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Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other?

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197774 Year: Pages: 102 DOI: 10.3389/978-2-88919-777-4 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Abstract

Somatic stem cells reside in definite compartments, known as “niches”, within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organ, including brain and heart. The adult bone marrow, in particular, houses a complex multifunctional niche comprising hemopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), that intensely interact. HSCs represent the common precursors of all mature blood cells. MSCs are instead able to differentiate along multiple mesodermal lineages and are believed to represent the key somatic stem cell within the skeletogenic niche, being conceptually able to produce any tissue included within a mature skeletal segment (bone, cartilage, blood vessels, adipose tissue, and supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal lineages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors’ lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreaking research achievements in the field of regenerative medicine, along with the pressing need for effective innovative tools for the treatment of neurodegeneration and neurologic disorders, have been forcing experimental clinical applications, which, despite their scientific weakness, have recently stimulated the public opinion. Based on this contemporary background, this Research Topic wish to provide an in-depth revision of the state of the art on relevant scientific milestones addressing the differences and possible interconnections and overlaps, between the osteogenic and the neurogenic niches. Dissertations on both basic research and clinical aspects, along with ethical and regulatory issues on the use of somatic stem cells for in vivo transplantation, have been covered.

Blood-Derived Products for Tissue Repair/Regeneration

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ISBN: 9783039218608 / 9783039218615 Year: Pages: 178 DOI: 10.3390/books978-3-03921-861-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-01-07 09:08:26
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This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.

Keywords

platelets --- burns --- growth factors --- platelet rich plasma --- quantification --- articular cartilage --- cartilage repair --- redifferentiation --- collagen hydrogels --- biologics --- hyperacute serum --- platelet-rich plasma --- fibrosis --- myoblasts --- myofibroblasts --- myogenesis --- Platelet-Rich Plasma (PRP) --- Platelet-Poor Plasma (PPP) --- satellite cells --- skeletal muscle regeneration --- stem cell niche --- regenerative medicine --- hyperacute serum --- platelet-rich plasma --- blood derived products --- composition --- meniscus --- meniscus repair --- meniscus tear --- trephination --- platelet-rich plasma --- PRP --- chronic meniscal lesion --- horizontal meniscal tear --- periosteal sheet --- platelet-rich fibrin --- growth --- differentiation --- bone grafting material --- PRGF --- Carprofen --- dog --- fracture --- bone healing --- wrist osteoarthritis --- microfat --- platelet-rich plasma --- cell therapy --- adipose tissue --- PRP --- knee arthrosis --- growth factors --- autologous platelet concentrates --- bone defects --- bone grafting --- bone regeneration --- furcation defects --- periodontal defects --- periodontal regeneration --- periodontal surgery --- platelet-rich plasma --- platelet-rich fibrin --- plasma rich in growth factors --- tissue healing --- corneal epithelial defect --- cornea regeneration --- serum eye drops --- plasma rich plasma (PRP) --- serum derived from plasma rich in growth factors (s-PRGF) --- hyaluronic acid (NaHA) --- wound healing --- bone regeneration --- bone repair --- fibrin sealant --- biomaterial --- photobiomodulation therapy --- low-level laser therapy --- n/a

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