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Chapter 4 Globalisation, mobility and labour in African diasporic fiction (Book chapter)

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ISBN: 9781138713864 9781315229546 Year: Pages: 14 Language: English
Publisher: Taylor & Francis
Subject: Languages and Literatures
Added to DOAB on : 2019-05-28 11:21:11
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This chapter addresses the entanglement of mobility and labour in the global era, and suggests potential ways to study these issues in contemporary African diasporic fiction.

Beside You in Time

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ISBN: 9781478090045 9781478006350 9781478005049 9781478005674 Year: Pages: 240 DOI: 10.1215/9781478090045 Language: English
Publisher: Duke University Press
Subject: Sociology --- Gender Studies --- Languages and Literatures --- Linguistics
Added to DOAB on : 2019-11-08 11:21:03
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In Beside You in Time Elizabeth Freeman expands biopolitical and queer theory by outlining a temporal view of the long nineteenth century. Drawing on Foucauldian notions of discipline as a regime that yoked the human body to time, Freeman shows how time became a social and sensory means by which people assembled into groups in ways that resisted disciplinary forces. She tracks temporalized bodies across many entangled regimes—religion, secularity, race, historiography, health, and sexuality—and examines how those bodies act in relation to those regimes. In analyses of the use of rhythmic dance by the Shakers; African American slave narratives; literature by Mark Twain, Pauline Hopkins, Herman Melville, and others; and how Catholic sacraments conjoined people across historical boundaries, Freeman makes the case for the body as an instrument of what she calls queer hypersociality. As a mode of being in which bodies are connected to others and their histories across and throughout time, queer hypersociality, Freeman contends, provides the means for subjugated bodies to escape disciplinary regimes of time and to create new social worlds.

Making Sense of Bad English

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ISBN: 9781138237469 9781138237476 Year: Pages: 190 Language: English
Publisher: Taylor & Francis
Subject: Linguistics
Added to DOAB on : 2020-02-06 11:21:02
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Why is it that some ways of using English are considered "good" and others are considered "bad"? Why are certain forms of language termed elegant, eloquent or refined, whereas others are deemed uneducated, coarse, or inappropriate? Making Sense of "Bad English" is an accessible introduction to attitudes and ideologies towards the use of English in different settings around the world. Outlining how perceptions about what constitutes "good" and "bad" English have been shaped, this book shows how these principles are based on social factors rather than linguistic issues and highlights some of the real-life consequences of these perceptions.

Current Trajectories in Global Pentecostalism: Culture, Social Engagement, and Change

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ISBN: 9783038974536 9783038974543 Year: Pages: 200 DOI: 10.3390/books978-3-03897-454-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Arts in general --- Religion --- Social Sciences
Added to DOAB on : 2019-02-08 10:23:25
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This path-breaking collection brings together thirteen leading scholars from the humanities and social sciences to address some of the most pressing issues in contemporary global Pentecostalism. Representing institutions from eight different nations on four continents, these scholars perceptively illuminate vital matters ranging from politics, cultural performance, and sexual identity to history, theology, and socioeconomics. The articles are grounded in primary research conducted in Africa, Australia, Europe, and South America and informed by cutting-edge interdisciplinary perspectives, making "Current Trajectories in Global Pentecostalism: Culture, Social Engagement, and Change" a must-read for serious students of global Pentecostalism.

Welfare of Cultured and Experimental Fishes

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ISBN: 9783039217106 9783039217113 Year: Pages: 132 DOI: 10.3390/books978-3-03921-711-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Animal Sciences
Added to DOAB on : 2019-12-09 11:49:16
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Welfare is a multidimensional concept that can be described as the state of an animal as it copes with the environment. Captive environments can impact farmed animals at different levels, especially fishes, considering their highly complex sensory world. Understanding the ethology of a species is therefore essential to address fish welfare, and the interpretation of behavioral responses in specific rearing contexts (aquaculture or experimental contexts) demands knowledge of their underlying physiological, developmental, functional, and evolutionary mechanisms. In natural environments, the stress response has evolved to help animals survive challenging conditions. However, animals are adapted to deal with natural stressors, while anthropogenic stimuli may represent stressors that fishes are unable to cope with. Under such circumstances, stress responses may be maladaptive and cause severe damage to the animal. As welfare in captivity is affected in multiple dimensions, multiple possible indicators can be used to assess the welfare state of individuals. In the past, research on welfare has been largely focusing on health indicators and predominantly based on physiological stress. Ethological indicators, however, also integrate the mental perspective of the individual and have been gradually assuming an important role in welfare research: behavioral responses to stressors are an early response to adverse conditions, easily observable, and demonstrative of emotional states. Many behavioral indicators can be used as non-invasive measurements of welfare in practical contexts such as aquaculture and experimentation. Presently, research in fish welfare is growing in importance and interest because of the growing economic importance of fish farming, the comparative biology opportunities that experimental fishes provide, and the increasing public sensitivity to welfare issues.

Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday

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ISBN: 9783038974161 9783038974178 Year: Pages: 256 DOI: 10.3390/books978-3-03897-417-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-06-26 08:44:06
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Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

Keywords

Zingiber officinale --- gingerols --- cytotoxic activity --- oleanolic acid --- high-fat high-carbohydrate diet --- pre-diabetes --- glucose homeostasis --- insulin resistance --- atherosclerosis --- ROS --- HUVECs --- LOX-1 --- alkaloid --- granatane --- N-methylcadaverine --- N-methylpiperidine. reductive deamination --- Mucorales --- Rhizopus arrhizus --- sterol pattern --- antifungal effectivity --- gas chromatography-mass spectrometry (GC-MS) --- posaconazole --- sterol biosynthesis --- sterol 14?-demethylase --- sterol C24-methyltransferase --- mechanism-based inactivators --- antifungals --- azoles --- antiparasitic drugs --- human African trypanosomiasis --- Chagas disease --- synthesis --- squalene cyclase --- cycloartenol synthase --- triterpene --- fern --- Polystichum --- terpene --- isoprenoid --- divalent metal co-factor ligation --- antioxidant --- cholesterol --- degeneration --- oxysterol --- retina --- Smith-Lemli-Opitz syndrome --- algal sterols --- ergosterol biosynthesis --- infectious disease --- lipidomics --- oxyphytosterol --- pharmacognosy --- phytosterol --- sterolomics --- lupeol --- keratinocytes --- fibroblasts --- wound healing --- cell migration --- UV-radiation --- ZnO --- toxicity --- sterol content --- cholesterol --- leishmania --- solanaceae --- withanolides --- aurelianolides --- phytosterols --- mesocarp --- oilseed --- maturity --- pod-blast --- ?-tocopherol --- oil bodies --- campesterol --- stigmasterol --- ?-sitosterol --- sterol --- C4-demethylation complex (C4DMC) --- 4-methylsterol --- hormone --- steroid --- development --- genetic disease --- bile alcohol --- cholestanoic acid --- oxysterol --- sterolomics --- enzyme-assisted derivatization --- electrospray ionization-mass spectrometry --- Girard reagent --- n/a

Risk Analysis and Portfolio Modelling

Authors: ---
ISBN: 9783039216246 9783039216253 Year: Pages: 224 DOI: 10.3390/books978-3-03921-625-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Business and Management
Added to DOAB on : 2019-12-09 11:49:15
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Financial Risk Measurement is a challenging task, because both the types of risk and the techniques evolve very quickly. This book collects a number of novel contributions to the measurement of financial risk, which address either non-fully explored risks or risk takers, and does so in a wide variety of empirical contexts.

The Long-Term Perspective of Human Impact on Landscape for Environmental Change and Sustainability

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ISBN: 9783039217960 9783039217977 Year: Pages: 258 DOI: 10.3390/books978-3-03921-797-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Environmental Sciences
Added to DOAB on : 2019-12-09 11:49:16
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The research studies included in this Special Issue highlight the fundamental contribution of the knowledge of environmental history to conscious and efficient environment conservation and management. The long-term perspective of the dynamics that govern the human–climate ecosystem is becoming one of the main focuses of interest in biological and earth system sciences. Multidisciplinary bio-geo-archaeo investigations into the underlying processes of human impact on the landscape are crucial to envisage possible future scenarios of biosphere responses to global warming and biodiversity losses. This Special Issue seeks to engage an interdisciplinary dialog on the dynamic interactions between nature and society, focusing on long-term environmental data as an essential tool for better-informed landscape management decisions to achieve an equilibrium between conservation and sustainable resource exploitation.

Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

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ISBN: 9783039211524 9783039211531 Year: Pages: 240 DOI: 10.3390/books978-3-03921-153-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.

Keywords

polyamine transport inhibitor --- Drosophila imaginal discs --- difluoromethylorthinine --- DFMO --- polyamine --- cancer --- metabolism --- difluoromethylornithine --- polyamine transport inhibitor --- pancreatic ductal adenocarcinoma --- curcumin --- diferuloylmethane --- ornithine decarboxylase --- polyamine --- NF-?B --- chemoprevention --- carcinogenesis --- polyphenol --- ornithine decarboxylase --- polyamines --- untranslated region --- polyamines --- ?-difluoromethylornithine --- polyamine transport system --- melanoma --- mutant BRAF --- spermine --- spermidine --- putrescine --- polyamine metabolism --- mast cells --- eosinophils --- neutrophils --- M2 macrophages --- airway smooth muscle cells --- Streptococcus pneumoniae --- polyamines --- pneumococcal pneumonia --- proteomics --- capsule --- complementation --- metabolism --- cadaverine --- polyamines --- ornithine decarboxylase --- difluoromethylornithine --- eflornithine --- DFMO --- African sleeping sickness --- hirsutism --- colorectal cancer --- neuroblastoma --- aging --- atrophy --- autophagy --- oxidative stress --- polyamines --- skeletal muscle --- spermidine --- spermine oxidase --- transgenic mouse --- immunity --- T-lymphocytes --- B-lymphocytes --- tumor immunity --- metabolism --- epigenetics --- autoimmunity --- polyamines --- ornithine decarboxylase --- polyamine analogs --- spermidine/spermine N1-acetyl transferase --- spermine oxidase --- bis(ethyl)polyamine analogs --- breast cancer --- MCF-7 cells --- transgenic mice --- polyamines --- MYC --- protein synthesis in cancer --- neuroblastoma --- protein expression --- antizyme 1 --- ornithine decarboxylase --- CRISPR --- human embryonic kidney 293 (HEK293) --- cell differentiation --- DFMO --- ornithine decarboxylase --- osteosarcoma --- polyamines --- polyamines --- polyamine metabolism --- antizyme --- antizyme inhibitors --- ornithine decarboxylase --- Snyder-Robinson Syndrome --- spermine synthase --- X-linked intellectual disability --- polyamine transport --- spermidine --- spermine --- transglutaminase

