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Mechanisms of Innate Neuroprotection

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199297 Year: Pages: 138 DOI: 10.3389/978-2-88919-929-7 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Neurology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Abstract

As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.

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2016 (1)