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Recent Progress in Solid Dispersion Technology

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ISBN: 9783039215010 / 9783039215027 Year: Pages: 204 DOI: 10.3390/books978-3-03921-502-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

Silicon-Based Nanomaterials: Technology and Applications

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ISBN: 9783039210428 / 9783039210435 Year: Pages: 94 DOI: 10.3390/books978-3-03921-043-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-06-26 08:44:06
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Silicon has been proven to be remarkably resilient as a commercial electronic material. The microelectronics industry has harnessed nanotechnology to continually push the performance limits of silicon devices and integrated circuits. Rather than shrinking its market share, silicon is displacing “competitor” semiconductors in domains such as high-frequency electronics and integrated photonics. There are strong business drivers underlying these trends; however, an important contribution is also being made by research groups worldwide, who are developing new configurations, designs, and applications of silicon-based nanoscale and nanostructured materials. This Special Issue features a selection of papers which illustrate recent advances in the preparation of chemically or physically engineered silicon-based nanostructures and their application in electronic, photonic, and mechanical systems.

Beverage Sensory Modification

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ISBN: 9783039213931 / 9783039213948 Year: Pages: 104 DOI: 10.3390/books978-3-03921-394-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-12-09 11:49:15
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This Special Issue on “Beverage Sensory Modification” presents a series of articles that feature the broad sense of sensory modification with regards to beverages, either by improving their flavor, taste, and mouthfeel properties, or through prevention of spoilage. The scope goes further than the usual technological measures that modulate sensory properties and includes psychological and cross-modal influences, where the sensory modification occurs in the subject’s brain rather than as a result of modified physical–chemical properties of objects.

Welfare of Cultured and Experimental Fishes

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ISBN: 9783039217106 / 9783039217113 Year: Pages: 132 DOI: 10.3390/books978-3-03921-711-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Animal Sciences
Added to DOAB on : 2019-12-09 11:49:16
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Welfare is a multidimensional concept that can be described as the state of an animal as it copes with the environment. Captive environments can impact farmed animals at different levels, especially fishes, considering their highly complex sensory world. Understanding the ethology of a species is therefore essential to address fish welfare, and the interpretation of behavioral responses in specific rearing contexts (aquaculture or experimental contexts) demands knowledge of their underlying physiological, developmental, functional, and evolutionary mechanisms. In natural environments, the stress response has evolved to help animals survive challenging conditions. However, animals are adapted to deal with natural stressors, while anthropogenic stimuli may represent stressors that fishes are unable to cope with. Under such circumstances, stress responses may be maladaptive and cause severe damage to the animal. As welfare in captivity is affected in multiple dimensions, multiple possible indicators can be used to assess the welfare state of individuals. In the past, research on welfare has been largely focusing on health indicators and predominantly based on physiological stress. Ethological indicators, however, also integrate the mental perspective of the individual and have been gradually assuming an important role in welfare research: behavioral responses to stressors are an early response to adverse conditions, easily observable, and demonstrative of emotional states. Many behavioral indicators can be used as non-invasive measurements of welfare in practical contexts such as aquaculture and experimentation. Presently, research in fish welfare is growing in importance and interest because of the growing economic importance of fish farming, the comparative biology opportunities that experimental fishes provide, and the increasing public sensitivity to welfare issues.

Electrospun and Electrosprayed Formulations for Drug Delivery

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ISBN: 9783038979128 / 9783038979135 Year: Pages: 190 DOI: 10.3390/books978-3-03897-913-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 10:09:00
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This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.

Ultrasound B-mode Imaging: Beamforming and Image Formation Techniques

Authors: --- ---
ISBN: 9783039211999 / 9783039212002 Year: Pages: 146 DOI: 10.3390/books978-3-03921-200-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Ultrasound medical imaging stands out among the other diagnostic imaging modalities for its patient-friendliness, high temporal resolution, low cost, and absence of ionizing radiation. On the other hand, it may still suffer from limited detail level, low signal-to-noise ratio, and narrow field-of-view. In the last decade, new beamforming and image reconstruction techniques have emerged which aim at improving resolution, contrast, and clutter suppression, especially in difficult-to-image patients. Nevertheless, achieving a higher image quality is of the utmost importance in diagnostic ultrasound medical imaging, and further developments are still indispensable. From this point of view, a crucial role can be played by novel beamforming techniques as well as by non-conventional image formation techniques (e.g., advanced transmission strategies, and compounding, coded, and harmonic imaging). This Special Issue includes novel contributions on both ultrasound beamforming and image formation techniques, particularly addressed at improving B-mode image quality and related diagnostic content. This indeed represents a hot topic in the ultrasound imaging community, and further active research in this field is expected, where many challenges still persist.

