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La rivoluzione incompiuta

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ISBN: 9788855261630 Year: Pages: 210 Language: italian
Publisher: Ledizioni
Subject: Computer Science
Added to DOAB on : 2020-02-13 10:22:56
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Se si domanda a una persona di buon senso «a chi appartiene la scienza?», la risposta più probabile è: «a tutti!».Dietro il velo di una risposta istintiva e (apparentemente) superficiale si nasconde la storia dell’eterno conflitto tra apertura e chiusura della conoscenza, tra pubblicità e segretezza. Un conflitto che assume connotati peculiari nell’era digitale.All’alba dell’era di Internet una parte della comunità scientifica ha coltivato la speranza di potenziare il discorso scientifico e l’uso pubblico della ragione creando una Rete democratica delle menti. Questa speranza oggi appare minacciata dalla mercificazione della conoscenza e dalle forze che mirano ad accentrare il potere decisionale nelle mani di pochi. La scienza sembra sempre più in crisi.L’apertura può curare la crisi in cui versa la scienza? Cosa significa “scienza aperta”? Le risposte contenute nel libro sono parziali e attengono al dilemma evocato nel suo titolo: diritto d’autore o proprietà intellettuale?

Keywords

open access --- university --- culture --- OA

Spectral Geometry of Partial Differential Operators

Authors: --- ---
ISBN: 9781138360716 Year: Pages: 378 Language: English
Publisher: Taylor & Francis
Subject: Mathematics
Added to DOAB on : 2020-02-12 11:21:04
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Access; Differential; Durvudkhan; Geometry; Makhmud; Michael; OA; Open; Operators; Partial; Ruzhansky; Sadybekov; Spectral; Suragan

Keywords

Access --- Differential --- Durvudkhan --- Geometry --- Makhmud --- Michael --- OA --- Open --- Operators --- Partial --- Ruzhansky --- Sadybekov --- Spectral --- Suragan

Beitrag zur Vorbemessung der Biegeverstärkung von Stahlbetonbauteilen mit Rechteckquerschnitt mittels aufgeklebten CFK-Lamellen

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ISBN: 9783966270021 9783966270038 9783966270007 9783966270014 Year: Pages: 252 DOI: 10.33968/9783966270021-00 Language: German
Publisher: HTWK Leipzig - OA-Hochschulverlag
Subject: Agriculture (General)
Added to DOAB on : 2020-02-12 11:21:04
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"Since 2012, the subsequent reinforcement of reinforced concrete components with bonded reinforcement has been regulated in a separate guideline. This includes the dimensioning of the adhesively bonded strips made of carbon fiber reinforced plastic (CFRP), which, in addition to the complex iterative bending design, have a very complex bonding behavior. For this purpose, the German Committee for Structural Concrete developed a model for the verification based on experimental evaluations, in which the occurring tensile forces are partly transferred into the component via intermediate elements (partial distances between flexural cracks). Simultaneously, simplified but more inaccurate verification formats were made available to reduce the complexity of the verification. For an early assessment of the use of bonded CFRP strips, different tools have been developed in this paper for reinforced concrete components with a rectangular cross-section depending on the different verification formats. For this purpose, the design parameters were considered separately for pure bending strength and bonding behavior. For a simple calculation, tables for the design with dimensionless coefficients were obtained by analogy with the reinforced concrete construction, with which the required cross-section area for the CFRP strips can be determined by means of a limited stretching from the simplified verification of the flexural load bearing capacity. For a more economical solution, the more precise verification of the force transmission on the intermediate elements was configured in an Excel workbook, because this results in an extraordinary iterative calculation effort."

Open-Access-Publikationsworkflow für akademische Bücher

Authors: --- --- ---
ISBN: 9783966270175 9783966270182 9783966270151 9783966270168 Year: Pages: 440 DOI: 10.33968/9783966270175-00 Language: German
Publisher: HTWK Leipzig - OA-Hochschulverlag
Subject: Agriculture (General)
Added to DOAB on : 2020-03-18 11:21:02
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"The need for an immediate, transparent and sustainable dissemination of current research has become a prerequisite for the further development of science today. Making research results freely available online as Open Access is considered to achieve the widest possible dissemination worldwide. Everyone can access anywhere Open Access publications without any restrictions or paywalls. Meanwhile more and more academic institutions and universities have already started their own presses to publish books Open Access. In the present manual a sustainable and ideal workflow for producing and publishing academic books is presented. That workflow enables universities to publish their publications both as Open Access and printed books in a state-of-theart way and without any restrictions regarding the license, the variety of formats, print run etc. As proof of concepts we have processed different use cases which demonstrates the current status of the technically and economically possibilities in the publishing sector. Furthermore, data on time, costs and personnel resources were determined, which can be used by other universities and academic institutions to indicate the necessary investments for founding and operation of their own Open Access university presses."

