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Micro-, Meso- and Macro-Connectomics of the Brain

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Book Series: Research and Perspectives in Neurosciences ISSN: 0945-6082 ISBN: 9783319277769 9783319277776 Year: Pages: 166 DOI: 10.1007/978-3-319-27777-6 Language: English
Publisher: Springer
Subject: Neurology
Added to DOAB on : 2016-12-20 11:23:03
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This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.

Weißbuch Multiple Sklerose: Versorgungssituation in Deutschland

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ISBN: 9783662492031 9783662492048 Year: Pages: 145 DOI: 10.1007/978-3-662-49204-8 Language: German
Publisher: Springer
Subject: Neurology --- Biotechnology --- Therapeutics
Added to DOAB on : 2017-01-24 17:34:34
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Die Multiple Sklerose (MS) ist die häufigste entzündlich degenerative Erkrankung des zentralen Nervensystems im jungen Erwachsenenalter. Die Erkrankung ist bis heute nicht heilbar. In den vergangenen Jahren hat sich eine Vielzahl neuer therapeutischer Optionen aufgetan.Dieses Weißbuch hat das Ziel, aktuelles Wissen über die Erkrankung MS und ihrer Versorgung in Deutschland sachlich und umfassend darzustellen. Es beinhaltetInformationen zum Krankheitsbild, zur Epidemiologie und zu seiner gesundheitsökonomischen Relevanz.Aktuelle Entwicklungen und Behandlungsempfehlungen sind der realen Inanspruchnahme und den vorhandenen Angebotskapazitäten diagnostischer und therapeutischer Möglichkeiten gegenübergestellt.Die relevanten Akteure des Versorgungsgeschehens und wichtige Prozesse der Versorgungsgestaltung werden beschrieben.Namhafte medizinische Experten und Vertreter der gesetzlichen Krankenkasse haben das Weißbuch als Autoren begleitet. Mit seiner umfassenden Darstellung des Themas liefert das Buch wichtige Anstöße zum Verständnis der Erkrankung sowie für die zukünftige Gestaltung der Versorgung von Menschen mit MS. Es richtet sich an Gestalter und Vertreter des Versorgungsgeschehens aus Krankenkassen, Politik, Medizin, Gesundheitswissenschaften sowie an Patientenvertreter und Medienvertreter.

Keywords

Neurology --- Biotechnology

Micro-, Meso- and Macro-Dynamics of the Brain

Authors: ---
Book Series: Research and Perspectives in Neurosciences ISSN: 0945-6082 ISBN: 9783319288017 9783319288024 Year: Pages: 172 DOI: 10.1007/978-3-319-28802-4 Language: English
Publisher: Springer
Subject: Neurology
Added to DOAB on : 2016-12-20 11:07:42
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This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Clinical Recovery from CNS Damage

Authors: ---
ISBN: 9783318023084 9783318023091 Year: Language: English
Publisher: Karger Grant: Knowledge Unlatched - 102998
Subject: Medicine (General)
Added to DOAB on : 2019-11-26 11:22:14
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After decades of focusing on how to alleviate and prevent recurrence of acute CNS injuries, the emphasis has finally shifted towards repairing such devastating events and rehabilitation. This development has been made possible by substantial progress in understanding the scientific underpinnings of recovery as well as by novel diagnostic tools, and most importantly, by emerging therapies awaiting clinical trials. In this publication, several international experts introduce novel areas of neurological reorganization and repair following CNS damage. Principles and methods to monitor and augment neuroplasticity are explored in depth and supplemented by a critical appraisal of neurological repair mechanisms and possibilities to curtail disability using computer or robotic interfaces. Rather than providing a textbook approach of CNS restoration, the editors selected topics where progress is most imminent in this labyrinthine domain of medicine.

