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Deceptive Conducts before the Patent Office

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Book Series: Munich Intellectual Property Law Center – MIPLC ISBN: 9783748902577 Year: Volume: 37 Pages: 335 DOI: https://doi.org/10.5771/9783748902577 Language: English
Publisher: Nomos Verlagsgesellschaft mbH & Co. KG
Subject: Law
Added to DOAB on : 2019-10-25 11:43:48
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In an increasingly harmonized global patent landscape, few issues still distinguish the US patent system as much as its strict–and often criticized–duty of candor and its inequitable conduct doctrine. The EPO and most other countries around the world impose less burdensome disclosure duties upon patent applicants. What is there to learn from the experience in the US? Have these tools resulted in any benefit worth considering? Yet regardless of the disclosure duties imposed upon patent applicants, a deceptive conduct before the Patent Office could lead to unwarranted exclusive rights and have a negative impact on competition. Should antitrust law intervene? Is it a case of sham litigation? This work attempts to answer those questions through a comparative analysis, examining the law and case law in the US and in the EU from both a patent and a competition law perspective and seeking a workable theory of harm.

Genetic Determinants of Human Longevity

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ISBN: 9783039216789 9783039216796 Year: Pages: 118 DOI: 10.3390/books978-3-03921-679-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Genetics
Added to DOAB on : 2019-12-09 11:49:16
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In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes.

Environmental Fate of Emerging Organic Micro-Contaminants

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ISBN: 9783039213672 9783039213689 Year: Pages: 128 DOI: 10.3390/books978-3-03921-368-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Environmental Sciences
Added to DOAB on : 2019-12-09 11:49:15
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The toxicity and fate of pharmaceuticals and other emerging micro-organic contaminants in the natural and built environments have been the focus of much research over the last twenty years. Particular focus has recently centred on the fate of antimicrobial chemicals, including antibiotics and antifungals. The occurrence of such chemicals in the environment is thought to contribute to the selection of resistance in exposed microorganisms.This Special Issue (SI) brings together a broad range of recent advances in the field of emerging micro-organic contaminants, ranging from medicinal contaminants to industrial chemicals in the environment. Notably, these range from chemical extraction and large-scale analysis to adverse effects on non-target aquatic organisms and potential risk to humans via contaminated foodstuffs. Additionally, this Special Issue also presents novel contaminant treatment/degradation methods of both physical and biological nature.

Biomass Processing for Biofuels, Bioenergy and Chemicals

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ISBN: 9783039289097 / 9783039289103 Year: Pages: 428 DOI: 10.3390/books978-3-03928-910-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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Biomass can be used to produce renewable electricity, thermal energy, transportation fuels (biofuels), and high-value functional chemicals. As an energy source, biomass can be used either directly via combustion to produce heat or indirectly after it is converted to one of many forms of bioenergy and biofuel via thermochemical or biochemical pathways. The conversion of biomass can be achieved using various advanced methods, which are broadly classified into thermochemical conversion, biochemical conversion, electrochemical conversion, and so on. Advanced development technologies and processes are able to convert biomass into alternative energy sources in solid (e.g., charcoal, biochar, and RDF), liquid (biodiesel, algae biofuel, bioethanol, and pyrolysis and liquefaction bio-oils), and gaseous (e.g., biogas, syngas, and biohydrogen) forms. Because of the merits of biomass energy for environmental sustainability, biofuel and bioenergy technologies play a crucial role in renewable energy development and the replacement of chemicals by highly functional biomass. This book provides a comprehensive overview and in-depth technical research addressing recent progress in biomass conversion processes. It also covers studies on advanced techniques and methods for bioenergy and biofuel production.

