Search results: Found 8

Listing 1 - 8 of 8
Sort by
Biomedical Chemistry. Current Trends and Developments

Author:
ISBN: 9783110468755 9783110468878 Year: Pages: 361 DOI: 10.1515/9783110468755 Language: English
Publisher: De Gruyter
Subject: Biochemistry --- Organic Chemistry
Added to DOAB on : 2017-01-18 19:08:48
License:

Loading...
Export citation

Choose an application

Abstract

Biomedical Chemistry provides readers with an understanding of how fundamental chemical concepts are used to combat some diseases. The authors explain the interdisciplinary relationship of chemistry with biology, physics, pharmacy and medicine. The results of chemical research can be applied to understand chemical processes in cells and in the body, and new methods for drug transportation. Also, basic chemical ideas and determination of disease etiology are approached by developing techniques to ensure optimum interaction between drugs and human cells. This Book is an excellent resource for students and researchers in health-related fields with frontier topics in medicinal and pharmaceutical chemistry, organic chemistry and biochemistry.

Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198191 Year: Pages: 147 DOI: 10.3389/978-2-88919-819-1 Language: English
Publisher: Frontiers Media SA
Subject: Oncology --- Medicine (General)
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the “Pediatric Cancer Translational Genomics” conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on “Molecular Biology and Innovative Therapies in Sarcomas” (Pultusk, Poland, 2012), and the AACR special meeting on “Pediatric Cancer at the Crossroads – Translating Discovery into Improved Outcomes” (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists.

Reward- and aversion-related processing in the brain: translational evidence for separate and shared circuits

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198368 Year: Pages: 181 DOI: 10.3389/978-2-88919-836-8 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

Affective brain circuits underpin our moods and emotions. Appetitive and aversive stimuli from our exteroceptive and interoceptive worlds play a key role in the activity of these circuits, but we still do not know precisely how to characterize these so-called reward-related and aversion-related systems. Moreover, we do we yet understand how they interact anatomically or functionally. The aim of the current project was to gather some translational evidence to help clarify the role of such circuits. A multi-dimensional problem in its own right, the book contains 14 works from authors exploring these questions at many levels, from the cellular to the cognitive-behavioral, and from both experimental and conceptual viewpoints. The editorial which introduces the book provides brief summaries of each perspective (Hayes, Northoff, Greenshaw, 2015). While questions of how to accurately define affect- and emotion-related concepts at the psychological level are far from answered, here we have attempted to provide some insight into the brain-based underpinnings of such processes. The near future will undoubtedly involve making new inroads and will require the joint efforts of behavioral, brain-based, and philosophical perspectives to do so.

Challenging the Functional Connectivity Disruption in Neurodegenerative Diseases: New Therapeutic Perspectives through Non-Invasive Neuromodulation and Cutting-Edge Technologies

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455935 Year: Pages: 143 DOI: 10.3389/978-2-88945-593-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2019-01-23 14:53:43
License:

Loading...
Export citation

Choose an application

Abstract

The neurorehabilitation field is increasingly focused on understanding how to efficiently revert the effects that acute (i.e., stroke or traumatic brain injury) or chronic (i.e., neurodegenerative diseases) insults play either on small or large-scale networks, encompassing motor, sensory and cognitive domains. The link between the disrupted neuronal pulse generators and their effectors is being re-shaped through a wide scenario that embraces biorobotics, robot-aided rehabilitation, non-invasive neurostimulation, nanoprosthetics and neuroengineering. For the past decade and at an amazing speed, large investments and efforts allowed enthusiastic and only apparently heterogeneous researchers to borrow theories from neurophysiology, pharmacology, physics and quantum mechanics in order to generate together highly sophisticated tools that restore, resemble or even substitute the basic biological architecture. The idea of actually reverting weakened functions and/or replacing the faulty parts either of the human body or the central and peripheral nervous system is becoming a new reality, opening a fascinating era in this field.In this Research Topic, several researchers showed how the above principles became reality, from theory to the bedside of patients, providing full explanations of the whole mechanistic processes and how they were implemented, up to the final stage.

Molecular Pharmacology and Pathology of Strokes

Authors: ---
ISBN: 9783038975410 / 9783038975427 Year: Pages: 152 DOI: 10.3390/books978-3-03897-542-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics --- Cardiovascular
Added to DOAB on : 2019-02-11 11:33:53
License:

