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Neuroglia Molecular Mechanisms in Psychiatric Disorders

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889456987 Year: Pages: 154 DOI: 10.3389/978-2-88945-698-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2019-01-23 14:53:43
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Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. In the central nervous system (CNS) non-excitable neuroglia are represented by cells of ectodermal origin (astrocytes, mainly responsible for CNS homeostasis and oligodendrocytes that provide myelination and support for axons) and mesodermal origin (microglial cells that are scions of foetal macrophages entering the neural tube early in development; these cells provide for CNS defence and contribute to shaping neuronal networks). Pathological changes of neuroglia are complex; these changes are classified into reactive gliosis (astrogliosis, activation of microglia and hypertrophy of oligodendroglial precursors), gliodegeneration with loss of function and glial pathological remodelling. Combination of these processes defines the evolution of neurological diseases in general and neuropsychiatric disorders in particular.In this research topic we addressed the contribution of neuroglia to major neuropsychiatric pathologies including major depression, schizophrenia, and addictive disorders.

New Research in Obsessive-Compulsive Disorder and Major Depression

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ISBN: 9783039210909 9783039210916 Year: Pages: 102 DOI: 10.3390/books978-3-03921-091-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Psychology
Added to DOAB on : 2019-06-26 08:44:07
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Major depression and obsessive–compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16–17% and 2–3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20–30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD.

The Multi-Dimensional Contributions of Prefrontal Circuits to Emotion Regulation during Adulthood and Critical Stages of Development

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ISBN: 9783039217021 9783039217038 Year: Pages: 188 DOI: 10.3390/books978-3-03921-703-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-12-09 11:49:16
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The prefrontal cortex (PFC) plays a pivotal role in regulating our emotions. The importance of ventromedial regions in emotion regulation, including the ventral sector of the medial PFC, the medial sector of the orbital cortex and subgenual cingulate cortex, have been recognized for a long time. However, it is increasingly apparent that lateral and dorsal regions of the PFC, as well as neighbouring dorsal anterior cingulate cortex, also play a role. Defining the underlying psychological mechanisms by which these functionally distinct regions modulate emotions and the nature and extent of their interactions is a critical step towards better stratification of the symptoms of mood and anxiety disorders. It is also important to extend our understanding of these prefrontal circuits in development. Specifically, it is important to determine whether they exhibit differential sensitivity to perturbations by known risk factors such as stress and inflammation at distinct developmental epochs. This Special Issue brings together the most recent research in humans and other animals that addresses these important issues, and in doing so, highlights the value of the translational approach.

Updates in Pediatric Sleep and Child Psychiatry

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ISBN: 9783038979388 9783038979395 Year: Pages: 160 DOI: 10.3390/books978-3-03897-939-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Pediatrics
Added to DOAB on : 2019-06-26 08:44:06
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Sleep-related symptoms are common in the majority of psychiatric diagnostic categories. The overlap of sleep and psychiatric disorders have been demonstrated in numerous studies. The understanding of sleep and child psychiatry has progressively evolved in the last decade and newer insights have developed regarding the complex interaction between sleep and psychopathology. This collection of articles represents updates on sleep and psychiatric disorders with medical and neurological co-morbidities in children and adolescents.

Diagnosis of Dementia and Cognitive Impairment

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ISBN: 9783039218844 9783039218851 Year: Pages: 140 DOI: 10.3390/books978-3-03921-885-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-01-07 09:08:26
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In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment. The methods of the assessments discussed extend from simple neurological signs, which may be elicited in the clinical encounter, through cognitive screening instruments, to sophisticated analyses of neuroimaging and cerebrospinal fluid biomarkers of disease. It is hoped that these various methods may facilitate earlier diagnosis of dementia and its subtypes, and provide differential diagnosis of depression and functional cognitive disorders, as a prelude to meaningful interventions.

Internet and Mobile Phone Addiction. Health and Educational Effects

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ISBN: 9783038976042 Year: Pages: 328 DOI: 10.3390/books978-3-03897-605-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Psychology
Added to DOAB on : 2019-03-21 15:50:41
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Internet use-related addiction problems (e.g., Internet addiction, problem mobile phone use, problem gaming, and social networking) have been defined according to the same core element: the addictive symptomatology presented by individuals who excessively and problematically behave using the technology. Online activity is the most important factor in their lives, causing them the loss of control by stress and difficulties in managing at least one aspect of their daily life, affecting users’ wellbeing and health. In 2018, Gaming Disorder was included as a mental disease in the 11th Revision of the International Classification of Diseases by the World Health Organization. In 2013, the American Psychiatric Association requested additional research on Internet Gaming Disorder. The papers contained in this e-Book provide unique and original perspectives on the concept, development, and early detection of the prevention of these health problems. They are diverse in the nature of the problems they deal with, methodologies, populations, cultures, and contain insights and a clear indication of the impact of individual, social, and environmental factors on Internet use-related addiction problems. The e-Book illustrates recent progress in the evolution of research, with great emphasis on gaming and smartphone problems, signaling areas in which research would be useful, even cross-culturally.

