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Strafrechtliche Verantwortung im internationalen Kartellrecht

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Book Series: Münchener Schriften zum Europäischen und Internationalen Kartellrecht ISBN: 9783845275970 Year: Volume: 35 DOI: http://dx.doi.org/10.5771/9783845275970 Language: German
Publisher: Nomos Verlagsgesellschaft mbH & Co. KG
Subject: Law
Added to DOAB on : 2018-11-05 12:58:39
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The book examines the conflict situations at international level arising from the spread of criminal sanctions in national competition law and thereby in particular deals with the risks linked to criminal law provisions of several countries being applicable to one and the same international cartel. Before analyzing these conflicts, the author examines to what extent treaties and instruments of international cooperation and coordination, both from the sphere of criminal law and the sphere of competition law, apply to the enforcement of national criminal competition law provisions.

The Purpose of the First World War

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Book Series: Schriften des Historischen Kollegs ISBN: 9783110346220 9783110443486 9783110435993 Year: Volume: 91 Pages: 268,00 DOI: 10.1515/9783110443486 Language: English
Publisher: De Gruyter Oldenbourg Grant: Knowledge Unlatched - 102425
Subject: History
Added to DOAB on : 2019-04-25 11:21:04
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Ten million soldiers died during the First World War. But why, and for what reason? The Great War is widely seen as a "pointless carnage" (Pope Benedict XV). Was there a point, at least in the eyes of the political and military decision makers? International specialists analyse the hopes and expectations of the political and military leaders and try to explain why the contemporaries thought that they had to fight the Great War.

Keywords

History --- History --- World War 1

Internetbasiertes Fachinformationssystem zur Plattenkinematik

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ISBN: 3866440634 Year: Pages: XX, 140 p. DOI: 10.5445/KSP/1000004872 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Physics (General)
Added to DOAB on : 2019-07-30 20:02:00
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In der vorliegenden Arbeit wird ein internetbasiertes Fachinformationssystem zur Detektion krustaler Deformationen in den Ostkarpaten vorgestellt, welches im Rahmen des Sonderforschungsbereichs 461 Starkbeben: von wissenschaftlichen Grundlagen zu Ingenieurmaßnahmen entwickelt wurde.Im Vordergrund stehen die Konzeption und Implementierung eines Fachinformationssystems für regionale beziehungsweise globale GPS-Projekte, die zur Aufdeckung von Plattengrenzen und Analyse von Plattenbewegungen eingerichtet wird.

Comparative studies between HTLV-1 and HTLV-2 function and pathobiology

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194988 Year: Pages: 94 DOI: 10.3389/978-2-88919-498-8 Language: English
Publisher: Frontiers Media SA
Subject: Microbiology --- Science (General)
Added to DOAB on : 2015-11-16 15:44:59
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Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties.

Keywords

HTLV-1 --- HTLV-2 --- Expression --- Proteins --- Co-infection

Role of lipids in virus assembly

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195824 Year: Pages: 91 DOI: 10.3389/978-2-88919-582-4 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Microbiology --- Botany
Added to DOAB on : 2016-03-10 08:14:32
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RNA enveloped viruses comprise several families belonging to plus and minus strand RNA viruses, such as retroviruses, flavoviruses and orthomyxoviruses. Viruses utilize cellular lipids during critical steps of replication like entry, assembly and egress. Growing evidence indicate important roles for lipids and lipid nanodomains in virus assembly. This special topic covers key aspects of virus-membrane interactions during assembly and egress, especially those of retroviruses and Ebola virus (EBOV). Virus assembly and release involve specific and nonspecific interactions between viral proteins and membrane compartments. Retroviral Gag proteins assemble predominantly on the PM. Despite the great progress in identifying the factors that modulate retroviral Gag assembly on the PM, there are still gaps in our understanding of precise mechanisms of Gag-membrane interactions. Studies over the last two decades have focused on the mechanisms by which other retroviral Gag proteins interact with membranes during assembly. These include human immunodeficiency virus (HIV), Rous sarcoma virus (RSV), equine infectious anemia virus (EIAV), Mason-Pfizer monkey virus (M-PMV), murine leukemia virus (MLV), and human T-lymphotropic virus type (HTLV-1). Additionally, assembly of filoviruses such as EBOV also occurs on the inner leaflet of the PM. The articles published under this special topic highlight the latest understanding of the role of membrane lipids during virus assembly, egress and release.