Power Quality in Microgrids Based on Distributed Generators

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ISBN: 9783039280063 / 9783039280070 Year: Pages: 194 DOI: 10.3390/books978-3-03928-007-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-01-07 09:08:26
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This book comprises ten articles covering different aspects of power quality issues in microgrids and distributed generation (DG) systems, including 1) Detection and estimation of power quality; 2) Modeling; 3) Harmonic control for DG systems and microgrids; 4) Stability improvements for microgrids. Different power quality phenomena and solution were studied in the included papers, such as harmonics, resonance, frequency deviation, voltage sag, and fluctuation. From a network point of view, some papers studied the harmonic and stability issues in standalone microgrids which are more likely to cause power quality problems. Other papers discussed the power quality problems in microgrids which are weakly interconnected with the main distribution grid. In view of the published papers, there is a trend that increasingly advanced modeling, analysis, and control schemes were applied in the studies. Moreover, the latest works focus not only on single-unit problems but also multiple units or network issues. Although some of the hot topics are not included, this book covers multiple aspects of the current power quality research frontier, and represents a particularly useful reference book for frontier researchers in this field.

Clean Energy and Fuel (Hydrogen) Storage

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ISBN: 9783039216307 / 9783039216314 Year: Pages: 278 DOI: 10.3390/books978-3-03921-631-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Clean energy and fuel storage are often required for both stationary and automotive applications. Some of these clean energy and fuel storage technologies currently under extensive research and development include hydrogen storage, direct electric storage, mechanical energy storage, solar–thermal energy storage, electrochemical (batteries and supercapacitors), and thermochemical storage. The gravimetric and volumetric storage capacity, energy storage density, power output, operating temperature and pressure, cycle life, recyclability, and cost of clean energy or fuel storage are some of the factors that govern efficient energy and fuel storage technologies for potential deployment in energy harvesting (solar and wind farms) stations and onboard vehicular transportation. This Special Issue thus serves the need for promoting exploratory research and development on clean energy and fuel storage technologies while addressing their challenges to practical and sustainable infrastructures.

Keywords

dye-sensitized solar cells --- carbon materials --- Ag nanoparticles --- freestanding TiO2 nanotube arrays --- gas turbine engine --- lean direct injection --- four-point --- low emissions combustion --- carbonate gas reservoirs --- water invasion --- recovery factor --- aquifer size --- production rate --- hydrogen storage --- complex hydrides --- nanocatalyst --- LiNH2 --- MgH2 --- ball milling --- Li-ion batteries --- nanocomposite materials --- cathode --- anode --- binder --- separator --- ionic liquid --- vertically oriented graphene --- electrical double layers --- charge density --- capacitance --- gas storage --- material science --- rock permeability --- synthetic rock salt testing --- Klinkenberg method --- hydrogen storage systems --- hydrogen absorption --- thermochemical energy storage --- metal hydride --- magnetism --- heat transfer enhancement --- Power to Liquid --- Fischer–Tropsch --- dynamic modeling --- lab-scale --- lithium-ion batteries --- simplified electrochemical model --- state of charge estimator --- extended kalman filter --- hot summer and cold winter area --- PCM roof --- comprehensive incremental benefit --- conjugate phase change heat transfer --- lattice Boltzmann method --- large-scale wind farm --- auxiliary services compensation --- battery energy storage system --- optimal capacity --- equivalent loss of cycle life --- hydrogen storage --- porous media --- bacterial sulfate reduction --- methanogenesis --- gas loss --- diffusion --- reactive transport modeling --- PHREEQC --- energy discharge --- bubbles burst --- bubbles transportation --- crystal growth rates --- undercooling --- salt cavern --- leaching tubing --- flutter instability --- flow-induced vibration --- internal and reverse external axial flows --- thermal energy storage (TES) --- slag --- regenerator --- concentrated solar power (CSP) --- quality function deployment (QFD) --- failure mode and effect analysis (FMEA) --- thermal energy storage --- electrochemical energy storage --- hydrogen energy storage --- salt cavern energy storage

Computational Methods for Fracture

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ISBN: 9783039216864 / 9783039216871 Year: Pages: 404 DOI: 10.3390/books978-3-03921-687-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Computer Science
Added to DOAB on : 2019-12-09 11:49:16
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This book offers a collection of 17 scientific papers about the computational modeling of fracture. Some of the manuscripts propose new computational methods and/or how to improve existing cutting edge methods for fracture. These contributions can be classified into two categories: 1. Methods which treat the crack as strong discontinuity such as peridynamics, scaled boundary elements or specific versions of the smoothed finite element methods applied to fracture and 2. Continuous approaches to fracture based on, for instance, phase field models or continuum damage mechanics. On the other hand, the book also offers a wide range of applications where state-of-the-art techniques are employed to solve challenging engineering problems such as fractures in rock, glass, concrete. Also, larger systems such as fracture in subway stations due to fire, arch dams, or concrete decks are studied.

