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Disclosure Within HIV-Affected Families

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455263 Year: Pages: 130 DOI: 10.3389/978-2-88945-526-3 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-01-23 14:53:42
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While HIV/AIDS is a global public heath challenge, its impact is arguably greatest in the Sub-Saharan Africa (SSA), where new infections account for approximately 66% of the total number of HIV-positive persons globally. In SSA, medical, social, and economic resources are limited, thus necessitating innovative approaches to disease prevention. One of the mechanisms of prevention that is most promising occurs through HIV disclosure to family members (e.g., adult sexual partners) generally, and to children in particular. Our emphasis in this eBook is on HIV disclosure to children because it has multiple benefits, including improved adherence to antiretroviral medication treatment and understanding at an early age of the impact of sexual activity on the spread of HIV. While there is a noticeable gap in research on HIV disclosure to younger children, some of the general reasons for non-disclosure include concerns about fear of adult partners leaving relationships, and that children are too young to comprehend the severity of the situation and may tell others outside the family. Thus, it is critical to better understand how the HIV disclosure process happens (or does not happen) within HIV-affected families, as well as the best practices on how to disclose. In this eBook, we present a combination of empirical research studies and critical literature reviews that investigate the reasons for and for not disclosing HIV status within HIV-affected families and provide evidence-based practices that could be adopted by healthcare professionals to help HIV-positive parents facilitate disclosure activities within these families. This information can also be used by researchers, practitioners, and stakeholders who are in a position to influence policies on effective HIV disclosure practices, guidelines, and programs.

HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454617 Year: Pages: 171 DOI: 10.3389/978-2-88945-461-7 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2018-11-16 17:17:57
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Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarged during HIV-1 infection. Antibodies with the capacity to neutralize a broad range of HIV-1 isolates can be detected only in a minority of infected patients, after a year or more from acute infection. An open question is whether the inability of producing neutralizing HIV-1 antibodies is somehow linked to the B cell immunopathology observed in patients. In this research topic we invited scientists to summarize the current state of knowledge on regulation and development of B cells and antibody responses during HIV-1 infection; fifteen contributions were received comprising both reviews and original articles. The articles are related to B cell dysfunctions identified in HIV-1 infected individuals, production of different types of antibodies (neutralizing versus non neutralizing, and of different isotypes) in vivo during HIV-1 infection and the biological factors which may impact on this process, clinical potential and applications of anti-HIV antibodies and how to achieve neutralizing antibody responses to HIV-1 epitopes upon vaccination. The topic has gathered articles on front-line research undertaken in the field of B cells and antibodies in HIV-1 infection. It is our hope that the collection of articles presented in this book may be useful for new and experienced scholars in the field and add a piece to the complex puzzle of knowledge needed for the development of an HIV-1 vaccine.

Macromolecular Structure Underlying Recognition in Innate Immunity

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455270 Year: Pages: 151 DOI: 10.3389/978-2-88945-527-0 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2019-01-23 14:53:42
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Immune molecules have evolved to distinguish “self “molecules from “non-self”, “altered self” and “danger” molecules. Recognition is mediated via interactions between pattern recognition receptor molecules (PPRs) and their ligands, which include hydrophobic and electrostatic interactions between amino acid residues on the PPRs and uncharged or charged groups on amino acid residues, sugar rings or DNA/RNA molecules. Recognition in innate immunity range from cases (C1q, mannin-binding protein etc) where recognition is orchestrated by interaction between many ligands with one receptor molecule, and density of interaction is necessary for strong specific recognition, distinct from weak non-specific binding, and cases such as TLRs and NLRs where recognition involves complexation of single receptor and ligand, followed by oligomerisation of the receptor molecule. The majority of PPR molecules bind and recognise a wide variety of ligands, e.g TLR4 recognises LPS (gram negative bacteria), Lipotechoic acid (gram positive bacteria), heat shock protein hsp60, respiratory syncytial virus fusion protein etc, molecules that are structurally dissimilar to each other. This indicates considerable flexibility in their binding domains (amino acid residue variations) and modes (hydrophobic and charged, direct or mediated via an adaptor molecule). However, in many cases there is a dearth of structural and molecular data available, required to delineate the mechanism of ligand binding underlining recognition in pathogen receptors in innate immunity. Insights into requirements of conformation, charge, surface etc in the recognition and function of innate immunity receptors and their activation pathways, based on current data can suggest valuable avenues for future work.

Empirical Analysis of Determinants, Distribution and Dynamics of Poverty

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Book Series: Goettinger Studien zur Entwicklungsoekonomik / Goettingen Studies in Development Economics ISBN: 9783631573983 Year: Pages: 204 DOI: 10.3726/b13880 Language: English
Publisher: Peter Lang International Academic Publishing Group
Subject: Economics --- Political Science
Added to DOAB on : 2019-01-15 13:32:27
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Poverty and inequality persist in many dimensions in the developing world. In order to understand the determinants of poverty and its distribution between and within countries, it is necessary to know its dimensions and the channels through which poverty and inequality affect human well-being. This book analyzes the spatial disparities of the outcomes and determinants of poverty, the interdependencies of dimensions of poverty, the distribution of progress in human development over the population and the dynamics of poverty risk over time. The study takes into account the global spread of poverty. Based on cross-country comparisons of countries from Africa, Latin America, and South Asia, this study does not only consider on average outcomes and determinants of different indicators of human well-being, but also examines their distribution between and within countries.

The Future of Catholic Theological Ethics

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ISBN: 9783038427711 9783038427728 Year: Pages: 94 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences
Added to DOAB on : 2018-03-26 15:53:35
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'The Future of Catholic Theological Ethics' undertakes a search for new ways of making Catholic theological ethics relevant. It engages with a ground-breaking publication 'Reframing Catholic Theological Ethics' (Oxford University Press, 2016) by Joseph Selling, Emeritus Professor of Moral Theology, Catholic University Leuven. Selling opens the volume with a summary of the approach he developed in the above work. The papers presented here cover several major themes that, traditionally, Catholic theological ethics have considered but, according to the authors of the papers, need revisiting. Amongst these themes are: conscience, virtue, natural law, authority, ecumenism, the human person and the theology of theological ethics. The writers represent a variety of approaches, geographical locations and while most of them are Roman Catholic, there is an imbedded ecumenism and interreligious and inter-cultural slant in several discussions. The authors agree that Catholic theological ethics, in order to be relevant, it needs to become more context-sensitive, ecumenical, practice-based, experience-oriented, continuously discerning, pedagogically wide-ranging and theologically articulate. It must be unceasingly willing to review and renew its method as well as revisit its key concepts. It must neither dismiss its long tradition nor stick to its single interpretation.

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