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The frontiers of clinical research on transcranial direct current stimulation (tDCS) in Neuropsychiatry

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192878 Year: Pages: 210 DOI: 10.3389/978-2-88919-287-8 Language: English
Publisher: Frontiers Media SA
Subject: Psychiatry --- Medicine (General)
Added to DOAB on : 2015-12-10 11:59:07
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Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation intervention that induces changes in cortical activity and excitability according to the parameters of stimulation. TDCS effects have been reported since the 1800s with the development of the galvanic cell, although more systematic research has been conducted only from 1950-1970 and then from 1998 onwards. At the present time, most tDCS studies have been conducted in healthy volunteers, proving the properties of tDCS as a technique that induces long-lasting, polarity-dependent changes on specific brain areas. In addition, some studies have applied tDCS in selected neuropsychiatric samples, as to investigate its therapeutic effects, obtaining mixed albeit mostly positive results. Using tDCS in clinical practice could bring enormous gains for the treatment of several neuropsychiatric disorders, as tDCS is a portable, non-expensive and straightforward therapy, being therefore a putative candidate as an add-on or substitutive therapy for pharmacological treatments. However, there is still a gap between tDCS basic and clinical research, as it is still unknown whether and how the potent neuromodulatory effects observed after one tDCS session can be carried over for several weeks; therefore proving that tDCS is also a reliable clinical tool. In addition, another gap is observed in tDCS translational research, as results obtained from experimental animal models might not be fully generalizable to neuropsychiatric disorders in humans. Thus, advancing basic and experimental tDCS research as well as tailoring the optimal parameters of stimulation represents the frontiers of tDCS use in neuropsychiatry. In this special edition, our aim is to gather studies that contribute to the proposal of using tDCS for the treatment and investigation of neuropsychiatric disorders. Desired studies include (but are not limited to) the following topics: (1) clinical trials using tDCS as a treatment for neuropsychiatric disorders. (2) original studies investigating optimal parameters for daily tDCS stimulation. (3) safety and tolerability of tDCS, including reports of unexpected and serious adverse effects. (4) comprehensive reviews of putative mechanisms of action of tDCS for neuropsychiatric disorders. (5) translational research, testing different protocols of stimulation in experimental animals. (6) modeling tDCS studies, including studies testing different tDCS devices and montages. (7) studies of cost-efficacy analysis. (8) development of appropriate study designs for tDCS. (9) development of novel employments of tDCS, such as portable, safe devices that allow domestic utilization. (10) development of more precise and focal tDCS devices. To conclude, our ultimate aim is to host studies that contribute to bridge findings from basic and experimental tDCS research with clinical practice, therefore accelerating tDCS use as a novel arsenal for treating neuropsychiatric disorders.