Keywords

commuting --- well-being --- personality --- gender --- stress --- Internet addiction --- Internet gaming disorder --- game device usage pattern --- smartphone --- comorbidity --- Internet gaming disorder --- IGD --- emotional regulation --- cognitive reappraisal --- suppression --- depression --- hostility --- internet gaming disorder --- Dickman Impulsivity Inventory-Short Version (DII) --- Brief Self-Control Scale (BSCS) --- Symptom Checklist-90-Revised (SCL-90-R) --- Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) --- Diagnostic and Statistical Manual for Mental Disorders (DSM-5) --- gambling --- video-game addiction --- screen addiction --- immersion --- problematic Internet use --- comorbidity --- cognitive distortion --- problematic smartphone use --- smartphone addiction --- social media --- approaches to learning --- deep approach to learning --- surface approach to learning --- smartphone --- problematic mobile phone use --- convergent design --- focus group --- survey --- internet gaming disorder --- impulsivity --- depression --- interpersonal relationships --- serial mediation --- Internet addiction --- mobile phone addiction --- online social network --- university students --- technological addictions --- behavioral addictions --- CERI --- CERM --- mobile phone dependence --- mobile phone use --- impulsivity --- China --- Internet addiction --- Internet-use disorder --- Internet literacy --- expectancies --- personality --- cultural differences --- pathological video-game use --- Internet Gaming Disorder --- comorbid psychopathology --- review --- Internet Use Disorder --- prevalence --- epidemiology --- adolescence --- latent profile analysis --- anxiety --- depression --- Internet addiction --- smartphone addiction --- propensity score --- Internet addiction --- coping strategies --- personality traits --- young people --- mobile phone use --- smartphone use --- Problematic Mobile Phone Use --- Problematic Mobile Phone Use Questionnaire --- psychometric testing --- measurement invariance --- time --- gaming disorder --- interpersonal relations --- self-efficacy --- self-control --- expectations --- fear of missing out (FOMO) --- social media --- problematic social media use (PSMU) --- phubbing --- teenagers --- adolescents --- addiction --- internet addiction --- mobile phone (or smartphone) use --- young children --- early childhood education --- parenting --- emergent bilinguals --- intergenerational language transmission --- behavioural addictions --- generalised versus specific problem Internet uses --- Internet addiction --- gaming disorder --- social networking --- mixed methods research

Measures of Spirituality/Religiosity—Description of Concepts and Validation of Instruments

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ISBN: 9783038977582 9783038977599 Year: Pages: 148 DOI: 10.3390/books978-3-03897-759-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Religion
Added to DOAB on : 2019-04-25 16:37:17
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Why do we need more questionnaires to measure aspects of spirituality/religiosity when we already have so many well-tried instruments in use? One answer is that research in this field is growing and that new research questions continuously do arise. Several of these new questions cannot be easily answered with the instruments designed for previous questions. The field is expanding and, consequently, the research topics. Meanwhile several multidimensional instruments were developed which cover existential, prosocial, religious and non-religious forms of spirituality, hope, peace and trust&mdash;and several more. The &lsquo;disadvantage&rsquo; of these instruments is the fact that some are conceptually broad and often rather unspecific, but they might be suited quite well for culturally and spiritually diverse populations when the intention is to compare such diverse groups. This is the reason why more research on new instruments is needed as can be found in this Special Issue, and to stimulate a critical debate about their pros and cons.

Role of Natural Compounds in Inflammation and Inflammatory-Related Diseases

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ISBN: 9783039215522 9783039215539 Year: Pages: 174 DOI: 10.3390/books978-3-03921-553-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:15
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The papers reported here will contribute to proposing new insights into the mechanisms of several conditions, as well as suggesting new diagnostic alternatives and therapeutic targets in widespread pathologies such inflammation and inflammatory-based diseases. The discovery of the new is, as always, anchored in recourse to the old.

