Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The combinatorial number of possible methylomes in biological time and space is astronomical. Consequently, the computational analysis of methylomes needs to cater for a variety of data, throughput and resolution. Here, we review recent advances in 2nd generation sequencing (2GS) with a focus on the different methods used for the analysis of MeDIP-seq data. The challenges and opportunities presented by the integration of methylation data with other genomic data types are discussed as is the potential impact of emerging 3rd generation sequencing (3GS) based technologies on methylation analysis.

sequencing --- biochemistry

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Most infections and traumatic injuries are cleared or repaired relatively rapidly and metabolic homoeostasis is soon restored. However, there is a broad range of inflammatory diseases which involve chronic activation of the immune system and, as a result, chronic persistent inflammation. We have been studying the metabolic consequences of chronic inflammatory diseases with the aim of identifying metabolic fingerprints which may provide clues about why the localised tissue disease persists.

molecular biology --- biochemistry --- genetics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Učebnice Clinical Biochemistry ve svých 39 kapitolách pokrývá všechna důležitá témata moderní klinické biochemie. Od preanalytických vlivů na laboratorní vyšetření přes analytické a klinické vlastnosti metod, kontrolu kvality v klinické laboratoři, automatizaci po jednotlivé indikace a interpretace laboratorních testů v diagnostice a sledování různých onemocnění. Cílem je dovést čtenáře k propojení všech aspektů ovlivňujících laboratorní výsledek a jejich kritickému zhodnocení při péči o pacienta. Text je určen především pro pregraduální studenty všeobecného lékařství, avšak jako referenční příručku ji využijí i začínající lékaři všech oborů.Clinical Biochemistry textbook covers in its 39 chapters all important topics of modern clinical biochemistry. From preanalytical influences to laboratory results through analytical and clinical properties of laboratory methods, quality control in Clinical laboratory, automation to indication and interpretation of laboratory tests in diagnosis and follow up of a plenty of diseases. The goal of this publication is to lead a reader to intersection of all aspects that influence laboratory results and to its critical evaluation in taking care about a patient. The text is designed to pregradual students of general medicine. However, also young medical doctors of all medical specializations can use the textbook as a reference guide.

biochemistry, laboratory methods, textbook

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Molecular docking has always been and will be on the forefront of developments in the eminent field of drug design and medicinal chemistry. At the early days, drug discovery was based on blackboard drawings and expert intuition. However, as times move on, the amount of available information and overall knowledge base that needs to be analyzed cannot be processed manually. This, coupled by the rapid growth in computational infrastructure and processing power, has allowed for the efficient use of molecular docking tools and algorithms to be considered in the greater field of drug discovery. In the postgenomic era, molecular docking has become the key player for the screening of hundreds of thousands of compounds against a repertoire of pharmacological targets.

Life Sciences --- Biochemistry, Genetics and Molecular Biology --- Biochemistry --- Molecular Biology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Reduced glutathione (GSH) is the most important thiol in living organisms. It is the key component of antioxidant system and serves as a free radical scavenger. There is a cycle of GSH in biological systems and this cycle provides higher intracellular levels of GSH. GSH depletion and apparent oxidative stress may cause toxicity and can affect the general well-being of the organism. GSH was shown to be preventive against aging, cancer, heart disease, infections and dementia. This book is mainly focused on GSH in health and disease. The readers will gain qualified scientific knowledge on the diverse functions of GSH, the importance of GSH status against oxidative stress and the interaction between GSH and nervous system-related infections from this book.

Life Sciences --- Biochemistry, Genetics and Molecular Biology --- Biochemistry --- Molecular Biology