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Klinische Prüfungen mit Arzneimitteln in der Schwangerschaft

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ISBN: 9783863952334 Year: DOI: 10.17875/gup2015-885 Language: German
Publisher: Universitätsverlag Göttingen
Subject: Law
Added to DOAB on : 2016-06-21 11:02:28
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The clinical trial on medicinal products stands in the area of conflict between important scientific progress in favour of future patients on the one hand and the necessary protection of human subjects on the other hand. This conflict grows more acute when vulnerable persons – like pregnant women – are included in medical research. Whereas there are specific regulations for minors or incapacitated persons in the German Medicinal Products Act, legal regulations for the inclusion of pregnant women are missing. Based on this uncertain legal situation solutions are developed, which will show a way out of the dilemma. Insofar as the applicable law does not provide a handle for this problem, a need for reform is shown.

Judicial tribunals in England and Europe, 1200-1700: The trial in history, vol. I

Authors: ---
ISBN: 9781526137463 Year: Language: English
Publisher: Manchester University Press
Subject: Law
Added to DOAB on : 2011-11-04 00:00:00
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This book is about trials, civil and criminal, ecclesiastical and secular, in England and Europe between the thirteenth and the seventeenth centuries. The opening chapter provides a conceptual framework both for this book and for its companion volume on the eighteenth, nineteenth and twentieth centuries. Subsequent chapters provide a rounded view of trials conducted according to different procedures within contrasting legal systems, including English common law and Roman canon law. They consider the judges and juries and the amateur and professional advisers involved in legal processes as well as the offenders brought before the courts, with the reasons for prosecuting them and the defences they put forward. The cases examined range from a fourteenth century cause-célèbre, the attempted trial of Pope Boniface VIII for heresy, to investigations of obscure people for sexual and religious offences in the city states of Geneva and Venice. Technical terms have been cut to a minimum to ensure accessibility and appeal to lawyers, social, political and legal historians, undergraduate and postgraduates as well as general readers interested in the development of the trial through time. Domestic and international trials, 1700-2000: The trial in history, vol. II edited by Dr Rose Melikan, is also published by Manchester University Press.

Keywords

civil --- trials --- religion --- criminal --- pope

Strafrecht und Medien

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ISBN: 9783863952631 Year: DOI: 10.17875/gup2016-957 Language: German
Publisher: Universitätsverlag Göttingen
Subject: Law
Added to DOAB on : 2016-06-21 11:02:56
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Criminal trials often attract great public interest. This interest, again, is essential to criminal justice as such, for in democratic states under the rule of law criminal law and its application need to be asserted and accepted within the public discourse. However, most people do not follow criminal trials as spectators in the courtroom, but by means of public media, such as newspapers, television and – increasingly – the internet. Thus, media outlets gain influence on the public opinion and are able to paint the picture of criminal trials according to their own perception. The media tends to overdraw criminal cases rather than to report the unbiased facts. This leads to tensions between possibly diverging interests of the public, of the judiciary and of the media. This volume addresses these tensions from the perspectives of academics and practitioners, who discussed this issue during an interdisciplinary conference held at the Institute for Criminal Law at the Georg-August-University Göttingen.

Chapter: 'News from the Invisible World: The Publishing History of Tales of the Supernatural c.1660–1832' from book: Cultures of Witchcraft in Europe from the Middle Ages to the Present (Book chapter)

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Book Series: Palgrave Historical Studies in Witchcraft and Magic ISBN: 9783319637839 9783319637846 Year: Pages: 34 DOI: https://doi.org/10.1007/978-3-319-63784-6_9 Language: English
Publisher: Palgrave Macmillan
Subject: Religion
Added to DOAB on : 2017-11-23 16:26:06
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This chapter explores the transmission of tales of the supernatural during the very long eighteenth century (between c.1660 and c.1832). A genre of publications on this subject which have not been studied are those anthologies of supposedly true stories, usually relating to named people and places and sometimes dated, often each numbered separately, with relatively little discussion of their authenticity or significance, beyond perhaps a brief preface defending the reality of the world of spirits. A series of entrepreneurial publishers, mostly operating from Paternoster Row in London, experimented with anthologising these stories in varied combinations. Any attempt to analyse the stories must begin by unravelling the publishing history by which they were transmitted and (not fully studied here) modified and retold, as well as re-interpreted.

