Search results: Found 111

Listing 11 - 20 of 111 << page
of 12
>>
Sort by
The Role of the Plasminogen Activating System in Neurobiology

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450633 Year: Pages: 132 DOI: 10.3389/978-2-88945-063-3 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
License:

Loading...
Export citation

Choose an application

Abstract

This ebook contains a series of original publications, reviews and mini-reviews by leaders in the field that address the growing importance of the plasminogen activating system in neurobiology. The articles included cover the role of the plasminogen activating system as a key modulator of blood brain barrier permeability, and the implications of this in traumatic brain injury and in ischemic stroke. State-of-the-Art manuscripts are also included that address the regulatory mechanisms that control this important process.This ebook contains a series of original publications, reviews and mini-reviews by leaders in the field that address the growing importance of the plasminogen activating system in neurobiology. The articles included cover the role of the plasminogen activating system as a key modulator of blood brain barrier permeability, and the implications of this in traumatic brain injury and in ischemic stroke. State-of-the-Art manuscripts are also included that address the regulatory mechanisms that control this important process.

Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases?

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454259 Year: Pages: 161 DOI: 10.3389/978-2-88945-425-9 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Nutrition and Food Sciences --- Internal medicine
Added to DOAB on : 2018-11-16 17:17:57
License:

Loading...
Export citation

Choose an application

Abstract

Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.

Optimizing Exercise for the Prevention and Treatment of Type 2 Diabetes

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455140 Year: Pages: 115 DOI: 10.3389/978-2-88945-514-0 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Internal medicine --- Science (General) --- Physiology
Added to DOAB on : 2019-01-23 14:53:42
License:

Loading...
Export citation

Choose an application

Abstract

This eBook contains a collection of peer-reviewed original and review articles published in either Frontiers in Endocrinology or Frontiers in Physiology focused on the research topic Optimizing Exercise for the Prevention and Treatment of Type 2 Diabetes.

Noblesse française et noblesse polonaise : Mémoire, identité, culture xvie-xxe siècles

Authors: ---
ISBN: 9782858925896 DOI: 10.4000/books.msha.17602 Language: French
Publisher: Maison des Sciences de l’Homme d’Aquitaine
Subject: History
Added to DOAB on : 2019-12-06 13:15:39
License: OpenEdition Licence for Books

Loading...
Export citation

Choose an application

Abstract

D’Henri duc d’Anjou devenant roi de Pologne jusqu’à Stanislas Leszczynski ou Marie Lesczynska, l’histoire des familles régnantes, mais plus globalement des noblesses de ces deux pays apparaît intimement mêlée dans le cadre de voyages, d’unions matrimoniales ou d’échanges culturels, comme ce fut le cas avec les salons et les loges maçonniques de l’Europe des Lumières. Le Centre Aquitain d’Histoire Moderne et Contemporaine de l’Université Michel de Montaigne et l’Université polonaise Nicolas Copernic de Toruń travaillant depuis de nombreuses années sur le milieu nobiliaire, ont souhaité, dans le contexte de construction d’une histoire européenne, confronter et rapprocher leurs méthodes, en englobant leurs recherches sur les noblesses polonaise et française aux xive et xxe siècles pour terminer sur le rôle éminent de Michel Poniatowski, prince polonais au service de la République française.

Tsunami Science and Engineering II

Author:
ISBN: 9783039216727 9783039216734 Year: Pages: 194 DOI: 10.3390/books978-3-03921-673-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

Earthquake-tsunamis, including the 2004 Indian Ocean Tsunami and the 2011 T?hoku Tsunami in Japan, serve as tragic reminders that such waves pose a major natural hazard. Landslide-tsunamis, including the 1958 Lituya Bay case, may exceed 150 m in height, and similar waves generated in lakes and reservoirs may overtop dams and cause significant devastation. This book includes nine peer-review articles from some of the leading experts in the field of tsunami research. The collection represents a wide range of topics covering (i) wave generation, (ii) wave propagation, and (iii) their effects. Within (i), a tsunami source combining an underwater fault rupture and a landslide are addressed in the laboratory. Within (ii), frequency dispersion with the nonlinear shallow-water equations is considered and a detailed account of the 1755 Lisbon earthquake, tsunami, and fire in downtown Lisbon is presented. Two articles involve all three phases (i) to (iii), including runup and dam over-topping. Within (iii), a new semi-empirical equation for runup is introduced and the interaction of tsunamis with bridges and pipelines is investigated in large laboratory experiments. This state-of-the-art collection of articles is expected to improve modelling and mitigate the destructive effects of tsunamis and inspire many future research activities in this challenging and exciting research field.

