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Third-Generation Neuroimaging: Translating Research into Clinical Utility

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450442 Year: Pages: 224 DOI: 10.3389/978-2-88945-044-2 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Psychiatry
Added to DOAB on : 2018-02-27 16:16:44
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Psychiatric imaging needs to move away from simple investigations of the neurobiology underling the early phases of psychiatric diseases to translate imaging findings in the clinical field targeting clinical outcomes including transition, remission and response to preventative interventions. This research topic aims to bring psychiatric neuroimaging studies towards translational impacts in clinical practice, suggesting that brain abnormalities may be of potential use for detecting clinical outcomes as treatment response. First-generation psychiatric neuroimaging focused on simple structural brain alterations associated with the neurobiology of the illness. These early studies adopted imaging methods mainly including computerized tomography (CT) to investigate brain size. Second-generation psychiatric neuroimaging studies benefited from more sophisticated techniques which included structural methods (sMRI) coupled with whole-brain automated methods (voxel based morphometry, VBM), white-matter methods (diffusion tensor imaging, DTI and tractography), functional methods (functional magnetic resonance imaging, fMRI) and advanced neurochemical imaging (PET techniques addressing receptor bindings and pre/post synaptic functions, magnetic resonance spectroscopy, MRS) and sophisticated meta-analytical imaging methods. However, no consistent or reliable anatomical or functional brain alterations have been univocally associated with any psychiatric disorder and no clinical applications have been developed in psychiatric neuroimaging. There is thus urgent need of psychiatric imaging to move towards third-generation paradigms. In this research topic, these novel neuroimaging studies here requested to move away from simple investigations of the neurobiology to translate imaging findings in the clinical field targeting longitudinal outcomes including transition, remission and response to preventative interventions. With respect to methods, the most recent neuroimaging approaches (e.g. structural and functional MRI, EEG, DTI, spectroscopy, PET) are welcome. Third generation psychiatric imaging studies including multimodal approaches, multi-center analyses, mega-analyses, effective connectivity, dynamic causal modelling, support vector machines, structural equation modelling, or graph theory analysis are highly appreciated. Furthermore, these third-generation imaging studies may benefit from the incorporation of new sources of neurobiological information such as whole genome sequencing, proteomic, lipidomic and expression profiles and cellular models derived from recent induced pluripotent stem cells research. We collect Original Research, Reviews, Mini-Reviews, Book Review, Clinical Case Study, Clinical Trial, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Opinion, Perspective, and Technology Report from international researcher and clinicians in this field. The purpose of this research topic is intended to provide the field with current third-generation neuroimaging approaches in translational psychiatry that is hoped to improve and create therapeutic options for psychiatric diseases.

Mental Imagery in Clinical Disorders

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452620 Year: Pages: 106 DOI: 10.3389/978-2-88945-262-0 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Psychiatry
Added to DOAB on : 2018-02-27 16:16:44
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Mental imagery refers to the mental simulation or recreation of perceptual experience across different sensory modalities. The exploration of mental imagery represents a new and important area within clinical psychology, but arguably one still in its infancy. While mental imagery has featured prominently in recent theoretical accounts of disorders as diverse as post-traumatic stress disorder, phobia, body dysmorphic disorder, mood disorders, and psychosis, there remains an insufficiently strong theoretical and methodological foundation to enable comparison of the role of imagery across such different disorders. The current research topic presents a diverse range of cutting-edge papers focusing on investigating the underlying mechanisms and/or treatment interventions associated with mental imagery in clinical disorders, with the goal of helping establish those common elements most clinically relevant when investigating mental imagery. The research topic comprises fifteen articles drawn from the fields of psychiatry, psychology, and neuroscience. This is a unique collection of articles that combine different perspectives from the field of clinical psychology with more diverse perspectives drawn from the wider literature on mental imagery. The original research studies and theoretical articles presented are organised around four main chapters that cover imagery and eye movements, imagery and craving, imagery and autobiographical memory, and imagery and clinical disorders. We believe that the range of submissions presented in the research topic make a strong contribution to helping establish a theoretical and methodological foundation that can enable the effective study of imagery across different disorders and domains.

