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Advances in Hematopoietic Stem Cell Research

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ISBN: 9789533079301 Year: Pages: 478 DOI: 10.5772/1203 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:48

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This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine

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ISBN: 9789535128656 9789535128663 Year: Pages: 258 DOI: 10.5772/62607 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:49

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Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cells will have a crucial role in regenerative medicine. For this reason, these cells have been tested in several clinical trials and compassive treatments in children and adults, concerning a wide range of pathologies and diseases, for instance, for the treatment of cerebral paralysis. Considering the worldwide availability of UCB and UCT units and the absence of ethical concerns will probably become the best sources for cell-based therapies for hematological and nonhematological pathologies. The UCB will also have a crucial role in neonatology-predictive analysis in the near future.

Stem Cells in Clinical Practice and Tissue Engineering

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ISBN: 9781789230109 9781789230116 Year: Pages: 352 DOI: 10.5772/65995 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:51

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Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Ion Channels in Health and Sickness

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ISBN: 9781789842272 9781789842289 Year: Pages: 202 DOI: 10.5772/intechopen.72025 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:52

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Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.

Calcium and Signal Transduction

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Book Series: Physiology ISSN: 26318261 ISBN: 9781789842494 9781789842500 Year: Volume: 1 Pages: 202 DOI: 10.5772/intechopen.74489 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:52

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Since the development of microelectronic clamping methodology and fluorescent indicators for direct measurement of dynamic intracellular calcium transients, our understanding of biological signal transduction has progressed dramatically since the 1980s. Calcium is a universal signal in biology that modulates gene expression, transmitter and hormone release, muscular movement, and even ""programmed"" cell death. This book represents a compilation of chapters from a diverse set of expert biologists throughout the world who have conducted research in the general area of calcium signaling in organisms ranging from bacteria to humans. In accord with priorities of resolving human disease, the reader will also benefit from learning calcium's role in cellular signaling pathology relating to acute or chronic conditions such as vomiting, sepsis, obesity, hypertension, and cancer.

Keratin

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Book Series: Biochemistry ISSN: 26320983 ISBN: 9781789848045 9781789848052 Year: Volume: 2 Pages: 180 DOI: 10.5772/intechopen.73230 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:52

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Keratin is the proteinaceous body covering layer produced by mammals, birds, fish, reptiles, and amphibians. Hair and wool, horns, claws, hooves, feathers, and scales are made of keratin. Keratin is insoluble in water and is resistant to proteolysis. Importantly, keratin is also the intracellular structural protein that protects living epithelial cells from mechanical damage or stress. The fundamental keratin functions are revealed in congenital human skin diseases caused by mutations in keratin genes, e.g., Epidermolysis bullosa simplex or Epidermolytic hyperkeratosis. Most keratin gene mutations have a dominant-negative effect disrupting the filamentous structure formation even from the natural allele, and leaving the cell with a deficient cytoskeleton. However, industrial scale meat production results in vast quantities of keratin byproduct. Processing this byproduct is, on the one hand a major challenge, and on the other hand, a potential for useful recycling and exploitation.

Stromal Cells - Structure, Function, and Therapeutic Implications

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ISBN: 9781789849844 9781789849851 Year: Pages: 260 DOI: 10.5772/intechopen.71899 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:52

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Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.

Cell Culture

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ISBN: 9781789848663 9781789848670 Year: Pages: 292 DOI: 10.5772/intechopen.73709 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:52

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Cell culture is one of the major tools used in cellular and molecular biology, delivering an excellent model for studying the normal physiology and biochemistry of cells. This book covers some advanced aspects in cell culture methodologies. The book has four sections discussing different types of cell culture models, including 3D cell culture techniques, their advantages, and limitations in comparison to traditional 2D culturing; cell viability, autophagy, in vitro toxicity tests and live cell imaging; stem cell culture for cell-based therapeutics; and specific applications and methodologies for hybrid cell lines and cancer models. This book provides a comprehensive overview of some of the advanced cell culture methodologies and applications. It serves as a valuable source for scientists, researchers, clinicians and students.

Cell Signalling - Thermodynamics and Molecular Control

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ISBN: 9781838800659 9781838800666 Year: Pages: 84 DOI: 10.5772/intechopen.73411 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:53

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Intracellular signal transduction is an important topic of research in cell and molecular biology. It has a wide range of implications in growth, differentiation, development, animal polarity, cellular response monitoring, and many disease processes, including cancer. The functional homeostasis of a cell is assumed to be maintained by an intricate network of signaling that evolved through natural selection. This book includes chapters written in the frontier areas of research on cell signaling. Issues such as information thermodynamics, master regulation of immune tolerance, genetically encoded reporter circuits and their applications, hypoxia, and vitamin K2 mediated signaling processes are addressed and discussed by eminent researchers of the field.

Endoplasmic Reticulum

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Book Series: Physiology ISSN: 26318261 ISBN: 9781838800871 9781838800888 Year: Volume: 2 Pages: 106 DOI: 10.5772/intechopen.73456 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:53

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The purpose of this book is to concentrate on recent developments on endoplasmic reticulum. The articles collected in this book are contributions by invited researchers with a long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, not only scientists but also people with general background in many different biological sciences. This volume offers you up-to-date, expert reviews of the fast-moving field of endoplasmic reticulum. The book is divided in two sections: 1. Introduction and 2. Endoplasmic Reticulum Properties and Functions.

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