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Senescence - Physiology or Pathology

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ISBN: 9789535134619 9789535134626 Year: Pages: 166 DOI: 10.5772/65533 Language: English
Publisher: IntechOpen
Subject: Genetics
Added to DOAB on : 2019-10-03 07:51:50

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Abstract

In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence.

Alzheimer's Disease - The 21st Century Challenge

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ISBN: 9781789234626 9781789234633 Year: Pages: 162 DOI: 10.5772/intechopen.71628 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:51

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Abstract

Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.

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