Loading...
Export citation

Choose an application

Abstract

Stroke, a progressively non-communicable disease, is the second leading cause of death after coronary heart disease in developed countries. The present treatment options for stroke are adapting lifestyle practices, diabetes treatment, drugs, and the management of other factors, but no cure is yet available, despite new insights into molecular and therapeutic targets. Discoveries related to explicating the molecular pharmacology in cerebrovascular function and thrombosis have led to significant advancements in the current treatment paradigm for patients with stroke. Hence, this Special Issue invited scientific papers and reviews from researchers to provide solid evidence from a molecular point of view to scrutinize the molecular pharmacology and pathology of strokes. Platelet activation plays a major role in cardio and cerebrovascular diseases. Platelets also play a key role in the hemostatic process and are associated with various pathological events, such as arterial thrombosis and atherosclerosis. While the currently used anti-platelet drugs such as aspirin and clopidogrel demonstrate efficacy in many patients, they exert undesirable side effects. Therefore, the development of effective therapeutic strategies for the prevention and treatment of thrombotic diseases is a significant priority. Recently, precious metal drugs have conquered the subject of metal-based drugs, and several investigators have moved their attention to the synthesis of various ruthenium (Ru) and iridium (Ir) complexes due to their prospective therapeutic values. We have published this e-book about the “Molecular Pharmacology and Pathology of Strokes” and anticipate that readers will find this book useful regarding the significant challenges and current advances that are presently being made in stroke research, with the possibility of inspiring the application of novel drug development to enrich the devotion and treatment of patients with cardiovascular diseases.

Molecular Research of Endometrial Pathophysiology

Authors: ---
ISBN: 9783039214952 / 9783039214969 Year: Pages: 378 DOI: 10.3390/books978-3-03921-496-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 16:10:12
License:

Loading...
Export citation

Choose an application

Abstract

The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.

Keywords

RANK --- endometrium --- endometrial cancer --- prognosis --- immunohistochemistry --- gene expression --- endometriosis --- developmental pathway --- pathogenomics --- mesenchymal stem cells --- endometrial cancer --- mtDNA mutations --- deficit of complex I --- antioxidant response --- mitochondrial biogenesis --- mitochondrial dynamics --- mitophagy --- miRNA --- lncRNAs --- endometrial cancer --- endometriosis --- chronic endometritis --- cell contacts --- tight junction --- adherens junction --- gap junction --- endometrium --- implantation --- decidualization --- endometriosis --- endometrial cancer --- liquid biopsy --- uterine aspirate --- circulating tumour cells (CTCs) --- circulating tumour DNA (ctDNA) --- exosomes --- Vitamin D --- endometrium --- endometrial cancer --- endometrial cancer --- preclinical models --- translational research --- endometrial cancer --- type II endometrial carcinoma --- targeted therapy --- kinase inhibitor --- molecular marker --- protein kinase --- protein phosphatase --- PP2A --- PPP2R1A --- SMAP --- endometriosis --- infertility --- niche --- inflammation --- immunomodulation --- mesenchymal stem cell --- orthoxenograft --- uterine cancer --- avatar --- murine models --- personalized medicine --- targeted therapy --- preclinical studies --- translational research --- endometriosis --- TRP channels --- endometrial stromal cells --- eutopic and ectopic endometrium --- endometrial cell --- pathway --- proliferation --- decidualization --- migration --- angiogenesis --- regeneration --- breakdown --- implantation --- endometrial cancer --- orthotopic xenograft model --- estrogen dependent --- bioluminescence imaging --- contrast-enhanced CT scan --- endometrium --- adult stem cells --- endometrial regeneration --- stem cell markers --- endometriosis --- endometrial cancer --- decidualisation --- oestradiol --- aromatase --- testosterone --- dehydroepiandrosterone (DHEA) --- endometriosis --- endometrial cancer --- sulfatase --- endometriosis --- ectopic stroma --- microRNA --- small RNA sequencing --- EDN1 --- HOXA10 --- miR-139-5p --- miR-375 --- CTCF --- tumour suppressor gene --- haploinsufficiency --- zinc finger --- CRISPR/Cas9 --- cancer --- endometrial cancer --- gene editing --- phosphoinositide 3-kinase --- PIK3CA --- PIK3CB --- p110? --- p110? --- endometrial cancer --- LGR5 --- endometrium --- endometriosis --- menstrual cycle --- macrophages

Drug Delivery Technology Development in Canada

Authors: ---
ISBN: 9783039280049 / 9783039280056 Year: Pages: 352 DOI: 10.3390/books978-3-03928-005-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-01-07 09:21:22
License:

Loading...
Export citation

Choose an application

Abstract

Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community.

