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Molecular mechanisms for reprogramming hippocampal development and function by early-life stress

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198061 Year: Pages: 100 DOI: 10.3389/978-2-88919-806-1 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Abstract

The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive clinical and preclinical evidence has shown that traumatic events early in life have profound and persistent effects on hippocampal function and behavior. This research topic focuses on the acute and lasting effects of early-life stress on various developmental processes in the hippocampus, and aims to uncover the molecules that are responsible for early-life stress-programmed effects and underlie resilience or vulnerability to stress-related neuropsychiatric disorders later in life. We hope the articles in this research topic will provide novel insights and stimulate future studies on the mechanisms of early-life stress and brain development.

Frontiers in Synaptic Plasticity: Dendritic Spines, Circuitries and Behavior

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199471 Year: Pages: 109 DOI: 10.3389/978-2-88919-947-1 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Psychiatry --- Science (General) --- Neurology
Added to DOAB on : 2016-01-19 14:05:46
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The term “synaptic plasticity” is a broad concept, which is studied with a variety of experimental approaches. One focus is the impact of changes in synaptic, neuronal and glial morphology on brain circuitry and behavior. In this regard, unique animal models have been key to the study of affective and social behaviors and neurological and psychiatric diseases. However, there is a paucity of compilations directed toward the correlation of alterations in synaptic structure with various physiological and behavioral paradigms. This Frontiers Research Topic will, therefore, serve as an exciting forum for the exchange of novel hypotheses and data and an important resource and reference for investigators studying synaptic and brain plasticity, as well as those in related fields.

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2016 (2)