Data-Based Radiation Oncology - Design of Clinical Trials

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454389 Year: Pages: 109 DOI: 10.3389/978-2-88945-438-9 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology
Added to DOAB on : 2018-11-16 17:17:57
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In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients?Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable.In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management.

Clinical Trials in Ovarian Cancer

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ISBN: 9780813586472 9780813586496 9780813586489 Year: Language: English
Publisher: Rutgers University Press Grant: Knowledge Unlatched - 102219
Subject: Medicine (General)
Added to DOAB on : 2019-04-11 11:21:02
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The first book to collect and synthesize cutting-edge research findings on the treatment of gynecological malignancies into one easy-to-use reference, Clinical Trials in Ovarian Cancer provides physicians with an invaluable resource. Gynecologic oncologist Christine S. Walsh systematically outlines each of the seminal Phase III trials that have shaped the treatment of ovarian cancers, detailing the rationale for the trial, the patient population studied, treatment delivery methods, efficacy, toxicity, and trial conclusions.

Galeni In Hippocratis Epidemiarum librum I commentariorum I-III versio Arabica / Galen. Commentary on Hippocrates' Epidemics Book I

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Book Series: Corpus Medicorum Graecorum – Supplementum Orientale ISBN: 9783110405835 9783110406597 9783110406771 Year: Volume: 1 Pages: 736 DOI: 10.26530/OAPEN_531190 Language: English
Publisher: De Gruyter Grant: Wellcome Trust - 084192MA
Subject: Medicine (General)
Added to DOAB on : 2015-06-29 09:34:24
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The present volume offers the first critical edition of Book 1 of the medieval Arabic translation of Galen's Commentary on the Hippocratic Epidemics, produced by the celebrated translator Hunayn ibn Ishāq (d. ca. 870). The edition is based on all extant Arabic textual witnesses, including the Arabic secondary transmission. The translation of Galen's commentary became a crucial source for the development of medicine in the Islamic world, especially in the nascent field of clinical medicine. It was frequently read and quoted in later Arabic medical literature, and several Arabic authors used it to produce a wide range of didactic writings for medical students and practising physicians. The English translation, which aims to convey some of the flavour of the Arabic translation, comes with extensive notes on the differences between the Greek original and the Arabic translation. A thorough comparison between the two versions of the commentary provides important insights into the translation style and technique of Hunayn ibn Ishāq and his circle and Arabic medical terminology at the time.

Targeting PI3K/mTOR signaling in cancer

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192441 Year: Pages: 93 DOI: 10.3389/978-2-88919-244-1 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Biology --- Medicine (General) --- Oncology
Added to DOAB on : 2015-11-16 15:44:59
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The phosphatidylinositol 3-kinase (PI3K)/mTOR pathway integrates signals from growth factors with nutrient signals and other conditions and controls multiple cell responses, including proliferation, survival and metabolism. Deregulation of the PI3K pathway has been extensively investigated in connection to cancer. Somatic or inherited mutations frequently occur in tumor suppressor genes (PTEN, TSC1/2, LKB1) and oncogenes (PIK3CA, PIK3R1, AKT) in the PI3K/mTOR pathway. The fact that the PI3K/mTOR pathway is deregulated in a large number of human malignancies, and its importance for different cellular responses, makes it an attractive drug target. Pharmacological PI3K inhibitors have played a very important role in studying cellular responses involving these enzymes. Currently, a wide range of selective PI3K inhibitors have been tested in preclinical studies and some have entered clinical trials in oncology. Rapamycin and its analogs targeting mTOR are effective in many preclinical cancer models. Although rapalogs are approved for the treatment of some cancers, their efficacy in clinical trials remains the subject of debate. Due to the complexity of the PI3K/mTOR signaling pathway, developing an effective anti-cancer therapy remains a challenge. The biggest challenge in curing cancer patients with various signaling pathway abnormalities is to target multiple components of different signal transduction pathways with mechanism-based combinatorial treatments.

