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Molecular Docking

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ISBN: 9781789233544 9781789233551 Year: Pages: 188 DOI: 10.5772/intechopen.69830 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:51

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Molecular docking has always been and will be on the forefront of developments in the eminent field of drug design and medicinal chemistry. At the early days, drug discovery was based on blackboard drawings and expert intuition. However, as times move on, the amount of available information and overall knowledge base that needs to be analyzed cannot be processed manually. This, coupled by the rapid growth in computational infrastructure and processing power, has allowed for the efficient use of molecular docking tools and algorithms to be considered in the greater field of drug discovery. In the postgenomic era, molecular docking has become the key player for the screening of hundreds of thousands of compounds against a repertoire of pharmacological targets.

Free Radicals, Antioxidants and Diseases

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ISBN: 9781789235647 9781789235654 Year: Pages: 148 DOI: 10.5772/intechopen.70075 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:51

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The current book entitled Free Radicals, Antioxidants, and Diseases gives an idea of detecting free radicals in vivo by newer techniques and provides insights into the roles played by various antioxidants in combating diseases caused by oxidative stress. The chapters included in this volume showcase new investigation in this field by the research groups around the world.

Glutathione in Health and Disease

Authors: ---
ISBN: 9781789842753 9781789842760 Year: Pages: 92 DOI: 10.5772/intechopen.70965 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:52

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Reduced glutathione (GSH) is the most important thiol in living organisms. It is the key component of antioxidant system and serves as a free radical scavenger. There is a cycle of GSH in biological systems and this cycle provides higher intracellular levels of GSH. GSH depletion and apparent oxidative stress may cause toxicity and can affect the general well-being of the organism. GSH was shown to be preventive against aging, cancer, heart disease, infections and dementia. This book is mainly focused on GSH in health and disease. The readers will gain qualified scientific knowledge on the diverse functions of GSH, the importance of GSH status against oxidative stress and the interaction between GSH and nervous system-related infections from this book.

Polypeptide - New Insight into Drug Discovery and Development

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ISBN: 9781789234640 9781789234657 Year: Pages: 88 DOI: 10.5772/intechopen.68638 Language: English
Publisher: IntechOpen
Subject: Biology
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Peptides are the biomolecules that consist of several amino acid chains linked through peptide bonds. This class of biomolecules is commonly found in living matter, and some of which play an imperative role in their regulation and functional activities. Peptides have been extensively applied in every aspect of human life, including cosmetics, electronics, the food industries, and pharmaceutical fields. Ultimately, peptide commercialization has become a major trend, which has been growing significantly in recent years. Viewed from the scientific perspective described above, the editor believes that the development of peptides in every aspect of human life should be accelerated. As such, this book aims to provide insight and knowledge regarding the current research that has been conducted in this field; hence, this book may encourage the reader to emphasize the importance of peptides in human life and to inspire others to identify the potency of peptides for other applications that still need further exploration. In this book, some of the compelling applications of peptides in biological and health sciences will be introduced. This book comprises an introductory chapter, along with four chapters presented by several prominent scientists who work in the field of peptide research.

New Trends in Ion Exchange Studies

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ISBN: 9781789842470 9781789842487 Year: Pages: 92 DOI: 10.5772/intechopen.72067 Language: English
Publisher: IntechOpen
Subject: Biology --- Genetics --- Biochemistry
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This book covers new systems in technology that have developed our knowledge of ion exchange. This book discusses ion exchange resins to enhance cell growth; anion exchange membrane; nanosystems in ion exchange and ion exchange in environmental applications. The ion exchange system is used in bionanotechnology, cosmetic industry and water treatment.

Evolutionary Physiology and Biochemistry - Advances and Perspectives

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ISBN: 9789535138570 9789535138587 9789535139676 Year: Pages: 242 DOI: 10.5772/64635 Language: English
Publisher: IntechOpen
Subject: Microbiology
Added to DOAB on : 2019-10-03 07:51:50

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In 2016, it was 60 years since the eminent Soviet researcher, a disciple and a successor of Ivan Pavlov, Leon Orbeli had proclaimed the birth of a new branch of physiology, evolutionary physiology. In the same year, his ideas were embodied in the foundation in Leningrad, now Saint Petersburg, of the present Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences. This anniversary book includes the selected works carried out recently by his followers at the same institute. While addressing some hot aspects of evolutionary physiology and biochemistry, they demonstrate that this branch of physiology really represents a discipline in its own right.

Stem Cells in Clinical Practice and Tissue Engineering

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ISBN: 9781789230109 9781789230116 Year: Pages: 352 DOI: 10.5772/65995 Language: English
Publisher: IntechOpen
Subject: Cytology
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Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Bacterial Pathogenesis and Antibacterial Control

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ISBN: 9781789231601 9781789231618 Year: Pages: 154 DOI: 10.5772/intechopen.68288 Language: English
Publisher: IntechOpen
Subject: Animal Sciences --- Microbiology
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Bacterial pathogens have been becoming the main problem in hospital and community-acquired infections. It is hard to treat the strains that are resistant to antibiotics, due to the causing recurrent and untreatable infections. In recent years, the combination treatments and the novel technologies have been preferred to overcome the emergence of antibacterial resistance of pathogens. In this book, examples of pathogenesis by clinical cases, control by antibiotics and bioactive antimicrobials, control by novel technologies with the collection of up-to-date researches and reviews are presented. This book can be useful for researchers interested in antibacterials, bioactive compounds, and novel technologies.

Current Topics in Zika

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ISBN: 9781789232707 9781789232714 Year: Pages: 98 DOI: 10.5772/65145 Language: English
Publisher: IntechOpen
Subject: Animal Sciences --- Microbiology
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Zika was an arbovirus not considered relevant until the epidemics of 2007, where in the islands of the Pacific, Yap, Micronesia, and others, and later in the Americas in 2015-2016, it created a significant public health threat. Zika is a flavivirus that has been especially important not just for the high number of cases but also for its related morbidity. In the case of adult population, multiple neurological diseases are already associated and in pregnant women because of its confirmed teratogenic capacity, leading to microcephaly as well as other central nervous system (CNS) birth defects. This book tried to update the significant epidemiological and clinical research in many aspects with a multinational perspective.

Cancer Management and Therapy

Authors: ---
ISBN: 9781789232981 9781789232998 Year: Pages: 210 DOI: 10.5772/intechopen.68267 Language: English
Publisher: IntechOpen
Subject: Oncology
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There are many different types of cancer. Some are very common; others are rare. Having some similar features, each cancer has its own characteristics and symptoms, which vary according to the type of cancer and where it is in the body. The treatment selected may be influenced by the patient's age, concurrent health problems, life expectancy, characteristics of the individual's cancer, the patient's goals of treatment, and the bias of the treating physician. In preparing this book, we have considered and reflected on the concept of the recent advances in cancer management and therapy as well as molecular applications in cancer therapy. The readers can find detailed information about the treatment and management of specific cancers in these book chapters.

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