Kommunikationstechnische Optimierung eines energieautarken funkbasierten Sensorkonzepts

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ISBN: 9783966270069 9783966270076 9783966270045 9783966270052 Year: Pages: 94 DOI: 10.33968/9783966270069-00 Language: German
Publisher: HTWK Leipzig - OA-Hochschulverlag
Subject: Agriculture (General)
Added to DOAB on : 2019-10-21 11:21:20
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In this bachelor thesis, an existing wireless sensor concept was examined with regard to software optimization possibilities. First, the application possibilities of such sensor systems in the existing maintenance strategies were described. Subsequently, an analysis of the previous sensor concept was carried out, on the basis of which an alternative concept to communication optimisation was realised with the existing hardware. By replacing the previously used application protocol HTTP with the lightweight MQTT, an alternative sensor concept was created. In addition, a measurement concept was developed to determine the transmission time, which allows a comparison with the existing sensor concept. It was thus possible to evaluate the extent to which the objective had been achieved.

Analyse von Kundenaktivitäten und der Bereitstellungsqualität von Büchern aus Kundensicht

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ISBN: 9783966270106 9783966210113 9783966270083 9783966270090 9783966270113 Year: Pages: 160 DOI: 10.33968/9783966270106-00 Language: German
Publisher: HTWK Leipzig - OA-Hochschulverlag
Subject: Media and communication
Added to DOAB on : 2019-12-20 11:21:02
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"This master thesis explores service characteristics that are relevant for book readers when they evaluate a service as well as starting points for providers when they plan to optimize their services from a customer’s point of view. In the first part ways of accessing books (buying, borrowing, rent) and the reading behavior of Germans will be described. Then the concept “quality of provision” of books will be discussed which distinguishes five quality dimensions of a service: diversity of content and arranging of books, basic technology (printed book or digital environment), temporal and spatial access, costs of access and ease of use. By using secondary material for each dimension individual quality characteristics will be identified. Next the theoretical background of the activity theory and a special way of thinking, the customer-dominant-logic, from the Nordic school will be explained briefly. Based on this a set of consumer activities related to books will be presented and some activities that are relevant for the work will be described in more detail by means of secondary material (reading books, choosing books, organizing books and information). Further customization and personalization will be proposed as strategies for individualization of services and their function for consumers will be explained. The secondary data used in the work comes from empirical data out of consumer surveys in libraries and bookshops, nationally representative surveys and from results of academic research from different fields. In the final part of this thesis an own data collection will be conducted by using a content analysis of consumer comments of two e-book rental apps (n = 1,245 comments). The analysis should clarify, if the quality characteristics, the book-related activities and the strategies for individualization described before can be found in everyday reality of consumers. After that the results of the content analysis will be presented. Finally the major findings will be summarized and connected to the research questions."

Stadt als Schule

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ISBN: 9783966270144 9783966270120 Year: Pages: 68 DOI: 10.33968/9783966270144-00 Language: German
Publisher: HTWK Leipzig - OA-Hochschulverlag
Subject: Architecture
Added to DOAB on : 2019-10-21 11:21:20
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When a fire department called "Ostwache" in the eastern part of Leipzig closed down, it left their old building behind vacant. Soon after a neighbourhood initiative sought to use the space to establish a community center for the surrounding neighbourhood. At the same time, the municipal government was planning a new school on the same lot. This thesis presents a solution for this conflict. By bringing together architectural, urban planning and pedagogical perspectives, while aiming for synergies. Following the model of Freinet pedagogy, a community school was planned with a new building at the site of the old fire station and the community center is to be located in the existing building of the old Ostwache. Through a common courtyard, shared work and sports facilities and a shared lunch, the school opens up to the city and its neighborhood to the school. This is how city works as school and a school works as city.

