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Function and Flexibility: Friend or Foe?

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199723 Year: Pages: 102 DOI: 10.3389/978-2-88919-972-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that “form follows function”. When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that “function follows form” as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original “1 gene - 1 protein structure - 1 function” relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interacting with (a) partner molecule(s) are the most biologically relevant and in this context Sullivan’s quote is still appropriate: the conformation that the protein adopts follows from the function of that protein. Despite the fact that many well-characterized proteins have a well-folded structure, there is a growing interest in the conformational flexibility within proteins. This flexibility is also a balanced phenomenon: excess of flexibility can be detrimental for protein behaviour, as well as the lack thereof. Notwithstanding its importance, studying intrinsically disordered protein regions or conformational rearrangements can be a very challenging. Therefore, flexibility can be perceived as a friend or a foe, depending on the context. This e-book showcases the impact of the study of protein flexibility on the structural biology field and presents protein flexibility in the context of disease as well as its benign aspects. As detailed knowledge of the structural aspects of polypeptides remains essential to comprehend protein function, one of the future challenges for structural biology also lies with large macromolecular protein complexes. Also there the dynamics and flexibility are essential for proper functioning and molecular movement, which is an important aspect of living matter. This challenge stimulated the development of advanced techniques to study protein flexibility and the use of those techniques to address fundamental biological and biomedical problems. Those innovations should help us to unravel the intimate link between protein function and flexibility and explore new horizons.

China in Transition

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Book Series: Hohenheimer volkswirtschaftliche Schriften ISBN: 9783631633281 Year: Pages: 236 Language: English
Publisher: Peter Lang International Academic Publishing Group
Subject: Economics
Added to DOAB on : 2019-01-15 13:32:59
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In China, inequality in social welfare is of rising political concern. This case study analyzes the determinants of well-being of rural households in Hebei using a secondary panel data set (1986 to 2006). One key question is how well-being was affected by institutional changes in times of societal transition. Based on population grouping, the author analyzes poverty and income development. The study reveals impacts of new possibilities to provide labor outside the own farm on the allocation of households’ labor time and the stability of full- and part-time farming over time. The assessments ground on agricultural household models, microeconomic concepts of labor allocation, and welfare theories. Different methodologies, e.g. inequality decomposition or hazard analysis, are applied.

Cell Stress, Metabolic Reprogramming, and Cancer

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455652 Year: Pages: 68 DOI: 10.3389/978-2-88945-565-2 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology
Added to DOAB on : 2019-01-23 14:53:43
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The present eBook presents one review, five mini-reviews, and an opinion article on the achievements and perspectives of studies on important aspects of cancer cell metabolic reprogramming whose mechanisms and regulation are still largely elusive. It also sheds light on certain novel functional components, which rewires cell metabolism in tumor transformation.

Asian Century… on a Knife-edge: A 360 Degree Analysis of Asia's Recent Economic Development

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ISBN: 9789811071812 9789811071829 Year: Pages: 335 DOI: 10.1007/978-981-10-7182-9 Language: English
Publisher: Palgrave Macmillan Grant: Asian Century Institute
Subject: Political Science --- Economics
Added to DOAB on : 2018-05-31 18:10:53
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This book delves into the widely held belief that the 21st century will be the "Asian Century" by examining the Asia's rapid economic development in the post-war era and the challenges it faces in forging ahead of world leaders in the West. The impact of the current turbulent global political climate on Asia is critically analyzed, employing a holistic and multidisciplinary approach, combining economic, social, political and geopolitical perspectives. Written in an accessible style, the book offers students, business, government, and civil society players powerful insights on Asia.

The Geopolitics of the Global Energy Transition

Authors: ---
Book Series: Lecture Notes in Energy ISBN: 9783030390662 Year: Pages: 381 DOI: 10.1007/978-3-030-39066-2 Language: English
Publisher: Springer Nature
Subject: Political Science --- Agriculture (General) --- Environmental Sciences
Added to DOAB on : 2020-06-17 00:00:39
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The world is currently undergoing an historic energy transition, driven by increasingly stringent decarbonisation policies and rapid advances in low-carbon technologies. The large-scale shift to low-carbon energy is disrupting the global energy system, impacting whole economies, and changing the political dynamics within and between countries. This open access book, written by leading energy scholars, examines the economic and geopolitical implications of the global energy transition, from both regional and thematic perspectives. The first part of the book addresses the geopolitical implications in the world’s main energy-producing and energy-consuming regions, while the second presents in-depth case studies on selected issues, ranging from the geopolitics of renewable energy, to the mineral foundations of the global energy transformation, to governance issues in connection with the changing global energy order. Given its scope, the book will appeal to researchers in energy, climate change and international relations, as well as to professionals working in the energy industry.