Semiotische Effizienz interfachlicher Sprache-Bild-Textsorten

Author:
Book Series: Forum für Fachsprachen-Forschung ISBN: 9783732903009 9783732993543 9783732993642 Year: Pages: 488 DOI: 10.26530/OAPEN_1006684 Language: German
Publisher: Frank & Timme
Subject: Science (General) --- Linguistics
Added to DOAB on : 2020-01-08 11:21:03
License:

Loading...
Export citation

Choose an application

Abstract

Communicative efficiency can be measured with conventions. Besides linguistic means, pictures and diagrams are also an expression of such conventions. In the practice of technical editing, this refers to multimodal text types with technical language elements, photographs, technical drawings, various types of diagrams, etc. Alexander Holste uses the example of the text type specification sheet to show how an inter-disciplinary team of engineers, lawyers, business economists, etc. negotiates these conventions. The different, technically justified ideas of the text type conventions, especially with regard to the choice of multimodal means of expression, become clearly apparent. Requirement specifications are created in the context of the tendering of public contracts by public authorities. Since such contracts represent an important field of work for the companies involved, the efficient design of the specifications is highly relevant from a business management point of view. Alexander Holste, Dr. phil., studied German as well as business administration in Essen and Turin and headed the technical editorial department of a public transport company before he started teaching professional and scientific writing at the University of Duisburg-Essen in 2009, especially for engineering scientists. His research interests lie in the fields of semiotics, text linguistics, technical communication and writing didactics.

Current Challenges and Future Perspectives on Emerging Bioelectrochemical Technologies

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199044 Year: Pages: 121 DOI: 10.3389/978-2-88919-904-4 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Microbiology
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

The increasing demand for energy worldwide, currently evaluated at 13 terawatts per year, has triggered a surge in research on alternative energy sources more sustainable and environmentally friendly. Bio-catalyzed electrochemical systems (BESs) are a rapidly growing biotechnology for sustainable production of bioenergy and/or value-added bioproducts using microorganisms as catalysts for bioelectrochemical reactions at the electrode surface. In the last decades, this biotechnology has been intensively studied and developed as a flexible and practical platform for multiple applications such as electricity production, wastewater treatment, pollutants remediation, desalination and production of biogas, biofuels, or other commodities. BESs could have a critical impact on societies in many spheres of activity and become one of the solutions to reform our petroleum-based economy. However, BESs research has so far been limited to lab scale with the notable exceptions of pilot scale microbial fuel cells for brewery and winery wastewater treatment coupled with electricity generation. In general, more knowledge has to be acquired to overcome the issues that are stymieing BESs development and commercialization. For example, it is critical to understand better microbial physiology including the mechanisms responsible for the transfer of electrons between the microbes and the electrodes to start optimizing the systems in a more rational manner. There are many BES processes and for each one of them there is a multitude of biological and electrochemical specifications to investigate and adjust such as the nature of the microbial platform, electrode materials, the reactor design, the substrate, the medium composition, and the operating conditions. The ultimate goal is to develop highly energy efficient BESs with a positive footprint on the environment while maintaining low cost and generating opportunities to create value. BESs are complex systems developed with elements found in multiple fields of science such as microbiology, molecular biology, bioinformatics, biochemistry, electrochemistry, material science and environmental engineering. Given the high volume of research activities going on in the field of BESs today, this e-book explores the current challenges, the more recent progresses, and the future perspectives of BESs technologies. The BESs discussed here include microbial fuel cells, microbial electrolysis cells, microbial electrosynthesis cells, microbial electroremediation cells, etc.

Organogenesis From Development to Disease

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453184 Year: Pages: 110 DOI: 10.3389/978-2-88945-318-4 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Biology
Added to DOAB on : 2018-11-16 17:27:07
License:

Loading...
Export citation

Choose an application

Abstract

During embryonic development there are many processes that must take place to produce a viable and healthy fetus. Alterations in the cellular and/or molecular interactions within any particular organ can cause catastrophic defects leading to defective organogenesis and death of the embryo. Even slight malformations of the organs can cause developmental reprogramming and increase the likelihood of adult onset diseases. The use of experimental animals with genetic mutations that mimic many human conditions has lead to significant scientific advancement of these complex and multifaceted diseases. Furthermore, the utilization of organ culture systems has made for profound insights into the formation of organs. Over recent years, the technology related to molecular profiling and imaging of developing organs has dramatically improved, leading to the identification of subtle genetic and phenotypic alterations. This research topic will focus on the area of organ formation and modeling of human developmental diseases.

