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Chapter Twelve Revealing the Hidden Affliction (Book chapter)

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ISBN: 9781580469616 Year: Pages: 47 Language: English
Publisher: University of Rochester Press Grant: Wellcome Trust - 605972
Subject: Medicine (General)
Added to DOAB on : 2019-10-09 11:21:13
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By the turn of the twentieth century the British nation’s declining birthrate was increasingly the subject of anxious public and scientific debate, as the Registrar General’s annual reports continued to confirm a downward national trend, which had in fact commenced from the late 1870s.

Introduction (Book chapter)

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ISBN: 9781580469616 Year: Pages: 40 Language: English
Publisher: University of Rochester Press Grant: Wellcome Trust - 605972
Subject: Medicine (General)
Added to DOAB on : 2019-10-09 11:21:14
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This volume is a necessarily multidisciplinary collection dedicated to the extremely difficult task of uncovering and exploring what can be reconstructed of the dimensions and the scale of the historical impact of sexually transmitted infections (STIs) on human infertility. As a subject for inquiry, this comes close to Winston Churchill’s celebrated phrase, “a riddle, wrapped in a mystery, inside an enigma.”

Sex Steroids

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ISBN: 9789533078571 Year: Pages: 344 DOI: 10.5772/1314 Language: English
Publisher: IntechOpen
Subject: Gynecology and Obstetrics --- Internal medicine
Added to DOAB on : 2019-10-03 07:51:48

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This book, entitled ""Sex Steroids"", features a valuable collection of reviews and research articles written by experts in signal transduction, cellular biology, diseases and disorders. ""Sex Steroids"" is comprised of four sections, ""The Biology of Sex Steroids"", ""Sex Steroids, Memory, and the Brain"", ""Sex Steroids and the Immune Response"", and ""Therapy""; individual chapters address a broad range of recognized and predicted functions and applications of sex steroids. ""Sex Steroids"" is intended to provide seasoned veterans as well as newcomers to this area of research with informative, resourceful, and provocative insights. Readers of ""Sex Steroids"" should emerge with an appreciation and understanding of the multitude and complexity of biologic processes attributed to these important hormones, and possible future directions of research in this fascinating and ever evolving field.

Testes and Ovaries - Functional and Clinical Differences and Similarities

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ISBN: 9789535136897 9789535136903 9789535139928 Year: Pages: 106 DOI: 10.5772/65984 Language: English
Publisher: IntechOpen
Subject: Gynecology and Obstetrics --- Internal medicine
Added to DOAB on : 2019-10-03 07:51:50

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Male and female reproductive system similarities as well as differences should be taken into consideration by all scientists interested in this field. Some embryological, anatomical, histological, and clinical examples are addressed in this book. The message of the book is to increase orientation of all scientists interested in the field of similar and dissimilar issues in males and females. Reading this book will lead to a better understanding of management of both sexes, and the understanding of infertility that will hopefully reduce the effort, the time, the psychological, and the financial burden of the infertile couple and the society at large.

Advances in Testosterone Action

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ISBN: 9781789845129 9781789845136 Year: Pages: 118 DOI: 10.5772/intechopen.72493 Language: English
Publisher: IntechOpen
Subject: Gynecology and Obstetrics --- Internal medicine
Added to DOAB on : 2019-10-03 07:51:52

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This book describes recent findings on androgens. The chapters include information on physiological and pathological conditions such as alteration in testosterone production by Leydig cells, prostate cancer, and metabolic disorders. Moreover, this book refers to the potential use of androgens in assisted human reproduction treatments and bovine breeding. Since each chapter contains background information based on evidence and emphasizes basic science, this book is aimed at professionals who already have a basic understanding of the principles of androgen biochemistry and endocrine-related diseases.

Menstrual Cycle

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ISBN: 9781789239348 9781789856736 9781789856743 Year: Pages: 146 DOI: 10.5772/intechopen.76123 Language: English
Publisher: IntechOpen
Subject: Gynecology and Obstetrics --- Internal medicine
Added to DOAB on : 2019-10-03 07:51:53

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Abstract

In this book, Menstrual Cycle, we cover certain interesting aspects of the physiology and endocrinology of the female body, as well as clinical diagnosis and treatment of various gynecological diseases and disorders in women of reproductive age. In this way, scholars, postgraduates, students, and others will be able to become acquainted with modern scientific research into menstrual cycle. For others, this book will be the impetus for further research in this area.

