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Marine Natural Products and Obesity

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ISBN: 9783039211913 9783039211920 Year: Pages: 194 DOI: 10.3390/books978-3-03921-192-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-08-28 11:21:27
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Obesity and related co-morbidities are increasing worldwide and pose a serious health problem. Changes in lifestyle and diet would be the best remedies to fight obesity; however, many people will still rely on medical aid. Marine organisms have been prolific in the production of bioactive compounds for many diseases, e.g., cancer, and promise to be an excellent source for natural-derived molecules and novel nutraceuticals. Bioactive compounds with beneficial activities towards obesity have been described from diverse marine organism including marine algae, bacteria, sponges, fungi, crustaceans or fish. This Special Issue will highlight the progress in the following topics: Bioactive compounds for the treatment of obesity and obesity-related co-morbidities (diabetes, fatty liver, hyperlipidemia) from marine organisms; the isolation of novel compounds, the bioactivity screening of marine organisms and the elucidation of molecular mode of action of marine bioactive compounds.

Selected Papers from the 9th Symposium on Micro-Nano Science and Technology on Micromachines

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ISBN: 9783039216963 9783039216970 Year: Pages: 170 DOI: 10.3390/books978-3-03921-697-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2019-12-09 16:10:12
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This Special Issue presents selected papers from the 8th

Keywords

vibration-induced flow --- micro-pillar --- numerical analysis --- micro-PIV --- acoustofluidics --- microscale thermophoresis --- multiphase flow --- microfluidic channels --- nano/microparticle separation --- micro-electro-mechanical-systems (MEMS) technologies --- magneto-impedance sensor --- thin-film --- high frequency --- logarithmic amplifier --- nondestructive inspection --- microfluidics --- biofabrication --- adipose tissue --- lipolysis --- tactile display --- thermal tactile display --- thermal sensation --- thermal conductivity --- liquid metal --- flexible device --- stretchable electronic substrate --- kirigami structure --- mechanical metamaterials --- surface mounting --- flexible electronic device --- contact resistance --- contact pressure --- myoblast --- skeletal muscle --- core-shell hydrogel fiber --- cyclic stretch --- engineered muscle --- laser direct writing --- femtosecond laser --- glyoxylic acid Cu complex --- reduction --- Cu micropattern --- near-infrared --- spectroscopy --- surface plasmon resonance --- Schottky barrier --- grating --- Si --- connector --- artificial blood vessel --- medical device --- blood coagulation --- implant --- artificial kidney --- biocompatible --- 4D printing --- 3D printing --- stimuli-responsive hydrogel --- electrical impedance measurement --- three-dimensional cell culture --- adipocyte --- lipid droplet --- 3T3-L1 --- functional surface --- condensation --- molecular dynamics --- wettability --- nanoscale structure --- n/a

Lignans

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ISBN: 9783038979081 9783038979098 Year: Pages: 384 DOI: 10.3390/books978-3-03897-909-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Organic Chemistry
Added to DOAB on : 2019-06-26 10:09:00
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Lignans are a class of natural products found mainly in plants. They have a wide variety of structures and exhibit a range of potent biological activities. Lignans are also well-known components of a number of widely eaten foods and are frequently studied for their dietary impact. Owing to these factors, lignans have been extensively studied by scientists from a large number of disciplines. This collection of research and review articles describes topics ranging in scope from the recent isolation and structural elucidation of new lignans, strategies towards the chemical synthesis of lignans, assessment of their biological activities and potential for further therapeutic development. Research showing the impact of lignans in the food and agricultural industries is also presented.