Keywords

doxorubicin --- MG63 --- Vitamin D --- DOX-Vit D --- hypoxia-induced chemoresistance --- cisplatin --- polymeric micelle --- EGFR-targeted therapy --- STAT3 --- HIF-1 --- GE11 peptide --- pharmacological Inhibitors of HIF-1 and STAT3 --- combination therapy --- pharmacokinetics --- antibodies --- radiolabeling --- biodistribution --- mouse models --- oral formulation --- amphotericin B --- fungal infections --- parasitic infections --- developing world --- drug delivery --- liposomes --- drug delivery systems --- innovation --- lipid nanoparticles --- Metaplex --- triggered drug release --- liposomes --- ultrasound --- magnetic fields --- radiation --- oral delivery --- biological barriers --- co-delivery --- throughput --- sustained delivery --- phospholipid complex --- rosmarinic acid --- bioaccessibility --- dissolution --- TNO gastrointestinal model --- gastrointestinal simulator --- phytosterols --- tocopherols --- liposomes --- canola oil deodorizer distillate --- model orange juice --- virus --- plant --- bacteriophage --- phage display --- drug discovery --- encapsulation --- drug delivery --- blood-brain barrier --- intra-arterial chemotherapy --- malignant gliomas --- primary central nervous system lymphomas --- transdermal drug delivery --- Canada --- skin --- permeation enhancers --- oral, head and neck squamous cell carcinoma --- targeted therapies --- drug delivery systems --- nanoparticles --- controlled drug delivery --- circadian clock --- chronotherapy --- precision medicine --- cationic gemini surfactant --- melphalan --- inclusion complex --- ROESY NMR spectroscopy --- 3D spheroid --- drug-resistant melanoma --- liposome --- water miscible solvents --- remote loading --- staurosporine --- cancer --- gambogic acid --- loading gradients --- mefloquine --- child friendly formulation --- blood-brain barrier (BBB) --- drug delivery --- transient modulation --- HAV6 cadherin peptide --- adenanthin --- magnetic resonance imaging (MRI) --- medulloblastoma --- drug delivery --- pharmaceutics --- drug development --- formulation and dosage form development --- translational research --- biologicals --- small molecules --- clinical trials --- pharmacokinetics --- medical devices --- route of administration --- nifedipine --- emulsion --- flavonoids --- topical formulation --- quercetin --- photostabilizers

Plant Development and Organogenesis: From Basic Principles to Applied Research

Author:
ISBN: 9783039281268 / 9783039281275 Year: Pages: 246 DOI: 10.3390/books978-3-03928-127-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Plant Sciences --- Biology --- Science (General)
Added to DOAB on : 2020-01-30 16:39:46
License:

Loading...
Export citation

Choose an application

Abstract

The way plants grow and develop organs significantly impacts the overall performance and yield of crop plants. The basic knowledge now available in plant development has the potential to help breeders in generating plants with defined architectural features to improve productivity. Plant translational research effort has steadily increased over the last decade due to the huge increase in the availability of crop genomic resources and Arabidopsis-based sequence annotation systems. However, a consistent gap between fundamental and applied science has yet to be filled. One critical point often brought up is the unreadiness of developmental biologists on one side to foresee agricultural applications for their discoveries, and of the breeders to exploit gene function studies to apply to candidate gene approaches when advantageous on the other. In this book, both developmental biologists and breeders make a special effort to reconcile research on the basic principles of plant development and organogenesis with its applications to crop production and genetic improvement. Fundamental and applied science contributions intertwine and chase each other, giving the reader different but complementary perspectives from only apparently distant corners of the same world.

Keywords

wheat-rye hybrids --- genes of reproductive isolation --- stem apical meristem --- molecular marker --- Rht18 --- reduced height --- wheat --- semi-dwarf --- linkage map --- CLE --- CLV --- WUS --- stem cells --- meristem --- SAM --- signaling --- locule --- Arabidopsis --- auxin --- HD-Zip transcription factors --- light environment --- photoreceptors --- wounding --- root plasticity --- hydrogen peroxide --- protoxylem --- plant development and organogenesis --- proline biosynthesis --- RolD --- rol genes --- Vasculature --- Organogenesis --- Development --- Brassicaceae --- Asteraceae --- flowering time --- photoperiod --- vernalization --- ambient temperature --- gibberellins --- age --- plant breeding --- grass --- ligule --- organogenesis --- boundaries --- shoot meristem --- morphogenesis --- molecular regulation --- cell wall --- cytoskeleton --- Arabidopsis --- root --- stem cells --- root development --- differentiation --- ground tissue --- radial patterning --- proximodistal patterning --- Plant in vitro cultures --- somatic cell selection --- hairy roots --- rol genes --- Agrobacterium rhizogenes --- genetic transformation --- recalcitrant species --- KNOX transcription factors --- plant development --- tree phase change --- transformation --- morphogenic --- embryogenesis --- meristem formation --- organogenesis --- GRETCHEN HAGEN 3 (GH3) IAA-amido synthase group II --- root apical meristem --- auxin --- cytokinin --- lateral root cap --- auxin minimum --- auxin conjugation --- plant development and organogenesis --- translational research --- crop productivity --- genetic improvement --- Arabidopsis thaliana --- regulatory networks --- phytohormones --- rol genes --- plant cell and tissue culture

Listing 1 - 8 of 8
Sort by
Narrow your search