Nanoscale Photonic Imaging

Authors: --- ---
Book Series: Topics in Applied Physics ISBN: 9783030344139 Year: Pages: 634 DOI: 10.1007/978-3-030-34413-9 Language: English
Publisher: Springer Nature
Subject: Mathematics --- Biology --- Computer Science --- Agriculture (General)
Added to DOAB on : 2020-06-16 23:59:44
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This open access book, edited and authored by a team of world-leading researchers, provides a broad overview of advanced photonic methods for nanoscale visualization, as well as describing a range of fascinating in-depth studies. Introductory chapters cover the most relevant physics and basic methods that young researchers need to master in order to work effectively in the field of nanoscale photonic imaging, from physical first principles, to instrumentation, to mathematical foundations of imaging and data analysis. Subsequent chapters demonstrate how these cutting edge methods are applied to a variety of systems, including complex fluids and biomolecular systems, for visualizing their structure and dynamics, in space and on timescales extending over many orders of magnitude down to the femtosecond range. Progress in nanoscale photonic imaging in Göttingen has been the sum total of more than a decade of work by a wide range of scientists and mathematicians across disciplines, working together in a vibrant collaboration of a kind rarely matched. This volume presents the highlights of their research achievements and serves as a record of the unique and remarkable constellation of contributors, as well as looking ahead at the future prospects in this field. It will serve not only as a useful reference for experienced researchers but also as a valuable point of entry for newcomers.

Research of Pathogenesis and Novel Therapeutics in Arthritis

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ISBN: 9783038970651 9783038970668 Year: Pages: 366 DOI: 10.3390/books978-3-03897-066-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
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Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.

Keywords

biosimilars --- Th9 lymphocytes --- rheumatoid arthritis --- infliximab --- rheumatoid arthritis --- bone erosion --- osteoblasts --- next-generation sequencing --- bioinformatics --- microRNA --- messenger RNA --- osteoarthritis --- cell signaling --- IL1? --- WNT --- antagonists --- computational modeling --- nitric oxide --- clodronate --- gene expression --- osteoarthritis --- progenitor cells --- SOX9 --- spondyloarthropathies --- inflammation --- mesenchymal stem cells --- visfatin --- IL-6 --- TNF-? --- osteoarthritis --- miR-199a-5p --- Epstein-Barr virus --- glycoprotein 42 --- rheumatoid arthritis --- shared epitope --- triptolide --- rheumatoid arthritis --- basic research --- clinical translation --- osteoarthritis (OA) --- articular cartilage --- molecular pathology --- therapeutics --- rheumatoid arthritis --- antibodies --- collagen --- glycosylation --- disease pathways --- therapy --- experimental arthritis --- TNF? --- etanercept --- infliximab --- adalimumab --- certolizumab pegol --- golimumab --- rheumatoid arthritis --- therapeutic antibody --- structure --- fraxinellone --- collagen-induced arthritis --- rheumatoid arthritis --- inflammatory arthritis --- osteoclastogenesis --- sclareol --- rheumatoid arthritis --- synovial cell --- collagen --- mice --- cytokines --- Th17 --- MAPK --- arthritis --- osteoarthritis --- rheumatoid arthritis --- small-molecule inhibitor --- chondrocytes --- tumor necrosis factor-alpha --- inflammation --- rheumatoid arthritis --- osteoarthritis --- angiogenesis --- cytokines --- chemokines --- early osteoarthritis --- articular cartilage --- proliferation --- fibroblast growth factor 2 --- mitogen activated protein kinase --- transforming growth factor ? --- SMA- and MAD-related protein --- interleukin --- nuclear factor kappa B --- miRNA --- adjuvant arthritis --- arthritis --- biomarkers --- celastrol --- inflammation --- microRNA --- miRNA --- rat --- rheumatoid arthritis --- Traditional Chinese medicine --- tripterine --- triterpenoid --- spinal fusion --- biological --- osteoblast --- osteoclast --- bisphosphonate --- parathyroid hormone --- bone morphogenetic protein --- receptor activator of nuclear factor ?B --- stem cell --- drug delivery system --- anticitrullinated peptide antibodies --- antirheumatic drug --- autoimmune --- disease-modifying --- immunology --- pathology --- rheumatoid factor --- rheumatoid arthritis --- osteoarthritis --- adipokines --- obesity --- rheumatoid arthritis --- osteoarthritis --- anti-arthritis --- biomarkers

