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Capsaicin and its Human Therapeutic Development

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ISBN: 9781789235203 9781789235210 Year: Pages: 124 DOI: 10.5772/intechopen.73124 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:51

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The enormous field of this topic is clearly shown by the following facts: during the last ten years (2007-2016) around 500 papers/ year and 523 review articles are listed in the PubMed database on capsaicin, and over 200/year are under keywords of ""capsaicin human"". Recently, two major studies on the mortality of consumers of spicy food containing capsaicin and nonconsumers (over 350000 men and women aged 30-79 with heart disease, cancer, and stroke at baseline over 3.5 million person-years, 2004-2013) showed that the relative risk in total mortality was reduced by 14% in 10 diverse geographic areas of China (2015). Similarly, in the USA, (16,179 participants during over 2,70,000 person/year with the median of 18.9 years) the total mortality was reduced by 13% in populations consuming hot chili (2017). Recently, the book series ""Progress in Drug Research"" the 68th volume dealt for the first time on ""Capsaicin as a Therapeutic Molecule"" (Springer, Basel, 2014). Five excellent chapters are found in this book dealing with procedures of capsaicin from capsicum plants, emerging technologies to improve capsaicin delivery, capsaicinoid diversity and its human food preference, capsaicin and lipid metabolism, and predictors in treatment response to capsaicin. The results of these observations clearly indicate that the capsaicin research has changed direction to include human medical treatment with capsaicin. The book gathers knowledge from experts in basic and clinical sciences, pharmacologists, in the nutrition and food industry, in the drug industry, technologists, plant cultivators, as well as experts across a wide scale of medical branches.

Adenosine Triphosphate in Health and Disease

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Book Series: Physiology ISSN: 26318261 ISBN: 9781838802035 9781838802042 Year: Volume: 3 Pages: 84 DOI: 10.5772/intechopen.73455 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:53

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This book covers a very important research field; specifically, it tries to decrease the gap between theoretical and clinical research. The tendency of world research is to gain a detailed insight into the living organs of animals and humans. However, we must not lose sight of the problems that these organs can present; for example, we need to understand their molecular and biochemical mechanisms, as well as new drug productions to counteract diseases. Very deep mechanisms can offer new therapeutic pathways in hematology and oncology, among other fields. However, at least 8-l0 years of further clinical studies are necessary to make a final decision regarding the real clinical importance of basic research. Ideally, an interdisciplinary efforts among basic and clinical researchers are necessary in common research fields. At the same time, genetic research is increasing dramatically (e.g. enzyme mutations). The primary aim of this book is to demonstrate how such research can be used in both fields. This book gathers knowledge from experts in basic and clinical science, biochemistry, pharmacology, molecular pharmacology, genetics, and other fields.

Constipation

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ISBN: 9781838818722 9781838818739 9781838818746 Year: Pages: 118 DOI: 10.5772/intechopen.73896 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:53

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Constipation is a problem with multifactorial origin that affects both children and adults. It is a difficult problem to treat because there is no clear diagnostic criteria and there are only limited therapeutic options. This book presents information on constipation, including pathology, diagnosis, imaging, nutrition, and management, among other topics. It is written for physicians and interested readers alike.

The Gut Microbiome - Implications for Human Disease

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ISBN: 9789535127505 9789535127512 Year: Pages: 112 DOI: 10.5772/61423 Language: English
Publisher: IntechOpen
Subject: Microbiology
Added to DOAB on : 2019-10-03 09:47:10

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In the last decades, the importance of gut microbiome has been linked to medical research on different diseases. Developments of other medical disciplines (human clinical pharmacology, clinical nutrition and dietetics, everyday medical treatments of antibiotics, changes in nutritional inhabits in different countries) also called attention to study the changes in the gut microbiome. This book contains five excellent review chapters in the field of gut microbiome, written by researchers from the USA, Canada, China, and India. These chapters present a critical review about some clinically important changes in the gut microbiome in the development of some human diseases and therapeutic possibilities (liver disease, cardiovascular diseases, brain diseases, gastrointestinal diseases). The book brings to attention the essential role of gut microbiome in keeping our life healthy. This book is addressed to experts of microbiology, podiatrists, gastroenterologists, internists, nutritional experts, cardiologists, basic and clinical researchers, as well as experts in the field of food industry.

Membrane-bound Atp-dependent Energy Systems and the Gastrointestinal Mucosal Damage and Protection

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ISBN: 9789535144434 9789535122517 Year: Pages: 366 DOI: 10.5772/60095 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:49

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The book on Membrane-bound Atp-dependent Energy Systems and the Gastrointestinal Mucosal Damage and Protection deals with various aspects of peptic ulcer disease, like clinical pharmacology, nutrition, molecular biochemical pharmacology as well as clinical aspects, and especially with the evaluation of certain biochemical mechanisms in human gastric mucosa and in animal gastric tissues obtained from different ulcer models. This book can be useful to physiologists; biochemists; pharmacologists, particularly molecular and biochemical pharmacologists; internists; gastroenterologists; biologists; surgeons and pharmacists.

Gastric Cancer

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ISBN: 9789535135272 9789535135289 Year: Pages: 298 DOI: 10.5772/65828 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:50

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Gastric cancer remains an important issue in the world of oncology. In 2013, it ranked fifth by global incidence and second by mortality. Really, it is true that the death rates have decreased significantly in the USA and in Europe over the 100-year period; meanwhile, gastric cancer can be characterized by poor prognosis and high mortality, with the exception of early diagnosed patients. Oncological (basic and clinical) research increased extremely in the last decades (including gastric cancer). The authors participating in this book are internationally well-known experts from 11 countries of the world, working in different fields of gastric cancer research, and they summarize the results obtained in the last years. The conclusions of these abovementioned observations fall between the findings of classical prospective, randomized, multiclinical, multinational (and meta-analyzed) generally accepted studies (in accordance with the presently applied and internationally accepted protocols) and the scientifically-based (however individual) molecular targeting organ therapies. The book gathers experts in basic science, molecular pharmacologists, biochemical pharmacologists, basic and clinical oncologists, internists, surgeons, gastroenterologists, tumor pharmacologists as well as experts working in the field of oncology.

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