Psychiatry of Parkinson's Disease

Authors: --- ---
ISBN: 9783805598002 9783805598019 Year: Language: English
Publisher: Karger Grant: Knowledge Unlatched - 103010
Subject: Medicine (General)
Added to DOAB on : 2019-11-26 11:24:34
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Psychiatric symptoms are common in the neurological and geriatric care of patients with Parkinson’s disease. This book assembles short reviews from experts in the field to chart the various psychiatric syndromes known in Parkinson’s disease, their presentation, etiology and management. Presented are special topics on epidemiology of psychiatric symptoms, affective disorders and apathy, early cognitive impairment through to dementia, visuoperceptual dysfunction, psychotic disorders, sleep disturbances, impulse disorders and sexual problems. Further, rarely discussed issues, such as the relationship between somatoform disorders and parkinsonism are reviewed. This publication is essential reading for old age psychiatrists, gerontologists and neurologists who work with patients suffering from Parkinson’s disease.

Corps/texte. Pour une théorie de la lecture empathique : Cooper, Danielewski, Frey, Palahniuk

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ISBN: 9782847886658 DOI: 10.4000/books.enseditions.3992 Language: French
Publisher: ENS Éditions
Subject: Languages and Literatures
Added to DOAB on : 2019-12-06 13:15:31
License: OpenEdition Licence for Books

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Un livre peut-il faire mal  ? Plongé dans un texte littéraire, le lecteur fait parfois l’expérience de sensations tactiles, douloureuses, musculaires, viscérales. C’est la « lecture empathique ». Mais comment expliquer ce passage du sens au sensori-moteur  ? Neuropsychologie, phénoménologie, études culturelles, théories de la fiction et de la littérature sont ici convoquées pour répondre à cette question intrigante, au fil d’un parcours révélant les œuvres de quatre auteurs qui ont marqué la littérature américaine des années 1990 et 2000 (Dennis Cooper, James Frey, Chuck Palahniuk et Mark Z. Danielewski). En mettant l’accent sur l’expérience de la littérature plutôt que sur son interprétation, le modèle développé dans cet ouvrage permet de repenser la question de la valeur artistique en termes de puissance sensorielle et d’immersion, dessinant le projet d’une lecture plus corporelle, d’une lecture empathique. Illustration de couverture : autoportrait de David Nebreda © David Nebreda - 2004 - Éditions Léo Scheer

Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196791 Year: Pages: 283 DOI: 10.3389/978-2-88919-679-1 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2016-08-16 10:34:25
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Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances.

Alzheimer's Disease Pathogenesis - Core Concepts, Shifting Paradigms and Therapeutic Targets

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ISBN: 9789533076904 Year: Pages: 704 DOI: 10.5772/951 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:48

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Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.

Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring

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ISBN: 9789533074856 Year: Pages: 572 DOI: 10.5772/1252 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:48

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Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring focuses on biological mechanisms, prevention, neuroprotection and even monitoring of disease progression. This book emphasizes the general biological processes of neurodegeneration in different neurodegenerative diseases. Although the primary etiology for different neurodegenerative diseases is different, there is a high level of similarity in the disease processes. The first three sections introduce how toxic proteins, intracellular calcium and oxidative stress affect different biological signaling pathways or molecular machineries to inform neurons to undergo degeneration. A section discusses how neighboring glial cells modulate or promote neurodegeneration. In the next section an evaluation is given of how hormonal and metabolic control modulate disease progression, which is followed by a section exploring some preventive methods using natural products and new pharmacological targets. We also explore how medical devices facilitate patient monitoring. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.

Update on Amyotrophic Lateral Sclerosis

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ISBN: 9789535126003 9789535126010 9789535141839 Year: Pages: 280 DOI: 10.5772/61682 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:49

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This book contains selected peer-reviewed chapters which cover updated information on ALS written by international researchers. Update on Amyotrophic Lateral Sclerosis is comprised of 13 chapters from some of the world's top central nervous system researchers and neurologists to provide a timely review of the most recent developments in ALS, covering historic aspects, experimental animal models, genetics, pathogenesis, clinical aspects and imagenology among others. Contributors from Belgium, France, Japan, India, Italy, Mexico, Russia, South Africa, and Switzerland have collaborated enthusiastically and efficiently, dedicating their time to create this reader-friendly yet comprehensive work which includes many explanatory figures, tables and photos to enhance legibility and make the book clinically useful. We are looking forward with confidence and pride in the remarkable role that this book will play for a new vision and mission.

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