New Advances on Zika Virus Research

Authors: ---
ISBN: 9783038977643 Year: Pages: 552 DOI: 10.3390/books978-3-03897-765-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine --- Medicine (General)
Added to DOAB on : 2019-04-05 10:34:31
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Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Keywords

Ziks virus --- silvestrol --- antiviral --- eIF4A --- hepatocytes --- flavivirus --- arbovirus --- Zika --- sexual transmission --- testis --- prostate --- Zika virus --- ZIKV --- rhesus macaques --- Non-human primates --- NHP --- infection --- natural history --- Asian-lineage --- African-lineage --- zika virus --- ZIKV–host interactions --- viral pathogenesis --- cell surface receptors --- antiviral responses --- viral counteraction --- cytopathic effects --- microcephaly --- ZIKV-associated neurologic disorders --- Zika virus --- serology --- flavivirus --- microsphere immunoassay --- validated --- optimised --- dengue virus --- ZIKV --- reporter virus --- cryptic promoter silencing --- full-length molecular clone --- subgenomic replicon --- plasmid toxicity --- Zika virus --- dengue viruses --- flavivirus --- ELISA --- indirect immunofluorescence --- plaque reduction neutralization test --- polymerase chain reaction --- cross-reactions --- Zika virus --- flavivirus --- infectious cDNA --- replication --- gene expression --- neuropathogenesis --- viral genetic variation --- host genetic variation --- flavivirus --- Zika virus --- therapy --- host-directed antivirals --- Aedes aegypti --- RNA-seq --- insecticide resistance --- Zika virus --- detoxification and immune system responses --- Zika virus --- mosquito-borne flavivirus --- emerging arbovirus --- outbreak control --- molecular diagnostics --- laboratory preparedness --- assay standardization --- external quality assessment --- EQA --- QCMD --- flavivirus --- eye --- zika virus --- blood-retinal barrier --- ocular --- innate response --- Zika virus --- pregnancy --- fetal infection --- congenital Zika syndrome --- Asian lineage --- Zika virus --- Full-length cDNA infectious clones --- Bacterial artificial chromosome --- NS2A protein --- Zika virus --- neural progenitor cells --- neurons --- Zika virus --- antivirals --- therapeutics --- research models and tools --- flavivirus --- Zika virus (ZIKV) --- reverse genetics --- infectious clone --- full-length molecular clone --- bacterial artificial chromosome --- replicon --- infectious RNA --- Zika virus --- flavivirus --- arbovirus --- sexual transmission --- host genetic variation --- immune response --- Zika virus --- flaviviruses --- vaccines --- virus like particles --- clinical trials --- ZIKV --- NS1 protein --- Zika virus --- diagnosis --- monoclonal antibodies --- ELISA --- zika virus --- placenta cells --- microglia cells --- siRNA --- TLR7/8 --- Zika --- viral evolution --- genetic variability --- Bayesian analyses --- Zika virus --- reverse genetics --- infectious cDNA --- Tet-inducible --- MR766 --- FSS13025 --- flavivirus --- ZIKV --- NS5 --- type I IFN antagonist --- point-of-care diagnostics --- isothermal nucleic acid amplification --- nucleic acid computation --- nucleic acid strand exchange --- zika virus --- mosquito --- mosquito surveillance --- multiplex nucleic acid detection --- boolean logic-processing nucleic acid probes --- Zika virus --- flavivirus --- astrocytomas --- dsRNA --- viral fitness --- antiviral --- heme-oxygenase 1 --- Zika virus --- viral replication --- Zika virus --- antiviral compounds --- neural cells --- viral replication --- flavivirus --- Zika virus --- viral persistence --- testicular cells --- testes --- Zika virus --- prM-E proteins --- viral pathogenicity --- virus attachment --- viral replication --- viral permissiveness --- viral survival --- apoptosis --- cytopathic effects --- mutagenesis --- chimeric viruses --- human brain glial cells --- Zika virus --- flavivirus --- microRNAs --- neurons --- neuroinflammation --- anti-viral immunity --- Zika virus --- dengue virus --- secondary infections --- cross-reactions --- IgA --- IgG avidity tests

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MDPI - Multidisciplinary Digital Publishing Institute (8)

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english (11)


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2019 (11)