Plant Medicines for Clinical Trial

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ISBN: 9783038970231 9783038970248 Year: Pages: X, 124 Language: english
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics
Added to DOAB on : 2018-08-09 10:40:08
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Plant medicines are the original medicines that humans have always used. Many people continue to use plant medicines today including teas, coffee, chocolate, ginger, and other medicines. Traditional medicine is based on plant medicines and is the primary form of medicine for many people throughout the world. The current volume discusses traditional medicines and presents various plant medicines that could be tested in clinical trials. Modern medicine continues to use many drugs that are derived from plants. The current work has much to teach modern medicine about the treatment of several diseases. Traditional healers have used plant medicines to treat psychiatric and other conditions that modern medicine struggles with. Safety issues are always a concern with plant medicines, especially allergies to plant medicines. Clinical trials must be conducted with plant medicines to help bring these traditional treatments into use by modern medicine.

Field Trials of Health Interventions, 3rd edition

Authors: --- ---
ISBN: 9780198732860 Year: Pages: 480 DOI: 10.1093/med/9780198732860.001.0001 Language: English
Publisher: Oxford University Press Grant: Wellcome Trust - 063410
Subject: Public Health
Added to DOAB on : 2015-07-30 11:01:12
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Before new interventions can be used in disease control programmes, it is essential that they are carefully evaluated in “field trials”, which may be complex and expensive undertakings. Descriptions of the detailed procedures and methods used in trials that have been conducted in the past have generally not been published. As a consequence, those planning such trials have few guidelines available and little access to previously accumulated knowledge. In this book the practical issues of trial design and conduct are discussed fully and in sufficient detail for the text to be used as a “toolbox” by field investigators. The toolbox has now been extensively tested through use of the first two editions and this third edition is a comprehensive revision, incorporating the many developments that have taken place with respect to trials since 1996 and involving more than 30 contributors. Most of the chapters have been extensively revised and 7 new chapters have been added.

Targeting PI3K/mTOR signaling in cancer

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192441 Year: Pages: 93 DOI: 10.3389/978-2-88919-244-1 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Biology --- Medicine (General) --- Oncology
Added to DOAB on : 2015-11-16 15:44:59
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The phosphatidylinositol 3-kinase (PI3K)/mTOR pathway integrates signals from growth factors with nutrient signals and other conditions and controls multiple cell responses, including proliferation, survival and metabolism. Deregulation of the PI3K pathway has been extensively investigated in connection to cancer. Somatic or inherited mutations frequently occur in tumor suppressor genes (PTEN, TSC1/2, LKB1) and oncogenes (PIK3CA, PIK3R1, AKT) in the PI3K/mTOR pathway. The fact that the PI3K/mTOR pathway is deregulated in a large number of human malignancies, and its importance for different cellular responses, makes it an attractive drug target. Pharmacological PI3K inhibitors have played a very important role in studying cellular responses involving these enzymes. Currently, a wide range of selective PI3K inhibitors have been tested in preclinical studies and some have entered clinical trials in oncology. Rapamycin and its analogs targeting mTOR are effective in many preclinical cancer models. Although rapalogs are approved for the treatment of some cancers, their efficacy in clinical trials remains the subject of debate. Due to the complexity of the PI3K/mTOR signaling pathway, developing an effective anti-cancer therapy remains a challenge. The biggest challenge in curing cancer patients with various signaling pathway abnormalities is to target multiple components of different signal transduction pathways with mechanism-based combinatorial treatments.

