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Bridging Australia and Japan Volume 2

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ISBN: 9781760463755 Year: DOI: 10.22459/BAJ.2020 Language: English
Publisher: ANU Press
Subject: Languages and Literatures --- Medicine (General) --- Political Science --- Sociology
Added to DOAB on : 2020-09-03 00:01:21
License: ANU Press

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This book is volume two of the writings of David Sissons, who first established his academic career as a political scientist specialising in Japanese politics, and later shifted his focus to the history of Australia–Japan relations. In this volume, we reproduce his writings on Japanese politics, the Pacific War and Australian war crimes trials after the war. He was a pioneer in these fields, carrying out research across cultural and language borders, and influenced numerous researchers who followed in his footsteps. Much of what he wrote, however, remained unpublished at the time of his death in 2006, and so the editors have included a selection of his hitherto unpublished work along with some of his published writings.

Evidence-Based Medicine - A Paradigm Ready To Be Challenged?

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ISBN: 9783476057037 Year: Pages: 148 DOI: 10.1007/978-3-476-05703-7 Language: English
Publisher: Springer Nature
Subject: Science (General) --- Philosophy --- Medicine (General)
Added to DOAB on : 2020-07-15 23:59:18
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This open access book aims to clarify the term „evidence-based medicine“ (EBM) from a philosophy of science perspective. The author, Marie-Caroline Schulte discusses the importance of evi-dence in medical research and practice with a focus on the ethical and methodological prob-lems of EBM. The claims that EBM can herald a new theory of epistemology and a Kuhnian paradigm will be refuted. The solution is to describe EBM as a necessary development in medicine to deal with the increasing amount of evidence and medical data without loosing the single patient out of sight. ​

Leveraging Data Science for Global Health

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ISBN: 9783030479947 Year: Pages: 475 DOI: 10.1007/978-3-030-47994-7 Language: English
Publisher: Springer Nature
Subject: Medicine (General) --- Computer Science --- Economics
Added to DOAB on : 2020-09-01 00:01:25
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This open access book explores ways to leverage information technology and machine learning to combat disease and promote health, especially in resource-constrained settings. It focuses on digital disease surveillance through the application of machine learning to non-traditional data sources. Developing countries are uniquely prone to large-scale emerging infectious disease outbreaks due to disruption of ecosystems, civil unrest, and poor healthcare infrastructure – and without comprehensive surveillance, delays in outbreak identification, resource deployment, and case management can be catastrophic. In combination with context-informed analytics, students will learn how non-traditional digital disease data sources – including news media, social media, Google Trends, and Google Street View – can fill critical knowledge gaps and help inform on-the-ground decision-making when formal surveillance systems are insufficient.

Philosophical Issues in Sport Science

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ISBN: 9783039218882 9783039218899 Year: Pages: 140 DOI: 10.3390/books978-3-03921-889-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Sports Science
Added to DOAB on : 2020-04-07 23:07:08
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The role and value of science within sport increases with ever greater professionalization and commercialization. Scientific and technological innovations are devised to increase performance, ensure greater accuracy of measurement and officiating, reduce risks of harm, enhance spectatorship, and raise revenues. However, such innovations inevitably come up against epistemological and metaphysical problems related to the nature of sport and physical competition. This Special Issue identifies and explores key and contemporary philosophical issues in relation to the science of sport and exercise. It is divided into three sections: 1. Scientific evidence, causation, and sport; 2. Science technology and sport officiating; and 3. Scientific influences on the construction of sport. It brings together scholars working on philosophical problems in sport to examine issues related to the values and assumptions behind sport and exercise science and key problems resulting from these and to provide recommendations for improving its practice.

