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Magnetic Resonance Imaging of Healthy and Diseased Brain Networks

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194353 Year: Pages: 365 DOI: 10.3389/978-2-88919-435-3 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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An important aspect of neuroscience is to characterize the underlying connectivity patterns of the human brain (i.e., human connectomics). Over the past few years, researchers have demonstrated that by combining a variety of different neuroimaging technologies (e.g., structural MRI, diffusion MRI and functional MRI) with sophisticated analytic strategies such as graph theory, it is possible to noninvasively map the patterns of structural and functional connectivity of human whole-brain networks. With these novel approaches, many studies have shown that human brain networks have nonrandom properties such as modularity, small-worldness and highly connected hubs. Importantly, these quantifiable network properties change with age, learning and disease. Moreover, there is growing evidence for behavioral and genetic correlates. Network analysis of neuroimaging data is opening up a new avenue of research into the understanding of the organizational principles of the brain that will be of interest for all basic scientists and clinical researchers. Such approaches are powerful but there are a number of challenging issues when extracting reliable brain networks from various imaging modalities and analyzing the topological properties, e.g., definitions of network nodes and edges and reproducibility of network analysis. We assembled contributions related to the state-of-the-art methodologies of brain connectivity and the applications involving development, aging and neuropsychiatric disorders such as Alzheimer’s disease, schizophrenia, attention deficit hyperactivity disorder and mood and anxiety disorders. It is anticipated that the articles in this Research Topic will provide a greater range and depth of provision for the field of imaging connectomics.

Between the Plough and the Pick

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ISBN: 9781760461713 Year: DOI: 10.22459/BPP.03.2018 Language: English
Publisher: ANU Press
Subject: Science (General) --- Economics
Added to DOAB on : 2018-04-10 11:01:51
License: ANU Press

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"Between the Plough and the Pick deepens our understanding of informal, artisanal and small-scale mining, popularly known as ASM. The book engages with wider scholarly conceptualisations of contemporary global social, agrarian and political changes, whilst underlining the roles that local social‑political-historical contexts play in shaping mineral extractive processes and practices. It shows that the people who are engaged in these mining practices are often the poorest and most exploited labourers—erstwhile peasants caught in the vortex of global change, who perform the most insecure and dangerous tasks. Although these people are located at the margins of mainstream economic life, they collectively produce enormous amounts of diverse material commodities and find a livelihood (and often a pathway out of oppressive poverty). The contributions to this book bring these people to the forefront of debates on resource politics. The contributors are international scholars and practitioners who explore the complexities in the histories, in labour and production practices, the forces driving such mining, the creative agency and capacities of these miners, as well as the human and environmental costs of ASM. They show how these informal, artisanal and small‑scale miners are inextricably engaged with, or bound to, global commodity values, are intimately involved in the production of new extractive territories and rural economies, and how their labour reshapes agrarian communities and landscapes of resource access and control.&#xD;This book drives home the understanding that, collectively, this social and economic milieu redefines our conceptualisation of resource politics, mineral‑dependent livelihoods, extractive geographies of resources and commodities, and their multiple meanings."

Partitions and Atoms of Clause Structure

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Book Series: Routledge Leading Linguists ISBN: 9780203982372 9780415169264 9781134701308 9781134701292 9781134701254 Year: DOI: 10.4324/9780203982372 Language: English
Publisher: Taylor & Francis
Subject: Linguistics
Added to DOAB on : 2019-11-08 11:21:16
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This collection brings together some of Dominique Sportiche's best work, including essays that are published here for the first time. The articles discuss the architecture of syntax in natural languages and Sportiche suggests that languages do not differ at all in their syntactic organization. This view takes shape through the analysis of a variety of syntactic configurations and essays examine what it means to be a Subject, how Case marking functions, how it relates to Agreement, and how Pronominal Clitic Constructions should be analyzed.

Grammaticalization and Language Change in Chinese

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Book Series: Routledge Studies in Asian Linguistics ISBN: 9780203420645 9780415336031 9780415864558 9781134307272 9781134307265 9781134307227 Year: DOI: 10.4324/9780203420645 Language: English
Publisher: Taylor & Francis
Subject: Political Science --- Sociology --- Science (General)
Added to DOAB on : 2019-11-08 11:21:23
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This innovative study on the phenomenon of 'grammaticalization' and its manifestation in Chinese provides new insights into language change in Chinese and a large number of grammatical topics. Grammaticalization occurs in all of the world's languages. Xiu-Zhi Zoe Wu demonstrates general linguistic principles present and active in the phenomenon of grammaticalization whilst also describing the modelling of language in formal theoretical approaches to syntax; so this book fills two major gaps in the current study of linguistics. Grammaticalization and Language Change in Chinese illuminates how studies of language development and change provide special insights into the understanding of current, synchronic systems of language. Using patters from Chinese, the author establishes cross-linguistic generalizations about language change and grammaticalization. This book should be of great interest to Chinese linguists and readers interested in language change in different languages.

