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Celiac Disease - From the Bench to the Clinic

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ISBN: 9781789850499 9781789850505 Year: Pages: 100 DOI: 10.5772/intechopen.73847 Language: English
Publisher: IntechOpen
Subject: Microbiology
Added to DOAB on : 2019-10-03 07:51:52

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Celiac disease (CD) occurs in about 1% of people worldwide. Diagnosis rates are increasing due to a true rise in incidence, rather than increased awareness and detection. CD affects genetically susceptible individuals who are triggered by the ingestion of gluten. The disease has many clinical manifestations, ranging from severe to minimally symptomatic or non-symptomatic presentations. Diagnosis requires the presence of duodenal chronic inflammation, and most patients have circulating antibodies against tissue transglutaminase. Our understanding of the basic and clinical aspects of CD increases, which is as a major health problem of almost global occurrence. Case finding, distinguishing CD from other gluten-sensitive conditions, better care, and balanced use of resources are the current challenges.

Immune Response Activation and Immunomodulation

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ISBN: 9781789851519 9781789851526 Year: Pages: 178 DOI: 10.5772/intechopen.73708 Language: English
Publisher: IntechOpen
Subject: Microbiology
Added to DOAB on : 2019-10-03 07:51:53

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Immune Response Activation and Immunomodulation has been written to address the perceived needs of both medical school and undergraduate curricula and to take advantage of new understandings in immunology. We have tried to achieve several goals and present the most important principles governing the function of the immune system. Our fundamental objective has been to synthesize the key concepts from the vast amount of experimental data that have emerged in the rapidly advancing field of immunology. The choice of what is most important is based on what is most clearly established by experimentation, what our students find puzzling, and what explains the wonderful efficiency and economy of the immune system. Inevitably, however, such a choice will have an element of bias, and our bias is toward emphasizing the cellular interactions in immune response by limiting the description of many of the underlying biochemical and molecular mechanisms to the essential facts. This book gives an insight into the role of cytokines in activating immune response during pathogenic invasion. Immunomodulation, aryl hydrocarbons, the role of the protein defensin and nucleated cells in provoking immune response, Bcl protein/gene-based apoptotic pathways, and plant-derived phytochemical-mediated immune response are all central themes of this book.

Vaccines - the History and Future

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ISBN: 9781789238037 9781789238044 9781838800468 Year: Pages: 108 DOI: 10.5772/intechopen.77910 Language: English
Publisher: IntechOpen
Subject: Microbiology
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Vaccines is a well-written book on the subject of providing crucial information to students and researchers in the field of vaccinology. The introductory chapter, contributed by the editor (Dr. Vijay Kumar) of the book, provides the brief introduction to the history of the development of current forms of vaccine, which is difficult to find easily in one place. In addition, other chapters of the book are written by experts in the field. For example, the second chapter looks at the emerging role of developing countries in the innovation and production of vaccines. Other chapters provide information regarding different types of vaccines, development of vaccines for zoonotic viral infections, and regulatory affairs for genetically modified organism vaccines.

Neutrophils

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ISBN: 9781789852851 9781789852868 Year: Pages: 98 DOI: 10.5772/intechopen.73927 Language: English
Publisher: IntechOpen
Subject: Microbiology
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This book highlights the numerous important properties of neutrophils and their role in various diseases, and as a possible therapeutic target as well. The first chapter briefly discusses the main effector neutrophil functions, which is followed by two chapters discussing the importance of different neutrophil receptors (cannabinoid and Fc?R) and their role in various disease conditions. The fourth chapter discusses the differential expression profile of CD16+CD11b+ on the surface of neutrophils as a tool for the diagnosis of acute infections. The last chapter discusses the physics of the NADPH oxidase system and the use of different chemiluminigenic probes for the detection of various reactive oxygen intermediates of the circulating neutrophils.

Chronic Autoimmune Epithelitis - Sjogren's Syndrome and Other Autoimmune Diseases of the Exocrine Glands

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Book Series: Rheumatology ISSN: 26319233 ISBN: 9781789852110 9781789852127 9781789854152 Year: Volume: 3 Pages: 120 DOI: 10.5772/intechopen.73892 Language: English
Publisher: IntechOpen
Subject: Microbiology
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Epithelial tissue does not spring to mind as an obvious source of autoimmune phenomena. Yet, genetic predisposition and influence of various environmental and epigenetic factors may lead to epithelium becoming a springboard for the development of autoimmune diseases, such as Sjögren’s syndrome, primary biliary cholangitis, autoimmune pancreatitis, or IgG4-related diseases. This book is intended as an introduction to the problem of “autoimmune epithelitis” and diseases closely related to the immune disturbances of the epithelium, with special emphasis on those affecting exocrine glands. Both theoretical and practical knowledge, presented by authors from a wide range of medical specialties, should be of help for medical professionals who have to deal with this difficult problem in their daily practice.

