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Biomimetic Radical Chemistry and Applications

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ISBN: 9783039283927 9783039283934 Year: Pages: 300 DOI: 10.3390/books978-3-03928-393-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Science (General)
Added to DOAB on : 2020-04-07 23:07:09
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Abstract

The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator.

Keywords

type 2 diabetes --- glycogen phosphorylase --- anomeric spironucleosides --- 1,6-dioxa-4-azaspiro[4.5]decane --- [1,5]-radical translocation --- DNA --- guanine quadruplexes --- radicals --- electron holes --- oxidative damage --- photo-ionization --- time-resolved spectroscopy --- inhomogeneous reactions --- radiosensitizers --- stationary radiolysis --- pulse radiolysis --- modified nucleosides --- cellular response --- liposomal somatostatin --- retarded delivery --- free radicals --- isomerization --- trans lipid --- peroxidation --- photolysis --- laser flash photolysis --- ?-radiolysis --- singlet oxygen --- nucleosides --- free radicals --- reaction mechanism --- catalase activity --- iron(IV)-oxo --- hydrogen peroxide --- oxidation --- kinetic studies --- gold nanoparticles --- albumin --- EPR spectroscopy --- Raman spectroscopy --- circular dichroism --- beta cells --- diabetes --- confocal microscopy --- lipidomics --- membrane fluidity maps --- cell micropolarity maps --- DNA damage --- 5?,8-cyclopurines --- 8-oxo-dG --- free radicals --- pulse radiolysis --- gamma radiolysis --- Fenton reaction --- oligonucleotides --- oxidative DNA damage --- DNA replication stress --- replication fork stalling --- genomic and epigenomic instability --- DNA methylation --- histone modifications --- miRNAs --- iron porphyrin --- heme --- ATRPase --- iron-mediated ATRP --- bio-mimicking catalyst --- biomimetic radical reaction --- bioinspired chemical catalysis --- protein labeling --- DNA oxidation --- DNA hole transfer --- DNA --- quantum dynamics --- electron transfer --- charge transfer --- radical reaction --- azidoalkylation --- carboazidation --- sulfones --- azides --- Julia–Kocienski olefination --- DNA damage --- copper --- chemical nuclease --- intercalation --- free radical oxidation --- protein stability --- therapeutic proteins --- thiyl radicals --- oxidation --- fragmentation --- cross-link --- 2-thiouracil --- radiosensitizers --- ?OH and ?N3 radicals --- 2c-3e S?S-bonded intermediates --- pulse radiolysis --- TD-DFT methods --- thiobases --- nucleobase derivatives --- reactive aldehydes --- hydroxynonenal --- oxononenal --- free fatty acids --- mitochondrial uncoupling protein --- lipid bilayer membranes

DNA Replication Stress

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ISBN: 9783039213894 9783039213900 Year: Pages: 368 DOI: 10.3390/books978-3-03921-390-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 16:10:12
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This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.

Keywords

barley --- chromosome --- DNA replication pattern --- EdU --- mutagens --- DNA replication --- DNA damage --- DNA repair --- genome integrity --- A549 cells --- H1299 cells --- heterogeneity --- DNA damage response --- 8-chloro-adenosine --- DNA replication --- S phase --- origin firing --- TopBP1 --- ATR --- DNA fiber assay --- APE2 --- ATR-Chk1 DDR pathway --- Genome integrity --- SSB end resection --- SSB repair --- SSB signaling --- DNA replication stress --- genome stability --- ubiquitin --- replication fork restart --- translesion synthesis --- template-switching --- homologous recombination --- Fanconi Anemia --- G protein-coupled receptor (GPCR) --- aging --- DNA damage --- ?-arrestin --- G protein-coupled receptor kinase (GRK) --- interactome --- G protein-coupled receptor kinase interacting protein 2 (GIT2) --- ataxia telangiectasia mutated (ATM) --- clock proteins --- energy metabolism --- neurodegeneration --- cellular senescence --- ageing --- Alzheimer’s disease --- multiple sclerosis --- Parkinson’s disease --- lipofuscin --- SenTraGorTM (GL13) --- senolytics --- DNA replication --- DNA repair --- DNA damage response --- DNA translocation --- DNA helicase --- superfamily 2 ATPase --- replication restart --- fork reversal --- fork regression --- chromatin remodeler --- C9orf72 --- ALS --- motor neuron disease --- R loops, nucleolar stress --- neurodegeneration --- Difficult-to-Replicate Sequences --- replication stress --- non-B DNA --- Polymerase eta --- Polymerase kappa --- genome instability --- common fragile sites --- Microsatellites --- cancer --- DNA double-strand repair --- premature aging --- post-translational modification --- protein stability --- replication stress --- Werner Syndrome --- Werner Syndrome Protein --- dormant origins --- replicative stress --- replication timing --- DNA damage --- genome instability --- cancer --- Thermococcus eurythermalis --- endonuclease IV --- AP site analogue --- spacer --- DNA repair --- DNA repair --- double strand break repair --- exonuclease 1 --- EXO1 --- mismatch repair --- MMR --- NER --- nucleotide excision repair --- strand displacements --- TLS --- translesion DNA synthesis --- POL? --- mutation frequency --- mutations spectra --- SupF --- mutagenicity --- oxidative stress --- DNA damage --- DNA repair --- replication --- 8-oxoG --- epigenetic --- gene expression --- helicase --- cell cycle checkpoints --- genomic instability --- G2-arrest --- cell death --- repair of DNA damage --- adaptation --- n/a

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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english (2)


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2020 (1)

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