Dinophysis Toxins: Distribution, Fate in Shellfish and Impacts

Authors: ---
ISBN: 9783039213634 9783039213641 Year: Pages: 376 DOI: 10.3390/books978-3-03921-364-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-12-09 11:49:15
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Several species of Dinophysis produce one or two groups of lipophilic toxins: okadaic acid (OA) and its derivatives; or the dinophysistoxins (DTXs) (also known as diarrhetic shellfish poisons or DSP toxins) and pectenotoxins (PTXs). DSP toxins are potent inhibitors of protein phosphatases, causing gastrointestinal intoxication in consumers of contaminated seafood. Forty years after the identification of Dinophysis as the causative agent of DSP in Japan, contamination of filter feeding shellfish exposed to Dinophysis blooms is recognized as a problem worldwide. DSP events affect public health and cause considerable losses to the shellfish industry. Costly monitoring programs are implemented in regions with relevant shellfish production to prevent these socioeconomic impacts. Harvest closures are enforced whenever toxin levels exceed regulatory limits (RLs). Dinophysis species are kleptoplastidic dinoflagellates; they feed on ciliates (Mesodinium genus) that have previously acquired plastids from cryptophycean (genera Teleaulax, Plagioselmis, and Geminigera) nanoflagellates. The interactions of Dinophysis with different prey regulate their growth and toxin production. When Dinophysis cells are ingested by shellfish, their toxins are partially biotransformed and bioaccumulated, rendering the shellfish unsuitable for human consumption. DSP toxins may also affect shellfish metabolism. This book covers diverse aspects of the abovementioned topics—from the laboratory culture of Dinophysis and the kinetics of uptake, transformation, and depuration of DSP toxins in shellfish to Dinophysis population dynamics, the monitoring and regulation of DSP toxins, and their impact on the shellfish industry in some of the aquaculture regions that are traditionally most affected, namely, northeastern Japan, western Europe, southern Chile, and New Zealand.

Keywords

harmful algal bloom --- Diarrheic Shellfish Poisoning --- okadaic acid --- toxin accumulation --- toxin vectors --- trophic transfer --- Brazil --- diarrhetic shellfish toxins (DST) --- Mytilus galloprovincialis --- DST accumulation --- DST esterification --- suspended particulate matter (SPM) --- harmful algal blooms --- okadaic acid --- Argopecten irradians --- transcriptomic response --- deep sequencing --- pectenotoxins --- surf clam --- accumulation --- biotransformation --- depuration --- diarrhetic shellfish toxins --- accumulation --- dinophysistoxin --- Japanese scallop --- dinophysis --- LC/MS/MS --- statistical analysis --- Dinophysis --- HAB monitoring --- DSP toxins --- aquaculture --- shellfish toxicity --- human health --- time-series --- seasonality --- Scotland --- DSP toxins --- bivalves --- mussel --- resistance --- RNA-Seq --- qPCR --- metabolism --- defense --- immunity --- DSP toxins --- pectenotoxins --- Dinophysis acuminata --- Mesodinium rubrum --- bacterial community --- high throughput sequencing --- diarrhetic shellfish toxins --- Dinophysis --- wild harvest --- bivalve shellfish --- pipis (Plebidonax deltoides) --- Sydney rock oyster (Saccostrea glomerata) --- okadaic acid --- pectenotoxins --- Dinophysis toxins --- accumulation --- digestion --- biotransformation --- compartmentalization --- depuration --- kinetics --- Dinophysis --- diarrhetic shellfish poisoning --- marine toxins --- pectenotoxin --- okadaic acid --- dinophysistoxin --- okadaic acid --- pectenotoxins --- Dinophysis --- D. acuminata-complex --- D. caudata --- Argopecten purpuratus --- Dinophysis --- Mesodinium --- cryptophytes --- predator-prey preferences --- Diarrhetic Shellfish Toxins (DST) --- pectenotoxins (PTXs) --- mixotrophic cultures --- mass culture conditions --- Dinophysis acuminata --- Protoceratium reticulatum --- Reloncaví Fjord --- OMI analysis --- WitOMI analysis --- Mesodinium cf. rubrum --- El Niño Southern Oscillation --- Southern Annual Mode --- Dinophysis acuta --- Dinophysis acuminata --- DSP --- physical–biological interactions --- niche partitioning --- climatic anomaly --- Dinophysis acuminata --- Mesodinium rubrum --- lysate --- organic matter --- diarrhetic shellfish poisoning --- okadaic acid --- dinophysistoxin --- pectenotoxins --- dinophysis --- DSP --- toxins --- OA --- DTX-2 --- PTXs --- Dinophysis acuminata --- dinophysistoxins --- pectenotoxins --- Port Underwood --- New Zealand --- Dinophysis --- Diarrhetic shellfish toxins --- marine biotoxins --- blooms --- n/a

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