Estrogen

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ISBN: 9781838808662 9781838808679 9781838808686 Year: Pages: 88 DOI: 10.5772/intechopen.73419 Language: English
Publisher: IntechOpen
Subject: Gynecology and Obstetrics --- Internal medicine
Added to DOAB on : 2019-10-03 07:51:53

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Abstract

This short book contains the most up to date thinking on estrogen and its related functions. Here, the reader will find thoughtful writings on various topics by renowned authors in their respective fields. This book aims to serve as a compressive guide on estrogen function.

Barren Women. Religion and Medicine in the Medieval Middle East

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Book Series: Islam – Thought, Culture, and Society ISSN: 2628-4286 ISBN: 9783110596588 Year: Volume: 2 Pages: 324 DOI: 10.1515/9783110596588 Language: English
Publisher: De Gruyter
Subject: Religion --- History --- Medicine (General)
Added to DOAB on : 2020-05-08 10:43:54
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This book explores the ramifications of being infertile in the medieval Arab-Islamic world by examining legal texts, medical treatises, and works of religious preaching. Sara Verskin illuminates how attitudes toward mixed-gender interactions legal theories pertaining to marriage, divorce, and inheritance and scientific theories of reproduction contoured the intellectual and social landscape infertile women had to navigate.

microRNA Regulation in Health and Disease

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ISBN: 9783039217144 9783039217151 Year: Pages: 154 DOI: 10.3390/books978-3-03921-715-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Genetics
Added to DOAB on : 2020-04-07 23:07:08
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MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.

Molecular Research of Endometrial Pathophysiology

Authors: ---
ISBN: 9783039214952 9783039214969 Year: Pages: 378 DOI: 10.3390/books978-3-03921-496-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 16:10:12
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Abstract

The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.

Keywords

RANK --- endometrium --- endometrial cancer --- prognosis --- immunohistochemistry --- gene expression --- endometriosis --- developmental pathway --- pathogenomics --- mesenchymal stem cells --- endometrial cancer --- mtDNA mutations --- deficit of complex I --- antioxidant response --- mitochondrial biogenesis --- mitochondrial dynamics --- mitophagy --- miRNA --- lncRNAs --- endometrial cancer --- endometriosis --- chronic endometritis --- cell contacts --- tight junction --- adherens junction --- gap junction --- endometrium --- implantation --- decidualization --- endometriosis --- endometrial cancer --- liquid biopsy --- uterine aspirate --- circulating tumour cells (CTCs) --- circulating tumour DNA (ctDNA) --- exosomes --- Vitamin D --- endometrium --- endometrial cancer --- endometrial cancer --- preclinical models --- translational research --- endometrial cancer --- type II endometrial carcinoma --- targeted therapy --- kinase inhibitor --- molecular marker --- protein kinase --- protein phosphatase --- PP2A --- PPP2R1A --- SMAP --- endometriosis --- infertility --- niche --- inflammation --- immunomodulation --- mesenchymal stem cell --- orthoxenograft --- uterine cancer --- avatar --- murine models --- personalized medicine --- targeted therapy --- preclinical studies --- translational research --- endometriosis --- TRP channels --- endometrial stromal cells --- eutopic and ectopic endometrium --- endometrial cell --- pathway --- proliferation --- decidualization --- migration --- angiogenesis --- regeneration --- breakdown --- implantation --- endometrial cancer --- orthotopic xenograft model --- estrogen dependent --- bioluminescence imaging --- contrast-enhanced CT scan --- endometrium --- adult stem cells --- endometrial regeneration --- stem cell markers --- endometriosis --- endometrial cancer --- decidualisation --- oestradiol --- aromatase --- testosterone --- dehydroepiandrosterone (DHEA) --- endometriosis --- endometrial cancer --- sulfatase --- endometriosis --- ectopic stroma --- microRNA --- small RNA sequencing --- EDN1 --- HOXA10 --- miR-139-5p --- miR-375 --- CTCF --- tumour suppressor gene --- haploinsufficiency --- zinc finger --- CRISPR/Cas9 --- cancer --- endometrial cancer --- gene editing --- phosphoinositide 3-kinase --- PIK3CA --- PIK3CB --- p110? --- p110? --- endometrial cancer --- LGR5 --- endometrium --- endometriosis --- menstrual cycle --- macrophages

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