Keywords

elite sports --- sport nutrition --- standards of evidence --- evidence-based practices --- randomized controlled trials --- philosophy of medicine --- casuistry --- umpiring and refereeing --- technological assistance to match officials --- justice and continuity in match officiating --- ball trackers --- goal-line technology --- football --- cricket --- tennis --- transgender --- trans women --- sport --- testosterone --- gender --- gender binary --- sports tournaments --- team rankings --- intransitive dominance --- win-loops --- social choice theory --- Condorcet’s paradox --- championship pluralism --- technology --- running --- fairness --- competition --- accuracy --- officiating --- justice --- the human element --- technology --- Hawk-Eye --- aesthetics of sports --- counterfactuals --- absence causation --- causal necessity --- causal contingency --- david kellogg lewis --- prelusory goal --- possible sport worlds --- metaphysics of sport --- causation in sport --- sport ethics --- technology --- the spirit of sport --- excellence --- anti-doping --- nature --- governance --- ethics --- testosterone --- discrimination --- integrity --- science --- fair-play --- sport --- athletics --- exercise science --- philosophy --- sport psychology --- materialism --- Aristotle --- causation and nature --- exercise professional --- professional knowledge --- health --- wellbeing --- philosophy --- medicalization --- scientism --- biomedicine --- sport science --- epistemology --- ontology --- causation --- technology --- evidence

Seaweeds Secondary Metabolites: Successes in and/or Probable Therapeutic Applications

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ISBN: 9783039283002 9783039283019 Year: Pages: 320 DOI: 10.3390/books978-3-03928-301-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-04-07 23:07:08
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Seaweeds are recognized as highly nutritious, and their use in gastronomy is increasing. Their health benefits and their potential to prevent several diseases have also been established. In this Special Issue several health effects are discussed, with more emphasis on their antitumor activity and potential use to treat Alzheimer’s disease. The key bioactive metabolites, from which phlorotannins can be highlighted, are presented, as well as some important in vivo studies. Altogether, the chapters provide in-depth information about the biological activities of seaweed metabolites, contributing to elucidate the health effects of seaweed.

Keywords

Padina pavonica --- osteosarcoma --- apoptosis --- algae --- chemo-preventive agent --- phytol --- fucosterol --- fatty acid --- laurinterol --- Laurencia --- antitumoral --- breast cancer explants --- organotypic culture --- ex vivo --- phlorotannin --- eckmaxol --- high-speed counter-current chromatography --- NMR spectroscopy --- mass spectrometry --- isolation and purification --- Ecklonia maxima --- fucoidan --- age-related macular degeneration --- VEGF --- oxidative stress --- Saccharina latissima --- Fucus vesiculosus --- Fucus distichus subsp. evanescens --- Fucus serratus --- Laminaria digitata --- Symphyocladia latiuscula --- bromophenols --- mushroom tyrosinase --- B16F10 --- melanin --- red seaweed --- bioactives --- extraction --- biorefinery --- seaweed --- gut microbiota --- prebiotics --- dietary fibre --- complex polysaccharides --- polyphenols --- polyunsaturated fatty acids --- carotenoids --- phytochemicals --- Padina pavonica --- marine algae --- osteoporosis --- bone metabolism --- bone health --- nutraceutical --- Bifurcaria bifurcata --- linear diterpenes --- extraction --- identification --- biological activities --- macroalgae --- high value applications --- phlorotannin --- amyloid-? aggregation --- insulin glycation --- dynamic simulation --- kidney --- ischemia-reperfusion injury --- Ecklonia cava --- phlorotannins --- Alzheimer’s disease --- seaweeds --- cholinesterases --- beta-secretase --- beta-amyloid aggregation --- neuroprotection --- K14HPV16 --- genotoxicity assay --- papillomavirus --- cancer --- seaweeds --- hyperpigmentation --- skin aging --- skincare --- photo-protection --- seaweeds --- secondary metabolites --- in vivo studies --- clinical trials --- health effects --- dieckol --- eckol --- fucoxanthin --- kahalalide F

Intelligent Marine Robotics Modelling, Simulation and Applications

Authors: ---
ISBN: 9783039281329 / 9783039281336 Year: Pages: 242 DOI: 10.3390/books978-3-03928-133-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Pathology
Added to DOAB on : 2020-06-09 16:38:57
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The biennial Congress of the Italian Society of Oral Pathology and Medicine (SIPMO) is an International meeting dedicated to the growing diagnostic challenges in the oral pathology and medicine field. The III International and XV National edition will be a chance to discuss clinical conditions which are unusual, rare, or difficult to define. Many consolidated national and international research groups will be involved in the debate and discussion through special guest lecturers, academic dissertations, single clinical case presentations, posters, and degree thesis discussions. The SIPMO Congress took place from the 17th to the 19th of October 2019 in Bari (Italy), and the enclosed copy of Proceedings is a non-exhaustive collection of abstracts from the SIPMO 2019 contributions.