Keywords

lignocellulose --- pretreatment --- hardwood --- extrusion --- enzymatic digestibility --- bioethanol --- renewable energy --- biofuel --- environment --- technology development --- co-combustion --- sewage sludge --- thermogravimetric analysis --- Fourier transform infrared spectroscopy --- synergistic effect --- single-pellet combustion --- biodiesel --- fatty acid methyl ester --- free fatty acids --- oxidation stability --- antioxidant --- hydrogen --- coffee mucilage --- organic wastes --- dark fermentation --- anaerobic digestion --- biodiesel --- bio-jet fuel --- triacylglycerides --- Fatty Acid Methyl Ester --- lipids --- hydrodeoxygenation --- drop-in fuel --- rubber seed oil --- biodiesel production --- nanomagnetic catalyst --- subcritical methanol --- FAME yield --- Box-Behnken design --- GCI --- biodiesel --- diesel --- combustion --- emission --- renewable energy --- microwave --- free fatty acid --- crude oil --- renewable energy --- biomass --- waste --- black soldier fly larvae (BSFL) --- instar --- lipid --- fatty acid methyl ester (FAME) --- fermentation --- Rancimat method --- butylated hydroxyanisole --- tert-butylhydroquinone --- fatty acid methyl esters --- viscosity --- response surface --- anaerobic treatment --- biogas --- kinetic study --- potato peels --- cow manure --- thermophilic --- mesophilic --- palm oil mill effluent --- acclimatization --- direct carbon fuel cell --- biochar --- pyrolysis --- power density --- pre-treatment --- post-treatment --- combustion characteristics --- injection strategies --- compression ratio --- intake temperature --- torrefaction --- vacuum --- biomass pretreatment --- bioenergy --- energy yield --- biochar --- rice straw --- rice husk --- power generation --- gasification --- alternative fuel --- Rhus typhina biodiesel --- non-edible oil --- base-catalyzed transesterification --- Physico-chemical properties --- concentration polarization --- draw solution --- feed solution --- forward osmosis --- pressure-retarded osmosis --- operating conditions --- membrane fouling --- osmotic membrane --- bioenergy --- biofuel --- nanotechnology --- nano-catalysts --- nano-additives --- crude glycerol --- glycerol carbonate --- dimethyl carbonate --- microwave irradiation --- reaction kinetics

Amide Bond Activation

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ISBN: 9783039212033 9783039212040 Year: Pages: 466 DOI: 10.3390/books978-3-03921-204-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.

Keywords

fumardiamide --- primaquine --- succindiamide --- Michael acceptor --- biofilm eradication --- antibacterial screening --- antiviral activity --- cytostatic activity --- N,N-dimethylformamide --- DMF --- N,N-dimethylacetamide --- DMAc --- amination --- amidation --- thioamidation --- formylation --- carbonylation --- cyanation --- insertion --- cyclization --- amide --- arynes --- insertion --- activation --- heterocycles --- organic synthesis --- multi-component coupling reaction --- aryl thioamides --- thiourea --- C-H/C-N activation --- C-S formation --- transition-metal-free --- rotational barrier energy --- amide bond --- nuclear magnetic resonance --- kinetic --- density functional theory --- non planar amide --- base-catalyed hydrolysis --- water solvation --- entropy --- transamidation --- amide --- amine --- catalyst --- catalysis --- acylative cross-coupling --- trialkylborane --- amide activation --- palladium --- N-heterocyclic carbene --- ruthenium (Ru) --- N-heterocyclic carbenes (NHCs) --- homogeneous catalysis --- in situ --- amide bonds --- synthesis --- density functional theory --- cis/trans isomerization --- secondary amides --- dipeptides --- steric effects --- tert-butyl --- additivity principle --- amino acid transporters --- amide bond --- gemcitabine prodrug --- metabolic stability --- pancreatic cancer cells --- pharmacokinetics --- peptide bond cleavage --- amide bond resonance --- twisted amides --- enzymes --- metal complexes --- catalysts --- amide C–N bond activation --- nickel catalysis --- amidation --- DFT study --- reaction thermodynamics --- amide resonance --- anomeric effect --- HERON reaction --- pyramidal amides --- physical organic chemistry --- reaction mechanism --- amide --- activation --- amidicity --- carbonylicity --- transamidation --- acyl transfer --- excited state --- Suzuki-Miyaura --- cross-coupling --- aryl esters --- C–O activation --- Pd-catalysis --- amides --- carbanions --- C–H acidity --- nitro-aci tautomerism --- molecular dynamics --- density-functional theory --- alkynes --- C–H bond cleavage --- C–N bond cleavage --- cyclopentadienyl complexes --- N-(1-naphthyl)acetamide --- rhodium --- [2+2+2] annulation --- amide bond --- sulfonamide bond --- alkynes --- addition reaction --- aminoacylation --- aminosulfonylation --- pre-catalysts --- palladium catalysis --- amide bond activation --- ester bond activation --- cross-coupling --- amide bond --- bridged lactams --- twisted amides --- amides --- Winkler-Dunitz parameters --- N–C activation --- hypersensitivity --- nitrogen heterocycles --- distortion --- bridged sultams --- amides --- C-N ? bond cleavage --- sodium --- crown ether --- amide hydrolysis --- model compound --- intramolecular catalysis --- twisted amide --- protease --- intein --- C-H functionalization --- directing groups --- amides --- transition metals --- catalysis

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