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Dietary Protein and Muscle in Aging People

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ISBN: 9783038974574 / 9783038974581 Year: Pages: 160 DOI: 10.3390/books978-3-03897-458-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Nutrition and Food Sciences
Added to DOAB on : 2019-02-14 10:56:39
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Abstract

This Special Issue of Nutrients, entitled “Dietary Proteins and Muscle in Aging People”, welcomes the submission of manuscripts either reporting original research or reviewing the scientific literature. Manuscripts should focus on the mechanisms linking dietary protein with muscle quality and quantity. Articles presenting results from clinical trials testing protein interventions on muscle mass and function are welcome. The Special Issue aims at including articles spanning different disciplines to explore the topic of interest. Reports from basic to clinical and population research are suitable. Articles adopting a longitudinal approach or reporting data from life-long interventions/observations in the exploration of the theme will be given special consideration.Potential topics include, but are not limited to:•Description of patterns of dietary protein consumption across life•Influence of dietary protein intake on the functional status of older people•Preclinical and clinical studies describing the mechanisms through which protein intake modifies muscle mass and function•Protein/amino acid supplementation interventions against sarcopenia, cachexia, or disease conditions associated with muscle wasting in old age•Disease-specific alterations modifying the effects of dietary protein intake on skeletal muscles•Effects of the interactions of dietary protein intake and gut microbiota on skeletal muscles]

Dementia, Frailty and Aging

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455232 Year: Pages: 121 DOI: 10.3389/978-2-88945-523-2 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General)
Added to DOAB on : 2019-01-23 14:53:42
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The number of older subjects is rapidly increasingly worldwide. As a consequence, the nature of clinical conditions is also changing. Traditional medicine and models of care have been based on the evaluation and treatment of single and usually acute conditions occurring in relatively young individuals. Today, the usual clinical manifestation of diseases is characterized by multiple and often chronic conditions affecting older people. In this scenario, frailty and dementia have been triggering special interest both in research and clinical settings due to their high prevalence, impact on the individual’s quality of life, and consequences for public health worldwide. These conditions aptly reflect the complexity of age-related pathological conditions, finding as causal factor a myriad of heterogeneous, interacting, and often still unclear pathophysiological processes. Indeed, their study is strongly affected by the difficulty to differentiate the effects of a normal aging process from eventual pathological deviations of the underlying systems. Their occurrence and trajectories over time are strongly affected by a wide array of factors and determinants that can be hardly attributed to the deficit/involvement of single biological systems and/or health domains. Moreover, environment and social factors also play a key role in the determination of phenotypes.The present Research Topic is aimed at widening our understanding of the frailty and dementia phenomena occurring with aging, in order to improve the clinical and public health approaches to these burdening conditions.

From Brain to Body: The Impact of Nervous System Declines on Muscle Performance in Aging

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196869 Year: Pages: 154 DOI: 10.3389/978-2-88919-686-9 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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The deterioration of skeletal muscle performance (e.g., declines in muscle strength and motor performance) with advancing age has long been anecdotally recognized as Shakespeare pointed out nearly a half millennium ago in his monologue The Seven Ages of Man, and has been of scientific interest for well over a century. Over the past several decades the scientific and medical communities have recognized that reduced skeletal muscle performance is a debilitating and life threatening condition in the elderly. For example, the age-associated loss of muscle strength, as well as impairment in the ability to finely control movement, is highly associated with physical disability and difficulty performing activities of daily living. While the nervous system is widely recognized for its role in controlling skeletal muscle during motor function, its role in determining the performance characteristics of aged skeletal muscle has largely been understudied. Historically, it was believed that these reductions in muscle performance were primarily resultant of age-associated adaptations in skeletal muscle (e.g., muscle atrophy). However, aging is associated with widespread qualitative and quantitative changes in both the central and peripheral nervous systems that are likely to influence numerous aspects of muscle performance, such as muscle strength, fatigue, and motor control, as well as mobility. In this research topic, we sought to examine a broad range of issues surrounding: 1) the age-related changes in nervous system anatomical, physiological, and biochemical changes in the central and/or peripheral nervous systems; 2) the functional role of these nervous system changes in contributing to altered skeletal muscle performance and/or mobility; and 3) physical and pharmacologic interventions that act via the nervous system to enhance muscle performance and/or mobility. Researchers and academicians engaged in aging, neuroscience, and/or applied physiology research focused within the scope of this research topic, were encouraged to contribute an original research article, review article, clinical case study, hypothesis and theory article, method article, opinion article, or technology report to this research topic. Herein, we present a series of outstanding articles within this scope of work, including a last minute addition article from Wiesmeier, Dalin and Maurer that is not mentioned in the editorial, that we hope will help to vertically advance the intersecting fields of aging/geriatrics and neuroscience. Lastly, as the editors, we wish to thank all article contributors and peer reviewers for their efforts in contributing to this Research Topic journal issue/book. Additionally, we would like to thank people everywhere who volunteer their time and body for human subjects research studies, such that are presented herein. It is the wonderful individuals who are willing to participate in experiments that make scientific exploration and health and medical advancements possible.

Keywords

Muscle --- Sarcopenia --- dynapenia --- Aging --- Frailty --- weakness --- motor control

Aging and Mental Health

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451883 Year: Pages: 139 DOI: 10.3389/978-2-88945-188-3 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-08-28 14:01:09
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People are progressively ageing all over the world, and it is estimated that the number of persons aged 60 or over will more than triple by 2100. This emerging population will experience an inevitable rise in dementia, mental health problems and chronic diseases. According to GBD (2010), neuropsychiatric disorders among older adults account for 6.6% of the total disability (DALYs) for this age group, with 15% suffering from a mental disorder. Multiple social, psychological and biological factors are determinant of mental health, as well as life stressors. Among these, the lack of independence, limited mobility, chronic diseases, pain, frailty or other mental and physical problems require long-term care. Beyond this, the elderly are more prone to experience events such as bereavement, a drop in socio-economic status, disability, which leads to isolation, loss of independence, loneliness and psychological distress. Mental health problems and needs assessment by health-care professionals and older people themselves are under-recognised, and the stigma surrounding mental illness makes people reluctant to seek help. The early investigation and diagnosis of these situations are crucial, as well as prior management with an important combination of pharmacological and psychosocial interventions, in conjunction with caregivers' and families' support. The present book aims to contribute to the development of knowledge in Aging and Mental Health, taking different approaches from authors, coming from diverse scientific fields, with the final goal being the improvement of quality of life and healthy aging for this growing population.

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