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The Epithelial-to-Mesenchymal Transition (EMT) in Cancer

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ISBN: 9783038427933 9783038427940 Year: Pages: VI, 254 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-04-27 16:09:54
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The epithelial-to-mesenchymal transition (EMT) is a highly dynamic process with multiple transitional states, by which epithelial cells can convert into a mesenchymal phenotype. This process involves loss of cellular adhesion and cellular polarity, and an improvement in migratory and invasive properties. It occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing. It is also involved in tumor progression with metastatic expansion, and plays a major role in resistance to cancer treatment. In cancers, EMT inducers are hypoxia, cytokines and growth factors secreted by the tumor microenvironment, stroma crosstalk, metabolic changes, innate and adaptive immune responses, and treatment with antitumor drugs. Switch in gene expression from epithelial to mesenchymal phenotype is triggered by complex regulatory networks involving transcriptional control, non-coding RNAs, chromatin remodeling and epigenetic modifications, alternative splicing, post-translational regulation, protein stability and subcellular localization. Reversion of EMT, the mesenchymal-to-epithelial transition (MET), affects circulating cancer cells when they reach a desirable metastatic niche to develop secondary tumors. More knowledge and control of EMT to MET is necessary and will be beneficial for patients for cancer treatment. This current Special Issue entitled “Epithelial to Mesenchymal Transition in Cancer” will address these questions.

Indicator-based Sustainability Assessment of the German Energy System and its Transition

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ISBN: 9783731507925 Year: Pages: VII, 157 p. DOI: 10.5445/KSP/1000082161 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Business and Management
Added to DOAB on : 2019-07-28 18:37:01
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The energy transition not only has an impact on technical infrastructures but also leads to socio-economic changes. To evaluate the sustainability aspects of the German Energiewende, the authors have developed a monitoring system which includes 45 indicators and their corresponding target values for 2020, 2030, and 2050 as well as a rating system for the year 2020 based on a distance-to-target approach and traffic color lights.

Spin-Crossover Complexes

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ISBN: 9783038428251 9783038428268 Year: Pages: VI, 200 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-06-26 14:01:59
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The spin-crossover (SCO) phenomenon originates from the intrinsic bistability of the d-electron configuration, created by the competition between ligand-field splitting and spin-pairing energies in a first coordination sphere of transition metal ions. Since Cambi’s visionary finding of the SCO phenomenon in 1931, considerable knowledge concerning syntheses, crystal structures, magnetic and thermodynamic properties, spectroscopies, molecular orbital calculations, and theories of SCO complexes has accumulated in a very large number of inorganic molecular coordination compounds, and, in addition, inorganic cobaltates and bioinorganic molecular systems. Recent studies which have focused on other electronic properties exhibited by SCO complexes themselves, control of molecular assemblies, and moreover, multifunctionalization of SCO complexes with either different electronic properties or porous frameworks will open the possibility toward future practical applications of SCO complexes. Thus, the fundamentals and applications of SCO complexes afford a very exciting research field in inorganic coordination chemistry and continues to attract growing attention on a wide range of relevant research fields. This Special Issue aims at collecting research and review contributions concerning recent advances in all aspects of SCO and related phenomena and disseminating this extensive knowledge with a broader audience by means of open access publishing. I invite you to contribute papers in the following research areas so that your research can impact the next generation trends in this promising field.

Sustainability Transition Towards a Bio-Based Economy: New Technologies, New Products, New Policies

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ISBN: 9783038973805 9783038973812 Year: Pages: 256 DOI: 10.3390/books978-3-03897-381-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Ecology --- Environmental Sciences
Added to DOAB on : 2018-11-29 10:05:43
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This book proposes an array of 11 key papers aimed at investigating the complex and multifaceted nature of the bio-based economy, focusing both on a conceptual understanding of the transition and on the measurement issues associated with it. More specifically, the papers included in this book can be broadly divided in two groups: (1) those aiming at adding to our understanding of the transition process towards a sustainable bio-based economy; and (2) those aiming at adding to the definition and measurement of the emerging sustainable bio-based economy. The book offers a comprehensive view of the phenomenon, providing a logical framework for understanding the ongoing transition towards a bio-based economy, as well as an overview of existing tools to assess and measure it. Policy-makers will largely benefit from the book, which contributes to taking a further step towards the much-needed transition to sustainability.

Cell Stress, Metabolic Reprogramming, and Cancer

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455652 Year: Pages: 68 DOI: 10.3389/978-2-88945-565-2 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology
Added to DOAB on : 2019-01-23 14:53:43
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The present eBook presents one review, five mini-reviews, and an opinion article on the achievements and perspectives of studies on important aspects of cancer cell metabolic reprogramming whose mechanisms and regulation are still largely elusive. It also sheds light on certain novel functional components, which rewires cell metabolism in tumor transformation.

Asian Century… on a Knife-edge: A 360 Degree Analysis of Asia's Recent Economic Development

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ISBN: 9789811071812 9789811071829 Year: Pages: 335 DOI: 10.1007/978-981-10-7182-9 Language: English
Publisher: Palgrave Macmillan Grant: Asian Century Institute
Subject: Political Science --- Economics
Added to DOAB on : 2018-05-31 18:10:53
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This book delves into the widely held belief that the 21st century will be the "Asian Century" by examining the Asia's rapid economic development in the post-war era and the challenges it faces in forging ahead of world leaders in the West. The impact of the current turbulent global political climate on Asia is critically analyzed, employing a holistic and multidisciplinary approach, combining economic, social, political and geopolitical perspectives. Written in an accessible style, the book offers students, business, government, and civil society players powerful insights on Asia.

Buddhism and Politics in Thailand

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ISBN: 9782355960468 Year: DOI: 10.4000/books.irasec.2951 Language: English
Publisher: Institut de recherche sur l’Asie du Sud-Est contemporaine
Subject: Political Science
Added to DOAB on : 2019-12-06 13:15:36
License: OpenEdition Licence for Books

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Despite the often-repeated assertion that Buddhism and politics are, or at least must be, separate matters, Buddhism has been closely intertwined with politics one way or another since the Buddha’s time. In Thailand, Buddhism has been used since the end of the 19th century as a tool to legitimate state power. In the following decades, it has been progressively centralized under a national hierarchy, which is still existing today. This scheme was not altered after the change of the country’s political framework in 1932 and political tensions with the sangha came to the fore during the political troubles of the 1970s. The emergence of an increasing political divide in Thailand since the mid-2000s, around two broad groups which have been dubbed the Yellow Shirts and the Red Shirts, has engulfed the monastic community, leading to a growing activism by some Buddhist groups, some temples and some monks. Numerous monks mingled with Red Shirts demonstrators in April-May 2010, and some were on the front-line when the military gave the assault on the Red Shirts’ camp in downtown Bangkok. In the most recent years, these tensions have coalesced around the controversial Dhammakaya temple and have impacted the choice of the leader of the Thai monastic community. Although, tensions within the sangha are nothing new, they have weakened the ability of Buddhism – one of the national pillars of the Thai national ideology – to be a focal point as the country is going through a difficult transition with the end of seven-decades prestigious reign and political uncertainties clouding the horizon.

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