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[This book focus on the most recent advances related to the design and processing methods of different nanobiomaterials, films, and fibers; surface functionalization strategies, including biological performance assessment and cytocompatibility; and their applications in tissue engineering strategies.]

titania nanotubes --- anodic oxidation --- biointegration --- antibacterial properties --- photocatalytic activity --- magnetic nanoparticles --- nanotechnology --- cell sheet --- odontogenic cells --- epithelial-mesenchymal interactions --- dental enamel regeneration --- cornea endothelial cells --- tissue engineering --- regeneration --- silk fibroin --- lysophosphatidic acid --- graphene --- nanomaterials --- dental stem cells --- antibacterial activity --- dental implant --- bone regeneration --- osteoclastogenesis --- RANK-RANKL-OPG --- mimetic peptide --- Gadolinium chelate --- MRI --- protein --- nanofibers --- biomaterials fabrication --- medicine --- tissue engineering --- wound healing --- drug delivery

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This book focus principally on ions-releasing and other smart dental materials for application in preventive and restorative dentistry, as well as in endodontics in the form of adhesives, resin-based composites, pastes, varnishes, liners and dental cements. Special attention has been given to bioactive materials developed to induce cells differentiation/stimulation, hard tissue formation and exert antimicrobial actions. New innovations are necessary to continue to help reinforcing existing technologies and to introduce new paradigms for treating dental disease and restoring teeth seriously compromised by caries lesions via biomimetic and more biological operative approaches. Dental bioactive materials is arguably the latest research area in dentistry and thus the amount of new research is overwhelming. However, in this day and age of evidence based practice it important for this new information to be distilled into a practical and understandable format.

orthodontic resin --- photocatalyst TiO2 --- antibacterial --- cariogenic --- early colonizer --- hydrophilic properties --- irradiation --- calcium silicate cements --- pulpal response --- mineralization --- calcific barrier --- inflammation --- odontoblastic layer --- resin cements --- shrinkage stress --- water sorption --- hydroscopic expansion --- photoelastic investigation --- antibacterial --- calcium --- doxycycline --- nanoparticles --- zinc --- dental composites --- antibacterial properties --- silver --- mechanical properties --- degree of conversion --- sorption --- solubility --- color stability --- mechanical properties --- nanotubes --- resin composite --- Streptococcus mutans --- triclosan --- bleaching products --- diffusion --- cytotoxicity --- dental pulp --- stem cells --- nanoporous silica --- glass-ionomer cement --- calcium --- preclinical biosafety --- bone substitute --- mesenchymal stem cells --- ?-tricalcium phosphate --- tissue engineering --- dental sealant --- resin sealant --- calcium phosphate nanoparticles --- long-term ion release --- remineralization --- ion recharge --- dentin --- desmineralization --- microtensile bond strength --- adhesion --- bioactive --- cycling mechanical stress --- dentine --- longevity --- resin-modified glass ionomer cements --- polyacrylic acid treatment --- bone regeneration --- ?-tricalcium phosphate --- calcium sulfate --- bone substitutes --- animal study --- n/a --- adhesion --- cycling mechanical stress --- dentine --- longevity --- glass-ionomer cements --- universal adhesives

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The importance of bioactive natural compounds in pharmacology and other biotechnological fields has stimulated the scientific community to explore new environmental contexts and their associated microbial diversity. As the largest frontier in biological discovery, the sea represents a significant source of organisms producing novel secondary metabolites with interesting bioactivities. Of the available biological material, fungi have received increasing consideration, both due to their pervasive occurrence in varying habitats as well as their aptitude to develop symbiotic associations with higher organisms in numerous contexts. In many cases, fungal strains have been reported as the real producers of drugs originally extracted from marine plants and animals. Due to the constantly increasing number of marine-derived fungi yielding valuable bioactive products, it is now appropriate to present these findings to a recipient audience in a more organized form. This Special Issue of Marine Drugs, entitled “Bioactive Compounds from Marine-Derived Aspergillus, Penicillium, Talaromyces, and Trichoderma Species"" is specifically focused on a few genera of ascomycetous fungi which are widespread regarding marine contexts and are particularly inclined to establishing symbiotic relationships. For this project, we welcome submissions of full research papers, short notes, and review articles reporting the discovery and characterization of products showing antibiotic, antitumor, antiviral, insecticidal, antimalarial, antifouling, antioxidant, plant growth-promoting and/or resistance-inducing, as well as other less-exploited activities.

