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Neuronal and glial structural plasticity induced by drugs of abuse

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195985 Year: Pages: 90 DOI: 10.3389/978-2-88919-598-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Therapeutics
Added to DOAB on : 2016-03-10 08:14:32
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Drugs of abuse induce a host of alterations in brain structure and function, ranging from changes in gene expression and epigenetic processes to aberrant synaptic plasticity to volumetric changes in discrete brain regions. These alterations can be drug class-specific, and are not confined to neurons, as drugs of abuse also induce molecular and cellular alterations in various glial cell types such as astrocytes and microglia. The phenomenon of drug-induced plasticity includes changes in dendritic branching and architecture, dendritic spine density and morphology, astrocyte-neuronal interactions, dysregulation of glutamatergic and GABAergic signaling, and alterations in myelination or microglial phenotype. This drug-induced "rewiring" of the brain at numerous levels can contribute to the development, maintenance, and persistence of the addicted state, as well as associated deficits in normal cognitive functioning. The aim of this Research Topic is to collect recent and important findings related to the structural alterations produced by drug of abuse in neurons, glial, and other cell types of the central nervous system.

Keywords

plasticity --- Dendrite --- Spine --- Glutamate --- Dopamine --- GABA --- Neuron --- glia --- astrocyte --- Addiction

Frontiers in Synaptic Plasticity: Dendritic Spines, Circuitries and Behavior

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199471 Year: Pages: 109 DOI: 10.3389/978-2-88919-947-1 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Psychiatry --- Science (General) --- Neurology
Added to DOAB on : 2016-01-19 14:05:46
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The term “synaptic plasticity” is a broad concept, which is studied with a variety of experimental approaches. One focus is the impact of changes in synaptic, neuronal and glial morphology on brain circuitry and behavior. In this regard, unique animal models have been key to the study of affective and social behaviors and neurological and psychiatric diseases. However, there is a paucity of compilations directed toward the correlation of alterations in synaptic structure with various physiological and behavioral paradigms. This Frontiers Research Topic will, therefore, serve as an exciting forum for the exchange of novel hypotheses and data and an important resource and reference for investigators studying synaptic and brain plasticity, as well as those in related fields.

Surgery for Spine Disease and Intractable Pain

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ISBN: 9783039284788 9783039284795 Year: Pages: 88 DOI: 10.3390/books978-3-03928-479-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Surgery
Added to DOAB on : 2020-04-07 23:07:09
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Selected Papers from the 2018 41st International Conference on Telecommunications and Signal Processing (TSP)

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ISBN: 9783039210404 9783039210411 Year: Pages: 194 DOI: 10.3390/books978-3-03921-041-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This Special Issue contains a series of excellent research works on telecommunications and signal processing, selected from the 2018 41st International Conference on Telecommunications and Signal Processing (TSP) which was held on July 4–6, 2018, in Athens, Greece. The conference was organized in cooperation with the IEEE Region 8 (Europe, Middle East, and Africa), IEEE Greece Section, IEEE Czechoslovakia Section, and IEEE Czechoslovakia Section SP/CAS/COM Joint Chapter by seventeen universities from the Czech Republic, Hungary, Turkey, Taiwan, Japan, Slovak Republic, Spain, Bulgaria, France, Slovenia, Croatia, and Poland, for academics, researchers, and developers, and serves as a premier international forum for the annual exchange and promotion of the latest advances in telecommunication technology and signal processing. The aim of the conference is to bring together both novice and experienced scientists, developers, and specialists, to meet new colleagues, collect new ideas, and establish new cooperation between research groups from universities, research centers, and private sectors worldwide. This collection of 10 papers is highly recommended for researchers, and believed to be interesting, inspiring, and motivating for readers in their further research.