Reward Processing in Motivational and Affective Disorders

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199860 Year: Pages: 117 DOI: 10.3389/978-2-88919-986-0 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2016-01-19 14:05:46
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Preferential reward processing is the hallmark of addiction, where salient cues become overvalued and trigger compulsion. In depression, rewards appear to lose their incentive properties or become devalued. In the context of schizophrenia, aberrations in neural reward signalling are thought to contribute to the overvaluation of irrelevant stimuli on the one hand and the onset of negative symptoms on the other. Accordingly, reward processing has emerged as a key variable in contemporary, evidence based, diagnostic frameworks, such as the Research Domain Criteria launched by the United States National Institute of Mental Health. Delineation of the underlying mechanisms of aberrant or blunted reward processing can be of trans-diagnostic importance across several neuropsychiatric disorders. Reward processing can become automatic thus raising the question of cognitive control, a core theme of this Topic, which aims at justifying the necessity of reward processing as a potential therapeutic target in clinical settings. Empirical and theoretical contributions on the following themes were expected to: *Explore new avenues of research by investigating the processing of rewards at the cognitive, behavioral, motivational, neural systems and individual difference levels. A developmental focus is promising in this regard, probing the core processes that shape reward processing and thus subsequent liability to motivational and affective disorders. *Develop and refine conceptual models of reward processing from computational neuroscience. *Promote greater understanding and development of emergent therapeutic approaches such as cognitive bias modification and behavioural approach or avoidance training. A key question is the feasibility of reversing or modifying maladaptive patterns of reward processing to therapeutic ends. *Refine and augment the evidential database for tried and tested therapies such as Contingency Management and Behavioral Activation by focusing on core cognitive processes mediating rewards. *Provide a potential dimensional approach for reward processing deficits that can be of trans-diagnostic importance in clinically relevant disorders, including depression and addiction * Investigate the subjective experience of pleasure- the hedonic aspect of reward seeking and consumption – and how this can be distinguished from the motivational, sometimes compulsive, component of reward pursuit. This promises more nuanced and effective interventions. Depression, for instance, could be seen as the restricted pursuit of pleasure rather than blunted pleasure experience; addiction can be viewed as accentuated drug seeking despite diminished consummatory pleasure. This aims to place motivation centre stage in both scenarios, emphasising the transdiagnostic theme of the Topic. *Temporal discounting of future rewards, whereby smaller, more immediate rewards are chosen even when significantly more valuable deferred rewards are available, is another trans-diagnostic phenomenon of interest in the in the present context. Factors that influence this, such as discounting of future reward are thought to reflect compulsion in the addictive context and hopelessness on the part of people experiencing depression. The executive cognitive processes that regulate this decision making are of both scientific and clinical significance. Empirical findings, theoretical contributions or commentaries bearing on cognitive or executive control were therefore welcome.

Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation

Authors: ---
ISBN: 9783039212651 9783039212668 Year: Pages: 356 DOI: 10.3390/books978-3-03921-266-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-08-28 11:21:27
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Transcriptional regulation is a critical biological process involved in the response of a cell, a tissue or an organism to a variety of intra- and extra-cellular signals. Besides, it controls the establishment and maintenance of cell identity throughout developmental and differentiation programs. This highly complex and dynamic process is orchestrated by a huge number of molecules and protein networks and occurs through multiple temporal and functional steps. Of note, many human disorders are characterized by misregulation of global transcription since most of the signaling pathways ultimately target components of transcription machinery. This book includes a selection of papers that illustrate recent advances in our understanding of transcriptional regulation and focuses on many important topics, from cis-regulatory elements to transcription factors, chromatin regulators and non-coding RNAs, other than several transcriptome studies and computational analyses.

Keywords

major depressive disorder --- glioblastoma --- differentially expressed genes --- transcriptomics --- common pathway --- mouse --- miR-25-3p --- Akt1 --- AP-2? --- promoter --- cell metabolism --- p57Kip2 --- CDKN1C --- epigenetics --- disease --- cell differentiation --- placenta --- long non-coding RNA (lncRNA) --- human --- pregnancy --- high-throughput RNA sequencing (RNA-Seq) --- transcriptome --- Rsh regulon --- Novosphingobium pentaromativorans US6-1 --- sphingomonads --- RNA-seq --- N-acyl-l-homoserine lactone --- ppGpp --- selenium --- selenocysteine --- selenoproteins --- selenocysteine insertion sequence --- nonsense-mediated decay --- G-quadruplex --- transcriptional regulation --- promoter --- CRISPR/Cas9 --- PRDM gene family --- TCGA data analysis --- somatic mutations --- transcriptome profiling --- human malignancies --- tristetraprolin (TTP) --- tumorigenesis --- posttranscriptional regulation --- adenosine and uridine-rich elements (AREs) --- circRNA-disease associations --- pathway --- heterogeneous network --- Patau Syndrome --- cytogenetics --- FOXO1 --- transcription factor --- molecular pathways --- bioinformatics --- molecular docking --- and drug design --- transcription regulation --- gene expression --- causal inference --- enhancer activity --- insect --- transcription factors --- structures and functions --- research methods --- progress and prospects --- Pax3 --- Pteria penguin (Röding, 1798) --- tyrosinase --- melanin --- RNA interference --- liquid chromatograph-tandem mass spectrometer (LC-MS/MS) --- epigenetics --- gene expression --- nutrition --- transcription --- disorders --- mechanisms --- Crassostrea gigas --- Pacific oyster --- pediveliger larvae --- bioadhesive --- transcriptome --- gene expression --- interactome --- microscopy --- fertilization --- self-incompatibility --- transcriptome --- tea --- long non-coding RNAs --- cancer --- acute leukemia --- therapeutic targets --- Adiponectin --- cancer --- Adiponectin receptors --- obesity --- inflammatory response --- inflammation --- nutritional status --- n/a