Kupfer- und Eisenoxide als Konversions-Elektrodenmaterialien für Lithium-Ionen-Batterien: Thermodynamische und Elektrochemische Untersuchungen

Author:
Book Series: Schriftenreihe des Instituts für Angewandte Materialien, Karlsruher Institut für Technologie ISSN: 21929963 ISBN: 9783731504825 Year: Volume: 56 Pages: XVI, 291 p. DOI: 10.5445/KSP/1000051891 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
License:

Loading...
Export citation

Choose an application

Abstract

Conversion-type electrodes are promising electrode materials for future lithium ion batteries since they exhibit high specific capacities compared to intercalation-type eclectrodes. In this work, a thermodynamic approach was used to elucidate the electrochemical behavior of conversion-type electrodes using Li-Cu-O and Li-Fe-O as model material systems. electrochemical properties can be calculated using self-sonstistent thermodynamic descriptions developed in this work.

Dietary Intake and Type 2 Diabetes

Author:
ISBN: 9783039217045 9783039217052 Year: Pages: 322 DOI: 10.3390/books978-3-03921-705-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-01-07 09:08:26
License:

Loading...
Export citation

Choose an application

Abstract

The prevalence of diabetes is on the increase in the UK and worldwide, partly due to changes in lifestyle which predispose individuals to overweight and obesity. It is estimated that about 90% of the currently diagnosed adults have type 2 diabetes, and based on the World Health Organisation (WHO) report, about 422 million adults were living with diabetes in 2014 compared with 108 million in 1980; this condition caused about 1.5 million deaths in 2012. In the United States of America, it is estimated that about 30.3 million adults are living with diabetes, with a further 1.5 million new diabetes cases diagnosed every year, representing an increasing prevalence of this condition. Diabetes represents a major public health challenge, despite advances in technology and the pharmaceutical industry. These problems may be in the form of acute or long-term complications. Therefore, in order to attenuate the problems of diabetes, management strategies usually include lifestyle changes such as increased physical activity and dietary interventions. Studies which evaluate the role of nutrition in the management of type 2 diabetes often involve human and animal models as these approaches enable us to have a broader and more in-depth understanding of the condition. In some cases, diabetes may co-exist with other conditions, such as stroke, and these may present unique challenges with regard to nutritional interventions. This Special Issue aims to evaluate the risk factors associated with type 2 diabetes and the role of the diet in the management of people with this condition. This evidence is drawn from both human and animal studies.

Keywords

aronia --- ginseng --- mushroom --- pancreatectomy --- type 2 diabetes --- gut microbiome --- insulin secretion --- energy restricted diet --- low energy diet --- carbohydrate restricted diet --- low carbohydrate diet --- diabetes --- Japanese --- tempeh --- lactic acid bacteria --- short chain fatty acids --- metabolic syndrome --- high fat diet --- feces --- type 2 diabetes mellitus --- peanut --- almond --- glycemic control --- body mass index --- lipids --- interleukin-6 --- muscle --- insulin resistance --- free fatty acids (FFA) --- diabetes --- rosemary extract --- AMPK --- prediabetes --- type 2 diabetes --- total body fat --- total body lean --- appendicular fat --- appendicular lean --- body composition --- cohort study --- micronutrients --- trace elements --- food --- glycated hemoglobin A --- hyperglycemia --- dietary pattern --- triglyceride --- high-density lipoprotein cholesterol --- type 2 diabetes --- type 2 diabetes mellitus --- nutrition --- DASH --- diet quality --- diabetes management --- dietary intake --- longitudinal analysis --- lifestyle management --- carbohydrate counting --- protein and fat counting --- insulin dosage --- glucose monitoring --- diabetes mellitus --- type 1 diabetes --- type 2 diabetes --- Hedychium coronarium --- type 2 diabetes --- aldosterone --- streptozotocin --- metabolic syndrome --- folk medicine --- calcium intake --- dairy products --- vitamin D --- type 2 diabetes --- diabetes --- diabetes reversal --- bariatric surgery --- very-low-calorie --- low-carbohydrate --- zinc intake --- zinc status --- trace elements --- type 2 diabetes mellitus --- systematic review --- meta-analysis --- epidemiology --- PUFA --- polyunsaturated fatty acids --- glycemic control --- nuts --- fish --- fish oil --- vegetable oil --- type 2 diabetes --- vitamin D deficiency --- 25-OH-D --- women --- cardiovascular risk factors --- T2DM --- obesity --- glycaemic index --- incretins --- subjective appetite --- isomaltulose --- sucromalt --- nutritional supplement --- type 2 diabetes --- gestational diabetes --- glycemic index --- randomised controlled trial --- lipid profile --- inflammatory parameters --- diabetes specific formula --- standard formula --- type 2 diabetes --- enteral nutrition --- enteral tube feeding --- lipids --- fasting blood glucose --- glycated haemoglobin --- type 2 diabetes --- dietary intake --- glycaemic control --- dietary management approaches --- micronutrients --- macronutrients --- nutrition --- chronic conditions --- lipid parameters

Listing 11 - 20 of 111 << page
of 12
>>
Sort by