Emerging Technology Applications to Promote Physical Activity and Health

Authors: ---
ISBN: 9783038977087 Year: Pages: 176 DOI: 10.3390/books978-3-03897-709-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Sociology --- Social Sciences
Added to DOAB on : 2019-04-05 10:34:31
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As technology becomes an ever-more prevalent part of everyday life, and population-based physical activity programs seek new ways to increase life-long engagement with physical activity, these two ideas have become increasingly linked. This Special Issue attempts to offer a thorough and critical examination of emerging technologies in physical activity and health promotion, considering technological interventions in different contexts (communities, clinics, schools, homes, etc.) among various populations, exploring the challenges of integrating technology into physical activity promotion, and offering solutions for its implementation. This Special Issue aims to take a broadly positive stance toward interactive technology initiatives and, while discussing some negative implications of an increased use of technology, offers practical recommendations for promoting physical activity through various emerging technologies, including, but not limited to: Active video games (exergaming); social media; mobile device apps; health wearables; mobile games, augmented reality games, global positioning and geographic information systems; and virtual reality. Offering a logical and clear critique of emerging technologies in physical activity and health promotion, this Special Issue will provide useful suggestions and practical implications for researchers, practitioners, and educators in the fields of public health, kinesiology, physical activity and health, and healthcare.

Keywords

anxiety --- depression --- exercise --- mental health --- virtual reality --- senior citizens --- perceived environmental factor --- recreational physical activity --- screen based sedentary behavior --- pedometers --- accelerometers --- measurement --- physical activity levels --- active video games --- motor activity --- intelligence quotient --- young children --- physical activity --- quality of life --- social cognitive theory --- wearable technology --- real-time physical activity --- wearable technology --- fitness --- Fitbits --- breast cancer --- mammogram --- mobile phone-based health intervention --- mHealth --- app --- health navigator --- Korean American immigrant women --- Autism --- autism spectrum disorder --- augmented reality --- technology --- Google Glass --- social communication --- safety --- smartglasses --- digital health --- Amazon --- Amazon Web Services --- Google --- sedentary behaviour --- air quality --- socio-ecological model --- wrist-worn activity tracker --- active video games --- cardiorespiratory fitness --- locomotor skills --- motor skill competence --- musculoskeletal fitness --- object control skills --- active video game --- accelerometry --- physical activity assessment --- epoch --- placement site --- heart rate --- preoperative anxiety --- virtual reality game --- preoperative experience --- active video game --- light physical activity --- moderate-to-vigorous physical activity --- sedentary behavior --- sex difference --- active video gaming --- serious games --- physical activity --- physical exercise --- sedentary behavior --- narrative review

Emerging Advances in Petrophysics. Porous Media Characterization and Modeling of Multiphase Flow

Authors: --- --- ---
ISBN: 9783038977940 9783038977957 Year: Pages: 258 DOI: 10.3390/books978-3-03897-795-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General) --- Geophysics and Geomagnetism
Added to DOAB on : 2019-04-25 16:37:17
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Due to the influence of pore-throat size distribution, pore connectivity, and microscale fractures, the transport, distribution, and residual saturation of fluids in porous media are difficult to characterize. Petrophysical methods in natural porous media have attracted great attention in a variety of fields, especially in the oil and gas industry. A wide range of research studies have been conducted on the characterization of porous media covers and multiphase flow therein. Reliable approaches for characterizing microstructure and multiphase flow in porous media are crucial in many fields, including the characterization of residual water or oil in hydrocarbon reservoirs and the long-term storage of supercritical CO2 in geological formations. This book gathers together 15 recent works to emphasize fundamental innovations in the field and novel applications of petrophysics in unconventional reservoirs, including experimental studies, numerical modeling (fractal approach), and multiphase flow modeling/simulations. The relevant stakeholders of this book are authorities and service companies working in the petroleum, subsurface water resources, air and water pollution, environmental, and biomaterial sectors.

Keywords

Wilkins equation --- non-laminar flow --- turbulence modelling --- porous media --- oil tanker --- temperature drop --- oscillating motion --- numerical simulation --- soil-water characteristic curve --- initial void ratio --- air-entry value --- fractal dimension --- fractal model --- oil properties --- diffusion coefficient --- supercritical CO2 --- Peng-Robinson equation of state (PR EOS) --- CT --- digital rock --- microfractures --- Lattice Boltzmann method --- pore-scale simulations --- tight sandstone --- pore structure --- multifractal --- classification --- Ordos Basin --- loose media --- coal --- porosity --- true density --- bulk density --- overburden pressure --- particle size --- tight conglomerate --- fracture characterization and prediction --- fractal method --- salt rock --- creep --- damage --- fractional derivative --- acoustic emission --- marine gas hydrate --- submarine landslide --- greenhouse gas emission --- lifecycle management --- hazard prevention --- multilayer reservoir --- interlayer interference --- producing degree --- seepage resistance --- wellbore multiphase flow --- inclined angle --- liquid rate --- gas rate --- pressure drawdown model with new coefficients --- base-level cycle --- pore structure --- mouth bar sand body --- Huanghua Depression --- isotopic composition --- methane --- gas hydrate --- South China Sea --- Bakken Formation --- pore structure --- controlling factors --- low-temperature nitrogen adsorption --- petrophysics --- fractal porous media --- unconventional reservoirs --- multiphase flow

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