NA-inhibitory peptide --- influenza virus --- neuraminidase --- molecular docking --- adsorption --- host defense peptide --- antimicrobial peptide --- anti-LPS factor --- host?microbe relationship --- functional diversity --- invertebrate immunity --- crustacean --- antimicrobial activity --- antimicrobial peptide --- polychaeta --- innate immunity --- BRICHOS domain --- recombinant peptide --- ?-helix --- Rana-box --- nuclear magnetic resonance (NMR) --- antimicrobial peptide --- cytotoxicity --- ?-hairpin --- polyphemusins --- tachyplesins --- cell death --- signaling pathways --- Neptunea arthritica cumingii --- multi-functional peptides --- antioxidant activity --- ACE-inhibitory activity --- anti-diabetic activity --- Arenicola marina --- antimicrobial peptides --- arenicin --- complement --- C3a --- acid-sensing ion channel --- animal models --- pain relief --- toxin --- Ugr 9-1 --- APETx2 --- hairtail (Trichiurus japonicas) --- muscle --- peptide --- antioxidant activity --- half-fin anchovy hydrolysates --- Maillard reaction products --- antibacterial peptide --- identification --- self-production of hydrogen peroxide --- membrane damage --- Perinereis aibuhitensis --- decapeptide --- lung cancer --- cell proliferation --- apoptosis --- conotoxins --- conopeptides --- computational studies --- molecular dynamics --- machine learning --- docking --- review --- drug design --- ion channels --- Conus --- conotoxin --- transcriptome sequencing --- phylogeny --- venom duct --- abalone --- peptide --- vasculogenic mimicry --- metastasis --- MMPs --- HIF-1? --- dexamethasone --- myotube atrophy --- protein synthesis --- proteolytic system --- Pyropia yezoensis peptide --- PYP15 --- QAGLSPVR --- antihypertensive effect --- Caco-2 cell monolayer --- transport routes --- oyster zinc-binding peptide --- peptide-zinc complex --- caco-2 cells --- intestinal absorption --- zinc bioavailability --- Chlorella pyrenoidosa protein hydrolysate (CPPH) --- Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) --- calcium absorption --- gene expression --- gut microbiota --- cone snails --- conotoxins --- ion channels --- function --- structure --- marine peptides --- arenicin-1 --- molecular symmetry --- structure–activity relationship --- antibacterial --- cytotoxic --- chemical synthesis --- molecular dynamics --- tilapia --- HUVEC --- angiotensin II --- NF-?B --- Nrf2 --- endothelial dysfunction --- conotoxin --- cone snail --- Conus --- Conus ateralbus --- Kalloconus --- n/a

Isolation and Structure Elucidation of Bioactive Compounds (Dedicated to the memory of the late Professor Charles D. Hufford)

Authors: ---
ISBN: 9783038977803 9783038977810 Year: Pages: 276 DOI: 10.3390/books978-3-03897-781-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-04-25 16:37:17
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Abstract

We are very pleased to introduce the Book Version of our Special Issue in Molecules dedicated to the memory of the late Professor Dr. Charles D. Hufford. The issue has been a huge success, with 22 full-length peer-reviewed papers and a tribute by Professor Alice M.Clark. Authors, reviewers, and collaborators from many countries across the worldhave contributed to this endeavour, and we are truly grateful to all. This Special Issue isrepresentative of the broad impact that &ldquo;Charlie&rdquo; had on the field of bioactive naturalproducts. This Special Issue comprises papers from Professor Hufford&rsquo;s former students,colleagues, and collaborators throughout the world who have utilized a wide array ofstate-of-the-art techniques to examine diverse natural sources to isolate and identify avariety of natural products with a wide spectrum of biological activities, including somenew microbial transformations and insights into bioactive molecules. Many new bioactive compounds are described and reported here for the first time. Bioactivities reportedinclude cytotoxicity, antimicrobial activity, anti-inflammatory activity, antileishmanialactivity, antitrypanosomal activity, antimalarial activity, analgesic activity, and beneficialliver activities, just to name a few. This Special Issue will undoubtedly have a lasting impact on the field of bioactive natural products, as exemplified by the career of Dr. Hufford.Lastly, without the timely and outstanding contributions from all of you, this Special Issue would not have been possible. We thank you all very much for your contributions and your time devoted to this Special Issue in memory of a special person. Finally, we express ourgratitude and thanks to the journal Molecules and their excellent team of expert reviewers for giving us the support and opportunity to make this Special Issue a huge success!

Keywords

fusidic acid --- Cunninghamella echinulata --- C-26-oxidation --- C-27-oxidation --- Morus alba L. --- aldose reductase inhibitor --- neuroprotective agent --- natural products --- Mitracarpus scaber Zucc. --- pentalogin --- anti-inflammatory --- MS/MS --- Il-8 --- Crinum amabile --- augustine N-oxide --- buphanisine N-oxide --- biological activities --- Cryptococcus neoformans --- cryptococcosis --- HepG2 --- Prosopis glandulosa --- prosopilosidine --- amphotericin B --- fluconazole --- resveratrol --- dietary supplement --- gastro-resistant --- microparticles --- obesity --- HPLC --- Jatropha pelargoniifolia --- alkaloids --- flavonoids --- coumarinolignans --- diterpenes --- anti-inflammatory --- analgesic --- antipyretic --- Cochlospermum vitifolium --- Cochlospermaceae --- flavonoids --- lignans --- aromatic compounds --- carotenoids --- sterols --- liver activity --- Arthrinium sp. --- chromone --- polyketide --- antioxidant activity --- Rubiaceae --- jenipapo --- HPLC-ESI-IT-MS/MS --- flavonoids glycosides --- Baccharis --- antimalarial activity --- antitrypanosomal activity --- insecticidal activity --- GC/MS --- DNA barcoding --- microscopy --- antibacterial --- channel catfish --- columnaris disease --- Flavobacterium columnare --- stilbenes --- muscadine --- pyranoanthocyanin --- anti-leishmanial activity --- Leishmania donovani --- maleimides --- cytotoxicity --- SAR --- phlorogluciniol --- acylphloroglucinol --- anti-inflammatory --- iNOS --- NF-?B --- endophytic fungi --- sesterterpene --- cytotoxic activity --- pancreatic cancer --- Stevia rebaudiana --- diterpene glycosides --- rebaudioside A isomers --- 13(S)-hydroxyatisenoic acid derivative --- iso-stevioside X-ray structure --- Litsea cubeba --- cytotoxicity --- isolation and elucidation --- lignans --- antimicrobial resistance --- multi-drug resistant (MDR) --- methicillin resistant Staphylococcus aureus (MRSA) --- Zingiber monatnum --- terpenes --- (E)-8(17),12-labdadiene-15,16-dial --- zerumbol --- microbial transformation --- hop prenylflavanone --- isoxanthohumol --- cardiomyogenesis --- factor VII --- factor X --- inflammation --- thrombosis --- vasculogenesis --- herbal medicine --- n/a --- Nemania --- Xylariaceae --- Torreya taxifolia --- plant pathogenic and endophytic fungi --- cytochalasins --- malaria --- cytotoxicity --- phytotoxicity --- acacetin 7-methyl ether --- acacetin --- monoamine oxidase-A --- monoamine oxidase-B --- molecular docking --- molecular dynamics --- neurological disorder --- Turnera diffusa

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