Kition-Bamboula VII : Fouilles dans les nécropoles de Kition (2012-2014)

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ISBN: 9782356681805 DOI: 10.4000/books.momeditions.2903 Language: French
Publisher: MOM Éditions
Subject: Social Sciences
Added to DOAB on : 2019-12-06 13:15:38
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Les nécropoles de l’ancienne Kition (sous la ville moderne de Larnaca) ont fait l’objet de nombreuses fouilles depuis le xixe siècle : aux recherches d’antiquités ont succédé des fouilles d’urgence, sans qu’aucune exploration toutefois n’ait pu se faire de façon programmée, avec les méthodes de l’analyse stratigraphique et anthropologique. Entre 2012 et 2014, la mission archéologique de Kition a conduit des fouilles systématiques dans une des nécropoles de l’âge du Fer de la ville, au lieu-dit Pervolia. Programmée dans le cadre d’une étude générale de la topographie urbaine à l’âge du Fer, cette fouille a permis de conduire une étude exhaustive, à la fois à l’échelle du site (occupation diachronique de l’espace) et à celle de la tombe (architecture, cycle d’utilisation, pratiques funéraires). Les résultats de ces travaux occupent la majeure partie de ce volume, que complètent la publication du matériel de tombes découvertes lors de fouilles plus anciennes sur le même site et celle des fouilles d’urgence réalisées par le Département des Antiquités de Chypre en 2012 dans une autre nécropole de la ville, au lieu-dit Tourapi. Le volume est dirigé par Anna Cannavò, Sabine Fourrier et Alexandre Rabot, en collaboration avec Anna Satraki pour la publication des fouilles de Kition-Tourapi. Plusieurs spécialistes ont bien voulu apporter leur concours : Fabien Belhaoues, Rémi Corbineau, Nathalie Delhopital, Nathalia Denninger, Lluis Garcia Petit, Armelle Gardeisen, Anna Georgiadou, Evangéline Markou, Maria A. Socratous et Prisca Vareilles. Les archives scientifiques de la fouille de la mission à Kition-Pervolia sont consultables en libre accès sur le portail chypre.mom.fr, développé par Bruno Morandière (MOM).

Industry 4.0 for SMEs

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ISBN: 9783030254254 Year: Pages: 412 DOI: 10.1007/978-3-030-25425-4 Language: English
Publisher: Springer
Subject: Business and Management
Added to DOAB on : 2020-02-05 11:21:06
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This open access book explores the concept of Industry 4.0, which presents a considerable challenge for the production and service sectors. While digitization initiatives are usually integrated into the central corporate strategy of larger companies, smaller firms often have problems putting Industry 4.0 paradigms into practice. Small and medium-sized enterprises (SMEs) possess neither the human nor financial resources to systematically investigate the potential and risks of introducing Industry 4.0. Addressing this obstacle, the international team of authors focuses on the development of smart manufacturing concepts, logistics solutions and managerial models specifically for SMEs. Aiming to provide methodological frameworks and pilot solutions for SMEs during their digital transformation, this innovative and timely book will be of great use to scholars researching technology management, digitization and small business, as well as practitioners within manufacturing companies.

Regulation by non-coding RNAs

ISBN: 9783038420057 9783038420101 Year: Volume: 1 Pages: 844 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-01-12 11:03:39
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Regulatory non-protein-coding RNA genes and their transcripts were first found and characterized in bacteria but encompass all biological kingdoms. The complexity of non-coding RNAs (ncRNAs) in terms of number and types increases with degree of biological development, whereby humans and other primates appear to have the largest number. Many regulatory ncRNAs base-pair to a target RNA or DNA and inhibit target function. Bacterial ncRNA genes largely respond to environmental stress conditions and help protect the organism from adverse conditions. The prokaryotic RNAs are for the most part small (<200 bp) and are commonly referred to as small regulatory RNAs (sRNAs). Eukaryotic RNAs consist of small <200 nt RNAs and large >200 nt (termed lncRNAs). The eukaryotic small RNAs include miRNAs, siRNAs, and piRNAs. miRNAs inhibit mRNA functions and may also be associated with cancer. lncRNAs functions are multifaceted and include epigenetic regulation and animal development. The bacterial and archeal immune system CRISPR, and the eukaryotic piwi-interacting RNAs (piRNA) immune system that inhibits mobile elements in germ line cells both function by via RNA transcript/ target DNA heteroduplex base-pairing are a specific class of RNAs that protect cells from invading transposons/and or viruses. siRNAs function in plant and invertebrate immune systems and protect against viral infections. [...]