Intrinsically Biocompatible Polymer Systems

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ISBN: 9783039284207 9783039284214 Year: Pages: 270 DOI: 10.3390/books978-3-03928-421-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Materials
Added to DOAB on : 2020-04-07 23:07:09
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Biocompatibility refers to the ability of a biomaterial to perform its desired function with respect to a medical therapy, without eliciting any undesirable local or systemic effects in the recipient or beneficiary of that therapy, but generating the most appropriate beneficial cellular or tissue response in that specific situation, and optimizing the clinically relevant performance of that therapy, which reflects current developments in the area of intrinsically biocompatible polymer systems. Polymeric biomaterials are presently used as, for example, long-term implantable medical devices, degradable implantable systems, transient invasive intravascular devices, and, recently, as tissue engineering scaffolds. This Special Issue welcomes full papers and short communications highlighting the aspects of the current trends in the area of intrinsically biocompatible polymer systems.

Keywords

antimicrobial peptides --- biodegradable polymers --- biocompatible polymers --- drug delivery systems --- controlled release --- citropin --- temporin --- ionic liquids --- chitooligosaccharide --- polyurethane --- biodegradability --- physicochemical properties --- hemocompatibility --- biological activity --- crosslinking --- drug delivery --- cosmetic --- food-supplement --- functionalization --- hyaluronan applications --- hyaluronan derivatives --- hyaluronan synthases --- hyaluronic acid --- hyaluronidases --- physico-chemical properties --- cyclohexanone --- ?-butyrolactone --- chloroform --- extraction --- polyhydroxyalkanoates --- PHB --- electrospraying --- biodegradable nano/microparticles --- drug delivery --- septic arthritis --- release characteristics --- biopolymers --- silk fibroin --- konjac glucomannan --- porous beads --- scaffolds --- tissue engineering --- microcarriers --- Poly (l-lactic) acid --- Chitosan --- nanohydroxyapatite --- osteoblasts --- ion-releasing materials --- shrinkage stress --- water sorption --- hydroscopic expansion --- photoelastic investigation --- enzymatic polymerization --- chemical polymerization --- poly(benzyl malate) --- biocompatible nanoparticles --- cell uptake --- cytotoxicity --- HepaRG cells --- human macrophages --- star polymers --- solution behavior --- ATRP --- SPION --- contrast agent --- MRI --- cancer diagnosis --- folate receptor --- pluronic F127 --- polylactide --- hydrolytic degradation --- mechanical properties --- PEEK copolymer synthesis --- PEEK composite --- Spine cage application --- In vitro biosafety --- degradation --- saliva --- mechanical properties --- molecular weight --- thermal properties --- activation energy of thermal decomposition --- anterior cruciate ligament reconstruction --- bone tunnel enlargement --- X-ray microtomography --- polylactide --- n/a

Intelligent Imaging and Analysis

Authors: ---
ISBN: 9783039219209 9783039219216 Year: Pages: 492 DOI: 10.3390/books978-3-03921-921-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-04-07 23:07:08
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Imaging and analysis are widely involved in various research fields, including biomedical applications, medical imaging and diagnosis, computer vision, autonomous driving, and robot controls. Imaging and analysis are now facing big changes regarding intelligence, due to the breakthroughs of artificial intelligence techniques, including deep learning. Many difficulties in image generation, reconstruction, de-noising skills, artifact removal, segmentation, detection, and control tasks are being overcome with the help of advanced artificial intelligence approaches. This Special Issue focuses on the latest developments of learning-based intelligent imaging techniques and subsequent analyses, which include photographic imaging, medical imaging, detection, segmentation, medical diagnosis, computer vision, and vision-based robot control. These latest technological developments will be shared through this Special Issue for the various researchers who are involved with imaging itself, or are using image data and analysis for their own specific purposes.