Vectors and Vector-Borne Zoonotic Diseases

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ISBN: 9781789852936 9781789852943 Year: Pages: 132 DOI: 10.5772/intechopen.77985 Language: English
Publisher: IntechOpen
Subject: Animal Sciences --- Microbiology
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Vectors and Vector-Borne Zoonotic Diseases is about a group of diseases that can infect humans and animals, and that are transmitted by vectors. These diseases are called vector-borne zoonotic diseases. This book is meant to be used by veterinarians, medical doctors, entomologists, and other experts, as well as students, animal owners, nature lovers, etc. The book has several sections: ""Introduction,"" ""Vectors"", ""Vector-Borne Diseases and Pathogens,"" and ""Vector Control."" Each of the sections concerns one stage of a vector-borne disease. Each group of authors has dedicated their work to one of the topics with key roles on pathogens or vectors that are of great public health interest in their country or region. In this book, the authors have tried to show which vectors and diseases are the most interesting, having in mind that their spreading represents a danger to health. With this book, we hope to broaden readers' knowledge by sharing experiences with vector-borne diseases,with the aim to upgrade the knowledge of general public health from a One Health perspective.

Osteoarthritis Biomarkers and Treatments

Authors: ---
Book Series: Rheumatology ISSN: 26319233 ISBN: 9781789857375 9781789857382 Year: Volume: 2 Pages: 114 DOI: 10.5772/intechopen.76957 Language: English
Publisher: IntechOpen
Subject: Microbiology
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This book presents exclusive and comprehensive insight into the detailed molecular mechanisms of osteoarthritis (OA) initiation, progression and current advancements in the field. Inputs from clinician scientists, research and expertise offer a complete explanation of the current understanding of the pathogenesis of OA and practice in imaging and treatments strategies. Contributions from leading scientists provide a detailed introduction in the use of biomarkers in clinical research as well as in clinical practice and OA diagnosis. This book further discusses the potential of regenerative therapies and recent advances in cardiovascular and functional capacity on patients with OA.

Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods

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ISBN: 9781789857894 9781789857900 Year: Pages: 152 DOI: 10.5772/intechopen.78751 Language: English
Publisher: IntechOpen
Subject: Microbiology
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To prevent bacterial adherence, invasion and infection, antimicrobials such as antibiotics are being used and vastly researched nowdays. Several factors such as natural selection, mutations in genes, the presence of efflux pumps, impermeability of the cell wall, structural changes in enzymes and receptors, biofilm formation, and quorum sensing cause microorganisms to develop resistance against antimicrobials. Isolates that synthesize extended spectrum-β-lactamases (ESBL), induced β-lactamases (IBL), carbapenamases, metallo-β-lactamases (MBLs), and New Delhi metallo-β-lactamases (NDM) have emerged. Determining virulence factors such as biofilms and the level of antimicrobial activities of antimicrobial agents alone and in combination with appropriate doses against microorganisms is very important for the diagnosis, inhibition, and prevention of microbial infection. The goal of this book is to provide information on all these topics.

Autoantibodies and Cytokines

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ISBN: 9781789848526 9781789848533 Year: Pages: 216 DOI: 10.5772/intechopen.68834 Language: English
Publisher: IntechOpen
Subject: Microbiology
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The mechanism of autoantibodies cannot be explained without the detail knowledge of cytokines and interferon. These active molecules of immunology are very much dependent on each other and their function cannot be completed without their interaction towards each other. Currently, this the most updated book on this subject that helps the readers/students to upgrade their knowledge by going through chapter by chapter. Contribution by the renounced authors across the globe makes this book really unique and consider as one of the most updated textbook on this subject. This book provides a comprehensive guide to the function and types of autoantibodies and cytokines in basic and clinical field.

Parasites and Parasitic Diseases

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ISBN: 9781838801274 9781838801281 Year: Pages: 98 DOI: 10.5772/intechopen.73726 Language: English
Publisher: IntechOpen
Subject: Animal Sciences --- Microbiology
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Parasitic diseases are considered nowadays as an important public health problem due to the high morbidity and mortality rates registered in the world. These diseases result in more severe consequences for the social order of tropical and subtropical countries because many of them have low economic income that makes it even more difficult to design and implement health control programs. This situation opens the door to the emergence and reemergence of these diseases; therefore, it is convenient, necessary, and essential to study and update the epidemiological behavior of tropical diseases with the objective of offering official health professionals and institutions current information for decision-making in this area to ensure social welfare.

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