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Interventions against child abuse and violence against women

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Book Series: Cultural Encounters in Intervention Against Violence ISBN: 9783847410294 9783847420477 Year: Pages: 320 Language: English
Publisher: Verlag Barbara Budrich
Subject: Social Sciences
Added to DOAB on : 2019-11-19 11:21:04
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This book offers insights and perspectives from a study of “Cultural Encounters in Intervention Against Violence” (CEINAV) in four EU-countries. Seeking a deeper understanding of the underpinnings of intervention practices in Germany, Portugal, Slovenia and the United Kingdom, the team explored variations in institutional structures and traditions of law, policing, and social welfare. Theories of structural inequality and ethics are discussed and translated into practice.

Violence against Women and Ethnicity: Commonalities and Differences across Europe

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ISBN: 9783866495708 9783866494091 Year: Pages: 426 Language: English
Publisher: Verlag Barbara Budrich
Subject: Social Sciences
Added to DOAB on : 2019-11-19 11:21:05
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This book draws together both: theory and practice on minority/migrant women and gendered violence. The interplay of gender, ethnicity, religion, class, generation and sexuality in shaping the lives, experiences and choices of minority/migrant women affected by violence has not always been adequately theorised within much of the existing writing on violence against women. Feminist theory, especially the insights provided by the concept of intersectionality, are central to the editors’ conceptual frameworks.

„Uns wurde die Würde genommen“

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ISBN: 9783863884048 9783863888107 Year: Pages: 295 DOI: 10.3224/86388810 Language: German
Publisher: Verlag Barbara Budrich
Subject: Social Sciences
Added to DOAB on : 2020-03-13 11:21:03
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Die Heime der Brüdergemeinde Korntal und Wilhelmsdorf sind ein weiteres „Fallbeispiel“ für die Heimwirklichkeit in den ersten Jahrzehnten der Bundesrepublik Deutschland. Diese war für viele Kinder gekennzeichnet durch eine strenge religiöse und gewaltförmige Erziehung, die in der Tradition der autoritären Fürsorgeerziehung steht. Die Gespräche mit über 100 ehemaligen Heimkindern und die Analyse von Akten zeigen die Formen und Ausmaße von physischer, sexualisierter und psychischer Gewalt, die Kinder erlitten haben.

Multidrug resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196159 Year: Pages: 99 DOI: 10.3389/978-2-88919-615-9 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology --- Science (General) --- Therapeutics
Added to DOAB on : 2016-08-16 10:34:25
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More than 40 years ago, the observation that doxorubicin-resistant tumor cells were cross-resistant to several structurally different anticancer agents was the first step in the discovery of P-glycoprotein (P-gp). P-gp belongs to the superfamily of ATP-binding cassette (ABC) transporters;its overexpression has become a therapeutic target for overcoming multidrug resistance in tumors. However, P-gp is also expressed in cells of normal tissues where it plays a physiological role, by protecting them from the toxic effects of xenobiotics. Also, ABCB1 gene polymorphisms may influence the response to anticancer drugs substrate of P-gp. Several strategies to overcome P-gp tumor drug resistance have been suggested. P-gp 'circumvention’ is the most explored and is based on the coadministration of anticancer agents and pump inhibitors (P-gp modulators). Despite the positive findings obtained in preclinical studies, results of clinical trials are not yet successful and clinical research is still ongoing. Other investigational approaches have been studied (e.g. P-gp targeting antibodies, use of antisense strategies or transcriptional regulators targeting ABCB1 gene expression) but their use is still circumscribed to the preclinical setting. A further approach is represented by the encapsulation of P-gp substrate anticancer drugs into liposomes or nanoparticles. This strategy has shown higher efficacy in tumor previously treated with the free drug. The reasons explaining the increased efficacy of liposomal/nanoparticle-based drugs in Pgp-overexpressing tumors include the coating with specific surfactants, the composition changes in the plasma membrane microdomains where P-gp is embedded, the direct impairment of P-gp catalytic mechanisms exerted by specific component of the liposomal shell, but are not yet fully understood. A second strategy to overcome P-gp tumor drug resistance is represented by exploiting the P-gp presence. Actually, P-gp-overexpressing cells show increased sensitivity (collateral sensitivity) to some drugs (e.g. verapamil, narcotic analgesics) and to some investigational compounds (e.g. NSC73306). P-gp-overexpressing cell are hypersensitive to reactive oxygen species, to agents perturbing the energetic metabolic pathways, changing the membrane compositions, reducing the efflux of endogenous toxic catabolites. However, the mechanisms explaining collateral sensitivity have not been fully elucidated. Another approach to exploit P-gp is represented by ABCB1 gene transfer to transform bone marrow progenitor cells into a drug resistant state which may allow conventional or higher doses of anticancer drug substrates of P-gp to be administered safely after transplantation. More recently the development and introduction in the clinics of anticancer drugs which are not substrates of P-gp (e.g. new microtubule modulators, topoisomerase inhibitors) has provided a new and promising strategy to overcome P-gp tumor drug resistance (P-gp 'evasion'). This ‘research topic’ issue aims at exploding the above mentioned matters, in particular by: -retracing the history of the first researches on P-gp - describing the physiological role of P-gp - describing the molecular basis, structural features and mechanism of action of P-gp - describing diagnostic laboratory methods useful to determine the expression of P-gp and its transporter function - describing strategies to overcome tumor drug resistance due to P-gp and other ABC transporters - indicating novel approaches to overcome P-gp multidrug resistance, ranging from basic research studies to pre-clinical/clinical studies.