Das Volk sitzt zu Gericht

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ISBN: 103706541262 Year: Pages: 496 Seiten Language: German
Publisher: Studien Verlag Grant: Austrian Science Fund - D 3784
Added to DOAB on : 2019-01-15 13:34:19

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From December 1944 until the end of March 1945, there existed a forced labour camp for Hungarian Jews in Engerau (today town district Petrzalka of the Slovakian capital Bratislava), which war part of the "Reich Defense Line" ("Wüdostwall"). There, more than 2000 Hungarian Jews had to work like slaves, digging up entrechments to "defend" the German Reich against the approaching soviet troops. Approximate 400 of the forced labourers died of exhaustion, deseases or were beaten to death by Viennese SA men. During the last days of WW II the camp was evacuated. A spezial detachment shot those were sic kor unfit to march, others were killed while the following footmarch to Bad Deutsch-Altenburg. Destination was the concentratio camp of Mauthausen. Those abominable crimes caused a series of legal proceedings in post war Austria against more than 70 accused - the so called "Engerau-trias". In five main trials between 1945 and 1954 against 21 defendants the Vienna "Peoples Court" - a spezial court with the task to punish nazi-crimes - imposed 9 death sentences and 1 life imprisonment. The publication analyzes the legal actions of this spezial court on the basis of the trial records located in the district court in Vienna, puts the proceedings in the lager context of the coping with the Nazi past by Austrian courts, but also in Austrian society, presents biographies of judges, attorneys and counsels of the trials, describes the coverage in the newspapers and gives attention to the gender-aspect and the reflection of the "Engerau-trials" in historiography. This is the first publication, which gives a systematic overview of the first ten years of the 2nd republic focussing post war judiciary in the soviet occupation zone and the archievements of Austrian judiciary in respect to punishing nazi-crimes on the basis of the most extensive Holocaust proceeding in Austria.

Censuses and mapping (Book chapter)

Book title: Field Trials of Health Interventions, 3rd edition

Authors: --- ---
ISBN: 9780198732860 Year: Pages: 480 Language: English
Publisher: Oxford University Press Grant: Wellcome Trust - 063410
Subject: Public Health
Added to DOAB on : 2019-01-15 13:34:50

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Abstract

Before new interventions can be used in disease control programmes, it is essential that they are carefully evaluated in “field trials”, which may be complex and expensive undertakings. Descriptions of the detailed procedures and methods used in trials that have been conducted in the past have generally not been published. As a consequence, those planning such trials have few guidelines available and little access to previously accumulated knowledge. In this book the practical issues of trial design and conduct are discussed fully and in sufficient detail for the text to be used as a “toolbox” by field investigators. The toolbox has now been extensively tested through use of the first two editions and this third edition is a comprehensive revision, incorporating the many developments that have taken place with respect to trials since 1996 and involving more than 30 contributors. Most of the chapters have been extensively revised and 7 new chapters have been added.

Dedication (Book chapter)

Book title: Field Trials of Health Interventions, 3rd edition

Authors: --- ---
ISBN: 9780198732860 Year: Pages: 480 Language: English
Publisher: Oxford University Press Grant: Wellcome Trust - 063410
Subject: Public Health
Added to DOAB on : 2019-01-15 13:34:50

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Abstract

Before new interventions can be used in disease control programmes, it is essential that they are carefully evaluated in “field trials”, which may be complex and expensive undertakings. Descriptions of the detailed procedures and methods used in trials that have been conducted in the past have generally not been published. As a consequence, those planning such trials have few guidelines available and little access to previously accumulated knowledge. In this book the practical issues of trial design and conduct are discussed fully and in sufficient detail for the text to be used as a “toolbox” by field investigators. The toolbox has now been extensively tested through use of the first two editions and this third edition is a comprehensive revision, incorporating the many developments that have taken place with respect to trials since 1996 and involving more than 30 contributors. Most of the chapters have been extensively revised and 7 new chapters have been added.

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