Keywords

image inspection --- non-referential method --- feature extraction --- fault pattern learning --- weighted kernel density estimation (WKDE) --- rail surface defect --- UAV image --- defect detection --- gray stretch maximum entropy --- image enhancement --- defect segmentation --- semi-automatic segmentation --- MR spine image --- vertebral body --- graph-based segmentation --- correlation --- surface defect of steel sheet --- image segmentation --- saliency detection --- low-rank and sparse decomposition --- intervertebral disc --- segmentation --- convolutional neural network --- fine grain segmentation --- U-net --- deep learning --- magnetic resonance image --- lumbar spine --- image adjustment --- colorfulness --- contrast --- sharpness --- high dynamic range --- local registration --- iterative closest points --- multimodal medical image registration --- machine vision --- point cloud registration --- greedy projection triangulation --- local correlation --- three-dimensional imaging --- optimization arrangement --- cavitation bubble --- water hydraulic valve --- defect inspection --- image processing --- feature extraction --- classification methods --- medical image registration --- image alignment in medical images --- misalignment correction in MRI --- midsagittal plane extraction --- symmetry detection --- PCA --- conformal mapping --- mesh parameterization --- mesh partitioning --- pixel extraction --- texture mapping --- image analysis --- image retrieval --- spatial information --- image classification --- computer vision --- image restoration --- motion deburring --- image denoising --- sparse feedback --- Image processing --- segmentation --- spline --- grey level co-occurrence matrix --- gradient detection --- threshold selection --- OpenCV --- machine learning --- transfer learning --- Inception-v3 --- geological structure images --- convolutional neural networks --- image segmentation --- active contour model --- level set --- signed pressure force function --- image segmentation --- deep learning --- synthetic aperture radar (SAR) --- oil slicks --- segnet --- pectus excavatum --- nuss procedure --- patient-specific nuss bar --- minimally invasive surgery --- computerized numerical control bending machine --- computer-aided design --- computer-aided manufacturing --- statistical body shape model --- self-intersection penalty term --- 3D pose estimation --- 3D semantic mapping --- incrementally probabilistic fusion --- CRF regularization --- road scenes --- deep learning --- medical image classification --- additional learning --- CT image --- automatic training --- GoogLeNet --- intelligent evaluation --- automated cover tests --- deviation of strabismus --- pupil localization --- shape from focus --- wear measurement --- sprocket teeth --- normal distribution operator image filtering --- adaptive evaluation window --- reverse engineering --- human parsing --- depth-estimation --- computational efficiency --- capacity optimization --- underwater visual localization method --- line segment features --- PL-SLAM --- face sketch synthesis --- face sketch recognition --- joint training model --- data imbalance --- Contrast Tomography (CT) --- pre-training strategy --- segmentation --- super-resolution --- dual-channel --- residual block --- convolutional kernel parameter --- long-term and short-term memory blocks --- n/a

Molecular Mechanism of Alzheimer's Disease

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ISBN: 9783039214075 9783039214082 Year: Pages: 228 DOI: 10.3390/books978-3-03921-408-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.

Keywords

?-secretase --- amyloid beta --- calcium signaling --- drug target discovery --- endoplasmic reticulum --- inositol 1,4,5-trisphosphate receptor --- ion channel --- oxidative stress --- ryanodine receptor --- therapy --- amyloid-? oligomer --- protein aggregation --- A?O receptors --- Alzheimer’s disease --- neurodegeneration --- amyloid ? --- Alzheimer’s disease --- cognitive function --- dairy products --- dementia --- inflammation --- microglia --- Alzheimer’s disease --- yeast --- Tau --- amyloid ? --- ubiquitin --- aggregation --- oligomerization --- prion --- CDK5R1 --- lncRNAs --- Alzheimer’s disease --- miR-15/107 --- NEAT1 --- HOTAIR --- MALAT1 --- heat shock response --- heat shock protein --- Alzheimer’s disease --- beta amyloid --- yeast --- Alzheimer’s disease --- complement receptor 1 --- CR1 length polymorphism --- CR1 density --- complement C3b/C4b receptor --- complement --- dementia --- molecular biology --- neurosciences --- genetic risk --- Alzheimer’s disease --- brain glucose metabolism --- neuronal differentiation --- neuronal degeneration --- Prolyl isomerases --- Pin1 --- type 2 diabetes --- type 3 diabetes --- miR-34c --- dendritic spine --- Alzheimer’s disease --- Alzheimer’s disease --- positron emission tomography (PET) --- magnetic resonance imaging (MRI) --- Alzheimer’s disease --- cystathionine-?-lyase CTH gene --- DNA methylation --- epigenetics --- epigenome-wide association study --- methylome --- methylenetetrahydrofolate reductase MTHFR gene --- nutrition --- S-adenosylmethionine --- vitamin B complex --- Alzheimer’s disease --- sleep disturbance --- sleep fragmentation --- slow-wave sleep --- amyloid beta --- tau --- proteostasis --- default-mode network --- cognitive behavioral therapy for insomnia --- APOE gene --- apolipoprotein E --- DNA methylation --- mild cognitive impairment --- Hispanics

