Search results: Found 1

Listing 1 - 1 of 1
Sort by
Toxins in Drug Discovery and Pharmacology

Author:
ISBN: 9783038428619/9783038428626 Year: Pages: XII, 304 Language: English
Publisher: MDPI AG - Multidisciplinary Digital Publishing Institute
Subject: Public Health
Added to DOAB on : 2018-05-04 11:37:49
License:

Loading...
Export citation

Choose an application

Abstract

Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as untapped cocktails of biologically active compounds that are being increasingly recognized as a new emerging source of peptide-based therapeutics. Venomous animals are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharmacology for their own biological purposes by producing venoms that contain a structural and functional diversity of neurotoxins. These neurotoxins appear to be highly selective ligands for a wide range of ion channels and receptors. Therefore, they represent interesting lead compounds for the development of analgesics, anti-cancer drugs, drugs for neurological disorders such as multiple sclerosis, Parkinson' s disease, Alzheimer' s disease, and other therapeutics.This Special Issue of Toxins aims to provide a comprehensive look at toxins and toxin-inspired leads and will focus on the mechanisms of action, structure–function relationships, and evolution of pharmacologically interesting venom components, including the most recent developments related to the emergence of venoms as an underutilized source of highly evolved bioactive peptides with clinical potential.

Listing 1 - 1 of 1
Sort by
Narrow your search

Publisher

MDPI AG - Multidisciplinary Digital Publishing Institute (1)


License

CC by-nc-nd (1)


Language

english (1)


Year
From To Submit

2018 (1)