Keywords

plate --- FSDT --- HSDT --- Mindlin --- incompatible approximation --- fracture --- screened-Poisson model --- gradient-enhanced model --- damage-plasticity model --- implicit gradient-enhancement --- rock --- shear failure --- elastoplastic behavior --- extended scaled boundary finite element method (X-SBFEM) --- stress intensity factors --- fracture process zone (FPZ) --- thermomechanical analysis --- moderate fire --- finite element simulations --- metallic glass matrix composite --- finite element analysis --- shear band --- microstructure --- ductility --- peridynamics --- fatigue --- rolling contact --- damage --- rail squats --- cracks --- steel reinforced concrete frame --- reinforced concrete core tube --- progressive collapse analysis --- loss of key components --- self-healing --- damage-healing mechanics --- super healing --- anisotropic --- brittle material --- Brittle Fracture --- cell-based smoothed-finite element method (CS-FEM) --- Phase-field model --- ABAQUS UEL --- the Xulong arch dam --- yielding region --- cracking risk --- overall stability --- dam stress zones --- concrete creep --- prestressing stress --- compressive stress --- FE analysis --- force transfer --- grouting --- fracture network modeling --- numerical simulation --- fluid–structure interaction --- bulk damage --- brittle fracture --- rock fracture --- random fracture --- Mohr-Coulomb --- Discontinuous Galerkin --- EPB shield machine --- conditioned sandy pebble --- particle element model --- parameters calibration --- geometric phase --- photonic orbital angular momentum --- topological insulator --- topological photonic crystal --- fatigue crack growth --- surface crack --- crack shape change --- three-parameter model --- LEFM --- XFEM/GFEM --- SBFEM --- phase field --- n/a

Recent Advances in Urban Ventilation Assessment and Flow Modelling

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ISBN: 9783038978060 9783038978077 Year: Pages: 448 DOI: 10.3390/books978-3-03897-807-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General)
Added to DOAB on : 2019-04-25 16:37:17
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This book contains twenty-one original papers and one review paper published by internationally recognized experts in the Atmosphere Special Issue ""Recent Advances in Urban Ventilation Assessment and Flow Modelling"", years 2017&ndash;2019. The Special Issue includes contributions on recent experimental and modelling works, techniques, and developments mainly tailored to the assessment of urban ventilation on flow and pollutant dispersion in cities. The study of ventilation is of critical importance, as it addresses the capacity with which a built urban structure is capable of replacing the polluted air with ambient fresh air. Here, ventilation is recognized as a transport process that improves local microclimate and air quality and closely relates to the term &ldquo;breathability&rdquo;. The efficiency with which street canyon ventilation occurs depends on the complex interaction between the atmospheric boundary layer flow and the local urban morphology.The individual contributions to this Issue are summarized and categorized into four broad topics: (1) outdoor ventilation efficiency and application/development of ventilation indices, (2) relationship between indoor and outdoor ventilation, (3) effects of urban morphology and obstacles to ventilation, and (4) ventilation modelling in realistic urban districts. The results and approaches presented and proposed will be of great interest to experimentalists and modelers, and may constitute a starting point for the improvement of numerical simulations of flow and pollutant dispersion in the urban environment, for the development of simulation tools, and for the implementation of mitigation strategies.

Keywords

street canyon --- seasonal variation --- air flow --- pollutant dispersion --- pollutant removal --- natural ventilation --- residential wind environments --- building arrangements --- space pattern --- ventilation efficiency --- CFD simulation --- air change rate (ACH) --- flow and turbulence profiles --- hypothetical urban areas --- street-level ventilation --- ventilation assessment --- wind-tunnel dataset --- street vegetation --- CFD --- aerodynamic and deposition --- tree scenarios --- urban planning --- indoor-outdoor --- mass concentration --- nanoparticles --- particle number concentration (PNC) --- PM10 --- PM2.5 --- sampling --- Total Suspended Particles (TSP) --- ultrafine particles (UFP) --- urban street canyon --- wind enhancement --- architectural intervention --- water channel experiment --- CFD simulation --- passive ventilation --- street canyon --- computational fluid dynamics (CFD) --- ventilation effectiveness --- the age of air --- convective boundary layer --- LES --- street-level ventilation --- small open space --- air change rate per hour (ACH) --- concentration decay method --- urban age of air --- computational fluid dynamic (CFD) simulation --- natural ventilation --- residential building --- climate zone --- thermal comfort --- natural ventilation hour --- Japan cities --- building energy use --- inter-building effect --- highly-reflective building envelope --- BEopt analysis --- source apportionment --- data assimilation --- urban air quality modelling --- wind environment --- Natural Ventilation Potential (NVP) --- PM2.5 --- building–tree grouping patterns --- Computational Fluid Dynamics (CFD) --- LES --- ventilation --- urban planning --- dispersion --- air quality --- street canyon --- traffic tidal flow --- numerical simulation --- vehicular pollution --- non-uniform distribution of the pollution source --- on-road air quality --- traffic composition --- high emitting vehicles --- street canyon --- mobile laboratory --- CFD model --- heat loss --- optimisation --- residential building --- air quality --- carbon dioxide concentration --- ventilation system --- wind pressure coefficient --- airflow network --- multiple linear regression --- natural ventilation --- urban layout --- surrogate model --- schematic urban environment --- wind tunnel --- LES --- validation --- street canyon --- coherent structures --- road tunnel --- natural ventilation --- wind catcher --- intake fraction --- street canyon --- CFD --- Large Eddy Simulation (LES) --- urban air quality --- pedestrian exposure --- concentration fluctuation --- outdoor ventilation --- urban morphology --- building site coverage --- ventilation efficiency --- n/a

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