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MERS-CoV

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ISBN: 9783039218509 9783039218516 Year: Pages: 274 DOI: 10.3390/books978-3-03921-851-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-01-07 09:08:26
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Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic coronavirus. First identified in 2012, MERS-CoV has caused over 2460 infections and a fatality rate of about 35% in humans. Similar to severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV likely originated from bats; however, different from SARS-CoV, which potentially utilized palm civets as its intermediate hosts, MERS-CoV likely transmits to humans through dromedary camels. Animal models, such as humanized mice and nonhuman primates, have been developed for studying MERS-CoV infection. Currently, there are no vaccines and therapeutics approved for the prevention and treatment of MERS-CoV infection, although a number of them have been developed preclinically or tested clinically. This book covers one editorial and 16 articles (including seven review articles and nine original research papers) written by researchers working in the field of MERS-CoV. It describes the following three main aspects: (1) MERS-CoV epidemiology, transmission, and pathogenesis; (2) current progress on MERS-CoV animal models, vaccines, and therapeutics; and (3) challenges and future prospects for MERS-CoV research. Overall, this book will help researchers in the MERS-CoV field to further advance their work on the virus. It also has important implications for other coronaviruses as well as viruses outside the coronavirus family with pandemic potentials.

Equine Viruses

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ISBN: 9783039283200 / 9783039283217 Year: Pages: 230 DOI: 10.3390/books978-3-03928-321-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-06-09 16:38:57
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The Food and Agriculture Organization of the United Nations has recently estimated that the world equid population exceeds 110 million. Working equids (horses, ponies, donkeys, and mules) remain essential to ensure the livelihood of poor communities around the world. In many developed countries, the equine industry has significant economical weight, with around 7 million horses in Europe alone. The close relationship between humans and equids and the fact that the athlete horse is the terrestrial mammal that travels the most worldwide after humans are important elements to consider in the transmission of pathogens and diseases, amongst equids and to other species. The potential effect of climate change on vector ecology and vector-borne diseases is also of concern for both human and animal health. In this Special Issue, we intend to explore our understanding of a panel of equine viruses, looking at their pathogenicity, their importance in terms of welfare and potential association with diseases, their economic importance and impact on performance, and how their identification can be helped by new technologies and methods.

Keywords

equine papillomaviruses --- horse --- genital wart --- phylogeny --- evolution --- Venezuelan equine encephalitis virus --- vaccine --- strain selection --- Animal Rule --- cDNA cloned virus --- virus stock propagation --- African horse sickness --- virus structure --- replication --- vaccine strategies --- Equid alphaherpesvirus 1 --- horse --- PCR --- sequencing --- ORF30 --- ORF33 --- ORF34 --- ORF68 --- equine herpesvirus type 1 --- outbreak --- respiratory disease --- abortion --- neuropathogenic strain --- myeloencephalopathy --- phylogeny --- ORF30 --- MLST --- Parvoviridae --- Eqcopivirus --- horse parvovirus-CSF --- equine hepacivirus --- equine parvovirus H --- bosavirus --- virome --- equine coronavirus --- Ireland --- enteric disease --- equine rhinitis virus A --- Thoroughbred racehorses --- loss of performance --- equine parvovirus-hepatitis --- Germany --- risk factors --- transmission --- arbovirus --- flavivirus --- hematophagous arthropod --- hepacivirus A --- hepatitis --- insects --- mosquito-borne virus --- virus transmission --- equine coronavirus --- spike S1 protein --- ELISA --- virus neutralization --- seroprevalence --- MxA --- equine Mx1 --- influenza A viruses --- polymerase activity --- interspecies transmission --- nucleoprotein --- equine influenza --- non-primate hepacivirus --- equine hepacivirus --- in utero transmission --- horse --- fetuses --- encephalitis --- arbovirus --- rabies --- Equid herpesviruses --- Borna disease virus --- West Nile virus --- horses --- n/a

microRNA Regulation in Health and Disease

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ISBN: 9783039217144 9783039217151 Year: Pages: 154 DOI: 10.3390/books978-3-03921-715-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Genetics
Added to DOAB on : 2020-04-07 23:07:08
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MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.

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