Regulation by non-coding RNAs

ISBN: 9783038420064 9783038420118 Year: Volume: 2 Pages: 244 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-01-12 11:06:27
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Regulatory non-protein-coding RNA genes and their transcripts were first found and characterized in bacteria but encompass all biological kingdoms. The complexity of non-coding RNAs (ncRNAs) in terms of number and types increases with degree of biological development, whereby humans and other primates appear to have the largest number. Many regulatory ncRNAs base-pair to a target RNA or DNA and inhibit target function. Bacterial ncRNA genes largely respond to environmental stress conditions and help protect the organism from adverse conditions. The prokaryotic RNAs are for the most part small (<200 bp) and are commonly referred to as small regulatory RNAs (sRNAs). Eukaryotic RNAs consist of small <200 nt RNAs and large >200 nt (termed lncRNAs). The eukaryotic small RNAs include miRNAs, siRNAs, and piRNAs. miRNAs inhibit mRNA functions and may also be associated with cancer. lncRNAs functions are multifaceted and include epigenetic regulation and animal development. The bacterial and archeal immune system CRISPR, and the eukaryotic piwi-interacting RNAs (piRNA) immune system that inhibits mobile elements in germ line cells both function by via RNA transcript/ target DNA heteroduplex base-pairing are a specific class of RNAs that protect cells from invading transposons/and or viruses. siRNAs function in plant and invertebrate immune systems and protect against viral infections. [...]

Recent Advances of Epigenetics in Crop Biotechnology

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198542 Year: Pages: 189 DOI: 10.3389/978-2-88919-854-2 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Epigenetics is a new field that explains gene expression at the chromatin structure and organization level. Three principal epigenetic mechanisms are known and hundreds of combinations among them can develop different phenotypic characteristics. DNA methylation, histone modifications and small RNAs have been identified, and their functions are being studied in order to understand the mechanisms of interaction and regulation among the different biological processes in plants. Although, fundamental epigenetic mechanisms in crop plants are beginning to be elucidated, the comprehension of the different epigenetic mechanisms, by which plant gene regulation and phenotype are modified, is a major topic to develop in the near future in order to increase crop productivity. Thus, the importance of epigenetics in improving crop productivity is undoubtedly growing. Current research on epigenetics suggest that DNA methylation, histone modifications and small RNAs are involved in almost every aspect of plant life including agronomically important traits such as flowering time, fruit development, responses to environmental factors, defense response and plant growth. The aim of this Research Topic is to explore the recent advances concerning the role of epigenetics in crop biotechnology, as well as to enhance and promote interactions among high quality researchers from different disciplines such as genetics, cell biology, pathology, microbiology, and evolutionary biology in order to join forces and decipher the epigenetic mechanisms in crop productivity.

Security in a Small Nation

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Book Series: Open Reports Series ISBN: 9781783742707 Year: Pages: 250 DOI: 10.11647/OBP.0078 Language: English
Publisher: Open Book Publishers
Subject: Political Science
Added to DOAB on : 2017-08-22 11:01:03
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"The 2014 Referendum on Scottish independence sparked debate on every dimension of modern statehood. Levels of public interest and engagement were unprecedented, as demonstrated by record-breaking voter turnout. Yet aside from Trident, the issue of security was relatively neglected in the campaigns, and there remains a lack of literature on the topic. In this volume Andrew Neal has collated a variety of interdisciplinary perspectives on security and constitutional change in Scotland and the UK, including writing from experts in foreign policy analysis, intelligence studies, parliamentary studies, and journalism. Security in a Small Nation provides an illuminating analysis of the politics of security. Its authors reflect on a number of related issues including international comparisons, alliances, regional cooperation, terrorism, intelligence sharing, democratic oversight, and media coverage. It has a particular focus on what security means for small states and democratic politics. &#xD;The book draws on current debates about the extent of intelligence powers and their implications for accountability, privacy, and human rights. It examines the foreign and security policy of other small states through the prism of Scottish independence, providing unique insight into the bureaucratic and political processes associated with multi-level security governance. These contributions provide a detailed picture of the changing landscape of security, including the role of diverse and decentralised agencies, and new security interdependencies within and between states.&#xD;The analysis presented in this book will inform ongoing constitutional debates in the UK and the study of other secessionist movements around the world. Security in a Small Nation is essential reading for any follower of UK and Scottish politics, and those with an interest in security and nationhood on a global scale."

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