Keywords

lignans --- chemometrics --- neolignans --- flavonolignans --- chemical space --- drug-like --- Lespedeza cuneata --- lignan glycoside --- flavonoid glycoside --- cytotoxicity --- adipocyte and osteoblast differentiation --- Bursera --- Burseraceae --- lignans --- lignan --- molecular dynamics --- intermolecular interactions --- graph theory --- lignans --- heilaohu --- tujia ethnomedicine --- chemical characterization --- cytotoxicity --- antioxidant --- cultivar --- environment --- flax --- flavonol --- genetic --- hydroxycinnamic acid --- lignan --- seed --- aryldihydronaphthalene lignan --- arylnaphthalene lignan --- oxidation --- synthesis --- lignans --- dibenzyl butyrolactones --- anti-proliferative --- acyl-Claisen --- stereoselective synthesis --- Schisandra rubriflora --- Schisandra chinensis --- red-flowered Chinese magnolia vine --- Chinese magnolia vine --- lignans --- phytochemical analysis --- UHPLC-MS/MS --- anti-inflammatory activity --- LOX --- COX --- sPLA2 --- lignans --- neolignans --- Lauraceae --- chemical components --- chemical structures --- dietary lignans --- national databases --- food groups --- dietary intake --- harmonized databases --- lignans --- in silico studies --- podophyllotoxin --- antibacterial activity --- acetylcholinesterase inhibitors --- antioxidant activity --- cytotoxicity --- natural products --- total synthesis --- lignan --- Bursera fagaroides --- podophyllotoxin-type lignans --- cell cycle --- cell migration --- epiboly --- microtubules --- F-actin --- cancer --- lignans --- animal health --- cattle --- enterolignan --- human health --- pharmacokinetic --- ruminant --- secoisolariciresinol diglucoside --- Lignan --- bitterness --- taste-active compound --- quantification --- oak ageing --- lignans --- norlignans --- 9-norlignans --- semisynthesis --- hydroxymatairesinol --- bioactivity --- lignans --- oxidation --- lignans --- diet --- antioxidants --- health promotion --- chronic diseases --- Schisandrae Chinensis Fructus --- wild --- cultivated --- multiple bioactive components --- simultaneous quantitation

Carotenoids and Human Health

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ISBN: 9783039218325 9783039218332 Year: Pages: 308 DOI: 10.3390/books978-3-03921-833-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-01-07 09:08:26
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Carotenoids are a group of approximately 600 compounds synthesized by photosynthetic organisms. These pigments are abundant in fruits and vegetables, as well as in certain animal products such as eggs and salmon, being responsible for their colorful appearance. The bioactive properties of certain carotenoids in human health are clear, as some of these compounds have antioxidant properties and serve as the only precursors of vitamin A in nature. The aim of this Special Issue entitled “Carotenoids and Human Health” is to provide the scientific community with an updated perspective of this exciting and growing research area. We compiled 19 papers from some of the most prominent scientists in the carotenoid field, including seven literature reviews and 12 original publication, covering topics such as cancer, obesity, vision, cognitive function, and skin health.

Keywords

carotenoids --- lycopene --- gastric cancer --- H. pylori --- smoking --- case-control study --- Korea --- cancer-related cognitive impairment --- cognition --- carotenoid --- memory --- inflammation --- mango by-products --- lutein --- ?-carotene --- ?-tocopherol --- mangiferin --- food ingredients --- astaxanthin --- Akkermansia --- alcoholic fatty liver disease --- inflammation --- gut microbiota --- lycopene --- carotene --- retinoic acid --- retinoid --- vitamin A --- RAR --- RXR --- ?-carotene --- ?-carotene --- ?-cryptoxanthin --- carotenoids --- lutein --- provitamin A --- retinol --- vitamin A --- breastfeeding --- new-born --- full-term mothers --- preterm mothers --- xanthophylls --- carotenes --- lutein --- colostrum --- mature milk --- ?-Cryptoxanthin --- carotenoids --- Caenorhabditis elegans --- fat reduction --- oxidative stress --- transcriptomic analysis --- metabolic syndrome --- aging --- prostate cancer --- tomato --- lycopene --- androgen --- cell culture --- animal --- obesity --- hippocampus --- nutrition --- overweight --- carotenoids --- Phaeodactylum tricornutum --- microalgae --- fucoxanthin --- eicosapentanoic acid --- obesity --- browning --- brown adipose tissue --- carotenes --- xanthophylls --- bioavailability --- intestine --- membrane transporters --- Vitamin A --- adipocyte --- ?-carotene oxygenase 1 --- hypertension --- carotenoids --- tomato extract --- lycopene --- phytoene --- phytofluene --- bioavailability --- glaucoma --- antioxidants --- oxidative stress --- macular pigment --- lutein --- colourless carotenoids --- cosmeceuticals --- functional foods --- nutraceuticals --- nutricosmetics --- photoprotection --- phytoene --- phytofluene --- public health --- nutrition --- chronic disease --- lutein --- zeaxanthin --- lycopene --- beta-carotene --- alpha-carotene --- beta-cryptoxanthin --- adipocytes --- adipose tissue --- brain --- carotenoids --- obesity --- retinoids --- carotenoids --- bioactive compounds