mangrove endophytic fungus --- coumarin --- chromone --- sterone --- antifungal activity --- Aspergillus clavatus --- Aspergillus --- candidusin --- aspetritone --- cytotoxic --- antibacterial --- bioactive products --- drug discovery --- endophytic fungi --- mangroves --- Talaromyces --- marine-derived fungi --- Penicillium sp. TJ403-1 --- breviane spiroditerpenoid --- IDH1 inhibitory activity --- cytotoxicity --- Aspergillus candidus --- Aspergillaceae --- sponge-associated fungus --- bis-indolyl benzenoids --- hydroxypyrrolidine --- antibacterial activity --- cytotoxicity --- sesquiterpenoid --- diterpenoid --- Talaromyces purpurogenus --- NMR data calculations --- ECD calculations --- cytotoxicities --- breast cancer --- BK (Maxi-K) channel --- EGFR --- HER2 --- penitrem A --- gefitinib --- lapatinib --- TNF-? --- Penicillium raistrickii --- polyketides --- diastereomers --- thermo-change strategy --- marine-derived fungi --- secondary metabolites --- indole-diterpenoids --- cytotoxicity --- n/a

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This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.

electrospinning --- Eudragit --- nanofibers --- drug release --- carvedilol --- poly (vinylpyrrolidone-co-vinyl acetate) --- high-speed electrospinning --- high-shear mixing --- homogenization --- Raman mapping --- sieve analysis --- amorphous composite --- coaxial electrospinning --- fast dissolution --- insoluble drug --- solid dispersion --- electrospinning --- parameters --- drug delivery --- applications --- solid dispersion --- aqueous solubility enhancement --- amorphous --- crystalline --- oral drug delivery --- electrospinning --- cyclodextrin --- electrospinning --- drug delivery --- nanofibers --- cyclodextrin-inclusion complexes --- essential oils --- electrospun nanofibers --- poly-cyclodextrin --- antibacterial --- antibiotics --- PMVE/MA --- electrospinning --- nanofibers --- capsaicin --- psoriasis --- TRPV1 --- PCL --- electrospinning --- combination therapy --- photothermal therapy --- NIR-triggered drug release --- xanthan gum --- electrospinning --- gallic acid --- permeability --- electrospinning --- tissue engineering --- drug delivery

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In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones.

sponge --- saponins --- deep-sea --- Poecillastra compressa --- Neothyonidium magnum --- triterpene glycosides --- magnumosides --- sea cucumber --- cytotoxic activity --- radioactive irradiation --- sea cucumber --- Eupentacta fraudatrix --- triterpene glycoside --- liquid chromatography–tandem mass spectrometry --- metabolite profiling --- holostane --- nonholostane --- cucumarioside --- cytotoxic --- antifungal --- glycosides --- Conus pulicarius --- steroidal glycoside --- cholesterol sulfate --- cytotoxicity --- leukemia --- cancer --- frondoside A --- tumor growth --- metastases --- apoptosis --- invasion --- angiogenesis --- Culcita novaeguineae --- starfish --- polyhydroxysteroidal glycoside --- cytotoxicity --- mangrove-derived Streptomyces --- angucycline --- urdamycin --- marine organisms --- carbohydrate --- glycoside --- antioxidant --- anticoagulant --- anti-inflammatory --- antitumor --- antimicrobial --- glycolipids --- glycosphingolipids --- glycoglycerolipids --- natural products --- total synthesis --- triterpene glycosides --- saponin --- sea cucumber --- mass spectrometry --- MALDI --- ESI --- LC-MS --- Holothuroidea --- marine ginseng --- structure elucidation --- marine invertebrate --- natural products --- bioactive compounds --- antifungal --- antibacterial --- antioxidant --- Streptomyces --- angucycline glycosides --- saquayamycin --- cytotoxicity --- apoptosis --- SMMC-7721