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Enzymes from Extreme Environments

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198306 Year: Pages: 103 DOI: 10.3389/978-2-88919-830-6 Language: English
Publisher: Frontiers Media SA
Subject: Biotechnology --- General and Civil Engineering
Added to DOAB on : 2016-01-19 14:05:46
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Enzymes are nature’s biocatalysts empowered with high catalytic power and remarkable substrate specificity. Enzymes perform a wide range of functions throughout nature, and guide the biochemistry of life with great precision. The majority of enzymes perform under conditions considered normal for mesophilic, neutrophilic, terrestrial microorganisms. However, the Earth’s biosphere contains several regions that are extreme in comparison, such as hypersaline lakes and pools, hydrothermal vents, cold oceans, dry deserts and areas exposed to intensive radiation. These areas are inhabited by a large number of extremophilic microorganisms which produce enzymes capable of functioning in unusual conditions. There is an increasing biotechnological and industrial demand for enzymes stable and functioning in harsh conditions, and over the past decade screening for, isolation and production of enzymes with unique and extreme properties has become one of the foremost areas of biotechnology research. The development of advanced molecular biology tools has facilitated the quest for production of enzymes with optimized and extreme features. These tools include large-scale screening for potential genes using metagenomics, engineering of enzymes using computational techniques and site-directed mutagenesis and molecular evolution techniques. The goal of this Research Topic is to present reports on latest advances in enzymes from all types of extreme environments. Contributions dealing with isolation of enzymes from extremophilic microorganisms or directly from natural environments, screening for and expression of enzymes with extreme properties using metagenomic approaches are welcome. In addition, contributions dealing with all forms of biocatalyst production and improvement are welcome, such as fermentation technology, protein engineering, directed evolution, rational design, and immobilization techniques.

Manufacturing Transformation: Comparative Studies of Industrial Development in Africa and Emerging Asia

Authors: --- --- --- --- et al.
Book Series: WIDER Studies in Development Economics ISBN: 9780198776987 Year: Pages: 336 DOI: 10.1093/acprof:oso/9780198776987.001.0001 Language: English
Publisher: Oxford University Press Grant: UNU WIDER
Subject: Economics
Added to DOAB on : 2016-08-05 11:01:21
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While it is possible for economies to grow based on abundant land or natural resources, more often structural change—the shift of resources from low-productivity to high-productivity sectors—is the key driver of economic growth. Structural transformation is vital for Africa. The region’s much-lauded growth turnaround since 1995 has been the result of fewer economic policy mistakes, robust commodity prices, and new discoveries of natural resources. At the same time, Africa’s economic structure has changed very little. Primary commodities and natural resources still account for the bulk of exports. Industry is most often the leading driver of structural transformation. Africa’s experience with industrialization over the past thirty years has been disappointing. In 2010, sub-Saharan Africa’s average share of manufacturing value added in GDP was 10 per cent, unchanged from the 1970s. In fact the share of medium- and high-tech goods in manufacturing production has been falling since the mid-1990s. Per capita manufactured exports are less than 10 per cent of the developing country average. Consequently, Africa’s industrial transformation has yet to take place. This book presents results of comparative country-based research that sought to answer a seemingly simple but puzzling question: why is there so little industry in Africa? It brings together detailed country case studies of industrial policies and industrialization outcomes in eleven countries, conducted by teams of national researchers in partnership with experts on industrial development. It provides the most comprehensive description and analysis available of the contemporary industrialization experience in low-income Africa.

Precarious Claims: The Promise and Failure of Workplace Protections in the United States

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ISBN: 9780520288782 9780520963603 Year: Pages: 190 DOI: 10.1525/luminos.19 Language: English
Publisher: University of California Press
Subject: Law --- Sociology
Added to DOAB on : 2016-10-10 11:01:24
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Precarious Claims tells the human story behind the bureaucratic process of fighting for justice in the U.S. workplace. The global economy has fueled vast concentrations of wealth that have driven a demand for cheap and flexible labor. Workplace violations such as wage theft, unsafe work environments, and discrimination are widespread in low-wage industries such as restaurants, retail, hospitality, and domestic work, where jobs are often held by immigrants and other vulnerable workers. Despite the challenges they face, these workers do seek justice. Why and how do they come forward,and what happens once they do? Based on extensive fieldwork in Northern California, Shannon Gleeson investigates the array of gatekeepers with whom workers must negotiate in the labor standards enforcement bureaucracy and, ultimately, the limited reach of formal legal protections. Gleeson also tracks how workplace injustices—and the arduous process of contesting them—have long-term effects on their everyday lives. Workers sometimes win, but their chances are precarious at best.