Towards translating research to clinical practice: Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193912 Year: Pages: 178 DOI: 10.3389/978-2-88919-391-2 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2015-12-03 13:02:24
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Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in huge direct and indirect costs to society. Although guidelines for the management of patients have been developed and more than 200 clinical trials have been conducted, they have resulted in few improvements in clinical outcomes and no effective therapies approved for TBI. It is now apparent that the heterogeneity of clinical TBI is underlain by molecular phenotypes more complex and interactive than initially conceived and current approaches to the characterization, management and outcome prediction of TBI are antiquated, unidimensional and inadequate to capture the interindividual pathophysiological heterogeneity. Recent advances in proteomics and biomarker development provide unparalleled opportunities for unraveling substantial injury-specific and patient-specific variability and refining disease characterization. The identification of novel, sensitive, objective tools, referred to as biomarkers, can revolutionize pathophysiological insights, enable targeted therapies and personalized approaches to clinical management. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. Finally, suggestions are provided for the way forward, with an emphasis on need for a multidimensional approach that integrate a panel of pathobiologically diverse biomarkers with clinical variables and imaging-based assessments to improve diagnosis and classification of TBI and to develop best clinical practice guidelines.

New treatment perspectives in autism spectrum disorders

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195305 Year: Pages: 161 DOI: 10.3389/978-2-88919-530-5 Language: English
Publisher: Frontiers Media SA
Subject: Pediatrics --- Medicine (General)
Added to DOAB on : 2015-12-10 11:59:06
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Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways disrupted in the disease, thus contributing to identify novel drug targets.

Galeni in Hippocratis Epidemiarum librum II commentariorum I-VI versio Arabica. Volume II: Commentaria IV-VI

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Book Series: Corpus Medicorum Graecorum – Supplementum Orientale ISBN: 9783110462982 9783110463989 Year: Volume: 2,2 Pages: 541 DOI: 10.26530/OAPEN_612444 Language: English
Publisher: De Gruyter Grant: Wellcome Trust - 084192MA
Subject: Medicine (General)
Added to DOAB on : 2016-07-28 11:01:16
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This two-volume monograph offers the first critical edition of the medieval Arabic translation of Galen's Commentary on Book 2 of the Hippocratic Epidemics produced by Hunayn ibn Ishaq (d. ca. 870). The edition is based on all extant Arabic textual witnesses, including the Arabic secondary transmission. The Greek original of this text is lost; the Arabic translation is therefore the only witness to this important work. The number and extent of quotations from this commentary in medieval Arabic medical writings, which are documented in the introduction to the volume, demonstrate that it became a crucial source for the development of medicine in the Islamic world. It also gave rise to a wide range of didactic writings which illustrate its importance for medical teaching. The English translation that accompanies the edition aims to convey some of the flavour of the Arabic text. It also comes with comprehensive indices that map out the terminology and style of the translation.

Galeni In Hippocratis Epidemiarum librum II commentariorum I-VI versio Arabica. Volume I: Commentaria I-III

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Book Series: Corpus Medicorum Graecorum – Supplementum Orientale ISBN: 9783110453485 9783110454055 Year: Volume: 2,1 Pages: 611 DOI: 10.26530/OAPEN_612443 Language: English
Publisher: De Gruyter Grant: Wellcome Trust - 084192MA
Subject: Medicine (General)
Added to DOAB on : 2016-07-28 11:01:18
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This two-volume monograph offers the first critical edition of the medieval Arabic translation of Galen's Commentary on Book 2 of the Hippocratic Epidemics produced by Hunayn ibn Ishaq (d. ca. 870). The edition is based on all extant Arabic textual witnesses, including the Arabic secondary transmission. The Greek original of this text is lost; the Arabic translation is therefore the only witness to this important work. The number and extent of quotations from this commentary in medieval Arabic medical writings, which are documented in the introduction to the volume, demonstrate that it became a crucial source for the development of medicine in the Islamic world. It also gave rise to a wide range of didactic writings which illustrate its importance for medical teaching. The English translation that accompanies the edition aims to convey some of the flavour of the Arabic text. It also comes with comprehensive indices that map out the terminology and style of the translation.

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