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Natural Products and Drug Discovery

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ISBN: 9783039287468 / 9783039287475 Year: Pages: 392 DOI: 10.3390/books978-3-03928-747-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-06-09 16:38:57
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Abstract

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Keywords

cytotoxicity-guided --- phenolic derivatives --- Dryopteris fragrans --- chemical derivatization --- immuno-regulation activity --- Imperata cylindrica --- HPLC --- ESI-MS/MS --- growth inhibitory activity --- cancer --- cardamonin --- antinociceptive --- TRPV1 --- glutamate --- opioid --- siphonous green algae --- sulfated coumarins --- Dasycladus vermicularis --- isolation and quantification --- Orobanche s.l. --- Orobanchaceae --- Lamiales --- natural products --- secondary metabolites --- phenylpropanoid glycosides --- phenylethanoid glycosides --- bioactivities of natural products --- chemosystematics --- FSE --- T2DM --- GLUT4 --- Ca2+ --- L6 cell --- marine peptides --- proliferation --- migration --- angiogenesis --- zebrafish --- antioxidant activity --- flavonoids --- isoflavones --- phenolics --- proanthocyanidins --- Trifolium --- Leea indica --- HPLC-ESI-microTOF-Q-MS/MS --- phenolics --- dihydrochalcones --- Humulus lupulus --- prenylated phenolic compounds --- antimicrobial agents --- methicillin-resistant Staphylococcus aureus --- Leishmania mexicana mexicana --- Trypanosoma brucei brucei --- Astragalus boeticus L. --- spectroscopic analysis --- cytotoxic activity --- human colon cancer cell lines --- acetylated astragalosides --- Fabaceae --- aging --- cancer --- cardiovascular disease --- dementia --- diabetes --- inflammation --- oxidative stress --- Harpagophytum procumbens --- devil’s claw --- harpagoside --- spagyric tincture --- antioxidant activity --- Cleistocalyx operculatus --- 2?,4?-dihydroxy-6?-methoxy-3?,5?-dimethylchalcone (DMC) --- pPancreatic cancer --- PANC-1 --- ACE inhibitory peptide --- antihypertensive --- bioactive peptides --- hypertension --- marine resources --- terpenes --- terpenoids --- antimicrobial resistance --- synergy --- Phyllanthus orbicularis --- C-glycoside --- flavonoid --- natural products --- traditional medicine --- Cuba --- Phyllanthus chamacristoides --- chromatography --- mass spectrometry --- NMR --- circular dichroism --- stereochemistry --- Fideloside --- cytokines --- anti-inflammatory activity --- metabolomics --- multivariate data analysis --- molecular network --- Bacopa monnieri --- LC-MS --- diabetic neuropathy --- neuropathic pain --- glucosinolates --- Eruca sativa --- glucoerucin --- H2S --- Kv7 potassium channels --- artemisinin --- Physcomitrella patens --- sesquiterpenoids --- malaria --- biotechnology --- ketamine --- psychosis --- cerebellum --- celastrol --- oxidative stress --- NADPH oxidases --- n/a

Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential

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ISBN: 9783039215324 9783039215331 Year: Pages: 442 DOI: 10.3390/books978-3-03921-533-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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Abstract

This Special Issue Book, “Marine Bioactive Peptides: Structure, Function, andTherapeutic Potential"" includes up-to-date information regarding bioactivepeptides isolated from marine organisms. Marine peptides have been found invarious phyla, and their numbers have grown in recent years. These peptidesare diverse in structure and possess broad-spectrum activities that have greatpotential for medical applications. Various marine peptides are evolutionaryancient molecular factors of innate immunity that play a key role in host defense.A plethora of biological activities, including antibacterial, antifungal, antiviral,anticancer, anticoagulant, endotoxin-binding, immune-modulating, etc., makemarine peptides an attractive molecular basis for drug design. This Special IssueBook presents new results in the isolation, structural elucidation, functionalcharacterization, and therapeutic potential evaluation of peptides found inmarine organisms. Chemical synthesis and biotechnological production of marinepeptides and their mimetics is also a focus of this Special Issue Book.

Keywords

sea cucumber --- ACE-inhibitory peptide --- molecular docking --- structure-activity relationship --- plastein reaction --- Gracilariopsis lemaneiformis --- ACE-inhibitory activity --- peptide --- molecular docking --- SHRs --- prostate cancer --- Anthopleura anjunae oligopeptide --- DU-145 cells --- PI3K/AKT/mTOR signaling pathway --- cod skin --- NA-inhibitory peptide --- influenza virus --- neuraminidase --- molecular docking --- adsorption --- host defense peptide --- antimicrobial peptide --- anti-LPS factor --- host?microbe relationship --- functional diversity --- invertebrate immunity --- crustacean --- antimicrobial activity --- antimicrobial peptide --- polychaeta --- innate immunity --- BRICHOS domain --- recombinant peptide --- ?-helix --- Rana-box --- nuclear magnetic resonance (NMR) --- antimicrobial peptide --- cytotoxicity --- ?-hairpin --- polyphemusins --- tachyplesins --- cell death --- signaling pathways --- Neptunea arthritica cumingii --- multi-functional peptides --- antioxidant activity --- ACE-inhibitory activity --- anti-diabetic activity --- Arenicola marina --- antimicrobial peptides --- arenicin --- complement --- C3a --- acid-sensing ion channel --- animal models --- pain relief --- toxin --- Ugr 9-1 --- APETx2 --- hairtail (Trichiurus japonicas) --- muscle --- peptide --- antioxidant activity --- half-fin anchovy hydrolysates --- Maillard reaction products --- antibacterial peptide --- identification --- self-production of hydrogen peroxide --- membrane damage --- Perinereis aibuhitensis --- decapeptide --- lung cancer --- cell proliferation --- apoptosis --- conotoxins --- conopeptides --- computational studies --- molecular dynamics --- machine learning --- docking --- review --- drug design --- ion channels --- Conus --- conotoxin --- transcriptome sequencing --- phylogeny --- venom duct --- abalone --- peptide --- vasculogenic mimicry --- metastasis --- MMPs --- HIF-1? --- dexamethasone --- myotube atrophy --- protein synthesis --- proteolytic system --- Pyropia yezoensis peptide --- PYP15 --- QAGLSPVR --- antihypertensive effect --- Caco-2 cell monolayer --- transport routes --- oyster zinc-binding peptide --- peptide-zinc complex --- caco-2 cells --- intestinal absorption --- zinc bioavailability --- Chlorella pyrenoidosa protein hydrolysate (CPPH) --- Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) --- calcium absorption --- gene expression --- gut microbiota --- cone snails --- conotoxins --- ion channels --- function --- structure --- marine peptides --- arenicin-1 --- molecular symmetry --- structure–activity relationship --- antibacterial --- cytotoxic --- chemical synthesis --- molecular dynamics --- tilapia --- HUVEC --- angiotensin II --- NF-?B --- Nrf2 --- endothelial dysfunction --- conotoxin --- cone snail --- Conus --- Conus ateralbus --- Kalloconus --- n/a

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