AMP-Activated Protein Kinase Signalling

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ISBN: 9783038976622 Year: Pages: 452 DOI: 10.3390/books978-3-03897-663-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-03-21 14:08:22
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Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included.

Keywords

exercise --- glucose uptake --- AMP-activated protein kinase --- TBC1D4 --- AS160 --- AMP-activated protein kinase --- developmental origins of health and disease (DOHaD) --- hypertension --- kidney disease --- nutrient-sensing signals --- oxidative stress --- renin-angiotensin system --- AMPK --- autophagy --- co-expression --- microarrays --- 3T3-L1 --- adipocyte --- differentiation --- AMPK --- tight junctions --- epithelial cells --- ZO-1 --- par complex --- MDCK --- nectin-afadin --- adherent junctions --- TAK1 --- AMPK --- phosphorylation --- AMPK kinase --- endothelial nitric-oxide synthase --- vasodilation --- phenylephrine --- vasoconstriction --- endothelial cells --- ionomycin --- AMPK --- liver --- lipid metabolism --- fatty acid oxidation --- indirect calorimetry --- atrophy --- regrowth --- sirtuin 1 (SIRT1) --- peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) --- heat shock protein --- fiber-type --- AMPK --- monocytes --- macrophages --- differentiation --- autophagy --- AML --- MDS --- CML --- CMML --- pregnancy --- catechol-O-methyltransferase --- 2-methoxyestradiol --- preeclampsia --- gestational diabetes mellitus --- AMPK --- IL-1? --- NLRP3 --- nutrition --- dietary fatty acids --- metabolic-inflammation --- nutrigenomics --- AMPK --- LKB1 --- autophagy --- proteasome --- hypertrophy --- atrophy --- skeletal muscle --- AICAR --- mTOR --- protein synthesis --- AMPK --- epigenetics --- chromatin remodeling --- histone modification --- DNA methylation --- medulloblastoma --- sonic hedgehog --- AMPK --- AMP-activated protein kinase (AMPK) --- spermatozoa --- motility --- mitochondria --- membranes --- signaling --- stress --- assisted reproduction techniques --- AMP-activated protein kinase --- epigenetics --- protein acetylation --- KATs --- HDACs --- acetyl-CoA --- NAD+ --- AMP-activated protein kinase --- glycogen --- exercise --- metabolism --- cellular energy sensing --- energy utilization --- liver --- skeletal muscle --- metabolic disease --- glycogen storage disease --- resveratrol --- AMPK --- hepatocyte --- liver --- steatosis --- transporter --- carrier --- pump --- membrane --- energy deficiency --- AMPK --- infection --- mycobacteria --- host defense --- energy metabolism --- AMPK --- activation loop --- AID --- ?-linker --- ?-linker --- CBS --- LKB1 --- CaMKK2 --- ?RIM --- hypothalamus --- adenosine monophosphate-activated protein kinase --- adipose tissue --- food intake --- adaptive thermogenesis --- beiging --- AMPK --- HDAC4/5 --- p70S6K --- MyHC I(?), motor endplate remodeling --- soleus muscle --- mechanical unloading --- hindlimb suspension --- AMPK --- synaptic activation --- PKA --- CREB --- soluble Adenylyl cyclase --- Immediate early genes --- transcription --- AMPK --- autophagy --- metabolism --- mTOR --- ULK --- AMP-activated protein kinase --- protein kinase B --- Akt --- insulin signalling --- A769662 --- endothelial function --- n/a

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2019 (5)