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Human Skin Cancers - Pathways, Mechanisms, Targets and Treatments

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ISBN: 9781789230949 9781789230956 Year: Pages: 212 DOI: 10.5772/68061 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:51

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Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.

Cancer Causing Substances

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ISBN: 9781789231403 9781789231410 Year: Pages: 80 DOI: 10.5772/intechopen.68247 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:51

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Cancer risk factors include exposure to certain substances, which may contribute to the development of cancer. However, substances can have different levels of cancer-causing potential, and the risk of developing cancer is dependent on several factors, including individual genetic background and the amount and duration of the exposure. This book focuses on various cancer risk factors, covering numerous known, probable, and possible carcinogens; their role in carcinogenesis; mechanisms of carcinogenicity; and methods for detecting carcinogens. And due to the growing concerns over the effects that substances and environmental exposures can have on human health, the chapters also emphasize on the vital need for further topic-related research as well as development and implementation of beneficial approaches.

Cervical Cancer - Screening, Treatment and Prevention - Universal Protocols for Ultimate Control

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ISBN: 9781789231441 9781789231458 Year: Pages: 130 DOI: 10.5772/intechopen.70225 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:51

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This book entitled Cervical Cancer - Screening, Treatment and Prevention Universal Protocols for Ultimate Control is the fourth successful endeavor of the Editor with InTech publisher. The four books serve as four pillars in cervical cancer control, globally. This book is unique and sensational. Public health ""topics"" are assuming a status of ""phenomenon,"" through deliberations and research. Screening is riddled with global limitations of availability, affordability, acceptability, and accessibility. The treatment of precancers has questionable efficiency. Prevention is costly with the inclusion of HPV vaccine. This book helps to find the solutions. The authors, editor, and InTech publisher wish the readers a pleasant and purposeful reading. This book is a ""readers' feast,"" ""receivers' choice,"" and ""respondents' delight."" Enjoy and treasure the international facts and flavors.

Brain Tumors - An Update

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ISBN: 9781789235562 9781789235579 Year: Pages: 248 DOI: 10.5772/intechopen.70986 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:51

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We all know that the field of neuro-oncology is heterogeneous and under continuous development with the addition of new knowledge and information on a regular basis. The present book ""Brain Tumor - An Update"" is an attempt to share the personal experiences of experts who are involved in neuro-oncology-related research. Through this book, the authors share their experiences and provide details about the pathophysiology, neuroimaging approaches, and management options, and how to go about decision-making in patients with brain tumors. We hope that the valuable contributions from the authors shall facilitate understanding about brain tumors. I am grateful to all the authors who have contributed their tremendous expertise, and I would like to acknowledge the outstanding support of Ms. Danijela Sakic, Author Service Manager, IntechOpen Science, who collaborated tirelessly in crafting this book.

Advances in Pancreatic Cancer

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ISBN: 9781789236408 9781789236415 Year: Pages: 224 DOI: 10.5772/intechopen.72393 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:51

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Pancreatic cancer is a growing source of cancer-related death and has poor survival rates, which have not improved in the last few decades. Its high-mortality rate is attributed to pancreatic cancer biology, difficulty in early diagnosis, and lack of standardized international guidelines in assessing the pancreatic masses. This book aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of the available diagnostic technology and therapy. The main modalities for diagnosis are imaging with HCT, MRI, USE, and PET. Some chapters review the improvements in the techniques used. Timely and accurate diagnosis of pancreatic cancer can lead to improve in the current poor outcome of this disease.

Ovarian Cancer - From Pathogenesis to Treatment

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ISBN: 9781789843330 9781789843347 Year: Pages: 364 DOI: 10.5772/66599 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:52

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Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Lung Cancer - Strategies for Diagnosis and Treatment

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ISBN: 9781789843491 9781789843507 Year: Pages: 204 DOI: 10.5772/intechopen.71993 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:52

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Among the deadliest type of cancers, lung cancer faces several challenges in diagnosis and treatment: late diagnosis and misdiagnosis, inadequate tumor sampling, and resistance development to current therapies, among others. Together with advances in the understanding of molecular features, factors, and mechanisms involved in initiation and tumor progression, important improvements have occurred in diagnostics and therapeutics in the shape of advances in molecular genotyping, procedures for sampling, new potential, and less invasive sources of samples for the diagnosis and development of new targeted therapies. The aim of this book is to provide an exciting read on strategies in the diagnosis and therapy of lung cancer.

Esophageal Cancer and Beyond

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ISBN: 9781789844122 9781789844139 Year: Pages: 92 DOI: 10.5772/intechopen.73883 Language: English
Publisher: IntechOpen
Subject: Oncology
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Human life relies on two basic supplies from nature: oxygen and food. Oxygen can be utilized directly, but food has to go through a process of digestion to become usable nutrients. The esophagus represents the beginning of this long journey. Because of its critical location, esophageal cancer is one of the deadliest malignancies in the world, and furthermore its incidence has been rising steadily year after year while other cancers are declining. It is predicted that by the year 2035 the esophageal cancer population will increase by 77.4% and become one of top global concerns. This book covers many aspects of esophageal cancer, through which we hope to raise the awareness of professionals as well as non-professionals about this disease.

Breast Cancer and Surgery

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ISBN: 9781789235661 9781789235678 Year: Pages: 226 DOI: 10.5772/intechopen.71739 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:52

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The book 'Breast Cancer and Surgery' summarizes the treatment options from the onset of breast carcinogenesis to early-local advanced and metastatic breast cancer. Chemotherapy alternatives, drug resistance and local and surgical treatment preferences are extensively discussed and this information is especially directed at clinicians, researchers, and students. This book includes a comparison between different chemotherapy agents and targeted therapies with published phase II-III studies. The importance of palliative care and dietary supplements administered during the treatment course in reducing the comorbidity of patients is emphasized. Photodynamic treatments have been included in this book. A comprehensive and up-to-date information exchange that can be accessed through a single source is provided to all researchers interested in breast cancer.

Liver Cancer

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ISBN: 9781789844481 9781789844498 Year: Pages: 186 DOI: 10.5772/intechopen.73806 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:52

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This book offers remarkable coverage of liver cancer from etiology to prevention and treatment. It provides an updated and new vision of this major cancer that continues to affect hundreds of thousands of people and remains one of the leading causes of cancer deaths around the world. To ensure the high quality of this book, important insights are included and rigorously discussed in a simple and authentic way. The book includes detailed and updated descriptions of the main causes of liver cancer and also the prevention and treatment of this disease. This book is a relevant source of knowledge, very useful for researchers, medical doctors, medical residents, students, healthcare providers, public health decision makers, and all individuals interested in the prevention of this disease.

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