Witchcraft, Demonology and Magic

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ISBN: 9783039289592 / 9783039289608 Year: Pages: 160 DOI: 10.3390/books978-3-03928-960-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Religion
Added to DOAB on : 2020-06-09 16:38:57
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Witchcraft and magic are topics of enduring interest for many reasons. The main one lies in their extraordinary interdisciplinarity: anthropologists, folklorists, historians, and more have contributed to build a body of work of extreme variety and consistence. Of course, this also means that the subjects themselves are not easy to assess. In a very general way, we can define witchcraft as a supernatural means to cause harm, death, or misfortune, while magic also belongs to the field of supernatural, or at least esoteric knowledge, but can be used to less dangerous effects (e.g., divination and astrology). In Western civilization, however, the witch hunt has set a very peculiar perspective in which diabolical witchcraft, the invention of the Sabbat, the persecution of many thousands of (mostly) female and (sometimes) male presumed witches gave way to a phenomenon that is fundamentally different from traditional witchcraft. This Special Issue of Religions dedicated to Witchcraft, Demonology, and Magic features nine articles that deal with four different regions of Europe (England, Germany, Hungary, and Italy) between Late Medieval and Modern times in different contexts and social milieus. Far from pretending to offer a complete picture, they focus on some topics that are central to the research in those fields and fit well in the current “cumulative concept of Western witchcraft” that rules out all mono-causality theories, investigating a plurality of causes.

New Insights into Parvovirus Research

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ISBN: 9783039283101 / 9783039283118 Year: Pages: 342 DOI: 10.3390/books978-3-03928-311-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2020-06-09 16:38:57
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Viruses in the Parvoviridae family constitute one of the most diverse and intriguing fields of research. While they all share an ssDNA genome and a small capsid, they can differ widely in structure, genome organization and expression, virus–cell interaction, and impact on the host. Exploring such diversity and unraveling the inherent complexity in these apparently simple viruses is an ongoing endeavor and commitment for the scientific community. The translational implications of research on parvoviruses are relevant. Within the family, some viruses are important human and veterinary pathogens, in need of diagnostic methods and antiviral strategies; other viruses have long been studied and engineered as tools for oncolytic therapy, or as sophisticated gene delivery vectors, and can now display their wide and expanding applicative potential. This Special Issue of Viruses collects recent contributions in the field of parvovirus research, with a focus on new insights and research on unresolved issues, as well as new approaches exploiting systemic methodologies. Evolution, structural biology, viral replication, virus–host interaction, pathogenesis and immunity, and viral oncotherapy are a selection of the topics addressed in the issue that can be of relevance to the community involved in parvovirus research and of interest to a wider audience.

Keywords

human bocavirus --- children --- acute gastroenteritis --- parvovirus --- human bocavirus 1 --- RNA-seq --- transcription profile --- human airway epithelia --- AAV2 --- adeno-associated virus --- bisulfite PCR --- CpG methylation --- DNA virus --- Parvoviridae --- telbivudine --- B19V --- circulating angiogenic cells --- apoptosis --- caspase-3 --- BIRC3 (cIAP-2) --- parvovirus --- viral metagenomics --- virus diversity --- virus phylogeny --- agricultural pests --- arthropod --- mite --- viral communities --- viral ecology --- Carnivore protoparvovirus 1 --- canine parvovirus --- feline panleukopenia virus --- NS1 --- NS2 --- sequence analysis --- evolution --- Bombyx mori bidensovirus --- RACE --- RT-qPCR --- transcription mapping --- overlapping promoters --- parvovirus --- densovirus --- single stranded DNA virus --- X-ray crystallography --- Cryo-EM --- antibody interactions --- receptor interactions --- parvovirus --- viral metagenomics --- canine chapparvovirus --- Adeno-associated virus --- AAV --- protease --- phospholipase-A2 --- PLA2 --- rodent protoparvoviruses --- oncolytic activity --- tumor microenvironment --- immunomodulation --- preclinical --- clinical trials --- B19V --- parvovirus --- uncoating --- divalent cations --- capsid stability --- genome externalization --- trafficking --- nuclear targeting --- equine parvovirus-hepatitis --- horses --- commercial horse serum --- phylogeny --- chapparvovirus --- parvovirus evolution --- endogenous viral elements --- Parvoviridae --- densovirus --- homology modeling --- new viruses --- oncolytic virus immune therapy --- rodent protoparvoviruses --- H-1PV --- combination therapies --- second generation parvovirus treatments --- parvovirus B19 --- B19V --- erythrovirus --- diagnosis --- dilated cardiomyopathy --- inflammatory cardiomyopathy --- myocarditis --- prognosis --- parvovirus B19 --- erythroid progenitor cells --- antiviral compounds --- intravenous immunoglobulin (IVIG) --- hydroxyurea --- cidofovir --- brincidofovir --- coumarin derivatives --- flavonoids --- alpaca --- virus --- Bocaparvovirus --- genome --- next-generation sequencing --- metagenomics --- parvovirus B19 --- adenoviral vector --- cell cycle arrest --- apoptosis --- anti-cancer --- insect --- Lepidoptera --- insect parvovirus --- chitin --- peritrophins --- glycans --- biocontrol --- parvovirus --- structural biology --- genetics --- oncolytic viruses --- antivirals

Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination

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ISBN: 9783039286980 / 9783039286997 Year: Pages: 366 DOI: 10.3390/books978-3-03928-699-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-06-09 16:38:57
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The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.

Keywords

circulating tumor cells --- circulating tumor DNA --- liquid biopsy --- metastatic colorectal cancer --- FOLFIRINOX --- circulating tumor cells --- CTC --- liquid biopsy --- CTM --- CTMat --- CTC biology --- CTC capture technology --- metastasis --- circulating tumor cells (CTCs) --- hepatocellular carcinoma (HCC) --- castration resistant prostate cancer (CRPC) --- epithelial-to-mesenchymal transition (EMT) --- fibronectin --- integrin B1 --- SLUG --- major histocompatibility complex class I (MHCI) --- immunomodulation --- bone marrow --- melanoma --- disseminated tumor cells --- solid cancers --- single-cell analysis --- enrichment and detection technologies --- flow cytometry --- tumor stem cells --- HMB-45 --- CD133 --- locally advanced rectal cancer --- circulating tumor cells --- RAD23B --- thymidylate synthase --- chemoradioresistance --- liquid biopsy --- circulating tumor cells --- epithelial–mesenchymal transition --- stem cells --- early breast cancer --- prostate cancer (PCa) --- circulating tumor cells (CTC) --- liquid biopsy --- circulating tumor cells --- metastasis --- xenograft models --- breast cancer --- prostate cancer --- CTC --- AR --- AR-V7 --- ctRNA --- exosome --- circulating tumor cells --- hematological cells --- neutrophils --- platelets --- liquid biopsy --- circulating tumor cells --- melanoma --- liquid biopsy --- EPISPOT --- CellSearch® --- liquid biopsy --- CTCs --- immune checkpoint inhibitors --- PD-L1 expression --- NSCLC --- small-cell lung carcinoma --- circulating tumor cells --- microfluidics --- gene expression analysis --- synaptophysin --- chromogranin A --- rovalpituzumab tesirine --- leukocyte-derived extracellular vesicles --- immunofluorescence imaging --- EpCAM enrichment --- CellSearch --- EasyCount slides --- ACCEPT --- CTC --- heterogeneity --- liquid biopsy --- liquid surgery --- clinical utility --- circulating tumor cells (CTCs) --- glioma --- biomarker --- rVAR2 --- malaria --- enrichment and detection technologies --- prostate cancer --- biomarkers --- circulating tumor cells --- androgen receptor --- ARV7 --- abiraterone --- enzalutamide --- metastasis --- tumor-initiating cells (TICs) --- circulating tumor cells (CTCs) --- CTC-derived xenografts --- CTC-derived ex vivo models --- cerebrospinal liquid biopsy --- in vivo flow cytometry --- tumor biomarkers --- circulating tumor cells --- ctDNA --- miRNA --- exosomes --- emboli --- targeted therapy --- circulating tumor cells --- tumor cell dissemination --- immune system --- microbiome --- circulating tumor cells (CTCs) --- clinical trials --- breast cancer --- CTC-based treatment decisions --- circulating tumour cells --- colorectal cancer --- colorectal surgery --- microsatellite instability --- microfluidics --- immunophenotyping --- fish --- liquid biopsy --- circulating leukemia cells --- circulating plasma cells --- n/a

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english (5)

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2020 (9)