Keywords

retroviruses --- HIV 1 --- Gag --- Matrix --- membrane --- NMR --- Ebola --- VP40

Horace’s Sermones Book 1. Credentials for Maecenas

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ISBN: 9783110642636 Year: Pages: 300 DOI: 10.1515/9783110642636 Language: English
Publisher: De Gruyter
Added to DOAB on : 2019-11-06 16:06:17
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This monograph interprets Sermones book 1 as a collection of Horace's credentials for Maecenas and traces his efforts in getting accepted as an associate of the latter after his miscalculation in joining Brutus. Although Horace regularly reflects on his poetic orientation and standards of good poetry, his primary objective was his self-presentation. The volume also examines his commentary on contemporary socio-political themes.

Characterization and Modeling of the Ratcheting Behavior of the Ferritic-Martensitic Steel P91

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Book Series: Schriftenreihe des Instituts für Angewandte Materialien, Karlsruher Institut für Technologie ISSN: 21929963 ISBN: 9783731505037 Year: Volume: 59 Pages: XXV, 180 p. DOI: 10.5445/KSP/1000053265 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
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In this work, the ratcheting-behavior of 9%Cr-1%Mo ferritic–martensitic steel is studied with uniaxial cyclic loading. To describe the ratcheting-behavior of this steel, a visco-plastic constitutive model with consideration of cyclic softening of Reduced Activation Ferritic Martensitic steels is further modified, based on the analysis of back stress.

Modellierung der Stoffübertragung beim Niederdruckcarbonitrieren mit Ammoniak und Acetylen

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Book Series: Schriftenreihe des Instituts für Angewandte Materialien, Karlsruher Institut für Technologie ISSN: 21929963 ISBN: 9783731505686 Year: Volume: 63 Pages: XXVIII, 159 p. DOI: 10.5445/KSP/1000057840 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:02
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A mathematical model has been developed for the description of the transport process for low-pressure carbonitriding with ammonia and acetylene. As an example the case hardening steel 18CrNi8 was used. It can be shown that the concentration profiles of carbon and nitrogen as well as the ammonia exhaust gas concentration are described well. Based on the modelling, first simulation runs could be carried out for further optimization of the heat treatment process.

HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454617 Year: Pages: 171 DOI: 10.3389/978-2-88945-461-7 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2018-11-16 17:17:57
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Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarged during HIV-1 infection. Antibodies with the capacity to neutralize a broad range of HIV-1 isolates can be detected only in a minority of infected patients, after a year or more from acute infection. An open question is whether the inability of producing neutralizing HIV-1 antibodies is somehow linked to the B cell immunopathology observed in patients. In this research topic we invited scientists to summarize the current state of knowledge on regulation and development of B cells and antibody responses during HIV-1 infection; fifteen contributions were received comprising both reviews and original articles. The articles are related to B cell dysfunctions identified in HIV-1 infected individuals, production of different types of antibodies (neutralizing versus non neutralizing, and of different isotypes) in vivo during HIV-1 infection and the biological factors which may impact on this process, clinical potential and applications of anti-HIV antibodies and how to achieve neutralizing antibody responses to HIV-1 epitopes upon vaccination. The topic has gathered articles on front-line research undertaken in the field of B cells and antibodies in HIV-1 infection. It is our hope that the collection of articles presented in this book may be useful for new and experienced scholars in the field and add a piece to the complex puzzle of knowledge needed for the development of an HIV-1 vaccine.

Ion Channel Trafficking and Cardiac Arrhythmias

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889456437 Year: Pages: 123 DOI: 10.3389/978-2-88945-643-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2019-01-23 14:53:43
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A well-adjusted expression of cardiac ion channels at the sarcolemma is of crucial importance for normal action potential formation and thus cardiac function. The cellular processes that transport channel proteins from the endoplasmic reticulum towards specified regions on the sarcolemmal membrane, and subsequently take them from the plasma membrane to the protein degradation machinery are commonly known as trafficking. The research field recognizes that aberrant channel trafficking stands at the basis of many congenital and acquired arrhythmias. The collection of papers in this eBook provides state-of-the-art insight into the world of ion channel trafficking research.

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