The Plight of Older Workers: Labor Market Experience after Plant Closure in the Swiss Manufacturing Sector

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Book Series: Life Course Research and Social Policies ISSN: 2211-7776 ISBN: 9783319397528 9783319397542 Year: Pages: 195 DOI: 10.1007/978-3-319-39754-2 Language: English
Publisher: Springer Nature
Subject: Economics --- Social Sciences
Added to DOAB on : 2017-02-14 10:13:43
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This open access book examines the economic, social, and psychological consequences of manufacturing plant closure at the individual level. Using an original data set of over 1,200 workers from Switzerland who lost their manufacturing jobs after the financial crisis of 2008, the author analyzes the determinants of reemployment, the sector of reemployment, and the change in wages over a two year period. In addition, coverage also explores how plant closure affects the social relationship between a displaced worker and his or her significant other, which includes a discussion of the coping strategies on the household level as well as how changes in a worker's social and occupational life affects overall satisfaction. Readers will discover that the burden of structural change disproportionately falls on the shoulders of workers aged 55 and older who often face substantial barriers when trying to return to employment. A larger portion of this group experience long-term unemployment and those who do manage to find a new job often suffer disproportionate wage loss.This result is intriguing in the context of the current demographic change and contradicts the common assumption that young and low-qualified individuals are at greatest risk of unemployment. Advanced age—and not low education—appears to be the primary obstacle to workers finding job satisfaction after being laid off because of market conditions.

Innovations in Derivatives Markets: Fixed Income Modeling, Valuation Adjustments, Risk Management, and Regulation

Authors: --- --- ---
Book Series: Springer Proceedings in Mathematics & Statistics ISSN: 2194-1009 ISBN: 9783319334455 9783319334462 Year: Volume: 165 Pages: 449 DOI: 10.1007/978-3-319-33446-2 Language: English
Publisher: Springer Nature
Subject: Mechanical Engineering --- Therapeutics --- Biotechnology --- Business and Management --- Chemical Technology
Added to DOAB on : 2017-03-08 12:08:06
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This book presents 20 peer-reviewed chapters on current aspects of derivatives markets and derivative pricing. The contributions, written by leading researchers in the field as well as experienced authors from the financial industry, present the state of the art in:• Modeling counterparty credit risk: credit valuation adjustment, debit valuation adjustment, funding valuation adjustment, and wrong way risk.• Pricing and hedging in fixed-income markets and multi-curve interest-rate modeling.• Recent developments concerning contingent convertible bonds, the measuring of basis spreads, and the modeling of implied correlations.The recent financial crisis has cast tremendous doubts on the classical view on derivative pricing. Now, counterparty credit risk and liquidity issues are integral aspects of a prudent valuation procedure and the reference interest rates are represented by a multitude of curves according to their different periods and maturities.A panel discussion included in the book (featuring Damiano Brigo, Christian Fries, John Hull, and Daniel Sommer) on the foundations of modeling and pricing in the presence of counterparty credit risk provides intriguing insights on the debate.

Nurse Writers of the Great War

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Book Series: Nursing History and Humanities ISBN: 9781784992521 9781526129352 Year: Language: English
Publisher: Manchester University Press Grant: Knowledge Unlatched - 100814
Subject: Medicine (General)
Added to DOAB on : 2018-03-16 11:02:30
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The First World War was the first 'total war'. Its industrial weaponry damaged millions of men and drove whole armies underground into dangerously unhealthy trenches. Many were killed. Many more suffered terrible, life-threatening injuries: wound infections such as gas gangrene and tetanus, exposure to extremes of temperature, emotional trauma and systemic disease. In an effort to alleviate this suffering, tens of thousands of women volunteered to serve as nurses. Of these, some were experienced professionals while others had undergone only minimal training. But regardless of their preparation, they would all gain a unique understanding of the conditions of industrial warfare. Until recently their contributions, both to the saving of lives and to our understanding of warfare, have remained largely hidden from view. By combining biographical research with textual analysis, Nurse writers of the great war opens a window onto their insights into the nature of nursing and the impact of war.

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