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Bone Marrow T Cells at the Center Stage in Immunological Memory

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450930 Year: Pages: 84 DOI: 10.3389/978-2-88945-093-0 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2017-07-06 13:27:36
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Abstract

Increasing evidence supports the notion that bone marrow (BM) represents a relevant player in T cell responses, particularly in its role as a specialized organ for long-term memory. Memory T cells are enriched in the BM over long times after priming, and can be recruited to the periphery upon antigenic challenge. The articles in this research topic include discussions of whether these T cells are passing-through or truly resident, as well as a debate on the extent of proliferation of BM memory T cells. Original research articles in this collection include an analysis of the number of memory T cells found in different bones as well as effects of B cell depletion on T cell memory in the BM. T cells in the BM can influence a number of processes, from bone remodeling, control of cancer, to effects on hemopoiesis or Graft versus Host Disease (GVHD). This research topic contains several contributions to these topics including discussions on how to translate BM T cell knowledge into medicine.

Inflammation and Cancer

Authors: ---
ISBN: 9783038426080 9783038426097 Year: Pages: VIII, 248 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-12-27 10:02:13
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Based on the most recent clinical and epidemiologic information, one out of seven newly diagnosed epithelial malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. This book draws contributions from international expert researchers from diverse disciplines, who addressed various aspects of experimental and clinical cancer biology, by selectively focusing on inflammation-mediated oncogenesis to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative/therapeutic strategies. This comprehensive and cutting-edge Special Issue “Inflammation and Cancer” promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of fighting the estimated 2200 inflammation-related oncogenesis fatalities occurring every day.

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