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Because of many misconceptions, the biological drug manufacturing industry does not fully utilize disposable components, despite their wide availability. These misconceptions include concerns for the quality of materials, running costs, scalability, the level of automation possible, and the training of staff needed to include these components in existing bioprocessing systems. Not fully realizing the long-term benefits, many manufacturers are unwilling to discard investments made in fixed equipment and traditional stainless steel systems. Regulatory and environmental concerns, however, will eventually compel manufacturers to adopt disposable systems. Making a strong case for disposables, Disposable Bioprocessing Systems demonstrates the true potential of these systems. Written by a researcher and professor with hands-on experience in designing, establishing, and validating biological manufacturing facilities worldwide, and creating model facilities using maximum disposable technology, this book is the first comprehensive introduction to understanding disposable systems. It gives an overview of the current state of the disposable bioprocessing industry, resolves all controversial issues, and guides readers in choosing disposable components that meet their needs. An important chapter on safety addresses facts and myths about the use of plastics and elastomers—including the issue of leaching—and how to ensure regulatory compliance. Helping readers understand their choices, the book describes the equipment and systems available to prepare the starting materials for the manufacturing of biological drugs—from disposable containers to filters. The author also discusses costs, regulations, and concerns about waste disposal, and shares his predictions for the future of the disposable bioprocessing industry. A practical manual for those interested in the transition to disposable systems, this book will also interest students of bioprocessing. It offers a timely view of disposable bioprocessing technology as a "game changer" that will facilitate developing new drugs and conducting research in the emerging field of stem cells and gene therapy.

Pre-clinical medicine: basic sciences --- Pharmacology --- Industrial chemistry & chemical engineering --- Biomedical engineering

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Suitable for practicing engineers and engineers in training, this book covers the most important operations involving particulate solids. Through clear explanations of theoretical principles and practical laboratory exercises, the text provides an understanding of the behavior of powders and pulverized systems. It also helps readers develop skills for operating, optimizing, and innovating particle processing technologies and machinery in order to carry out industrial operations. The author explores common bulk solids processing operations, including milling, agglomeration, fluidization, mixing, and solid-fluid separation.

Industrial Chemistry --- Food Chemistry --- FOOD --- CHEMLIB --- SCI-TECH --- CHEMICALENGINEERING --- CHEMISTRY --- STM --- bed --- distribution --- fluidized --- industry --- mass --- material --- particle-size --- processing --- technology --- transfer

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This open access book presents a collection of the most up-to-date research results in the field of steel development with a focus on pioneering alloy concepts that result in previously unattainable materials properties. Specifically, it gives a detailed overview of the marriage of high-performance steels of the highest strength and form-ability with damage-tolerant zirconia ceramics by innovative manufacturing technologies, thereby yielding a new class of high-performance composite materials. This book describes how new high-alloy stainless TRIP/TWIP steels (TRIP: TRansformation-Induced Plasticity, TWIP: TWinning-induced Plasticity) are combined with zirconium dioxide ceramics in powder metallurgical routes and via melt infiltration to form novel TRIP-matrix composites. This work also provides a timely perspective on new compact and damage-tolerant composite materials, filigree light-weight structures as well as gradient materials, and a close understanding of the mechanisms of the phase transformations. With a detailed application analysis of state-of-the-art methods in spatial and temporal high-resolution structural analysis, in combination with advanced simulation and modelling, this edited volume is ideal for researchers and engineers working in modern steel development, as well as for graduate students of metallurgy and materials science and engineering.

Structural Materials --- Metallic Materials --- Ceramics, Glass, Composites, Natural Materials --- Materials Engineering --- Mathematical Modeling and Industrial Mathematics --- Metals and Alloys --- Ceramics --- Steel-Matrix Composite --- Austenitic Stainless Steels --- Powder Metallurgy --- Fracture Toughness --- Mechanical Modeling --- Melt Flow Behavior --- CrMnNi Steels --- Ceramic Casting --- Melt Infiltration --- Open Access --- Materials science --- Structural engineering --- Metals technology / metallurgy --- Industrial chemistry & chemical engineering --- Mathematical modelling --- Maths for engineers