Museums in a Digital Culture

Authors: ---
ISBN: 9789048524808 9789089646613 Year: Pages: 146 Language: English
Publisher: Amsterdam University Press
Subject: Computer Science --- Arts in general
Added to DOAB on : 2019-10-23 11:21:10
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The experience of engaging with art and history has been utterly transformed by information and communications technology in recent decades. We now have virtual, mediated access to countless heritage collections and assemblages of artworks, which we intuitively browse and navigate in a way that wasn't possible until very recently. This collection of essays takes up the question of the cultural meaning of the information and communications technology that makes these new engagements possible, asking questions like: How should we theorise the sensory experience of art and heritage? What does information technology mean for the authority and ownership of heritage?

Distillation Control, Optimization, and Tuning: Fundamentals and Strategies

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ISBN: 9781439857489 Year: Pages: 144 Language: English
Publisher: Taylor & Francis
Subject: Mathematics
Added to DOAB on : 2020-07-29 23:58:46
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Emphasis on improved quality and performance of distilled products and the demand for reduced operating costs place a heavy burden on both the personnel responsible for profitability and the manufacturing department charged with operating the processing equipment. There have been dramatic improvements in the computer software and hardware used to simulate and model the distillation process and potential response to experimentation, but mastering the art of distillation process and control still requires solid understanding of a large body of information. With a focus on achieving product purity at low cost, Distillation Control, Optimization, and Tuning: Fundamentals and Strategies highlights core concepts. These include process variables for continuous binary distillation columns and the four basic control strategies, the distillate and bottoms product quality performance objectives, and the tuning of process control loops. Without dwelling on complex mathematical descriptions, the book presents the fundamentals of process control of a distillation column as a separation and purification unit operation. It covers the concepts and functional criteria that are critical to successful implementation of process control, as well as measurement and improvement of product quality performance. It describes how process control loops for distillation columns can be tuned for stable operation, with a balance between minimum variability from setpoint changes and excellent response to load disturbances. Designed for students, engineers, technicians, and plant operators alike, this book emphasizes the prevailing need to strike a balance between the details of hypotheses and good engineering judgment. The author outlines learning objectives at the beginning of each chapter and includes chapter-end summaries, exercises, and references to help readers acquire essential knowledge and understanding. The result is a resource that will inform future decisions for the design, operation, and troubleshooting of distillation process control systems.

Whose Responsibility?

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Book Series: UTS Shopfront Series ISBN: 9781863654210 Year: Pages: 47 DOI: 10.5130/978-1-86365-421-0 Language: English
Publisher: UTS ePRESS
Subject: Medicine (General)
Added to DOAB on : 2020-07-08 00:01:55
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This research monograph documents and analyses the many ways in which communities experiencing racism after September 11, 2001 have responded to increased prejudice, harassment and discrimination. While much research analyses the 'problem' of racism, this book highlights the responses developed by targeted communities, including strategies of Interfaith, cross-cultural education, media responses and community cultural development work. A follow-up to the 2006 work Targeted, the research underlying this book is based on extensive community consultations and interviews with Arab, Muslim and Sikh communities in Sydney. It maps the field and identifies common challenges with the aim of contributing to wider processes of innovation in community anti-racism work.

PAIN - Novel targets and new technologies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193943 Year: Pages: 95 DOI: 10.3389/978-2-88919-394-3 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2015-12-03 13:02:24
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The problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and supraspinal sites. However, pain can also be effectively controlled by peripheral pathways. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug targeting and novel targets to gain improved therapeutic efficiency. This e-Book "PAIN - Novel targets and new technologies" has brought together experts in the field of pain at the physiological, pharmacological and pharmaceutical levels to discuss novel pain targets and new pain technologies across the various types of pain. This information is presented as novel research findings, short communications and review articles. The goal of this e-Book is to generate further collaborative discussion on the future and direction of pain therapies.

Novel Therapeutic Targets and Emerging Treatments for Fibrosis

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453726 Year: Pages: 162 DOI: 10.3389/978-2-88945-372-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Therapeutics
Added to DOAB on : 2018-11-16 17:17:57
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For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs.Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder.This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level.

Media and Education in the Digital Age

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ISBN: 9783653044379 9783631651544 9783653044379 9783653986426 Year: DOI: 10.3726/9783653044379 Language: English
Publisher: Peter Lang International Academic Publishing Group Grant: Knowledge Unlatched - 103054
Subject: Education
Added to DOAB on : 2019-03-06 11:21:03
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This book is an invitation to informed and critical participation in the current debate on the role of digital technology in education and a comprehensive introduction to the most relevant issues in this debate. After an early wave of enthusiasm about the emancipative opportunities of the digital «revolution» in education, recent contributions invite caution, if not scepticism. This collection rejects extreme interpretations and establishes a conceptual framework for the critical questioning of this role in terms of concepts, assessments and subversions. This book offers conceptual tools, ideas and insights for further research. It also provides motivation and information to foster active participation in debates and politics and encourages teachers, parents and learners to take part in the making of the future of our societies.

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