Gluten-Free Diet

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ISBN: 9783038977360 9783038977377 Year: Pages: 318 DOI: 10.3390/books978-3-03897-737-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-04-25 16:37:17
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In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.

Keywords

Celiac Disease --- depression --- gluten-free diet --- dietary adherence --- gluten --- gastric emptying --- cholecyst --- celiac disease --- non celiac gluten sensitivity --- gluten-free diet --- gastrointestinal symptoms --- quality of life --- Brazilian CD-QoL --- quality of life --- celiac disease --- questionnaire --- coeliac disease --- celiac disease --- gluten --- gluten-free diet --- fortification --- micronutrient --- cost --- celiac disease --- diagnosis --- gliadin --- gluten --- glutenin --- non-celiac gluten sensitivity --- oral food challenge --- pepsin --- wheat allergy --- celiac disease (CD) --- quality of life (QoL) --- gluten-free diet --- disease duration --- place of residence --- educational level --- economic status --- body mass index (BMI) --- celiac disease --- gluten-free diet --- gut microbiota --- gluten-free diet --- celiac disease --- children --- teenagers --- gluten-related disorders --- celiac disease --- gut microbiota --- gluten-free diet --- Pseudomonas --- gluten-free diet --- mineral --- deficiency --- calcium --- iron --- magnesium --- zinc --- celiac disease --- non-celiac gluten sensitivity --- gut motility --- gluten-free diet --- gluten-related disorders --- gluten-free diet --- coeliac disease --- non-coeliac gluten sensitivity --- irritable bowel syndrome --- mood disorders --- affective disorders --- depression --- major depressive disorder --- mental health --- nutrition --- celiac disease --- gluten-free diet --- diary recommended intake --- food habit --- body composition --- non-coeliac gluten sensitivity --- gluten --- wheat --- low FODMAP diet --- irritable bowel syndrome --- beta cell --- beta-cell stress --- celiac disease --- gluten-free diet --- high-fat diet-induced obesity --- intestinal permeability --- islet of Langerhans --- NOD mouse --- type 1 diabetes --- type 2 diabetes --- FODMAP intake --- celiac disease --- irritable bowel syndrome --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- gluten-free diet --- effectiveness --- adherence --- nutritionists --- clinic --- serology --- duodenal biopsies --- structured questionnaires --- peptides derived from gluten in faeces and urine --- gluten --- adherence --- serology --- villous atrophy --- mucosal recovery --- threshold --- celiac disease --- body composition --- gluten free diet --- children --- celiac disease --- gluten --- gluten-free diet --- screening --- outcome --- gluten sensitivity --- osteoporosis --- non-celiac gluten sensitivity --- gluten re-introduction --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- ?-gliadin --- 33-mer --- DQ2.5-glia-?1 --- DQ2.5-glia-?2 --- DQ2.5-glia-?3 epitopes --- wheat species --- n/a --- gluten --- gluten-free diet --- coeliac disease --- non-celiac gluten sensitivity --- non-coeliac wheat sensitivity --- gliadin --- microbiota

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