The Future of Transport Between Digitalization and Decarbonization

Authors: --- ---
Book Series: SpringerBriefs in Energy ISBN: 9783030379667 Year: Pages: 112 DOI: 10.1007/978-3-030-37966-7 Language: English
Publisher: Springer Nature
Subject: Agriculture (General) --- Business and Management
Added to DOAB on : 2020-05-14 09:29:50
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Energy systems are rapidly transitioning towards decarbonization, thanks in part to innovative digital technologies and changing mobility demands. This open access book examines the decarbonization and digitalization transformation in the transport sector, with a particular focus on energy consumption. By studying historical trends and outlining future scenarios, the authors illustrate the evolution of energy consumption in the transport sector, compare alternative decarbonization strategies, and analyze digitalization trends and their effects on energy consumption. The book addresses a broad readership of both academics and professionals working in the energy and transport industries, as well as readers interested in the ongoing debate over energy, mobility and climate change.

China's Energy Revolution in the Context of the Global Energy Transition

Book Series: Advances in Oil and Gas Exploration & Production ISBN: 9783030401542 Year: Pages: 700 DOI: 10.1007/978-3-030-40154-2 Language: English
Publisher: Springer Nature
Subject: Environmental Technology --- Agriculture (General) --- Geology --- Earth Sciences
Added to DOAB on : 2020-06-16 23:59:04
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This open access book is an encyclopaedic analysis of the current and future energy system of the world’s most populous country and second biggest economy. What happens in China impacts the planet. In the past 40 years China has achieved one of the most remarkable economic growth rates in history. Its GDP has risen by a factor of 65, enabling 850,000 people to rise out of poverty. Growth on this scale comes with consequences. China is the world’s biggest consumer of primary energy and the world’s biggest emitter of CO2 emissions. Creating a prosperous and harmonious society that delivers economic growth and a high quality of life for all will require radical change in the energy sector, and a rewiring of the economy more widely. In China’s Energy Revolution in the Context of the Global Energy Transition, a team of researchers from the Development Research Center of the State Council of China and Shell International examine how China can revolutionise its supply and use of energy. They examine the entire energy system: coal, oil, gas, nuclear, renewables and new energies in production, conversion, distribution and consumption. They compare China with case studies and lessons learned in other countries. They ask which technology, policy and market mechanisms are required to support the change and they explore how international cooperation can smooth the way to an energy revolution in China and across the world. And, they create and compare scenarios on possible pathways to a future energy system that is low-carbon, affordable, secure and reliable. ;

Postwachstumsgeographien

Authors: --- --- ---
Book Series: Sozial- und Kulturgeographie ISBN: 9783839451809 Year: Pages: 456 DOI: 10.14361/9783839451809 Language: German
Publisher: transcript Verlag Grant: Leibniz-Gemeinschaft - [grantnumber unknown]
Subject: Environmental Sciences
Added to DOAB on : 2020-08-04 23:59:50
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Cultural Competence and the Higher Education Sector

Authors: --- ---
ISBN: 9789811553622 Year: Pages: 363 DOI: 10.1007/978-981-15-5362-2 Language: English
Publisher: Springer Nature
Subject: Education --- Sociology
Added to DOAB on : 2020-06-17 00:00:32
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This open access book explores cultural competence in the higher education sector from multi-disciplinary and inter-disciplinary perspectives. It addresses cultural competence in terms of leadership and the role of the higher education sector in cultural competence policy and practice. Drawing on lessons learned, current research and emerging evidence, the book examines various innovative approaches and strategies that incorporate Indigenous knowledge and practices into the development and implementation of cultural competence, and considers the most effective approaches for supporting cultural competence in the higher education sector. This book will appeal to researchers, scholars, policy-makers, practitioners and general readers interested in cultural competence policy and practice.

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