Human Health Engineering

Author:
ISBN: 9783039284085 9783039284092 Year: Pages: 428 DOI: 10.3390/books978-3-03928-409-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-04-07 23:07:09
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In this Special Issue on human health engineering, we invited submissions exploring recent contributions to the field of human health engineering, which is the technology used for monitoring the physical or mental health status of individuals in a variety of applications. Contributions focused on sensors, wearable hardware, algorithms, or integrated monitoring systems. We organized the different papers according to their contributions to the main aspects of the monitoring and control engineering scheme applied to human health applications, including papers focusing on measuring/sensing physiological variables, contributions describing research on the modelling of biological signals, papers highlighting health monitoring applications, and finally examples of control applications for human health. In comparison to biomedical engineering, the field of human health engineering also covers applications on healthy humans (e.g., sports, sleep, and stress) and thus not only contributes to develop technology for curing patients or supporting chronically ill people, but also more generally for disease prevention and optimizing human well-being.

Keywords

artefact correction --- head-shaped phantom --- spherical phantom --- gradient artefact --- simultaneous EEG–fMRI --- calcaneal spur --- pain minimum compressive pressure --- contour of shoe insole --- insole foot area --- health information --- interface formats --- older adults --- wearable devices --- usability --- emotional reaction --- ADHD --- screening --- machine learning --- SVM --- children --- novel --- nomophobia --- anxiety --- smartphone --- internet --- cyberaddiction --- new technologies --- chronic obstructive pulmonary disease --- COPD --- oxygen uptake --- VO2 --- kinetics --- exercise testing --- rehabilitation robotics --- soft walking assistive robot --- long-term effect --- gait characteristics --- elderly person --- blood pressure estimation --- photoplethysmogram --- pulse wave --- pulse oximeter --- wearable device --- Kano-TRIZ design theory --- quality function deployment --- four-wheeled rollator --- model predictive control --- orthosis control --- muscle modeling --- arm --- Hill muscle --- swarm optimization --- pneumatic artificial muscle --- sliding mode control --- fractional calculus --- antagonistic actuator --- weight loss --- mHealth --- dynamic model --- adaptive control --- spirometry --- airflow limitation --- airway resistance --- specific airway conductance --- COPD --- body-plethysmography --- forced expiration --- alveolar pressure --- emphysema --- computed tomography --- air-trapping --- thermal comfort --- bicycle helmet --- smart wearables --- adaptive model --- streaming data --- thermal sensation --- adaptive model --- personalized model --- machine leaning --- support-vector-machine --- adaptive control --- streaming algorithm --- thermoregulation --- homeostasis --- cold-induced-vasodilation --- cold-induced-vasoconstriction --- control system --- dynamic modelling --- powered mobility --- dyskinetic cerebral palsy --- dystonia --- choreoathetosis --- mobility scale --- movement disorder --- children --- youth --- reliability --- validity --- feature engineering --- intensive care unit --- mortality prediction --- hard-margin support vector machines --- driver drowsiness --- thermoregulation --- distal skin temperature --- decision tree --- heart model --- Van der Pol --- FitzHugh–Nagumo --- relaxation oscillator --- electrocardiographic signal --- bicycle helmets --- thermal manikin --- convective and evaporative heat loss --- zonal performance characteristics --- freestyle skiing aerials --- knee joint --- ligament --- finite element simulation --- lifting technique --- stoop --- squat --- work-related musculoskeletal disorders --- musculoskeletal modeling --- spine --- shoulder --- back loading --- harmonization --- meta-analysis --- missing data --- multiple imputations --- information technology --- remoteness --- cohort studies --- control parameter reference --- stance assistance --- magnetorheological brake --- body mass index --- walking speed --- ankle torque --- ankle angular velocity --- n/a

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